trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Liao HF et al. | Dnmt3l-knockout donor cells improve somatic cell nuclear transfer reprogramming efficiency. | 2015 | Reproduction | pmid:26159833 |
| Vadie N et al. | MYCNOS functions as an antisense RNA regulating MYCN. | 2015 | RNA Biol | pmid:26156430 |
| Ota C et al. | Histone deacetylase inhibitor restores surfactant protein-C expression in alveolar-epithelial type II cells and attenuates bleomycin-induced pulmonary fibrosis in vivo. | 2015 | Exp. Lung Res. | pmid:26151196 |
| Singh AK et al. | Evaluation of Epigenetic Drug Targeting of Heterogenous Tumor Cell Fractions Using Potential Biomarkers of Response in Ovarian Cancer. | 2015 | Clin. Cancer Res. | pmid:26130461 |
| Lee YR et al. | Extracellularly secreted APE1/Ref-1 triggers apoptosis in triple-negative breast cancer cells via RAGE binding, which is mediated through acetylation. | 2015 | Oncotarget | pmid:26125438 |
| Thangavel J et al. | Epigenetic modifiers reduce inflammation and modulate macrophage phenotype during endotoxemia-induced acute lung injury. | 2015 | J. Cell. Sci. | pmid:26116574 |
| Kanasaki H et al. | Trichostatin A reduces GnRH mRNA expression with a concomitant increase in retinaldehyde dehydrogenase in GnRH-producing neurons. | 2015 | Mol. Cell. Endocrinol. | pmid:26116234 |
| Dupré-Aucouturier S et al. | Trichostatin A, a histone deacetylase inhibitor, modulates unloaded-induced skeletal muscle atrophy. | 2015 | J. Appl. Physiol. | pmid:26112243 |
| Brandão FA et al. | Histone deacetylases inhibitors effects on Cryptococcus neoformans major virulence phenotypes. | 2015 | Virulence | pmid:26103530 |
| Liu J et al. | Trichostatin A suppresses lung adenocarcinoma development in Grg1 overexpressing transgenic mice. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26086099 |
| Huang J et al. | Trichostatin A reduces cisplatin-induced ototoxicity through the STAT6 signaling pathway. | 2015 | Int. J. Mol. Med. | pmid:26080623 |
| Huan Y et al. | Epigenetic Modification Agents Improve Gene-Specific Methylation Reprogramming in Porcine Cloned Embryos. | 2015 | PLoS ONE | pmid:26068219 |
| Huan Y et al. | Epigenetic Modification of Cloned Embryos Improves Nanog Reprogramming in Pigs. | 2015 | Cell Reprogram | pmid:26053519 |
| Iancu-Rubin C and Hoffman R | Role of epigenetic reprogramming in hematopoietic stem cell function. | 2015 | Curr. Opin. Hematol. | pmid:26049747 |
| Kaldre D et al. | Optimization of histone deacetylase inhibitor activity in non-secosteroidal vitamin D-receptor agonist hybrids. | 2015 | Bioorg. Med. Chem. | pmid:26048026 |
| Liu Y and Li S | A Cell Culture Model of Latent and Lytic Herpes Simplex Virus Type 1 Infection in Spiral Ganglion. | 2015 | ORL J. Otorhinolaryngol. Relat. Spec. | pmid:26022499 |
| Jost JO et al. | A miniaturized readout strategy for endogenous histone deacetylase activity. | 2015 | Mol Biosyst | pmid:26009008 |
| Singh RD et al. | Arsenic exposure causes epigenetic dysregulation of IL-8 expression leading to proneoplastic changes in kidney cells. | 2015 | Toxicol. Lett. | pmid:26008221 |
| Koppaka V et al. | Effect of HDAC Inhibitors on Corneal Keratocyte Mechanical Phenotypes in 3-D Collagen Matrices. | 2015 | Mol. Vis. | pmid:25999677 |
| Ukaegbu UE et al. | A Unique Virulence Gene Occupies a Principal Position in Immune Evasion by the Malaria Parasite Plasmodium falciparum. | 2015 | PLoS Genet. | pmid:25993442 |