Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Kumar KS et al. | Histone deacetylase inhibitors induce cell death in supratentorial primitive neuroectodermal tumor cells. | 2006 | Oncol. Rep. | pmid:17016591 |
Wee G et al. | Inheritable histone H4 acetylation of somatic chromatins in cloned embryos. | 2006 | J. Biol. Chem. | pmid:16371357 |
Alao JP et al. | Role of glycogen synthase kinase 3 beta (GSK3beta) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells. | 2006 | Mol. Cancer | pmid:17018141 |
Hsu MC et al. | HER-2/neu represses the metastasis suppressor RECK via ERK and Sp transcription factors to promote cell invasion. | 2006 | J. Biol. Chem. | pmid:16377629 |
Zhao LY et al. | An EBF3-mediated transcriptional program that induces cell cycle arrest and apoptosis. | 2006 | Cancer Res. | pmid:17018599 |
Majumder S et al. | Epigenetic regulation of metallothionein-i gene expression: differential regulation of methylated and unmethylated promoters by DNA methyltransferases and methyl CpG binding proteins. | 2006 | J. Cell. Biochem. | pmid:16329111 |
Kurschat P et al. | Neuron restrictive silencer factor NRSF/REST is a transcriptional repressor of neuropilin-1 and diminishes the ability of semaphorin 3A to inhibit keratinocyte migration. | 2006 | J. Biol. Chem. | pmid:16330548 |
Zhou H et al. | Epigenetic allele silencing unveils recessive RYR1 mutations in core myopathies. | 2006 | Am. J. Hum. Genet. | pmid:17033962 |
Suzuki M et al. | Site-specific DNA methylation by a complex of PU.1 and Dnmt3a/b. | 2006 | Oncogene | pmid:16331260 |
Ooi L et al. | BRG1 chromatin remodeling activity is required for efficient chromatin binding by repressor element 1-silencing transcription factor (REST) and facilitates REST-mediated repression. | 2006 | J. Biol. Chem. | pmid:17023429 |
Fan J et al. | [Expression of ER alpha in chemically induced MDA-MB-435 cells and its responsiveness to endocrine]. | 2006 | Zhonghua Zhong Liu Za Zhi | pmid:17533736 |
Gaymes TJ et al. | Histone deacetylase inhibitors (HDI) cause DNA damage in leukemia cells: a mechanism for leukemia-specific HDI-dependent apoptosis? | 2006 | Mol. Cancer Res. | pmid:16877702 |
Malone CS et al. | B29 gene silencing in pituitary cells is regulated by its 3' enhancer. | 2006 | J. Mol. Biol. | pmid:16920149 |
Herman D et al. | Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. | 2006 | Nat. Chem. Biol. | pmid:16921367 |
Topark-Ngarm A et al. | CTIP2 associates with the NuRD complex on the promoter of p57KIP2, a newly identified CTIP2 target gene. | 2006 | J. Biol. Chem. | pmid:16950772 |
Li Y et al. | A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity. | 2006 | Genes Dev. | pmid:16980585 |
Minetti GC et al. | Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors. | 2006 | Nat. Med. | pmid:16980968 |
Solomon JM et al. | Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. | 2006 | Mol. Cell. Biol. | pmid:16354677 |
Kishigami S et al. | Significant improvement of mouse cloning technique by treatment with trichostatin A after somatic nuclear transfer. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16356478 |
Hishikawa K and Fujita T | [Basic research for renal regeneration]. | 2006 | Nippon Rinsho | pmid:16895225 |
Baek SY et al. | Trichostatin A increases the thermosensitivity of human glioblastoma A172 cells. | 2006 | Neurosci. Lett. | pmid:16384639 |
Meisel A et al. | Inhibition of histone deacetylation protects wild-type but not gelsolin-deficient neurons from oxygen/glucose deprivation. | 2006 | J. Neurochem. | pmid:16895577 |
Bates EA et al. | Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity. | 2006 | J. Neurosci. | pmid:16525063 |
Chuang HC et al. | Histone deacetylase 3 binds to and regulates the GCMa transcription factor. | 2006 | Nucleic Acids Res. | pmid:16528103 |
Hsiao CH et al. | Fetal hemoglobin induction by histone deacetylase inhibitors involves generation of reactive oxygen species. | 2006 | Exp. Hematol. | pmid:16543060 |
Yamamoto G et al. | Correlation of invasion and metastasis of cancer cells, and expression of the RAD21 gene in oral squamous cell carcinoma. | 2006 | Virchows Arch. | pmid:16416296 |
Yang QC et al. | Inhibition of hypoxia-induced angiogenesis by trichostatin A via suppression of HIF-1a activity in human osteosarcoma. | 2006 | J. Exp. Clin. Cancer Res. | pmid:17310851 |
D'Andrea M et al. | Protein kinase C theta co-operates with calcineurin in the activation of slow muscle genes in cultured myogenic cells. | 2006 | J. Cell. Physiol. | pmid:16419034 |
Akiyama T et al. | Inadequate histone deacetylation during oocyte meiosis causes aneuploidy and embryo death in mice. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16651529 |
Hernandez M et al. | A histone deacetylation-dependent mechanism for transcriptional repression of the gap junction gene cx43 in prostate cancer cells. | 2006 | Prostate | pmid:16652385 |
Uchida H et al. | Human endometrial cytodifferentiation by histone deacetylase inhibitors. | 2006 | Hum. Cell | pmid:16643606 |
Peng C et al. | The transcriptional regulation role of BRD7 by binding to acetylated histone through bromodomain. | 2006 | J. Cell. Biochem. | pmid:16265664 |
Mori T et al. | Estrogen receptor-alpha methylation predicts melanoma progression. | 2006 | Cancer Res. | pmid:16818643 |
Sato K et al. | Deficient expression of the DPD gene is caused by epigenetic modification in biliary tract cancer cells, and induces high sensitivity to 5-FU treatment. | 2006 | Int. J. Oncol. | pmid:16820886 |
Tsuji H et al. | Dynamic and reversible changes in histone H3-Lys4 methylation and H3 acetylation occurring at submergence-inducible genes in rice. | 2006 | Plant Cell Physiol. | pmid:16774928 |
Kwon O et al. | NF-kappaB inhibition increases chemosensitivity to trichostatin A-induced cell death of Ki-Ras-transformed human prostate epithelial cells. | 2006 | Carcinogenesis | pmid:16774937 |
Zhao YM et al. | Effects of histone deacetylase inhibitors on transcriptional regulation of the hsp70 gene in Drosophila. | 2006 | Cell Res. | pmid:16775628 |
Sharma D et al. | Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctive corepressor complexes. | 2006 | Cancer Res. | pmid:16778215 |
Sato TA and Mitchell MD | Molecular inhibition of histone deacetylation results in major enhancement of the production of IL-1beta in response to LPS. | 2006 | Am. J. Physiol. Endocrinol. Metab. | pmid:16234266 |
Wu Y and Guo SW | Inhibition of proliferation of endometrial stromal cells by trichostatin A, RU486, CDB-2914, N-acetylcysteine, and ICI 182780. | 2006 | Gynecol. Obstet. Invest. | pmid:16778450 |
Iacomino G et al. | Effects of histone deacetylase inhibitors on p55CDC/Cdc20 expression in HT29 cell line. | 2006 | J. Cell. Biochem. | pmid:16795040 |
Vanniasinkam T et al. | Trichostatin-A enhances adaptive immune responses to DNA vaccination. | 2006 | J. Clin. Virol. | pmid:16765083 |
Li GC et al. | Histone deacetylase inhibitor trichostatin A inhibits the growth of bladder cancer cells through induction of p21WAF1 and G1 cell cycle arrest. | 2006 | Int. J. Urol. | pmid:16771729 |
Zhou C et al. | Inhibition of EGFR/PI3K/AKT cell survival pathway promotes TSA's effect on cell death and migration in human ovarian cancer cells. | 2006 | Int. J. Oncol. | pmid:16773209 |
Lu Z et al. | E2F-HDAC complexes negatively regulate the tumor suppressor gene ARHI in breast cancer. | 2006 | Oncogene | pmid:16158053 |
Hwang DY and Ismail-Beigi F | Control of Glut1 promoter activity under basal conditions and in response to hyperosmolarity: role of Sp1. | 2006 | Am. J. Physiol., Cell Physiol. | pmid:16162661 |
Sestáková B and Vachtenheim J | Distinct co-regulation of endogenous versus transfected MITF-dependent tyrosinase promoter. | 2006 | Folia Biol. (Praha) | pmid:17116288 |
El-Zawahry A et al. | In vitro efficacy of AdTRAIL gene therapy of bladder cancer is enhanced by trichostatin A-mediated restoration of CAR expression and downregulation of cFLIP and Bcl-XL. | 2006 | Cancer Gene Ther. | pmid:16167063 |
Yu Z and Kone BC | Targeted histone H4 acetylation via phosphoinositide 3-kinase- and p70s6-kinase-dependent pathways inhibits iNOS induction in mesangial cells. | 2006 | Am. J. Physiol. Renal Physiol. | pmid:16174862 |
Lee JH et al. | Histone deacetylase inhibitor enhances 5-fluorouracil cytotoxicity by down-regulating thymidylate synthase in human cancer cells. | 2006 | Mol. Cancer Ther. | pmid:17172411 |
Kozłowska A and Jagodziński PP | Effect of Trichostatin A on CD4 surface density in peripheral blood T cells. | 2006 | Folia Histochem. Cytobiol. | pmid:17219719 |
He J et al. | Effects of trichostatin A on HDAC8 expression, proliferation and cell cycle of Molt-4 cells. | 2006 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:17219959 |
Liu H et al. | Trichostatin A regulates hGCN5 expression and cell cycle on Daudi cells in vitro. | 2006 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:17219960 |
Sun C et al. | Anticancer activities of trichostatin A on maligant lymphoid cells. | 2006 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:17219961 |
Ryu JK et al. | SK-7041, a new histone deacetylase inhibitor, induces G2-M cell cycle arrest and apoptosis in pancreatic cancer cell lines. | 2006 | Cancer Lett. | pmid:16009488 |
Wang Q et al. | Histone phosphorylation and pericentromeric histone modifications in oocyte meiosis. | 2006 | Cell Cycle | pmid:16969090 |
Karvonen U et al. | Androgen receptor regulates nuclear trafficking and nuclear domain residency of corepressor HDAC7 in a ligand-dependent fashion. | 2006 | Exp. Cell Res. | pmid:16860317 |
Wagner S et al. | SET-mediated promoter hypoacetylation is a prerequisite for coactivation of the estrogen-responsive pS2 gene by PRMT1. | 2006 | J. Biol. Chem. | pmid:16861234 |
Zhang X et al. | Histone deacetylase inhibitor, trichostatin A, increases the chemosensitivity of anticancer drugs in gastric cancer cell lines. | 2006 | Oncol. Rep. | pmid:16865256 |
Villanueva R et al. | Histone deacetylase 3 represses HTLV-1 tax transcription. | 2006 | Oncol. Rep. | pmid:16865259 |
van den Boom J et al. | Identification of novel genes associated with astrocytoma progression using suppression subtractive hybridization and real-time reverse transcription-polymerase chain reaction. | 2006 | Int. J. Cancer | pmid:16865689 |
Das PM et al. | Methylation mediated silencing of TMS1/ASC gene in prostate cancer. | 2006 | Mol. Cancer | pmid:16848908 |
Puppin C et al. | HEX expression and localization in normal mammary gland and breast carcinoma. | 2006 | BMC Cancer | pmid:16854221 |
Dannenberg LO and Edenberg HJ | Epigenetics of gene expression in human hepatoma cells: expression profiling the response to inhibition of DNA methylation and histone deacetylation. | 2006 | BMC Genomics | pmid:16854234 |
Bell CW et al. | The extracellular release of HMGB1 during apoptotic cell death. | 2006 | Am. J. Physiol., Cell Physiol. | pmid:16855214 |
Olaharski AJ et al. | The histone deacetylase inhibitor trichostatin a has genotoxic effects in human lymphoblasts in vitro. | 2006 | Toxicol. Sci. | pmid:16857700 |
Lund P et al. | Oncogenic HRAS suppresses clusterin expression through promoter hypermethylation. | 2006 | Oncogene | pmid:16568090 |
Piacentini P et al. | Trichostatin A enhances the response of chemotherapeutic agents in inhibiting pancreatic cancer cell proliferation. | 2006 | Virchows Arch. | pmid:16568310 |
Alao JP et al. | The cyclin D1 proto-oncogene is sequestered in the cytoplasm of mammalian cancer cell lines. | 2006 | Mol. Cancer | pmid:16503970 |
Alao JP et al. | Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells. | 2006 | Mol. Cancer | pmid:16504004 |
Ostapkowicz A et al. | Lipid rafts remodeling in estrogen receptor-negative breast cancer is reversed by histone deacetylase inhibitor. | 2006 | Mol. Cancer Ther. | pmid:16505096 |
Hellebrekers DM et al. | Angiostatic activity of DNA methyltransferase inhibitors. | 2006 | Mol. Cancer Ther. | pmid:16505122 |
Kong X et al. | Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha. | 2006 | Mol. Cell. Biol. | pmid:16507982 |
Araki H et al. | Expansion of human umbilical cord blood SCID-repopulating cells using chromatin-modifying agents. | 2006 | Exp. Hematol. | pmid:16459182 |
Sonnemann J et al. | Histone deacetylase inhibitors induce cell death and enhance the susceptibility to ionizing radiation, etoposide, and TRAIL in medulloblastoma cells. | 2006 | Int. J. Oncol. | pmid:16465382 |
Kwon HS et al. | Retinoic acids and trichostatin A (TSA), a histone deacetylase inhibitor, induce human pyruvate dehydrogenase kinase 4 (PDK4) gene expression. | 2006 Mar-Apr | Biochim. Biophys. Acta | pmid:16757381 |
Turaga RV et al. | Werner syndrome protein prevents DNA breaks upon chromatin structure alteration. | 2007 | Aging Cell | pmid:17521388 |
Wu J et al. | Diverse histone modifications on histone 3 lysine 9 and their relation to DNA methylation in specifying gene silencing. | 2007 | BMC Genomics | pmid:17524140 |
Uchida H et al. | Histone deacetylase inhibitors stimulate cell migration in human endometrial adenocarcinoma cells through up-regulation of glycodelin. | 2007 | Endocrinology | pmid:17068141 |
Roy S and Tenniswood M | Site-specific acetylation of p53 directs selective transcription complex assembly. | 2007 | J. Biol. Chem. | pmid:17121856 |
Mayo C et al. | In vitro differentiation of HT-29 M6 mucus-secreting colon cancer cells involves a trychostatin A and p27(KIP1)-inducible transcriptional program of gene expression. | 2007 | J. Cell. Physiol. | pmid:17311291 |
Avila AM et al. | Trichostatin A increases SMN expression and survival in a mouse model of spinal muscular atrophy. | 2007 | J. Clin. Invest. | pmid:17318264 |
Snykers S et al. | Chromatin remodeling agent trichostatin A: a key-factor in the hepatic differentiation of human mesenchymal stem cells derived of adult bone marrow. | 2007 | BMC Dev. Biol. | pmid:17407549 |
Zhao Y et al. | Roles of histone acetylation modification in basal and inducible expression of hsp26 gene in D. melanogaster. | 2007 | Mol. Cell. Biochem. | pmid:17619947 |
El-Khoury V et al. | The histone deacetylase inhibitor trichostatin A downregulates human MDR1 (ABCB1) gene expression by a transcription-dependent mechanism in a drug-resistant small cell lung carcinoma cell line model. | 2007 | Br. J. Cancer | pmid:17667922 |
Khaw AK et al. | Inhibition of telomerase activity and human telomerase reverse transcriptase gene expression by histone deacetylase inhibitor in human brain cancer cells. | 2007 | Mutat. Res. | pmid:17669439 |
Rouhi A et al. | Plasticity of Ly49g expression is due to epigenetics. | 2007 | Mol. Immunol. | pmid:16750269 |
Yoshida M | [Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A]. | 2007 | Tanpakushitsu Kakusan Koso | pmid:18051427 |
Kenneth NS et al. | TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcription. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17848523 |
Ferreira R et al. | Site-specific acetylation of ISWI by GCN5. | 2007 | BMC Mol. Biol. | pmid:17760996 |
Ting CH et al. | Stat5 constitutive activation rescues defects in spinal muscular atrophy. | 2007 | Hum. Mol. Genet. | pmid:17220171 |
McCool KW et al. | The role of histone acetylation in regulating early gene expression patterns during early embryonic stem cell differentiation. | 2007 | J. Biol. Chem. | pmid:17204470 |
Bártová E et al. | Differentiation-specific association of HP1alpha and HP1beta with chromocentres is correlated with clustering of TIF1beta at these sites. | 2007 | Histochem. Cell Biol. | pmid:17205308 |
Zhang Y et al. | An epigenetic modifier results in improved in vitro blastocyst production after somatic cell nuclear transfer. | 2007 | Cloning Stem Cells | pmid:17907946 |
Noro R et al. | PTEN inactivation in lung cancer cells and the effect of its recovery on treatment with epidermal growth factor receptor tyrosine kinase inhibitors. | 2007 | Int. J. Oncol. | pmid:17912443 |
Alimirah F et al. | IFI16 in human prostate cancer. | 2007 | Mol. Cancer Res. | pmid:17339605 |
Wu Y and Guo SW | Suppression of IL-1beta-induced COX-2 expression by trichostatin A (TSA) in human endometrial stromal cells. | 2007 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:17296257 |
Cao D et al. | COX-2 expression induced by diesel particles involves chromatin modification and degradation of HDAC1. | 2007 | Am. J. Respir. Cell Mol. Biol. | pmid:17395887 |
Shivashimpi GM et al. | Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. | 2007 | Bioorg. Med. Chem. | pmid:17881232 |
Terry-Allison T et al. | Relaxed repression of herpes simplex virus type 1 genomes in Murine trigeminal neurons. | 2007 | J. Virol. | pmid:17855552 |