Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Huang N et al. | Inhibition of IL-8 gene expression in Caco-2 cells by compounds which induce histone hyperacetylation. | 1997 | Cytokine | pmid:9067093 |
Stein P et al. | Stage-dependent redistributions of acetylated histones in nuclei of the early preimplantation mouse embryo. | 1997 | Mol. Reprod. Dev. | pmid:9211426 |
Sommer A et al. | Cell growth inhibition by the Mad/Max complex through recruitment of histone deacetylase activity. | 1997 | Curr. Biol. | pmid:9197243 |
Jenster G et al. | Steroid receptor induction of gene transcription: a two-step model. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9223281 |
Nagy L et al. | Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. | 1997 | Cell | pmid:9150137 |
Lee E et al. | Involvement of histone hyperacetylation in triggering DNA fragmentation of rat thymocytes undergoing apoptosis. | 1996 | FEBS Lett. | pmid:8898091 |
Taunton J et al. | A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. | 1996 | Science | pmid:8602529 |
Van Lint C et al. | Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation. | 1996 | EMBO J. | pmid:8605881 |
Carmen AA et al. | HDA1 and HDA3 are components of a yeast histone deacetylase (HDA) complex. | 1996 | J. Biol. Chem. | pmid:8663039 |
Van Lint C et al. | The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation. | 1996 | Gene Expr. | pmid:8723390 |
Takahashi I et al. | Selective inhibition of IL-2 gene expression by trichostatin A, a potent inhibitor of mammalian histone deacetylase. | 1996 | J. Antibiot. | pmid:8682722 |
Zhang J et al. | Basis for the loss of aryl hydrocarbon receptor gene expression in clones of a mouse hepatoma cell line. | 1996 | Mol. Pharmacol. | pmid:8967965 |
Yoshida M | [Molecular targets of cell cycle inhibitors and their mode of action]. | 1996 | Tanpakushitsu Kakusan Koso | pmid:8890633 |
Sano M and Kitajima S | Inhibition of the nerve growth factor-induced outgrowth of neurites by trichostatin A requires protein synthesis de novo in PC12D cells. | 1996 | Brain Res. | pmid:9117395 |
Bartsch J et al. | Moderate increase in histone acetylation activates the mouse mammary tumor virus promoter and remodels its nucleosome structure. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8855250 |
Ogryzko VV et al. | Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent. | 1996 | Mol. Cell. Biol. | pmid:8756678 |
Yamamoto I et al. | Histone hyperacetylation plays a role in augmentation of IL-4-induced IgE production in LPS-stimulated murine B-lymphocytes by sodium butyrate. | 1996 | J. Biochem. | pmid:8827437 |
Thompson EM et al. | Real time imaging of transcriptional activity in live mouse preimplantation embryos using a secreted luciferase. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7877974 |
Futamura M et al. | Trichostatin A inhibits both ras-induced neurite outgrowth of PC12 cells and morphological transformation of NIH3T3 cells. | 1995 | Oncogene | pmid:7700637 |
Yoshida M et al. | Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function. | 1995 | Bioessays | pmid:7786288 |