Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Chen Z et al. | Promotion of Metastasis-associated Gene Expression in Survived PANC-1 Cells Following Trichostatin A Treatment. | 2015 | Anticancer Agents Med Chem | pmid:25991546 |
Mukhopadhyay NK et al. | Effectiveness of trichostatin A as a potential candidate for anticancer therapy in non-small-cell lung cancer. | 2006 | Ann. Thorac. Surg. | pmid:16488717 |
Swanson S | Invited commentary. | 2006 | Ann. Thorac. Surg. | pmid:16488718 |
Liu S et al. | Up-regulation of miR-182 expression after epigenetic modulation of human melanoma cells. | 2013 | Ann. Surg. Oncol. | pmid:22752337 |
Grabiec AM et al. | Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay. | 2012 | Ann. Rheum. Dis. | pmid:21953341 |
Iliopoulos D et al. | Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention. | 2007 | Ann. Rheum. Dis. | pmid:17502362 |
Jüngel A et al. | Trichostatin A sensitises rheumatoid arthritis synovial fibroblasts for TRAIL-induced apoptosis. | 2006 | Ann. Rheum. Dis. | pmid:16284094 |
Li RJ et al. | Down-regulation of mitochondrial ATPase by hypermethylation mechanism in chronic myeloid leukemia is associated with multidrug resistance. | 2010 | Ann. Oncol. | pmid:20038517 |
Narver HL et al. | Sustained improvement of spinal muscular atrophy mice treated with trichostatin A plus nutrition. | 2008 | Ann. Neurol. | pmid:18661558 |
Boutillier AL et al. | Constitutive repression of E2F1 transcriptional activity through HDAC proteins is essential for neuronal survival. | 2002 | Ann. N. Y. Acad. Sci. | pmid:12485907 |
Tian F et al. | Effects of histone deacetylase inhibitor Trichostatin A on epigenetic changes and transcriptional activation of Bdnf promoter 1 by rat hippocampal neurons. | 2010 | Ann. N. Y. Acad. Sci. | pmid:20633124 |
Parekh-Olmedo H et al. | The effect of hydroxyurea and trichostatin a on targeted nucleotide exchange in yeast and Mammalian cells. | 2003 | Ann. N. Y. Acad. Sci. | pmid:14751821 |
Williams PJ et al. | HDAC inhibitor trichostatin A suppresses osteoclastogenesis by upregulating the expression of C/EBP-β and MKP-1. | 2011 | Ann. N. Y. Acad. Sci. | pmid:22172035 |
Sourlingas TG et al. | Effect of the histone deacetylase inhibitor trichostatin a in human peripheral blood lymphocytes as a function of donor age. | 2007 | Ann. N. Y. Acad. Sci. | pmid:18056955 |
Yoshida M and Horinouchi S | Trichostatin and leptomycin. Inhibition of histone deacetylation and signal-dependent nuclear export. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10667200 |
Marsili G et al. | Role of acetylases and deacetylase inhibitors in IRF-1-mediated HIV-1 long terminal repeat transcription. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15659847 |
Sowa Y et al. | Histone deacetylase inhibitor activates the p21/WAF1/Cip1 gene promoter through the Sp1 sites. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10667218 |
Kim YB et al. | Selective induction of cyclin-dependent kinase inhibitors and their roles in cell cycle arrest caused by trichostatin A, an inhibitor of histone deacetylase. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10667219 |
Kraus J | Expression and functions of μ-opioid receptors and cannabinoid receptors type 1 in T lymphocytes. | 2012 | Ann. N. Y. Acad. Sci. | pmid:22823387 |
Yasui W et al. | Histone acetylation and gastrointestinal carcinogenesis. | 2003 | Ann. N. Y. Acad. Sci. | pmid:12724227 |
Wittayarat M et al. | Epigenetic modulation on cat-cow interspecies somatic cell nuclear transfer embryos by treatment with trichostatin A. | 2017 | Anim. Sci. J. | pmid:27506538 |
Cong P et al. | Effects of trichostatin A on histone acetylation and methylation characteristics in early porcine embryos after somatic cell nuclear transfer. | 2013 | Anim. Sci. J. | pmid:23607426 |
Himaki T et al. | Effects of trichostatin A on in vitro development and transgene function in somatic cell nuclear transfer embryos derived from transgenic Clawn miniature pig cells. | 2010 | Anim. Sci. J. | pmid:20887307 |
BurlibaÅŸa L and Zarnescu O | In vivo effects of Trichostatin A - A histone deacetylase inhibitor - On chromatin remodeling during Triturus cristatus spermatogenesis. | 2013 | Anim. Reprod. Sci. | pmid:24100069 |
Wu X et al. | Trichostatin A improved epigenetic modifications of transfected cells but did not improve subsequent cloned embryo development. | 2008 | Anim. Biotechnol. | pmid:18855246 |
Rebbaa A et al. | Novel function of the thyroid hormone analog tetraiodothyroacetic acid: a cancer chemosensitizing and anti-cancer agent. | 2008 | Angiogenesis | pmid:18386142 |
Xu T and Hu X | Copper-catalyzed 1,2-addition of α-carbonyl iodides to alkynes. | 2015 | Angew. Chem. Int. Ed. Engl. | pmid:25470461 |
Kim JY et al. | Probing lysine acetylation with a modification-specific marker ion using high-performance liquid chromatography/electrospray-mass spectrometry with collision-induced dissociation. | 2002 | Anal. Chem. | pmid:12433071 |
Zhang F et al. | Assessment of the effect of trichostatin A on HeLa cells through FT-IR spectroscopy. | 2015 | Anal. Chem. | pmid:25602746 |
Mackay CL et al. | Sensitive, specific, and quantitative FTICR mass spectrometry of combinatorial post-translational modifications in intact histone H4. | 2008 | Anal. Chem. | pmid:18457408 |
Zhang F et al. | Histone Acetylation Induced Transformation of B-DNA to Z-DNA in Cells Probed through FT-IR Spectroscopy. | 2016 | Anal. Chem. | pmid:27046421 |
Heltweg B and Jung M | A microplate reader-based nonisotopic histone deacetylase activity assay. | 2002 | Anal. Biochem. | pmid:11878795 |
Wegener D et al. | Improved fluorogenic histone deacetylase assay for high-throughput-screening applications. | 2003 | Anal. Biochem. | pmid:14511685 |
Marshall S et al. | Enhanced expression of uridine diphosphate-N-acetylglucosaminyl transferase (OGT) in a stable, tetracycline-inducible HeLa cell line using histone deacetylase inhibitors: kinetics of cytosolic OGT accumulation and nuclear translocation. | 2003 | Anal. Biochem. | pmid:12871726 |
Marengo E et al. | Identification of the regulatory proteins in human pancreatic cancers treated with Trichostatin A by 2D-PAGE maps and multivariate statistical analysis. | 2004 | Anal Bioanal Chem | pmid:15257427 |
Tian F et al. | NMDA receptor activation induces differential epigenetic modification of Bdnf promoters in hippocampal neurons. | 2010 | Amino Acids | pmid:19565326 |
Kicic A et al. | Decreased fibronectin production significantly contributes to dysregulated repair of asthmatic epithelium. | 2010 | Am. J. Respir. Crit. Care Med. | pmid:20110557 |
Bogaard HJ et al. | Suppression of histone deacetylases worsens right ventricular dysfunction after pulmonary artery banding in rats. | 2011 | Am. J. Respir. Crit. Care Med. | pmid:21297075 |
Zelko IN and Folz RJ | Regulation of Oxidative Stress in Pulmonary Artery Endothelium. Modulation of Extracellular Superoxide Dismutase and NOX4 Expression Using Histone Deacetylase Class I Inhibitors. | 2015 | Am. J. Respir. Cell Mol. Biol. | pmid:25749103 |
Koch A et al. | Mitogen-activated protein kinase modulation of nuclear factor-kappaB-induced granulocyte macrophage-colony-stimulating factor release from human alveolar macrophages. | 2004 | Am. J. Respir. Cell Mol. Biol. | pmid:12871851 |
Banerjee A et al. | Trichostatin A abrogates airway constriction, but not inflammation, in murine and human asthma models. | 2012 | Am. J. Respir. Cell Mol. Biol. | pmid:22298527 |
Sanders YY et al. | Epigenetic regulation of thy-1 by histone deacetylase inhibitor in rat lung fibroblasts. | 2011 | Am. J. Respir. Cell Mol. Biol. | pmid:20724553 |
Zelko IN et al. | Histone acetylation regulates the cell-specific and interferon-γ-inducible expression of extracellular superoxide dismutase in human pulmonary arteries. | 2011 | Am. J. Respir. Cell Mol. Biol. | pmid:21493784 |
Meja KK et al. | Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2. | 2008 | Am. J. Respir. Cell Mol. Biol. | pmid:18421014 |
Kim H et al. | The heparan sulfate proteoglycan GPC3 is a potential lung tumor suppressor. | 2003 | Am. J. Respir. Cell Mol. Biol. | pmid:12816733 |
Cao D et al. | COX-2 expression induced by diesel particles involves chromatin modification and degradation of HDAC1. | 2007 | Am. J. Respir. Cell Mol. Biol. | pmid:17395887 |
Sathe A et al. | MicroRNA let-7f: a novel regulator of innate immune response in human endocervical cells. | 2014 | Am. J. Reprod. Immunol. | pmid:24405266 |
Gill RK et al. | Regulation of intestinal serotonin transporter expression via epigenetic mechanisms: role of HDAC2. | 2013 | Am. J. Physiol., Cell Physiol. | pmid:23195070 |
Lu SC et al. | The essential role of Oct-2 in LPS-induced expression of iNOS in RAW 264.7 macrophages and its regulation by trichostatin A. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19279235 |
Zampetaki A et al. | Lacking cytokine production in ES cells and ES-cell-derived vascular cells stimulated by TNF-alpha is rescued by HDAC inhibitor trichostatin A. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17626239 |