Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Boutillier AL et al. | Selective E2F-dependent gene transcription is controlled by histone deacetylase activity during neuronal apoptosis. | 2003 | J. Neurochem. | pmid:12562525 |
Tomita K et al. | The effect of oxidative stress on histone acetylation and IL-8 release. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12565901 |
Kim Y et al. | Decreased syndecan-2 expression correlates with trichostatin-A induced-morphological changes and reduced tumorigenic activity in colon carcinoma cells. | 2003 | Oncogene | pmid:12584561 |
Mishra N et al. | Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse. | 2003 | J. Clin. Invest. | pmid:12588892 |
Glaser KB et al. | Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines. | 2003 | Mol. Cancer Ther. | pmid:12589032 |
Ailenberg M and Silverman M | Differential effects of trichostatin A on gelatinase A expression in 3T3 fibroblasts and HT-1080 fibrosarcoma cells: implications for use of TSA in cancer therapy. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12604329 |
Sakai N et al. | Involvement of histone acetylation in ovarian steroid-induced decidualization of human endometrial stromal cells. | 2003 | J. Biol. Chem. | pmid:12609987 |
Kim SY et al. | Glial cell-specific regulation of the JC virus early promoter by histone deacetylase inhibitors. | 2003 | J. Virol. | pmid:12610114 |
Ding Z et al. | Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain. | 2003 | Mol. Cell. Biol. | pmid:12482978 |
Obata T et al. | Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer. | 2003 | Clin. Cancer Res. | pmid:14695142 |
Terui T et al. | Induction of PIG3 and NOXA through acetylation of p53 at 320 and 373 lysine residues as a mechanism for apoptotic cell death by histone deacetylase inhibitors. | 2003 | Cancer Res. | pmid:14695212 |
Liu A et al. | Oligodendrocyte process outgrowth in vitro is modulated by epigenetic regulation of cytoskeletal severing proteins. | 2003 | Glia | pmid:14603467 |
Moreira JM et al. | The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses. | 2003 | BMC Cancer | pmid:14606959 |
Remiszewski SW et al. | N-hydroxy-3-phenyl-2-propenamides as novel inhibitors of human histone deacetylase with in vivo antitumor activity: discovery of (2E)-N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824). | 2003 | J. Med. Chem. | pmid:14521422 |
Noh EJ and Lee JS | Functional interplay between modulation of histone deacetylase activity and its regulatory role in G2-M transition. | 2003 | Biochem. Biophys. Res. Commun. | pmid:14521905 |
Li C et al. | Effect and comparison of sodium butyrate and trichostatin A on the proliferation/differentiation of K562. | 2003 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:14526425 |
Pivot-Pajot C et al. | Acetylation-dependent chromatin reorganization by BRDT, a testis-specific bromodomain-containing protein. | 2003 | Mol. Cell. Biol. | pmid:12861021 |
Grassi G et al. | Inhibitors of DNA methylation and histone deacetylation activate cytomegalovirus promoter-controlled reporter gene expression in human glioblastoma cell line U87. | 2003 | Carcinogenesis | pmid:12869421 |
Ammanamanchi S et al. | Acetylated sp3 is a transcriptional activator. | 2003 | J. Biol. Chem. | pmid:12837748 |
Krämer OH et al. | The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2. | 2003 | EMBO J. | pmid:12840003 |
Adam E et al. | Potentiation of tumor necrosis factor-induced NF-kappa B activation by deacetylase inhibitors is associated with a delayed cytoplasmic reappearance of I kappa B alpha. | 2003 | Mol. Cell. Biol. | pmid:12917341 |
Kishikawa S et al. | Control elements of Dnmt1 gene are regulated in cell-cycle dependent manner. | 2003 | Nucleic Acids Res. Suppl. | pmid:14510503 |
Wegener D et al. | Improved fluorogenic histone deacetylase assay for high-throughput-screening applications. | 2003 | Anal. Biochem. | pmid:14511685 |
Kim MS et al. | Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA. | 2003 | Cancer Res. | pmid:14612526 |
Miller TA et al. | Histone deacetylase inhibitors. | 2003 | J. Med. Chem. | pmid:14613312 |
Hitomi T et al. | p15(INK4b) in HDAC inhibitor-induced growth arrest. | 2003 | FEBS Lett. | pmid:14623092 |
Zhang Q et al. | Inhibition and reversal of nickel-induced transformation by the histone deacetylase inhibitor trichostatin A. | 2003 | Toxicol. Appl. Pharmacol. | pmid:14575637 |
Usenko T et al. | Transient expression of E1A and Ras oncogenes causes downregulation of c-fos gene transcription in nontransformed REF52 cells. | 2003 | Oncogene | pmid:14576829 |
Vasudevan A et al. | Heterocyclic ketones as inhibitors of histone deacetylase. | 2003 | Bioorg. Med. Chem. Lett. | pmid:14592473 |
Chung YL et al. | A therapeutic strategy uses histone deacetylase inhibitors to modulate the expression of genes involved in the pathogenesis of rheumatoid arthritis. | 2003 | Mol. Ther. | pmid:14599803 |
Marks J et al. | Two functionally divergent p53-responsive elements in the rat bradykinin B2 receptor promoter. | 2003 | J. Biol. Chem. | pmid:12791684 |
Marshall S et al. | Enhanced expression of uridine diphosphate-N-acetylglucosaminyl transferase (OGT) in a stable, tetracycline-inducible HeLa cell line using histone deacetylase inhibitors: kinetics of cytosolic OGT accumulation and nuclear translocation. | 2003 | Anal. Biochem. | pmid:12871726 |
Valls E et al. | The SV40 T antigen modulates CBP histone acetyltransferase activity. | 2003 | Nucleic Acids Res. | pmid:12799439 |
Ferguson M et al. | Histone deacetylase inhibition is associated with transcriptional repression of the Hmga2 gene. | 2003 | Nucleic Acids Res. | pmid:12799440 |
Ji Y et al. | A multistep mechanism for the activation of rearrangement in the immune system. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12802019 |
Nemajerová A et al. | Trichostatin A suppresses transformation by the v-myb oncogene in BM2 cells. | 2003 | J. Hematother. Stem Cell Res. | pmid:12804181 |
Park PH et al. | Acetylation of histone H3 at lysine 9 by ethanol in rat hepatocytes. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12804592 |
Kim H et al. | The heparan sulfate proteoglycan GPC3 is a potential lung tumor suppressor. | 2003 | Am. J. Respir. Cell Mol. Biol. | pmid:12816733 |
Klan N et al. | Trichostatin A and structurally related histone deacetylase inhibitors induce 5-lipoxygenase promoter activity. | 2003 | Biol. Chem. | pmid:12817474 |
Yamada Y et al. | Aberrant methylation of the vascular endothelial growth factor receptor-1 gene in prostate cancer. | 2003 | Cancer Sci. | pmid:12824880 |
Enright BP et al. | Epigenetic characteristics and development of embryos cloned from donor cells treated by trichostatin A or 5-aza-2'-deoxycytidine. | 2003 | Biol. Reprod. | pmid:12748129 |
Van Ommeslaeghe K et al. | Amide analogues of TSA: synthesis, binding mode analysis and HDAC inhibition. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12749885 |
Zhao S et al. | Requirement of a specific Sp1 site for histone deacetylase-mediated repression of transforming growth factor beta Type II receptor expression in human pancreatic cancer cells. | 2003 | Cancer Res. | pmid:12750289 |
Schauber J et al. | Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytes: relevance of signalling pathways. | 2003 | Gut | pmid:12692061 |
Rambhatla L et al. | Generation of hepatocyte-like cells from human embryonic stem cells. | 2003 | Cell Transplant | pmid:12693659 |
Lee SC et al. | Activation of terminal B cell differentiation by inhibition of histone deacetylation. | 2003 | Mol. Immunol. | pmid:12695118 |
Chandler SP et al. | Fragile X (CGG)n repeats induce a transcriptional repression in cis upon a linked promoter: evidence for a chromatin mediated effect. | 2003 | BMC Mol. Biol. | pmid:12659659 |
Zika E et al. | Histone deacetylase 1/mSin3A disrupts gamma interferon-induced CIITA function and major histocompatibility complex class II enhanceosome formation. | 2003 | Mol. Cell. Biol. | pmid:12697811 |
Mihaylova VT et al. | Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells. | 2003 | Mol. Cell. Biol. | pmid:12697826 |
Kao GD et al. | Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response. | 2003 | J. Cell Biol. | pmid:12668657 |