trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
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What genes are associated with trichostatin A?
Related references are published most in these journals:
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Arany I et al. | Epigenetic modifiers exert renal toxicity through induction of p66shc. | 2011 | Anticancer Res. | pmid:21965735 |
| Sasaki Y et al. | p53 negatively regulates the hepatoma growth factor HDGF. | 2011 | Cancer Res. | pmid:22006999 |
| Rajak H et al. | 2,5-Disubstituted-1,3,4-oxadiazoles/thiadiazole as surface recognition moiety: design and synthesis of novel hydroxamic acid based histone deacetylase inhibitors. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21875796 |
| He HM et al. | [The effects of a histone deacetylase (HDAC) inhibitor on endotoxin-induced endothelial cell injury]. | 2011 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:22005560 |
| Sanders YY et al. | Epigenetic regulation of thy-1 by histone deacetylase inhibitor in rat lung fibroblasts. | 2011 | Am. J. Respir. Cell Mol. Biol. | pmid:20724553 |
| Gaub P et al. | The histone acetyltransferase p300 promotes intrinsic axonal regeneration. | 2011 | Brain | pmid:21705428 |
| Song K et al. | Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3B1, a novel epithelial-mesenchymal transition inducer in pancreatic cancer. | 2011 | Cancer Biol. Ther. | pmid:21709440 |
| Hauff KD et al. | Mifepristone treatment results in differential regulation of glycerolipid biosynthesis in baby hamster kidney cells expressing a mifepristone-inducible ABCA1. | 2011 | Lipids | pmid:21710238 |
| Zhou S et al. | Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction. | 2011 | Circ. Res. | pmid:21778425 |
| Yoo YE and Ko CP | Treatment with trichostatin A initiated after disease onset delays disease progression and increases survival in a mouse model of amyotrophic lateral sclerosis. | 2011 | Exp. Neurol. | pmid:21712032 |
| Sar P et al. | 3, 3'5 Triiodo L thyronine induces apoptosis in human breast cancer MCF-7 cells, repressing SMP30 expression through negative thyroid response elements. | 2011 | PLoS ONE | pmid:21687737 |
| Cosner CC and Helquist P | Concise, convergent syntheses of (±)-trichostatin A utilizing a Pd-catalyzed ketone enolate α-alkenylation reaction. | 2011 | Org. Lett. | pmid:21688856 |
| Kojima S et al. | Asymmetric leaves2 and Elongator, a histone acetyltransferase complex, mediate the establishment of polarity in leaves of Arabidopsis thaliana. | 2011 | Plant Cell Physiol. | pmid:21700721 |
| Chik CL et al. | Histone modifications on the adrenergic induction of type II deiodinase in rat pinealocytes. | 2011 | Mol. Cell. Endocrinol. | pmid:21704117 |
| Hizaki K et al. | Epigenetic inactivation of calcium-sensing receptor in colorectal carcinogenesis. | 2011 | Mod. Pathol. | pmid:21317879 |
| Zhou X et al. | Trichostatin differentially regulates Th1 and Th2 responses and alleviates rheumatoid arthritis in mice. | 2011 | J. Clin. Immunol. | pmid:21305388 |
| Meli M et al. | Histone deacetylase inhibition modulates deoxyribonucleotide pools and enhances the antitumor effects of the ribonucleotide reductase inhibitor 3'-C-methyladenosine in leukaemia cells. | 2011 | Int. J. Oncol. | pmid:21318222 |
| Turovets N et al. | Human parthenogenetic stem cells produce enriched populations of definitive endoderm cells after trichostatin A pretreatment. | 2011 | Differentiation | pmid:21306817 |
| Xiao J et al. | Discovery, synthesis, and biological evaluation of novel SMN protein modulators. | 2011 | J. Med. Chem. | pmid:21819082 |
| Yang H et al. | Enrichment of Nur77 mediated by retinoic acid receptor β leads to apoptosis of human hepatocellular carcinoma cells induced by fenretinide and histone deacetylase inhibitors. | 2011 | Hepatology | pmid:21319187 |
| Patel T et al. | Chromatin remodeling resets the immune system to protect against autoimmune diabetes in mice. | 2011 | Immunol. Cell Biol. | pmid:21321581 |
| Chaurasia P et al. | Chromatin-modifying agents promote the ex vivo production of functional human erythroid progenitor cells. | 2011 | Blood | pmid:21355088 |
| Shi G et al. | The regulatory role of histone deacetylase inhibitors in Fgf4 expression is dependent on the differentiation state of pluripotent stem cells. | 2011 | J. Cell. Physiol. | pmid:21321941 |
| Furuta K et al. | The CKH2/PKL chromatin remodeling factor negatively regulates cytokinin responses in Arabidopsis calli. | 2011 | Plant Cell Physiol. | pmid:21357580 |
| Fan Y et al. | Derivation of cloned human blastocysts by histone deacetylase inhibitor treatment after somatic cell nuclear transfer with β-thalassemia fibroblasts. | 2011 | Stem Cells Dev. | pmid:21322785 |
| Kim YJ et al. | Comparison of potency between histone deacetylase inhibitors trichostatin A and valproic acid on enhancing in vitro development of porcine somatic cell nuclear transfer embryos. | 2011 | In Vitro Cell. Dev. Biol. Anim. | pmid:21359816 |
| Jang ER et al. | Different effect of protein kinase B/Akt and extracellular signal-regulated kinase inhibition on trichostatin A-induced apoptosis in epithelial ovarian carcinoma cell lines. | 2011 | Mol. Cell. Biochem. | pmid:21380726 |
| Fan T et al. | EZH2-dependent suppression of a cellular senescence phenotype in melanoma cells by inhibition of p21/CDKN1A expression. | 2011 | Mol. Cancer Res. | pmid:21383005 |
| Yang J et al. | [Study of RASSF1A expression and promoter demethylation in Hep-2 cell line]. | 2011 | Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi | pmid:21473137 |
| Dávalos-Salas M et al. | Gain of DNA methylation is enhanced in the absence of CTCF at the human retinoblastoma gene promoter. | 2011 | BMC Cancer | pmid:21663659 |
| El-Serafi AT et al. | Epigenetic modifiers influence lineage commitment of human bone marrow stromal cells: Differential effects of 5-aza-deoxycytidine and trichostatin A. | 2011 | Differentiation | pmid:20970916 |
| Zhang FQ et al. | Cell-cycle-dependent variations in the FTIR spectroscopy of HeLa cells treated with trichostatin A. | 2011 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:22007388 |
| Nagamine MK et al. | In vitro inhibitory effect of trichostatin A on canine grade 3 mast cell tumor. | 2011 | Vet. Res. Commun. | pmid:21472452 |
| Maruoka H et al. | Low-molecular-weight compounds having neurotrophic activity in cultured PC12 cells and neurons. | 2011 | J. Biochem. | pmid:21908547 |
| Li S et al. | Autotaxin is induced by TSA through HDAC3 and HDAC7 inhibition and antagonizes the TSA-induced cell apoptosis. | 2011 | Mol. Cancer | pmid:21314984 |
| Lee MJ et al. | Trichostatin A promotes the development of bovine somatic cell nuclear transfer embryos. | 2011 | J. Reprod. Dev. | pmid:20834196 |
| Sengupta S et al. | Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1. | 2011 | Oncogene | pmid:20856196 |
| Arzenani MK et al. | Genomic DNA hypomethylation by histone deacetylase inhibition implicates DNMT1 nuclear dynamics. | 2011 | Mol. Cell. Biol. | pmid:21791605 |
| Costa VL et al. | TCF21 and PCDH17 methylation: An innovative panel of biomarkers for a simultaneous detection of urological cancers. | 2011 | Epigenetics | pmid:21847011 |
| Akagi S et al. | Treatment with a histone deacetylase inhibitor after nuclear transfer improves the preimplantation development of cloned bovine embryos. | 2011 | J. Reprod. Dev. | pmid:20962457 |
| Mayor R et al. | Dynamics of bivalent chromatin domains upon drug induced reactivation and resilencing in cancer cells. | 2011 | Epigenetics | pmid:21852760 |
| Kumar A et al. | γ-radiation induces cellular sensitivity and aberrant methylation in human tumor cell lines. | 2011 | Int. J. Radiat. Biol. | pmid:21815748 |
| Tan L et al. | Trichostatin A restores Apaf-1 function in chemoresistant ovarian cancer cells. | 2011 | Cancer | pmid:20925046 |
| Ishiguro K et al. | Cutting edge: tubulin α functions as an adaptor in NFAT-importin β interaction. | 2011 | J. Immunol. | pmid:21278340 |
| Ma AN et al. | Histone deacetylation directs DNA methylation in survivin gene silencing. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21130077 |
| Pianta A et al. | Nucleophosmin delocalization in thyroid tumour cells. | 2011 | Endocr. Pathol. | pmid:21258971 |
| Gómez MC et al. | Trichostatin A modified histone covalent pattern and enhanced expression of pluripotent genes in interspecies black-footed cat cloned embryos but did not improve in vitro and in vivo viability. | 2011 | Cell Reprogram | pmid:21718106 |
| Whitehead L et al. | Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors. | 2011 | Bioorg. Med. Chem. | pmid:21723733 |
| Yin H et al. | Histonedeacetylase inhibitor Oxamflatin increase HIV-1 transcription by inducing histone modification in latently infected cells. | 2011 | Mol. Biol. Rep. | pmid:21181272 |
| Stoppani E et al. | Point mutated caveolin-3 form (P104L) impairs myoblast differentiation via Akt and p38 signalling reduction, leading to an immature cell signature. | 2011 | Biochim. Biophys. Acta | pmid:21182936 |