Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Huang L et al. | Activation of ATP-sensitive K channels protects hippocampal CA1 neurons from hypoxia by suppressing p53 expression. | 2006 | Neurosci. Lett. | pmid:16426753 |
Deng G et al. | Regional hypermethylation and global hypomethylation are associated with altered chromatin conformation and histone acetylation in colorectal cancer. | 2006 | Int. J. Cancer | pmid:16425274 |
D'Andrea M et al. | Protein kinase C theta co-operates with calcineurin in the activation of slow muscle genes in cultured myogenic cells. | 2006 | J. Cell. Physiol. | pmid:16419034 |
Yamamoto G et al. | Correlation of invasion and metastasis of cancer cells, and expression of the RAD21 gene in oral squamous cell carcinoma. | 2006 | Virchows Arch. | pmid:16416296 |
Lo PK et al. | Epigenetic suppression of secreted frizzled related protein 1 (SFRP1) expression in human breast cancer. | 2006 | Cancer Biol. Ther. | pmid:16410723 |
Bieler A et al. | Novel three-pronged strategy to enhance cancer cell killing in glioblastoma cell lines: histone deacetylase inhibitor, chemotherapy, and oncolytic adenovirus dl520. | 2006 | Hum. Gene Ther. | pmid:16409125 |
Fischer S et al. | Histone acetylation dependent allelic expression imbalance of BAPX1 in patients with the oculo-auriculo-vertebral spectrum. | 2006 | Hum. Mol. Genet. | pmid:16407370 |
Hansen KR et al. | Evolutionary-conserved telomere-linked helicase genes of fission yeast are repressed by silencing factors, RNAi components and the telomere-binding protein Taz1. | 2006 | Nucleic Acids Res. | pmid:16407326 |
Liu H et al. | [Antineoplastic effect of valproic acid and trichostatin on HL-60 and K562 cells]. | 2005 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:16403260 |
Chen LJ et al. | [hCG-PLZF-RARalpha/hCG-RARalpha-PLZF transgenic mice developing into leukemia]. | 2005 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:16403252 |
Bai T et al. | A novel mechanism for acquired cisplatin-resistance: suppressed translation of death-associated protein kinase mRNA is insensitive to 5-aza-2'-deoxycitidine and trichostatin in cisplatin-resistant cervical squamous cancer cells. | 2006 | Int. J. Oncol. | pmid:16391806 |
Takahashi K et al. | Homozygous deletion and reduced expression of the DOCK8 gene in human lung cancer. | 2006 | Int. J. Oncol. | pmid:16391785 |
Baek SY et al. | Trichostatin A increases the thermosensitivity of human glioblastoma A172 cells. | 2006 | Neurosci. Lett. | pmid:16384639 |
Wetzel M et al. | Effect of trichostatin A, a histone deacetylase inhibitor, on glioma proliferation in vitro by inducing cell cycle arrest and apoptosis. | 2005 | J. Neurosurg. | pmid:16383255 |
Hsu MC et al. | HER-2/neu represses the metastasis suppressor RECK via ERK and Sp transcription factors to promote cell invasion. | 2006 | J. Biol. Chem. | pmid:16377629 |
Wee G et al. | Inheritable histone H4 acetylation of somatic chromatins in cloned embryos. | 2006 | J. Biol. Chem. | pmid:16371357 |
Lee KY et al. | NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcription. | 2006 | J. Immunol. | pmid:16365456 |
Pazmany T and Tomasi TB | The major histocompatibility complex class II transactivator is differentially regulated by interferon-gamma and transforming growth factor-beta in microglial cells. | 2006 | J. Neuroimmunol. | pmid:16360884 |
Noh EJ et al. | Methyl CpG-binding domain protein 3 mediates cancer-selective cytotoxicity by histone deacetylase inhibitors via differential transcriptional reprogramming in lung cancer cells. | 2005 | Cancer Res. | pmid:16357148 |
Kishigami S et al. | Significant improvement of mouse cloning technique by treatment with trichostatin A after somatic nuclear transfer. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16356478 |
Solomon JM et al. | Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. | 2006 | Mol. Cell. Biol. | pmid:16354677 |
Nishiyama A et al. | Brd4 is required for recovery from antimicrotubule drug-induced mitotic arrest: preservation of acetylated chromatin. | 2006 | Mol. Biol. Cell | pmid:16339075 |
Gan Y et al. | Dual effects of histone deacetylase inhibition by trichostatin A on endothelial nitric oxide synthase expression in endothelial cells. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16338217 |
Jung JW et al. | Effects of the histone deacetylases inhibitors sodium butyrate and trichostatin A on the inhibition of gap junctional intercellular communication by H2O2- and 12-O-tetradecanoylphorbol-13-acetate in rat liver epithelial cells. | 2006 | Cancer Lett. | pmid:16337085 |
Kook SH et al. | Epstein-Barr virus-infected Akata cells are sensitive to histone deacetylase inhibitor TSA-provoked apoptosis. | 2005 | J. Biochem. Mol. Biol. | pmid:16336792 |
Garcia BA et al. | Resetting the epigenetic histone code in the MRL-lpr/lpr mouse model of lupus by histone deacetylase inhibition. | 2005 Nov-Dec | J. Proteome Res. | pmid:16335948 |
Cecconi D et al. | Proteomic analysis of pancreatic ductal carcinoma cells after combined treatment with gemcitabine and trichostatin A. | 2005 Nov-Dec | J. Proteome Res. | pmid:16335935 |
Suzuki M et al. | Site-specific DNA methylation by a complex of PU.1 and Dnmt3a/b. | 2006 | Oncogene | pmid:16331260 |
Kurschat P et al. | Neuron restrictive silencer factor NRSF/REST is a transcriptional repressor of neuropilin-1 and diminishes the ability of semaphorin 3A to inhibit keratinocyte migration. | 2006 | J. Biol. Chem. | pmid:16330548 |
Majumder S et al. | Epigenetic regulation of metallothionein-i gene expression: differential regulation of methylated and unmethylated promoters by DNA methyltransferases and methyl CpG binding proteins. | 2006 | J. Cell. Biochem. | pmid:16329111 |
Mogal A and Abdulkadir SA | Effects of Histone Deacetylase Inhibitor (HDACi); Trichostatin-A (TSA) on the expression of housekeeping genes. | 2006 | Mol. Cell. Probes | pmid:16326072 |
Kishigami S et al. | Epigenetic abnormalities of the mouse paternal zygotic genome associated with microinsemination of round spermatids. | 2006 | Dev. Biol. | pmid:16325170 |
Marchion DC et al. | Synergistic interaction between histone deacetylase and topoisomerase II inhibitors is mediated through topoisomerase IIbeta. | 2005 | Clin. Cancer Res. | pmid:16322310 |
Wei M et al. | BRCA1 promoter methylation in sporadic breast cancer is associated with reduced BRCA1 copy number and chromosome 17 aneusomy. | 2005 | Cancer Res. | pmid:16322213 |
Chen J and Kang JH | Quercetin and trichostatin A cooperatively kill human leukemia cells. | 2005 | Pharmazie | pmid:16320950 |
Williams SA et al. | NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. | 2006 | EMBO J. | pmid:16319923 |
Tai HH et al. | Dynamic histone acetylation of late embryonic genes during seed germination. | 2005 | Plant Mol. Biol. | pmid:16307366 |
Marengo E et al. | Use of Legendre moments for the fast comparison of two-dimensional polyacrylamide gel electrophoresis maps images. | 2005 | J Chromatogr A | pmid:16301071 |
Schroeder TM and Westendorf JJ | Histone deacetylase inhibitors promote osteoblast maturation. | 2005 | J. Bone Miner. Res. | pmid:16294278 |
Lee JH et al. | Interactions with p300 enhance transcriptional activation by the PDZ-domain coactivator Bridge-1. | 2005 | J. Endocrinol. | pmid:16293776 |
Jüngel A et al. | Trichostatin A sensitises rheumatoid arthritis synovial fibroblasts for TRAIL-induced apoptosis. | 2006 | Ann. Rheum. Dis. | pmid:16284094 |
Juranek SA et al. | snRNA and heterochromatin formation are involved in DNA excision during macronuclear development in stichotrichous ciliates. | 2005 | Eukaryotic Cell | pmid:16278460 |
Li XX et al. | Function of c-Fos-like and c-Jun-like proteins on trichostatin A-induced G2/M arrest in Physarum polycephalum. | 2005 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:16270156 |
Gao S et al. | CpG methylation of the PAI-1 gene 5'-flanking region is inversely correlated with PAI-1 mRNA levels in human cell lines. | 2005 | Thromb. Haemost. | pmid:16268485 |
Peng C et al. | The transcriptional regulation role of BRD7 by binding to acetylated histone through bromodomain. | 2006 | J. Cell. Biochem. | pmid:16265664 |
Bernes S et al. | Epigenetic and classical activation of Entamoeba histolytica heat shock protein 100 (EHsp100) expression. | 2005 | FEBS Lett. | pmid:16263115 |
Hohl M and Thiel G | Cell type-specific regulation of RE-1 silencing transcription factor (REST) target genes. | 2005 | Eur. J. Neurosci. | pmid:16262660 |
Hazzalin CA and Mahadevan LC | Dynamic acetylation of all lysine 4-methylated histone H3 in the mouse nucleus: analysis at c-fos and c-jun. | 2005 | PLoS Biol. | pmid:16262446 |
Burlibaşa L and Gavrilă L | Molecular and ultrastructural studies of the sperm chromatin from Triturus cristatus. | 2005 | Zygote | pmid:16261764 |
Columbaro M et al. | Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment. | 2005 | Cell. Mol. Life Sci. | pmid:16261260 |
Bártová E et al. | Nuclear levels and patterns of histone H3 modification and HP1 proteins after inhibition of histone deacetylases. | 2005 | J. Cell. Sci. | pmid:16254244 |
Place RF et al. | HDACs and the senescent phenotype of WI-38 cells. | 2005 | BMC Cell Biol. | pmid:16250917 |
Krishnan M et al. | Effects of epigenetic modulation on reporter gene expression: implications for stem cell imaging. | 2006 | FASEB J. | pmid:16246867 |
Kasper LH et al. | Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression. | 2005 | EMBO J. | pmid:16237459 |
Sato TA and Mitchell MD | Molecular inhibition of histone deacetylation results in major enhancement of the production of IL-1beta in response to LPS. | 2006 | Am. J. Physiol. Endocrinol. Metab. | pmid:16234266 |
Francia G et al. | Down-regulation of DNA mismatch repair proteins in human and murine tumor spheroids: implications for multicellular resistance to alkylating agents. | 2005 | Mol. Cancer Ther. | pmid:16227397 |
Chen G et al. | [Enhancive effect of histone deacetylase inhibitor trichostatin a on transfection efficiency of adenovirus in ovarian carcinoma cell line A2780]. | 2005 | Ai Zheng | pmid:16219132 |
Bai Y et al. | Protein acetylation regulates both PU.1 transactivation and Ig kappa 3' enhancer activity. | 2005 | J. Immunol. | pmid:16210620 |
Chou SD et al. | Histone acetylation regulates the cell type specific CIITA promoters, MHC class II expression and antigen presentation in tumor cells. | 2005 | Int. Immunol. | pmid:16210330 |
Fang MZ et al. | Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy. | 2005 | Clin. Cancer Res. | pmid:16203797 |
Liu AL et al. | [A new target of cancer therapy: advances in the study of histone deacetylase]. | 2005 | Yao Xue Xue Bao | pmid:16196262 |
Menegola E et al. | Inhibition of histone deacetylase activity on specific embryonic tissues as a new mechanism for teratogenicity. | 2005 | Birth Defects Res. B Dev. Reprod. Toxicol. | pmid:16193500 |
Mühlisch J et al. | Epigenetic repression of RASSF1A but not CASP8 in supratentorial PNET (sPNET) and atypical teratoid/rhabdoid tumors (AT/RT) of childhood. | 2006 | Oncogene | pmid:16186793 |
Chen CS et al. | Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes. | 2005 | J. Biol. Chem. | pmid:16186112 |
Yaneva M et al. | Non-homologous end joining, but not homologous recombination, enables survival for cells exposed to a histone deacetylase inhibitor. | 2005 | Nucleic Acids Res. | pmid:16177181 |
Xu CR et al. | Histone acetylation affects expression of cellular patterning genes in the Arabidopsis root epidermis. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16176989 |
Yu Z and Kone BC | Targeted histone H4 acetylation via phosphoinositide 3-kinase- and p70s6-kinase-dependent pathways inhibits iNOS induction in mesangial cells. | 2006 | Am. J. Physiol. Renal Physiol. | pmid:16174862 |
Johnson J et al. | Fetal hemoglobin induction by the histone deacetylase inhibitor, scriptaid. | 2005 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:16171558 |
El-Zawahry A et al. | In vitro efficacy of AdTRAIL gene therapy of bladder cancer is enhanced by trichostatin A-mediated restoration of CAR expression and downregulation of cFLIP and Bcl-XL. | 2006 | Cancer Gene Ther. | pmid:16167063 |
Chang CW et al. | Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa. | 2005 | Mol. Cell. Biol. | pmid:16166624 |
Di-Poï N et al. | Transcriptional repression of peroxisome proliferator-activated receptor beta/delta in murine keratinocytes by CCAAT/enhancer-binding proteins. | 2005 | J. Biol. Chem. | pmid:16166081 |
Rogier E et al. | A novel biological assay to detect the active form of TGF-beta in urine to monitor renal allograft rejection. | 2005 | Kidney Int. | pmid:16164666 |
Osada H et al. | Histone modification in the TGFbetaRII gene promoter and its significance for responsiveness to HDAC inhibitor in lung cancer cell lines. | 2005 | Mol. Carcinog. | pmid:16163707 |
Hwang DY and Ismail-Beigi F | Control of Glut1 promoter activity under basal conditions and in response to hyperosmolarity: role of Sp1. | 2006 | Am. J. Physiol., Cell Physiol. | pmid:16162661 |
Lu Z et al. | E2F-HDAC complexes negatively regulate the tumor suppressor gene ARHI in breast cancer. | 2006 | Oncogene | pmid:16158053 |
Medugno L et al. | The Krüppel-like zinc-finger protein ZNF224 represses aldolase A gene transcription by interacting with the KAP-1 co-repressor protein. | 2005 | Gene | pmid:16150558 |
Curtin BF et al. | Histone acetylase inhibitor trichostatin A induces acetylcholinesterase expression and protects against organophosphate exposure. | 2005 | J. Cell. Biochem. | pmid:16149071 |
Valenzuela-Fernández A et al. | Histone deacetylase 6 regulates human immunodeficiency virus type 1 infection. | 2005 | Mol. Biol. Cell | pmid:16148047 |
Young JC et al. | Inhibitors of histone deacetylases promote hematopoietic stem cell self-renewal. | 2004 | Cytotherapy | pmid:16146885 |
Yanada M et al. | Frequent hemizygous deletion at 1p36 and hypermethylation downregulate RUNX3 expression in human lung cancer cell lines. | 2005 | Oncol. Rep. | pmid:16142337 |
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Choi JH et al. | Trichostatin A exacerbates atherosclerosis in low density lipoprotein receptor-deficient mice. | 2005 | Arterioscler. Thromb. Vasc. Biol. | pmid:16141407 |
Hofmann A et al. | Epigenetic regulation of lentiviral transgene vectors in a large animal model. | 2006 | Mol. Ther. | pmid:16140581 |
Laribee RN and Klemsz MJ | Histone H4 HDAC activity is necessary for expression of the PU.1 gene. | 2005 | Biochim. Biophys. Acta | pmid:16139904 |
Shinji C et al. | Design and synthesis of phthalimide-type histone deacetylase inhibitors. | 2005 | Bioorg. Med. Chem. Lett. | pmid:16137884 |
Zhang Y et al. | Coordinated changes in DNA methylation and histone modifications regulate silencing/derepression of luteinizing hormone receptor gene transcription. | 2005 | Mol. Cell. Biol. | pmid:16135786 |
Lin KT et al. | Epigenetic activation of alpha4, beta2 and beta6 integrins involved in cell migration in trichostatin A-treated Hep3B cells. | 2005 | J. Biomed. Sci. | pmid:16132114 |
Somech R et al. | The nuclear-envelope protein and transcriptional repressor LAP2beta interacts with HDAC3 at the nuclear periphery, and induces histone H4 deacetylation. | 2005 | J. Cell. Sci. | pmid:16129885 |
Uchida H et al. | Histone deacetylase inhibitors induce differentiation of human endometrial adenocarcinoma cells through up-regulation of glycodelin. | 2005 | Endocrinology | pmid:16123169 |
Bradbury CA et al. | Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors. | 2005 | Leukemia | pmid:16121216 |
Kang JE et al. | Histone deacetylase-1 represses transcription by interacting with zinc-fingers and interfering with the DNA binding activity of Sp1. | 2005 | Cell. Physiol. Biochem. | pmid:16121030 |
Clem BF and Clark BJ | Association of the mSin3A-histone deacetylase 1/2 corepressor complex with the mouse steroidogenic acute regulatory protein gene. | 2006 | Mol. Endocrinol. | pmid:16109738 |
Lu Q et al. | Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. | 2005 | J. Med. Chem. | pmid:16107152 |
Krouwels IM et al. | A glue for heterochromatin maintenance: stable SUV39H1 binding to heterochromatin is reinforced by the SET domain. | 2005 | J. Cell Biol. | pmid:16103223 |
Blagosklonny MV et al. | Depletion of mutant p53 and cytotoxicity of histone deacetylase inhibitors. | 2005 | Cancer Res. | pmid:16103091 |
Ren C et al. | Peptide mass mapping of acetylated isoforms of histone H4 from mouse lymphosarcoma cells treated with histone deacetylase (HDACs) inhibitors. | 2005 | J. Am. Soc. Mass Spectrom. | pmid:16099169 |
Hirsch CL et al. | Src family kinase members have a common response to histone deacetylase inhibitors in human colon cancer cells. | 2006 | Int. J. Cancer | pmid:16094635 |
Nome RV et al. | Cell cycle checkpoint signaling involved in histone deacetylase inhibition and radiation-induced cell death. | 2005 | Mol. Cancer Ther. | pmid:16093439 |
GarcÃa-Morales P et al. | Histone deacetylase inhibitors induced caspase-independent apoptosis in human pancreatic adenocarcinoma cell lines. | 2005 | Mol. Cancer Ther. | pmid:16093438 |
Cismasiu VB et al. | BCL11B functionally associates with the NuRD complex in T lymphocytes to repress targeted promoter. | 2005 | Oncogene | pmid:16091750 |