trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kang KA et al. | Compound K, a metabolite of ginseng saponin, inhibits colorectal cancer cell growth and induces apoptosis through inhibition of histone deacetylase activity. | 2013 | Int. J. Oncol. | pmid:24100442 |
| BurlibaÅŸa L and Zarnescu O | In vivo effects of Trichostatin A - A histone deacetylase inhibitor - On chromatin remodeling during Triturus cristatus spermatogenesis. | 2013 | Anim. Reprod. Sci. | pmid:24100069 |
| Florea AM | DNA methylation pyrosequencing assay is applicable for the assessment of epigenetic active environmental or clinical relevant chemicals. | 2013 | Biomed Res Int | pmid:24093099 |
| Liu YQ et al. | Identification of a novel human testicular interstitial gene, RNF148, and its expression regulated by histone deacetylases. | 2013 | Genet. Mol. Res. | pmid:24089095 |
| Singh RK et al. | Kinetic and thermodynamic rationale for suberoylanilide hydroxamic acid being a preferential human histone deacetylase 8 inhibitor as compared to the structurally similar ligand, trichostatin a. | 2013 | Biochemistry | pmid:24079912 |
| Day JA and Cohen SM | Investigating the selectivity of metalloenzyme inhibitors. | 2013 | J. Med. Chem. | pmid:24074025 |
| Al-Nakhle H et al. | Regulation of estrogen receptor β1 expression in breast cancer by epigenetic modification of the 5' regulatory region. | 2013 | Int. J. Oncol. | pmid:24068253 |
| Wu DS et al. | Epigallocatechin-3-gallate and trichostatin A synergistically inhibit human lymphoma cell proliferation through epigenetic modification of p16INK4a. | 2013 | Oncol. Rep. | pmid:24064951 |
| Matsushita Y et al. | HDAC inhibitors restore C-fibre sensitivity in experimental neuropathic pain model. | 2013 | Br. J. Pharmacol. | pmid:24032674 |
| Sun DF et al. | Inhibition of mTOR signalling potentiates the effects of trichostatin A in human gastric cancer cell lines by promoting histone acetylation. | 2014 | Cell Biol. Int. | pmid:24030871 |
| Luo C et al. | Treatment of donor cells with trichostatin A improves in vitro development and reprogramming of buffalo (Bubalus bubalis) nucleus transfer embryos. | 2013 | Theriogenology | pmid:24007823 |
| Chikamatsu K et al. | Alteration of cancer stem cell-like phenotype by histone deacetylase inhibitors in squamous cell carcinoma of the head and neck. | 2013 | Cancer Sci. | pmid:23992541 |
| Knobloch J et al. | Resveratrol attenuates the release of inflammatory cytokines from human bronchial smooth muscle cells exposed to lipoteichoic acid in chronic obstructive pulmonary disease. | 2014 | Basic Clin. Pharmacol. Toxicol. | pmid:23981542 |
| Hennig D et al. | Novel insights into appropriate encapsulation methods for bioactive compounds into polymers: a study with peptides and HDAC inhibitors. | 2014 | Macromol Biosci | pmid:23966296 |
| Biernacka KM et al. | Hyperglycaemia-induced chemoresistance of prostate cancer cells due to IGFBP2. | 2013 | Endocr. Relat. Cancer | pmid:23959956 |
| Lu JC et al. | Trichostatin A modulates thiazolidinedione-mediated suppression of tumor necrosis factor α-induced lipolysis in 3T3-L1 adipocytes. | 2013 | PLoS ONE | pmid:23951179 |
| Kadiyala V et al. | Class I lysine deacetylases facilitate glucocorticoid-induced transcription. | 2013 | J. Biol. Chem. | pmid:23946490 |
| Fang J et al. | Epigenetic modulation of neuronal apoptosis and cognitive functions in sepsis-associated encephalopathy. | 2014 | Neurol. Sci. | pmid:23925573 |
| Jang SM et al. | Transcription factor Sox4 is required for PUMA-mediated apoptosis induced by histone deacetylase inhibitor, TSA. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23916609 |
| Yu CW et al. | Quinazolin-4-one derivatives as selective histone deacetylase-6 inhibitors for the treatment of Alzheimer's disease. | 2013 | J. Med. Chem. | pmid:23905680 |
| Lauffer BE et al. | Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability. | 2013 | J. Biol. Chem. | pmid:23897821 |
| Xu S et al. | Cytostatic and apoptotic effects of DNMT and HDAC inhibitors in endometrial cancer cells. | 2014 | Curr. Pharm. Des. | pmid:23888960 |
| Lim SY et al. | Trichostatin A enhances differentiation of human induced pluripotent stem cells to cardiogenic cells for cardiac tissue engineering. | 2013 | Stem Cells Transl Med | pmid:23884641 |
| Guo LH et al. | The Tumor Suppressor Roles of miR-433 and miR-127 in Gastric Cancer. | 2013 | Int J Mol Sci | pmid:23880861 |
| Sharma A et al. | Trichostatin-A modulates claudin-1 mRNA stability through the modulation of Hu antigen R and tristetraprolin in colon cancer cells. | 2013 | Carcinogenesis | pmid:23880304 |
| Moreaux J et al. | Gene expression-based prediction of myeloma cell sensitivity to histone deacetylase inhibitors. | 2013 | Br. J. Cancer | pmid:23868005 |
| Chen CQ et al. | Histone deacetylases inhibitor trichostatin A increases the expression of Dleu2/miR-15a/16-1 via HDAC3 in non-small cell lung cancer. | 2013 | Mol. Cell. Biochem. | pmid:23867991 |
| Oksenych V et al. | Histone methyltransferase DOT1L drives recovery of gene expression after a genotoxic attack. | 2013 | PLoS Genet. | pmid:23861670 |
| Okada T et al. | Identification of genes specifically methylated in Epstein-Barr virus-associated gastric carcinomas. | 2013 | Cancer Sci. | pmid:23829175 |
| Lopez-Atalaya JP et al. | Genomic targets, and histone acetylation and gene expression profiling of neural HDAC inhibition. | 2013 | Nucleic Acids Res. | pmid:23821663 |
| Feng T et al. | Novel N-hydroxyfurylacrylamide-based histone deacetylase (HDAC) inhibitors with branched CAP group (Part 2). | 2013 | Bioorg. Med. Chem. | pmid:23820574 |
| Keuser B et al. | Influences of histone deacetylase inhibitors and resveratrol on DNA repair and chromatin compaction. | 2013 | Mutagenesis | pmid:23814181 |
| Jo SJ et al. | Valproic acid promotes human hair growth in in vitro culture model. | 2013 | J. Dermatol. Sci. | pmid:23810771 |
| Huang L et al. | Down-regulation of miR-301a suppresses pro-inflammatory cytokines in Toll-like receptor-triggered macrophages. | 2013 | Immunology | pmid:23808420 |
| Diao JS et al. | Histone deacetylase inhibitor reduces hypertrophic scarring in a rabbit ear model. | 2013 | Plast. Reconstr. Surg. | pmid:23806955 |
| Gundersen B | Pair-bonding through epigenetics. | 2013 | Nat. Neurosci. | pmid:23799469 |
| Asthana J et al. | Inhibition of HDAC6 deacetylase activity increases its binding with microtubules and suppresses microtubule dynamic instability in MCF-7 cells. | 2013 | J. Biol. Chem. | pmid:23798680 |
| Zych J et al. | The epigenetic modifiers 5-aza-2'-deoxycytidine and trichostatin A influence adipocyte differentiation in human mesenchymal stem cells. | 2013 | Braz. J. Med. Biol. Res. | pmid:23797495 |
| Chatterjee N et al. | Histone deacetylase inhibitors modulate miRNA and mRNA expression, block metaphase, and induce apoptosis in inflammatory breast cancer cells. | 2013 | Cancer Biol. Ther. | pmid:23792638 |
| Fujiki R et al. | A proapoptotic effect of valproic acid on progenitors of embryonic stem cell-derived glutamatergic neurons. | 2013 | Cell Death Dis | pmid:23788034 |
| Aseem O et al. | Cubilin expression is monoallelic and epigenetically augmented via PPARs. | 2013 | BMC Genomics | pmid:23773363 |
| Welch MD et al. | Hypomethylation of the CTGF gene locus is a common feature of paediatric pre-B acute lymphoblastic leukaemia. | 2013 | Br. J. Haematol. | pmid:23772794 |
| Quan H et al. | Hepatitis C virus core protein epigenetically silences SFRP1 and enhances HCC aggressiveness by inducing epithelial-mesenchymal transition. | 2014 | Oncogene | pmid:23770846 |
| Liu Y et al. | MCM-2 is a therapeutic target of Trichostatin A in colon cancer cells. | 2013 | Toxicol. Lett. | pmid:23770000 |
| Doherty R et al. | Epigenetic regulation of the innate immune response to LPS in bovine peripheral blood mononuclear cells (PBMC). | 2013 | Vet. Immunol. Immunopathol. | pmid:23764468 |
| Zhao TC et al. | HDAC inhibition elicits myocardial protective effect through modulation of MKK3/Akt-1. | 2013 | PLoS ONE | pmid:23762381 |
| Jin YX et al. | Histone deacetylase inhibitor trichostatin A affects porcine oocyte maturation in vitro. | 2014 | Reprod. Fertil. Dev. | pmid:23759302 |
| Flight MH | Behaviour: epigenetically bonded. | 2013 | Nat. Rev. Neurosci. | pmid:23756635 |
| Pitta CA et al. | Reversal of ER-β silencing by chromatin modifying agents overrides acquired tamoxifen resistance. | 2013 | Cancer Lett. | pmid:23752064 |
| Jiao F et al. | Effect of dynamic DNA methylation and histone acetylation on cPouV expression in differentiation of chick embryonic germ cells. | 2013 | Stem Cells Dev. | pmid:23750509 |
| Wang YG et al. | Mechanisms of trichostatin A inhibiting AGS proliferation and identification of lysine-acetylated proteins. | 2013 | World J. Gastroenterol. | pmid:23745024 |
| Doñas C et al. | Trichostatin A promotes the generation and suppressive functions of regulatory T cells. | 2013 | Clin. Dev. Immunol. | pmid:23737814 |
| Luo B et al. | A possible strategy to produce pigs resistant to porcine reproductive and respiratory syndrome virus. | 2013 | Antiviral Res. | pmid:23732571 |
| Gao B et al. | Inhibition of histone deacetylase activity suppresses IFN-γ induction of tripartite motif 22 via CHIP-mediated proteasomal degradation of IRF-1. | 2013 | J. Immunol. | pmid:23729439 |
| Wang H et al. | Histone deacetylase inhibitors facilitate partner preference formation in female prairie voles. | 2013 | Nat. Neurosci. | pmid:23727821 |
| Saha A et al. | Synthesis and biological evaluation of a targeted DNA-binding transcriptional activator with HDAC8 inhibitory activity. | 2013 | Bioorg. Med. Chem. | pmid:23719282 |
| Meng F et al. | Inhibition of DNA methyltransferases, histone deacetylases and lysine-specific demethylase-1 suppresses the tumorigenicity of the ovarian cancer ascites cell line SKOV3. | 2013 | Int. J. Oncol. | pmid:23709006 |
| Van Beneden K et al. | Comparison of trichostatin A and valproic acid treatment regimens in a mouse model of kidney fibrosis. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23707763 |
| Fan J et al. | Inhibition of HDAC2 protects the retina from ischemic injury. | 2013 | Invest. Ophthalmol. Vis. Sci. | pmid:23696608 |
| Xia X et al. | Effects of trichostatin A in a rat model of acute graft-versus-host disease after liver transplantation. | 2013 | Transplantation | pmid:23694951 |
| Di Micco S et al. | Structural basis for the design and synthesis of selective HDAC inhibitors. | 2013 | Bioorg. Med. Chem. | pmid:23693069 |
| Kannan V et al. | Histone deacetylase inhibitors suppress immune activation in primary mouse microglia. | 2013 | J. Neurosci. Res. | pmid:23686642 |
| Zhang Z et al. | Stemness and inducing differentiation of small cell lung cancer NCI-H446 cells. | 2013 | Cell Death Dis | pmid:23681228 |
| Li M et al. | Upregulation of Toll-like receptor 2 gene expression by acetylation of AP-2 alpha in THP-1 cells, a human monocytic cell line. | 2013 | Int. J. Biochem. Cell Biol. | pmid:23680675 |
| Ignatius MS et al. | Distinct functional and temporal requirements for zebrafish Hdac1 during neural crest-derived craniofacial and peripheral neuron development. | 2013 | PLoS ONE | pmid:23667588 |
| Choi S et al. | Histone deacetylases inhibitor trichostatin A modulates the extracellular release of APE1/Ref-1. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23665318 |
| Matteucci E et al. | Epigenetic control of endothelin-1 axis affects invasiveness of breast carcinoma cells with bone tropism. | 2013 | Exp. Cell Res. | pmid:23660387 |
| Breuzard G et al. | Molecular mechanisms of Tau binding to microtubules and its role in microtubule dynamics in live cells. | 2013 | J. Cell. Sci. | pmid:23659998 |
| Arbuckle JH et al. | Mapping the telomere integrated genome of human herpesvirus 6A and 6B. | 2013 | Virology | pmid:23648233 |
| Majumder A et al. | Inhibition of DNA methyltransferases and histone deacetylases induces astrocytic differentiation of neural progenitors. | 2013 | Stem Cell Res | pmid:23644509 |
| Yang H et al. | Induction of the liver cancer-down-regulated long noncoding RNA uc002mbe.2 mediates trichostatin-induced apoptosis of liver cancer cells. | 2013 | Biochem. Pharmacol. | pmid:23643933 |
| Piazza R et al. | Epigenetic silencing of the proapoptotic gene BIM in anaplastic large cell lymphoma through an MeCP2/SIN3a deacetylating complex. | 2013 | Neoplasia | pmid:23633923 |
| Contreras AU et al. | Deacetylation of p53 induces autophagy by suppressing Bmf expression. | 2013 | J. Cell Biol. | pmid:23629966 |
| Hayakawa K et al. | Epigenetic switching by the metabolism-sensing factors in the generation of orexin neurons from mouse embryonic stem cells. | 2013 | J. Biol. Chem. | pmid:23625921 |
| Munro SK et al. | Histone deacetylase inhibition by trichostatin A mitigates LPS induced TNFα and IL-10 production in human placental explants. | 2013 | Placenta | pmid:23623485 |
| Neumann F et al. | EBV-transformed lymphoblastoid cell lines as vaccines against cancer testis antigen-positive tumors. | 2013 | Cancer Immunol. Immunother. | pmid:23619976 |
| Cong P et al. | Effects of trichostatin A on histone acetylation and methylation characteristics in early porcine embryos after somatic cell nuclear transfer. | 2013 | Anim. Sci. J. | pmid:23607426 |
| Oleksiewicz U et al. | Cytoglobin has bimodal: tumour suppressor and oncogene functions in lung cancer cell lines. | 2013 | Hum. Mol. Genet. | pmid:23591990 |
| Gang H et al. | Epigenetic regulation of canonical TNFα pathway by HDAC1 determines survival of cardiac myocytes. | 2013 | Am. J. Physiol. Heart Circ. Physiol. | pmid:23585133 |
| Elaut G et al. | Rat hepatocyte suspensions as a suitable in vitro model for studying the biotransformation of histone deacetylase inhibitors. | 2004 | Altern Lab Anim | pmid:23577441 |
| Culley KL et al. | Class I histone deacetylase inhibition modulates metalloproteinase expression and blocks cytokine-induced cartilage degradation. | 2013 | Arthritis Rheum. | pmid:23575963 |
| Matsubara K et al. | Dynamics and regulation of lysine-acetylation during one-cell stage mouse embryos. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23567968 |
| Chen CH et al. | Synergistic effect of trichostatin A and scriptaid on the development of cloned rabbit embryos. | 2013 | Theriogenology | pmid:23566670 |
| Höring E et al. | The histone deacetylase inhibitor trichostatin a promotes apoptosis and antitumor immunity in glioblastoma cells. | 2013 | Anticancer Res. | pmid:23564772 |
| Wang Y et al. | Role of histone deacetylase inhibitors in the aging of human umbilical cord mesenchymal stem cells. | 2013 | J. Cell. Biochem. | pmid:23564418 |
| Duncan HF et al. | Histone deacetylase inhibitors epigenetically promote reparative events in primary dental pulp cells. | 2013 | Exp. Cell Res. | pmid:23562654 |
| Wang P et al. | Trichostatin A protects against cisplatin-induced ototoxicity by regulating expression of genes related to apoptosis and synaptic function. | 2013 | Neurotoxicology | pmid:23558232 |
| Sato T et al. | Enhancement of inflammatory protein expression and nuclear factor Κb (NF-Κb) activity by trichostatin A (TSA) in OP9 preadipocytes. | 2013 | PLoS ONE | pmid:23555753 |
| Wang F et al. | HDAC inhibitor trichostatin A suppresses esophageal squamous cell carcinoma metastasis through HADC2 reduced MMP-2/9. | 2013 | Clin Invest Med | pmid:23544610 |
| Wong CH et al. | CTSL2 is a pro-apoptotic target of E2F1 and a modulator of histone deacetylase inhibitor and DNA damage-induced apoptosis. | 2014 | Oncogene | pmid:23542171 |
| Khan DH and Davie JR | HDAC inhibitors prevent the induction of the immediate-early gene FOSL1, but do not alter the nucleosome response. | 2013 | FEBS Lett. | pmid:23542037 |
| Yacqub-Usman K et al. | Preincubation of pituitary tumor cells with the epidrugs zebularine and trichostatin A are permissive for retinoic acid-augmented expression of the BMP-4 and D2R genes. | 2013 | Endocrinology | pmid:23539512 |
| Chambliss AB et al. | Simultaneously defining cell phenotypes, cell cycle, and chromatin modifications at single-cell resolution. | 2013 | FASEB J. | pmid:23538711 |
| Brown CO et al. | Scavenger receptor class A member 3 (SCARA3) in disease progression and therapy resistance in multiple myeloma. | 2013 | Leuk. Res. | pmid:23537707 |
| Wang Y et al. | Nuclear factor κB mediates suppression of canonical transient receptor potential 6 expression by reactive oxygen species and protein kinase C in kidney cells. | 2013 | J. Biol. Chem. | pmid:23525112 |
| Sato A et al. | Suppressive effect of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) on hepatitis C virus replication. | 2013 | J. Cell. Biochem. | pmid:23519646 |
| Azechi T et al. | Trichostatin A, an HDAC class I/II inhibitor, promotes Pi-induced vascular calcification via up-regulation of the expression of alkaline phosphatase. | 2013 | J. Atheroscler. Thromb. | pmid:23518467 |
| Ding SZ et al. | Epithelial-mesenchymal transition during oncogenic transformation induced by hexavalent chromium involves reactive oxygen species-dependent mechanism in lung epithelial cells. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23518002 |
| Poplineau M et al. | Epigenetically induced changes in nuclear textural patterns and gelatinase expression in human fibrosarcoma cells. | 2013 | Cell Prolif. | pmid:23510467 |
| Song BS et al. | Valproic acid enhances early development of bovine somatic cell nuclear transfer embryos by alleviating endoplasmic reticulum stress. | 2014 | Reprod. Fertil. Dev. | pmid:23506644 |