Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Zhang L et al. | Effect of histone deacetylase inhibitors on cell apoptosis and expression of the tumor suppressor genes RUNX3 and ARHI in ovarian tumors. | 2013 | Mol Med Rep | pmid:23504001 |
Jung AR et al. | Increased alternative lengthening of telomere phenotypes of telomerase-negative immortal cells upon trichostatin--a treatment. | 2013 | Anticancer Res. | pmid:23482750 |
Lee AR et al. | Nicotinamide: a class III HDACi delays in vitro aging of mouse oocytes. | 2013 | J. Reprod. Dev. | pmid:23474603 |
Arora DS et al. | Hyposensitivity to gamma-aminobutyric acid in the ventral tegmental area during alcohol withdrawal: reversal by histone deacetylase inhibitors. | 2013 | Neuropsychopharmacology | pmid:23474591 |
Hansberg-Pastor V et al. | The role of DNA methylation and histone acetylation in the regulation of progesterone receptor isoforms expression in human astrocytoma cell lines. | 2013 | Steroids | pmid:23474171 |
Miyatake Y et al. | Protective roles of epithelial cells in the survival of adult T-cell leukemia/lymphoma cells. | 2013 | Am. J. Pathol. | pmid:23474084 |
Sachweh MC et al. | Incompatible effects of p53 and HDAC inhibition on p21 expression and cell cycle progression. | 2013 | Cell Death Dis | pmid:23470540 |
Spallotta F et al. | A nitric oxide-dependent cross-talk between class I and III histone deacetylases accelerates skin repair. | 2013 | J. Biol. Chem. | pmid:23463510 |
Mateen S et al. | Silibinin synergizes with histone deacetylase and DNA methyltransferase inhibitors in upregulating E-cadherin expression together with inhibition of migration and invasion of human non-small cell lung cancer cells. | 2013 | J. Pharmacol. Exp. Ther. | pmid:23461975 |
Duo J et al. | Metformin synergistically enhances antitumor activity of histone deacetylase inhibitor trichostatin a against osteosarcoma cell line. | 2013 | DNA Cell Biol. | pmid:23451817 |
Chachadi VB et al. | Prostatic cell-specific regulation of the synthesis of MUC1-associated sialyl Lewis a. | 2013 | PLoS ONE | pmid:23451223 |
Viñuelas J et al. | Quantifying the contribution of chromatin dynamics to stochastic gene expression reveals long, locus-dependent periods between transcriptional bursts. | 2013 | BMC Biol. | pmid:23442824 |
Yeo M et al. | Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23440186 |
Kim YJ et al. | HDAC inhibitors induce transcriptional repression of high copy number genes in breast cancer through elongation blockade. | 2013 | Oncogene | pmid:23435418 |
Chen CQ et al. | Pure curcumin increases the expression of SOCS1 and SOCS3 in myeloproliferative neoplasms through suppressing class I histone deacetylases. | 2013 | Carcinogenesis | pmid:23430957 |
Camolotto SA et al. | PSG gene expression is up-regulated by lysine acetylation involving histone and nonhistone proteins. | 2013 | PLoS ONE | pmid:23418492 |
Yang F et al. | Histone hyperacetylation during meiosis interferes with large-scale chromatin remodeling, axial chromatid condensation and sister chromatid separation in the mammalian oocyte. | 2012 | Int. J. Dev. Biol. | pmid:23417411 |
Hudson RS et al. | Transcription signatures encoded by ultraconserved genomic regions in human prostate cancer. | 2013 | Mol. Cancer | pmid:23409773 |
Cho JS et al. | Effects of histone deacetylase inhibitor on extracellular matrix production in human nasal polyp organ cultures. | 2013 | Am J Rhinol Allergy | pmid:23406592 |
Tran HT et al. | Improved therapeutic effect against leukemia by a combination of the histone methyltransferase inhibitor chaetocin and the histone deacetylase inhibitor trichostatin A. | 2013 | J. Korean Med. Sci. | pmid:23400519 |
Koch M et al. | Overcoming chemotherapy resistance of ovarian cancer cells by liposomal cisplatin: molecular mechanisms unveiled by gene expression profiling. | 2013 | Biochem. Pharmacol. | pmid:23396090 |
Bhargavan B et al. | Epigenetic repression of LEDGF during UVB exposure by recruitment of SUV39H1 and HDAC1 to the Sp1-responsive elements within LEDGF promoter CpG island. | 2013 | Epigenetics | pmid:23386123 |
Laska MJ et al. | (Some) cellular mechanisms influencing the transcription of human endogenous retrovirus, HERV-Fc1. | 2013 | PLoS ONE | pmid:23382858 |
Li Y et al. | Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer. | 2013 | Mol. Cancer | pmid:23379261 |
Liu J et al. | Direct differentiation of hepatic stem-like WB cells into insulin-producing cells using small molecules. | 2013 | Sci Rep | pmid:23378917 |
Liu H et al. | Inhibition of class II histone deacetylase blocks proliferation and promotes neuronal differentiation of the embryonic rat neural progenitor cells. | 2012 | Acta Neurobiol Exp (Wars) | pmid:23377267 |
Szablowska-Gadomska I et al. | Treatment with small molecules is an important milestone towards the induction of pluripotency in neural stem cells derived from human cord blood. | 2012 | Acta Neurobiol Exp (Wars) | pmid:23377265 |
Wang Z et al. | Arabidopsis paired amphipathic helix proteins SNL1 and SNL2 redundantly regulate primary seed dormancy via abscisic acid-ethylene antagonism mediated by histone deacetylation. | 2013 | Plant Cell | pmid:23371947 |
Meng F et al. | Anticancer efficacy of cisplatin and trichostatin A or 5-aza-2'-deoxycytidine on ovarian cancer. | 2013 | Br. J. Cancer | pmid:23370212 |
Fernandez G et al. | Targeting IκB proteins for HIV latency activation: the role of individual IκB and NF-κB proteins. | 2013 | J. Virol. | pmid:23365428 |
Dagnas M et al. | HDAC inhibition facilitates the switch between memory systems in young but not aged mice. | 2013 | J. Neurosci. | pmid:23365234 |
Oikawa M et al. | RNAi-mediated knockdown of Xist does not rescue the impaired development of female cloned mouse embryos. | 2013 | J. Reprod. Dev. | pmid:23363561 |
Corvetta D et al. | Physical interaction between MYCN oncogene and polycomb repressive complex 2 (PRC2) in neuroblastoma: functional and therapeutic implications. | 2013 | J. Biol. Chem. | pmid:23362253 |
Peng L et al. | Epigenetic inactivation of ADAMTS9 via promoter methylation in multiple myeloma. | 2013 | Mol Med Rep | pmid:23358566 |
Theisen JW et al. | Biochemical analysis of histone deacetylase-independent transcriptional repression by MeCP2. | 2013 | J. Biol. Chem. | pmid:23349465 |
Ji Q et al. | Improvement of porcine cloning efficiency by trichostain A through early-stage induction of embryo apoptosis. | 2013 | Theriogenology | pmid:23347745 |
Iwashita J et al. | Histone deacetylase induces accelerated maturation in Xenopus laevis oocytes. | 2013 | Dev. Growth Differ. | pmid:23346879 |
Chan ST et al. | Quercetin enhances the antitumor activity of trichostatin A through upregulation of p53 protein expression in vitro and in vivo. | 2013 | PLoS ONE | pmid:23342112 |
Zhou G et al. | HSV carrying WT REST establishes latency but reactivates only if the synthesis of REST is suppressed. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23341636 |
Johnson D and Walmsley R | Histone-deacetylase inhibitors produce positive results in the GADD45a-GFP GreenScreen HC assay. | 2013 | Mutat. Res. | pmid:23340162 |
Horvat T et al. | Reversibility of membrane N-glycome of HeLa cells upon treatment with epigenetic inhibitors. | 2013 | PLoS ONE | pmid:23336012 |
Murko C et al. | Histone deacetylase inhibitor Trichostatin A induces neural tube defects and promotes neural crest specification in the chicken neural tube. | 2013 | Differentiation | pmid:23328540 |
Nunes MJ et al. | Histone deacetylase inhibition decreases cholesterol levels in neuronal cells by modulating key genes in cholesterol synthesis, uptake and efflux. | 2013 | PLoS ONE | pmid:23326422 |
Wolf G et al. | Epigenetic marking and repression of porcine endogenous retroviruses. | 2013 | J. Gen. Virol. | pmid:23324470 |
Tang X et al. | Protocadherin 10 is frequently downregulated by promoter methylation and functions as a tumor suppressor gene in non-small cell lung cancer. | 2012-2013 | Cancer Biomark | pmid:23321465 |
Wilson DW et al. | Defining the timing of action of antimalarial drugs against Plasmodium falciparum. | 2013 | Antimicrob. Agents Chemother. | pmid:23318799 |
Algamas-Dimantov A et al. | Epigenetic control of HNF-4α in colon carcinoma cells affects MUC4 expression and malignancy. | 2013 | Cell Oncol (Dordr) | pmid:23307400 |
Nepelska M et al. | Butyrate produced by commensal bacteria potentiates phorbol esters induced AP-1 response in human intestinal epithelial cells. | 2012 | PLoS ONE | pmid:23300800 |
Webster SJ et al. | Regulation of GTP-binding protein (Gαs) expression in human myometrial cells: a role for tumor necrosis factor in modulating Gαs promoter acetylation by transcriptional complexes. | 2013 | J. Biol. Chem. | pmid:23297421 |
Kuno A et al. | Resveratrol improves cardiomyopathy in dystrophin-deficient mice through SIRT1 protein-mediated modulation of p300 protein. | 2013 | J. Biol. Chem. | pmid:23297412 |
Gao C et al. | Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex. | 2013 | Blood | pmid:23287862 |
Zhang S et al. | Effect of trichostatin A and paclitaxel on the proliferation and apoptosis of lung adenocarcinoma cells. | 2013 | Chin. Med. J. | pmid:23286491 |
Gupta K et al. | Green tea polyphenols induce p53-dependent and p53-independent apoptosis in prostate cancer cells through two distinct mechanisms. | 2012 | PLoS ONE | pmid:23285096 |
Yang L et al. | Trichostatin A inhibits transforming growth factor-β-induced reactive oxygen species accumulation and myofibroblast differentiation via enhanced NF-E2-related factor 2-antioxidant response element signaling. | 2013 | Mol. Pharmacol. | pmid:23284002 |
Wang YJ et al. | Histone acetylation in the olfactory bulb of young rats facilitates aversive olfactory learning and synaptic plasticity. | 2013 | Neuroscience | pmid:23262233 |
Xie BT et al. | [Telomere lengthening by trichostatin A treatment in cloned pigs]. | 2012 | Yi Chuan | pmid:23262106 |
Hu XL et al. | [Effects of trichostatin A on the expressions of inflammatory cytokines and toll-like receptor 4 and the acetylation of nuclear factor-κB induced by lipopolysaccharide in macrophage]. | 2012 | Sheng Li Xue Bao | pmid:23258328 |
Li KK et al. | MIR-137 suppresses growth and invasion, is downregulated in oligodendroglial tumors and targets CSE1L. | 2013 | Brain Pathol. | pmid:23252729 |
Marek L et al. | Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells. | 2013 | J. Med. Chem. | pmid:23252603 |
Majumdar G et al. | Pan-histone deacetylase inhibitors regulate signaling pathways involved in proliferative and pro-inflammatory mechanisms in H9c2 cells. | 2012 | BMC Genomics | pmid:23249388 |
Kamiya H et al. | Enhanced transgene expression from chromatinized plasmid DNA in mouse liver. | 2013 | Int J Pharm | pmid:23247018 |
Lee MS et al. | Stabilization of p21 (Cip1/WAF1) following Tip60-dependent acetylation is required for p21-mediated DNA damage response. | 2013 | Cell Death Differ. | pmid:23238566 |
McCullough SD et al. | Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23236151 |
Li KK et al. | MiR-383 is downregulated in medulloblastoma and targets peroxiredoxin 3 (PRDX3). | 2013 | Brain Pathol. | pmid:23227829 |
Montero-Melendez T et al. | Gene expression signature-based approach identifies a pro-resolving mechanism of action for histone deacetylase inhibitors. | 2013 | Cell Death Differ. | pmid:23222458 |
Singh T et al. | Inhibition of class I histone deacetylases in non-small cell lung cancer by honokiol leads to suppression of cancer cell growth and induction of cell death in vitro and in vivo. | 2013 | Epigenetics | pmid:23221619 |
Seuter S et al. | The gene for the transcription factor BHLHE40/DEC1/stra13 is a dynamically regulated primary target of the vitamin D receptor. | 2013 | J. Steroid Biochem. Mol. Biol. | pmid:23220548 |
Nakazawa Y et al. | Evaluation of long-term transgene expression in piggyBac-modified human T lymphocytes. | 2013 | J. Immunother. | pmid:23211626 |
Hutz JE et al. | The multidimensional perturbation value: a single metric to measure similarity and activity of treatments in high-throughput multidimensional screens. | 2013 | J Biomol Screen | pmid:23204073 |
Shi H et al. | Synergistic induction of miR-126 by hypoxia and HDAC inhibitors in cardiac myocytes. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23201405 |
McBrian MA et al. | Histone acetylation regulates intracellular pH. | 2013 | Mol. Cell | pmid:23201122 |
Wunder T et al. | Expression of the coxsackie adenovirus receptor in neuroendocrine lung cancers and its implications for oncolytic adenoviral infection. | 2013 | Cancer Gene Ther. | pmid:23196273 |
Wessels I et al. | Activation of IL-1β and TNFα genes is mediated by the establishment of permissive chromatin structures during monopoiesis. | 2013 | Immunobiology | pmid:23195574 |
Gill RK et al. | Regulation of intestinal serotonin transporter expression via epigenetic mechanisms: role of HDAC2. | 2013 | Am. J. Physiol., Cell Physiol. | pmid:23195070 |
Li H et al. | Epigenetic regulation of CXCR4 expression by the ocular microenvironment. | 2013 | Invest. Ophthalmol. Vis. Sci. | pmid:23188729 |
Shah RR et al. | Regulation of primitive hematopoiesis by class I histone deacetylases. | 2013 | Dev. Dyn. | pmid:23184530 |
Jackson MF et al. | Genetic manipulation of myoblasts and a novel primary myosatellite cell culture system: comparing and optimizing approaches. | 2013 | FEBS J. | pmid:23173931 |
Dom G et al. | 5-aza-2'-deoxycytidine has minor effects on differentiation in human thyroid cancer cell lines, but modulates genes that are involved in adaptation in vitro. | 2013 | Thyroid | pmid:23167291 |
Ying H et al. | Selective histonedeacetylase inhibitor M344 intervenes in HIV-1 latency through increasing histone acetylation and activation of NF-kappaB. | 2012 | PLoS ONE | pmid:23166597 |
Ogura A et al. | Recent advancements in cloning by somatic cell nuclear transfer. | 2013 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:23166393 |
You BR and Park WH | Trichostatin A induces apoptotic cell death of HeLa cells in a Bcl-2 and oxidative stress-dependent manner. | 2013 | Int. J. Oncol. | pmid:23165748 |
Lakshmi SV et al. | Oxidative stress in coronary artery disease: epigenetic perspective. | 2013 | Mol. Cell. Biochem. | pmid:23160801 |
Liu W et al. | HDAC6 regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation in renal epithelial cells. | 2012 | PLoS ONE | pmid:23152903 |
Schor IE et al. | Perturbation of chromatin structure globally affects localization and recruitment of splicing factors. | 2012 | PLoS ONE | pmid:23152763 |
Liu RF et al. | Down-regulation of miR-517a and miR-517c promotes proliferation of hepatocellular carcinoma cells via targeting Pyk2. | 2013 | Cancer Lett. | pmid:23142219 |
Pelascini LP et al. | Histone deacetylase inhibition activates transgene expression from integration-defective lentiviral vectors in dividing and non-dividing cells. | 2013 | Hum. Gene Ther. | pmid:23140481 |
Carbajal A et al. | A novel method for purification of polymerizable tubulin with a high content of the acetylated isotype. | 2013 | Biochem. J. | pmid:23140207 |
Bianco C et al. | Regulation of human Cripto-1 expression by nuclear receptors and DNA promoter methylation in human embryonal and breast cancer cells. | 2013 | J. Cell. Physiol. | pmid:23129342 |
Gao SM et al. | Histone deacetylases inhibitor sodium butyrate inhibits JAK2/STAT signaling through upregulation of SOCS1 and SOCS3 mediated by HDAC8 inhibition in myeloproliferative neoplasms. | 2013 | Exp. Hematol. | pmid:23111066 |
Oliveira CS et al. | HDAC inhibition decreases XIST expression on female IVP bovine blastocysts. | 2013 | Reproduction | pmid:23104973 |
Seuter S et al. | Chromatin acetylation at transcription start sites and vitamin D receptor binding regions relates to effects of 1α,25-dihydroxyvitamin D3 and histone deacetylase inhibitors on gene expression. | 2013 | Nucleic Acids Res. | pmid:23093607 |
Fan H et al. | Sulforaphane causes a major epigenetic repression of myostatin in porcine satellite cells. | 2012 | Epigenetics | pmid:23092945 |
Ziesché E et al. | The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB. | 2013 | Nucleic Acids Res. | pmid:23087373 |
Su SF et al. | miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer. | 2013 | Oncogene | pmid:23085757 |
Maroni P et al. | Chemical and genetic blockade of HDACs enhances osteogenic differentiation of human adipose tissue-derived stem cells by oppositely affecting osteogenic and adipogenic transcription factors. | 2012 | Biochem. Biophys. Res. Commun. | pmid:23085045 |
Tran L et al. | Importance of epigenetic mechanisms in visceral pain induced by chronic water avoidance stress. | 2013 | Psychoneuroendocrinology | pmid:23084728 |
Soriano FX et al. | SMRT-mediated co-shuttling enables export of class IIa HDACs independent of their CaM kinase phosphorylation sites. | 2013 | J. Neurochem. | pmid:23083128 |
Bitman M et al. | Valproate activates ERK signaling pathway in primary human hepatocytes. | 2014 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub | pmid:23073524 |
Dar RD et al. | Transcriptional burst frequency and burst size are equally modulated across the human genome. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23064634 |
Eriksson I et al. | The histone deacetylase inhibitor trichostatin A reduces lysosomal pH and enhances cisplatin-induced apoptosis. | 2013 | Exp. Cell Res. | pmid:23063877 |