Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Huan Y et al. | Trichostatin A rescues the disrupted imprinting induced by somatic cell nuclear transfer in pigs. | 2015 | PLoS ONE | pmid:25962071 |
Mishra DR et al. | Identification of Critical Elements for Regulation of Inorganic Pyrophosphatase (PPA1) in MCF7 Breast Cancer Cells. | 2015 | PLoS ONE | pmid:25923237 |
Horvat T et al. | Reversibility of membrane N-glycome of HeLa cells upon treatment with epigenetic inhibitors. | 2013 | PLoS ONE | pmid:23336012 |
Vire B et al. | Anti-leukemia activity of MS-275 histone deacetylase inhibitor implicates 4-1BBL/4-1BB immunomodulatory functions. | 2009 | PLoS ONE | pmid:19759901 |
Ji Z et al. | Integrating genomics and proteomics data to predict drug effects using binary linear programming. | 2014 | PLoS ONE | pmid:25036040 |
Tseng AS et al. | HDAC activity is required during Xenopus tail regeneration. | 2011 | PLoS ONE | pmid:22022609 |
Merschbaecher K et al. | Acetylation-mediated suppression of transcription-independent memory: bidirectional modulation of memory by acetylation. | 2012 | PLoS ONE | pmid:23028801 |
Zhao ZN et al. | TSA suppresses miR-106b-93-25 cluster expression through downregulation of MYC and inhibits proliferation and induces apoptosis in human EMC. | 2012 | PLoS ONE | pmid:23028803 |
Banik D et al. | Interferon regulatory factor-8 is important for histone deacetylase inhibitor-mediated antitumor activity. | 2012 | PLoS ONE | pmid:23028998 |
Lv W et al. | Histone deacetylase 1 and 3 regulate the mesodermal lineage commitment of mouse embryonic stem cells. | 2014 | PLoS ONE | pmid:25412078 |
Lu HK et al. | Ex vivo response to histone deacetylase (HDAC) inhibitors of the HIV long terminal repeat (LTR) derived from HIV-infected patients on antiretroviral therapy. | 2014 | PLoS ONE | pmid:25409334 |
Yeakley JM et al. | A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling. | 2017 | PLoS ONE | pmid:28542535 |
Chandwani S et al. | Induction of DARPP-32 by brain-derived neurotrophic factor in striatal neurons in vitro is modified by histone deacetylase inhibitors and Nab2. | 2013 | PLoS ONE | pmid:24204683 |
Smirnova L et al. | MicroRNA profiling as tool for in vitro developmental neurotoxicity testing: the case of sodium valproate. | 2014 | PLoS ONE | pmid:24896083 |
Hassan MK et al. | Histone deacetylase inhibitors sensitize lung cancer cells to hyperthermia: involvement of Ku70/SirT-1 in thermo-protection. | 2014 | PLoS ONE | pmid:24728004 |
Li LF et al. | Trichostatin A attenuates ventilation-augmented epithelial-mesenchymal transition in mice with bleomycin-induced acute lung injury by suppressing the Akt pathway. | 2017 | PLoS ONE | pmid:28234968 |
Cao Z et al. | TSA and BIX-01294 Induced Normal DNA and Histone Methylation and Increased Protein Expression in Porcine Somatic Cell Nuclear Transfer Embryos. | 2017 | PLoS ONE | pmid:28114389 |
Kawasaki H et al. | Mouse embryonic stem cells inhibit murine cytomegalovirus infection through a multi-step process. | 2011 | PLoS ONE | pmid:21407806 |
Zhang F et al. | Role of HDAC3 on p53 expression and apoptosis in T cells of patients with multiple sclerosis. | 2011 | PLoS ONE | pmid:21346816 |
Han B et al. | Trichostatin A stabilizes the expression of pluripotent genes in human mesenchymal stem cells during ex vivo expansion. | 2013 | PLoS ONE | pmid:24312356 |
Zou JY and Crews FT | Release of neuronal HMGB1 by ethanol through decreased HDAC activity activates brain neuroimmune signaling. | 2014 | PLoS ONE | pmid:24551070 |
Gou Z et al. | Epigenetic modification of TLRs in leukocytes is associated with increased susceptibility to Salmonella enteritidis in chickens. | 2012 | PLoS ONE | pmid:22438967 |
Desjardins D et al. | Histone Deacetylase Inhibition Restores Retinal Pigment Epithelium Function in Hyperglycemia. | 2016 | PLoS ONE | pmid:27617745 |
Park IH et al. | Trichostatin A Inhibits Epithelial Mesenchymal Transition Induced by TGF-β1 in Airway Epithelium. | 2016 | PLoS ONE | pmid:27571418 |
Hu Y et al. | Trichostatin A selectively suppresses the cold-induced transcription of the ZmDREB1 gene in maize. | 2011 | PLoS ONE | pmid:21811564 |
Andrews KT et al. | Comparative gene expression profiling of P. falciparum malaria parasites exposed to three different histone deacetylase inhibitors. | 2012 | PLoS ONE | pmid:22384084 |
Amoêdo ND et al. | Energy metabolism in H460 lung cancer cells: effects of histone deacetylase inhibitors. | 2011 | PLoS ONE | pmid:21789245 |
Kondo Y et al. | Histone deacetylase inhibitor valproic acid promotes the differentiation of human induced pluripotent stem cells into hepatocyte-like cells. | 2014 | PLoS ONE | pmid:25084468 |
Fu S et al. | Involvement of histone acetylation of Sox17 and Foxa2 promoters during mouse definitive endoderm differentiation revealed by microRNA profiling. | 2011 | PLoS ONE | pmid:22132182 |
Chen J et al. | Histone Deacetylase Inhibitors Trichostatin A and MCP30 Relieve Benzene-Induced Hematotoxicity via Restoring Topoisomerase IIα. | 2016 | PLoS ONE | pmid:27058040 |
Reeves ME et al. | Evidence that RASSF1C stimulation of lung cancer cell proliferation depends on IGFBP-5 and PIWIL1 expression levels. | 2014 | PLoS ONE | pmid:25007054 |
MacTavish H et al. | Enhancement of vaccinia virus based oncolysis with histone deacetylase inhibitors. | 2010 | PLoS ONE | pmid:21283510 |
Gurgul A et al. | Evaluation of changes arising in the pig mesenchymal stromal cells transcriptome following cryopreservation and Trichostatin A treatment. | 2018 | PLoS ONE | pmid:29390033 |
Cavalieri V and Spinelli G | Ectopic hbox12 Expression Evoked by Histone Deacetylase Inhibition Disrupts Axial Specification of the Sea Urchin Embryo. | 2015 | PLoS ONE | pmid:26618749 |
Zhang Y et al. | The Induction Effect of Am80 and TSA on ESC Differentiation via Regulation of Stra8 in Chicken. | 2015 | PLoS ONE | pmid:26606052 |
Shakèd M et al. | Histone deacetylases control neurogenesis in embryonic brain by inhibition of BMP2/4 signaling. | 2008 | PLoS ONE | pmid:18628975 |
O'Leary DA et al. | Identification of small molecule and genetic modulators of AON-induced dystrophin exon skipping by high-throughput screening. | 2009 | PLoS ONE | pmid:20020055 |
Halaban R et al. | Integrative analysis of epigenetic modulation in melanoma cell response to decitabine: clinical implications. | 2009 | PLoS ONE | pmid:19234609 |
Gupta K et al. | Green tea polyphenols induce p53-dependent and p53-independent apoptosis in prostate cancer cells through two distinct mechanisms. | 2012 | PLoS ONE | pmid:23285096 |
Cabanel M et al. | Epigenetic Control of Macrophage Shape Transition towards an Atypical Elongated Phenotype by Histone Deacetylase Activity. | 2015 | PLoS ONE | pmid:26196676 |
Anderson L et al. | Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in Schistosoma mansoni. | 2017 | PLoS Negl Trop Dis | pmid:28406899 |
Oksenych V et al. | Histone methyltransferase DOT1L drives recovery of gene expression after a genotoxic attack. | 2013 | PLoS Genet. | pmid:23861670 |
Biacsi R et al. | SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome. | 2008 | PLoS Genet. | pmid:18369442 |
Shen L et al. | Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters. | 2007 | PLoS Genet. | pmid:17967063 |
Appanah R et al. | An unmethylated 3' promoter-proximal region is required for efficient transcription initiation. | 2007 | PLoS Genet. | pmid:17305432 |
Ukaegbu UE et al. | A Unique Virulence Gene Occupies a Principal Position in Immune Evasion by the Malaria Parasite Plasmodium falciparum. | 2015 | PLoS Genet. | pmid:25993442 |
Paddock MN et al. | The BRCT domain of PARP-1 is required for immunoglobulin gene conversion. | 2010 | PLoS Biol. | pmid:20652015 |
Hazzalin CA and Mahadevan LC | Dynamic acetylation of all lysine 4-methylated histone H3 in the mouse nucleus: analysis at c-fos and c-jun. | 2005 | PLoS Biol. | pmid:16262446 |
Diao JS et al. | Histone deacetylase inhibitor reduces hypertrophic scarring in a rabbit ear model. | 2013 | Plast. Reconstr. Surg. | pmid:23806955 |
Song Y et al. | Trichostatin A and 5-Aza-2'-Deoxycytidine influence the expression of cold-induced genes in Arabidopsis. | 2017 | Plant Signal Behav | pmid:29027833 |