| MeSH term | MeSH ID | Detail |
|---|---|---|
| Osteosarcoma | D012516 | 50 associated lipids |
| Brain Neoplasms | D001932 | 15 associated lipids |
| Leukemia, Erythroblastic, Acute | D004915 | 41 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Muscular Dystrophies | D009136 | 10 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Intellectual Disability | D008607 | 13 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hypertension, Pulmonary | D006976 | 32 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Prostatic Hyperplasia | D011470 | 20 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wilson DW et al. | Defining the timing of action of antimalarial drugs against Plasmodium falciparum. | 2013 | Antimicrob. Agents Chemother. | pmid:23318799 |
| Ogura A et al. | Recent advancements in cloning by somatic cell nuclear transfer. | 2013 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:23166393 |
| Dom G et al. | 5-aza-2'-deoxycytidine has minor effects on differentiation in human thyroid cancer cell lines, but modulates genes that are involved in adaptation in vitro. | 2013 | Thyroid | pmid:23167291 |
| Soriano FX et al. | SMRT-mediated co-shuttling enables export of class IIa HDACs independent of their CaM kinase phosphorylation sites. | 2013 | J. Neurochem. | pmid:23083128 |
| Tran L et al. | Importance of epigenetic mechanisms in visceral pain induced by chronic water avoidance stress. | 2013 | Psychoneuroendocrinology | pmid:23084728 |
| Chen J et al. | Prevention of cytotoxicity of nickel by quercetin: the role of reactive oxygen species and histone acetylation. | 2013 | Toxicol Ind Health | pmid:22294440 |
| Poplineau M et al. | Epigenetically induced changes in nuclear textural patterns and gelatinase expression in human fibrosarcoma cells. | 2013 | Cell Prolif. | pmid:23510467 |
| Ding SZ et al. | Epithelial-mesenchymal transition during oncogenic transformation induced by hexavalent chromium involves reactive oxygen species-dependent mechanism in lung epithelial cells. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23518002 |
| Azechi T et al. | Trichostatin A, an HDAC class I/II inhibitor, promotes Pi-induced vascular calcification via up-regulation of the expression of alkaline phosphatase. | 2013 | J. Atheroscler. Thromb. | pmid:23518467 |
| Duncan HF et al. | Histone deacetylase inhibitors epigenetically promote reparative events in primary dental pulp cells. | 2013 | Exp. Cell Res. | pmid:23562654 |
| Wang Y et al. | Role of histone deacetylase inhibitors in the aging of human umbilical cord mesenchymal stem cells. | 2013 | J. Cell. Biochem. | pmid:23564418 |
| Liu J et al. | Direct differentiation of hepatic stem-like WB cells into insulin-producing cells using small molecules. | 2013 | Sci Rep | pmid:23378917 |
| Shah RR et al. | Regulation of primitive hematopoiesis by class I histone deacetylases. | 2013 | Dev. Dyn. | pmid:23184530 |
| Gao SM et al. | Histone deacetylases inhibitor sodium butyrate inhibits JAK2/STAT signaling through upregulation of SOCS1 and SOCS3 mediated by HDAC8 inhibition in myeloproliferative neoplasms. | 2013 | Exp. Hematol. | pmid:23111066 |
| Liu RF et al. | Down-regulation of miR-517a and miR-517c promotes proliferation of hepatocellular carcinoma cells via targeting Pyk2. | 2013 | Cancer Lett. | pmid:23142219 |
| Jang SM et al. | Transcription factor Sox4 is required for PUMA-mediated apoptosis induced by histone deacetylase inhibitor, TSA. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23916609 |
| Liu YQ et al. | Identification of a novel human testicular interstitial gene, RNF148, and its expression regulated by histone deacetylases. | 2013 | Genet. Mol. Res. | pmid:24089095 |
| Florea AM | DNA methylation pyrosequencing assay is applicable for the assessment of epigenetic active environmental or clinical relevant chemicals. | 2013 | Biomed Res Int | pmid:24093099 |
| Liu S et al. | Up-regulation of miR-182 expression after epigenetic modulation of human melanoma cells. | 2013 | Ann. Surg. Oncol. | pmid:22752337 |
| Ononye SN et al. | Tropolones as lead-like natural products: the development of potent and selective histone deacetylase inhibitors. | 2013 | ACS Med Chem Lett | pmid:24900743 |
| Feng L et al. | Histone deacetylase 3 inhibits expression of PUMA in gastric cancer cells. | 2013 | J. Mol. Med. | pmid:22763818 |
| Kadiyala V et al. | Class I lysine deacetylases facilitate glucocorticoid-induced transcription. | 2013 | J. Biol. Chem. | pmid:23946490 |
| Jung AR et al. | Increased alternative lengthening of telomere phenotypes of telomerase-negative immortal cells upon trichostatin--a treatment. | 2013 | Anticancer Res. | pmid:23482750 |
| Piazza R et al. | Epigenetic silencing of the proapoptotic gene BIM in anaplastic large cell lymphoma through an MeCP2/SIN3a deacetylating complex. | 2013 | Neoplasia | pmid:23633923 |
| Hudson RS et al. | Transcription signatures encoded by ultraconserved genomic regions in human prostate cancer. | 2013 | Mol. Cancer | pmid:23409773 |
| Camolotto SA et al. | PSG gene expression is up-regulated by lysine acetylation involving histone and nonhistone proteins. | 2013 | PLoS ONE | pmid:23418492 |
| Zutz C et al. | Small chemical chromatin effectors alter secondary metabolite production in Aspergillus clavatus. | 2013 | Toxins (Basel) | pmid:24105402 |
| Viñuelas J et al. | Quantifying the contribution of chromatin dynamics to stochastic gene expression reveals long, locus-dependent periods between transcriptional bursts. | 2013 | BMC Biol. | pmid:23442824 |
| Kim TW et al. | Nuclear-encoded mitochondrial MTO1 and MRPL41 are regulated in an opposite epigenetic mode based on estrogen receptor status in breast cancer. | 2013 | BMC Cancer | pmid:24160266 |
| Chachadi VB et al. | Prostatic cell-specific regulation of the synthesis of MUC1-associated sialyl Lewis a. | 2013 | PLoS ONE | pmid:23451223 |
| Kim YJ et al. | HDAC inhibitors induce transcriptional repression of high copy number genes in breast cancer through elongation blockade. | 2013 | Oncogene | pmid:23435418 |
| Moreaux J et al. | Gene expression-based prediction of myeloma cell sensitivity to histone deacetylase inhibitors. | 2013 | Br. J. Cancer | pmid:23868005 |
| Yeo M et al. | Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23440186 |
| Matsushita Y et al. | HDAC inhibitors restore C-fibre sensitivity in experimental neuropathic pain model. | 2013 | Br. J. Pharmacol. | pmid:24032674 |
| Singh RK et al. | Kinetic and thermodynamic rationale for suberoylanilide hydroxamic acid being a preferential human histone deacetylase 8 inhibitor as compared to the structurally similar ligand, trichostatin a. | 2013 | Biochemistry | pmid:24079912 |
| Day JA and Cohen SM | Investigating the selectivity of metalloenzyme inhibitors. | 2013 | J. Med. Chem. | pmid:24074025 |
| Xia X et al. | Effects of trichostatin A in a rat model of acute graft-versus-host disease after liver transplantation. | 2013 | Transplantation | pmid:23694951 |
| Fan J et al. | Inhibition of HDAC2 protects the retina from ischemic injury. | 2013 | Invest. Ophthalmol. Vis. Sci. | pmid:23696608 |
| Li M et al. | Upregulation of Toll-like receptor 2 gene expression by acetylation of AP-2 alpha in THP-1 cells, a human monocytic cell line. | 2013 | Int. J. Biochem. Cell Biol. | pmid:23680675 |
| Zhang Z et al. | Stemness and inducing differentiation of small cell lung cancer NCI-H446 cells. | 2013 | Cell Death Dis | pmid:23681228 |
| Kannan V et al. | Histone deacetylase inhibitors suppress immune activation in primary mouse microglia. | 2013 | J. Neurosci. Res. | pmid:23686642 |
| Oleksiewicz U et al. | Cytoglobin has bimodal: tumour suppressor and oncogene functions in lung cancer cell lines. | 2013 | Hum. Mol. Genet. | pmid:23591990 |
| Breuzard G et al. | Molecular mechanisms of Tau binding to microtubules and its role in microtubule dynamics in live cells. | 2013 | J. Cell. Sci. | pmid:23659998 |
| Theisen JW et al. | Biochemical analysis of histone deacetylase-independent transcriptional repression by MeCP2. | 2013 | J. Biol. Chem. | pmid:23349465 |
| Nunes MJ et al. | Histone deacetylase inhibition decreases cholesterol levels in neuronal cells by modulating key genes in cholesterol synthesis, uptake and efflux. | 2013 | PLoS ONE | pmid:23326422 |
| Murko C et al. | Histone deacetylase inhibitor Trichostatin A induces neural tube defects and promotes neural crest specification in the chicken neural tube. | 2013 | Differentiation | pmid:23328540 |
| Algamas-Dimantov A et al. | Epigenetic control of HNF-4α in colon carcinoma cells affects MUC4 expression and malignancy. | 2013 | Cell Oncol (Dordr) | pmid:23307400 |
| Johnson D and Walmsley R | Histone-deacetylase inhibitors produce positive results in the GADD45a-GFP GreenScreen HC assay. | 2013 | Mutat. Res. | pmid:23340162 |
| Zhou G et al. | HSV carrying WT REST establishes latency but reactivates only if the synthesis of REST is suppressed. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23341636 |
| Chan ST et al. | Quercetin enhances the antitumor activity of trichostatin A through upregulation of p53 protein expression in vitro and in vivo. | 2013 | PLoS ONE | pmid:23342112 |