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Glucocorticoid receptor alpha and beta variant expression is associated with ASF/SF2 splicing factor upregulation in HT-29 colon cancer and MCF-7 breast carcinoma cells. |
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Epigenetics |
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Oncogene |
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Histone acetyltransferase GCN5 interferes with the miRNA pathway in Arabidopsis. |
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Cell Res. |
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Prostate |
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Dimethylated lysine 9 of histone 3 is elevated in schizophrenia and exhibits a divergent response to histone deacetylase inhibitors in lymphocyte cultures. |
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J Psychiatry Neurosci |
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Histone deacetylase inhibitors induce a very broad, pleiotropic anticancer drug resistance phenotype in acute myeloid leukemia cells by modulation of multiple ABC transporter genes. |
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BMC Cancer |
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2009 |
Zygote |
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Frequent loss of cystatin E/M expression implicated in the progression of prostate cancer. |
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Oncogene |
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Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2. |
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Mol. Cell Proteomics |
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Curr Cancer Drug Targets |
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Trichostatin A with adenovirus-mediated p53 gene transfer synergistically induces apoptosis in breast cancer cell line MDA-MB-231. |
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Interspecies somatic cell nucleus transfer with porcine oocytes as recipients: A novel bioassay system for assessing the competence of canine somatic cells to develop into embryos. |
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Theriogenology |
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Anticancer Res. |
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Cytotoxic triterpenoids from the stems of Microtropis japonica. |
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J. Nat. Prod. |
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Recent advances in the development of polyamine analogues as antitumor agents. |
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Use of epigenetic modification to induce FOXP3 expression in naïve T cells. |
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Cancer Res. |
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Am. J. Physiol. Renal Physiol. |
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The 26-amino acid beta-motif of the Pit-1beta transcription factor is a dominant and independent repressor domain. |
2009 |
Mol. Endocrinol. |
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NMDA receptor activation induces differential epigenetic modification of Bdnf promoters in hippocampal neurons. |
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Amino Acids |
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2009 |
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Structural and functional studies of the yeast class II Hda1 histone deacetylase complex. |
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PTEN/AKT pathway involved in histone deacetylases inhibitor induced cell growth inhibition and apoptosis of oral squamous cell carcinoma cells. |
2009 |
Oral Oncol. |
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[Recent advances in DNA demethylation in tumor therapy]. |
2009 |
Zhonghua Bing Li Xue Za Zhi |
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Histone deacetylases regulate multicellular development in the social amoeba Dictyostelium discoideum. |
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Hyperacetylation in prostate cancer induces cell cycle aberrations, chromatin reorganization and altered gene expression profiles. |
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15-hydroxyprostaglandin dehydrogenase is down-regulated in gastric cancer. |
2009 |
Clin. Cancer Res. |
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Hydroxychloroquine, chloroquine, and all-trans retinoic acid regulate growth, survival, and histone acetylation in breast cancer cells. |
2009 |
Anticancer Drugs |
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Gene expression-signature of belinostat in cell lines is specific for histone deacetylase inhibitor treatment, with a corresponding signature in xenografts. |
2009 |
Anticancer Drugs |
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Co-treatment with deoxycholic acid and azoxymethane accelerates secretion of HMGB1 in IEC6 intestinal epithelial cells. |
2009 |
Cell Prolif. |
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[Role of histone deacetylase in inhibiting invasion of human gastric carcinoma cell line SGC-7901 by PPARgamma-mediated pathway]. |
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Ai Zheng |
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Basal endothelial nitric oxide synthase (eNOS) phosphorylation on Ser(1177) occurs in a stable microtubule- and tubulin acetylation-dependent manner. |
2009 |
Exp. Cell Res. |
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Trichostatin A enhances proliferation and migration of vascular smooth muscle cells by downregulating thioredoxin 1. |
2010 |
Cardiovasc. Res. |
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Histone deacetylases facilitate sodium/calcium exchanger up-regulation in adult cardiomyocytes. |
2009 |
FASEB J. |
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MLH1 protects from resistance acquisition by the histone deacetylase inhibitor trichostatin A in colon tumor cells. |
2009 |
Int. J. Oncol. |
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Genistein and beta-carotene enhance the growth-inhibitory effect of trichostatin A in A549 cells. |
2010 |
Eur J Nutr |
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Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy. |
2009 |
Am. J. Physiol. Renal Physiol. |
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Microarray study of mechanism of trichostatin a inducing apoptosis of Molt-4 cells. |
2009 |
J. Huazhong Univ. Sci. Technol. Med. Sci. |
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Histone deacetylase inhibitor uses p21(Cip1) to maintain anergy in CD4+ T cells. |
2009 |
Int. Immunopharmacol. |
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Repression of induced apoptosis in the 2-cell bovine embryo involves DNA methylation and histone deacetylation. |
2009 |
Biochem. Biophys. Res. Commun. |
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Histone deacetylase inhibitor trichostatin A modulates cell cycles in A2780 human ovarian cancer cell lines. |
2009 |
Eur. J. Gynaecol. Oncol. |
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Troglitazone inhibits histone deacetylase activity in breast cancer cells. |
2010 |
Cancer Lett. |
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Abrogation of TGF-beta1-induced fibroblast-myofibroblast differentiation by histone deacetylase inhibition. |
2009 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
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Acetylation level of histone H3 in early embryonic stages affects subsequent development of miniature pig somatic cell nuclear transfer embryos. |
2009 |
J. Reprod. Dev. |
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Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides. |
2009 |
J. Med. Chem. |
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Regulation of Toll-like receptor 4-associated MD-2 in intestinal epithelial cells: a comprehensive analysis. |
2010 |
Innate Immun |
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Inhibition of type I histone deacetylase increases resistance of checkpoint-deficient cells to genotoxic agents through mitotic delay. |
2009 |
Mol. Cancer Ther. |
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Trichostatin A stimulates steroid 5alpha-reductase gene expression in rat C6 glioma cells via a mechanism involving Sp1 and Sp3 transcription factors. |
2010 |
J. Mol. Neurosci. |
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Krüppel-like factor 4 mediates histone deacetylase inhibitor-induced prevention of cardiac hypertrophy. |
2009 |
J. Mol. Cell. Cardiol. |
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Stress resistant human embryonic stem cells as a potential source for the identification of novel cancer stem cell markers. |
2010 |
Cancer Lett. |
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LARG at chromosome 11q23 has functional characteristics of a tumor suppressor in human breast and colorectal cancer. |
2009 |
Oncogene |
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Trichostatin A-induced TGF-beta type II receptor expression in retinoblastoma cell lines. |
2010 |
Invest. Ophthalmol. Vis. Sci. |
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AP-2alpha induces epigenetic silencing of tumor suppressive genes and microsatellite instability in head and neck squamous cell carcinoma. |
2009 |
PLoS ONE |
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[Effects of 5-Aza-2'-deoxycytidine and trichostatin A on P16, hMLH1 and MGMT genes and DNA methylation in human gastric cancer cells]. |
2009 |
Zhonghua Wei Chang Wai Ke Za Zhi |
pmid:19742343
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Impaired active demethylation of the paternal genome in pronuclear-stage rat zygotes produced by in vitro fertilization or intracytoplasmic sperm injection. |
2010 |
Mol. Reprod. Dev. |
pmid:19743475
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Dombrowsky H et al. |
Conserved responses to trichostatin A in rodent lungs exposed to endotoxin or stretch. |
2009 |
Pulm Pharmacol Ther |
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Dandrea M et al. |
MeCP2/H3meK9 are involved in IL-6 gene silencing in pancreatic adenocarcinoma cell lines. |
2009 |
Nucleic Acids Res. |
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Histone deacetylase inhibitors repress macrophage migration inhibitory factor (MIF) expression by targeting MIF gene transcription through a local chromatin deacetylation. |
2009 |
Biochim. Biophys. Acta |
pmid:19747950
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Sterthaus O et al. |
Evaluation of in vitro cultured rat oocytes, from different strains, by spindle morphology and maturation-promoting-factor activity combined with nuclear-transfer experiments. |
2009 |
Cloning Stem Cells |
pmid:19751114
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Correction of the abnormal trafficking of primary myelofibrosis CD34+ cells by treatment with chromatin-modifying agents. |
2009 |
Cancer Res. |
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Wnt antagonist gene DKK2 is epigenetically silenced and inhibits renal cancer progression through apoptotic and cell cycle pathways. |
2009 |
Clin. Cancer Res. |
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Up-regulation of GADD45alpha expression by NSAIDs leads to apoptotic and necrotic colon cancer cell deaths. |
2009 |
Apoptosis |
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Anti-leukemia activity of MS-275 histone deacetylase inhibitor implicates 4-1BBL/4-1BB immunomodulatory functions. |
2009 |
PLoS ONE |
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Trichostatin A affects histone acetylation and gene expression in porcine somatic cell nucleus transfer embryos. |
2009 |
Theriogenology |
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Trichostatin A inhibits osteoclastogenesis and bone resorption by suppressing the induction of c-Fos by RANKL. |
2009 |
Eur. J. Pharmacol. |
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Demonstration of all-or-none loss of imprinting in mRNA expression in single cells. |
2009 |
Nucleic Acids Res. |
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Obier N and Müller AM |
Chromatin flow cytometry identifies changes in epigenetic cell states. |
2010 |
Cells Tissues Organs (Print) |
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Expression and function of CD9 in melanoma cells. |
2010 |
Mol. Carcinog. |
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Cytochalasin B and trichostatin a treatment postactivation improves in vitro development of porcine somatic cell nuclear transfer embryos. |
2009 |
Cloning Stem Cells |
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Differential sensitivity of human leukemic cell lines to the histone deacetylase inhibitor, trichostatin A. |
2010 |
Leuk. Res. |
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Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis. |
2010 |
Mod Rheumatol |
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The Scar-in-a-Jar: studying potential antifibrotic compounds from the epigenetic to extracellular level in a single well. |
2009 |
Br. J. Pharmacol. |
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Stanniocalcin-2 is a HIF-1 target gene that promotes cell proliferation in hypoxia. |
2010 |
Exp. Cell Res. |
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Promoter histone H3 lysine 9 di-methylation is associated with DNA methylation and aberrant expression of p16 in gastric cancer cells. |
2009 |
Oncol. Rep. |
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High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growth. |
2009 |
Clin. Cancer Res. |
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