trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Osteosarcoma D012516 50 associated lipids
Brain Neoplasms D001932 15 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Melanoma D008545 69 associated lipids
Muscular Dystrophies D009136 10 associated lipids
Asthma D001249 52 associated lipids
Abnormalities, Multiple D000015 13 associated lipids
Intellectual Disability D008607 13 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Endometriosis D004715 29 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Prostatic Hyperplasia D011470 20 associated lipids
Alzheimer Disease D000544 76 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Leukemia D007938 74 associated lipids
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Per page 10 20 50 100 | Total 139

PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


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Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Charrier C et al. Synthesis and modeling of new benzofuranone histone deacetylase inhibitors that stimulate tumor suppressor gene expression. 2009 J. Med. Chem. pmid:19385600
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Gaymes TJ et al. Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes. 2009 Haematologica pmid:19407318
Kim SN et al. Regulation of adipocyte differentiation by histone deacetylase inhibitors. 2009 Arch. Pharm. Res. pmid:19407971
Han SB and Lee JK Anti-inflammatory effect of Trichostatin-A on murine bone marrow-derived macrophages. 2009 Arch. Pharm. Res. pmid:19407980
Yoshida M Chemical genomics: a key to the epigenome - an interview with Minoru Yoshida. Interview by Saadi Khochbin. 2009 Int. J. Dev. Biol. pmid:19412886
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Hirose N et al. ATF-2 regulates lipopolysaccharide-induced transcription in macrophage cells. 2009 Biochem. Biophys. Res. Commun. pmid:19422799
Park SJ et al. Trichostatin A sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by down-regulation of c-FLIPL via inhibition of EGFR pathway. 2009 Biochem. Pharmacol. pmid:19426671
Piotrowska H and Jagodzinski PP Glucocorticoid receptor alpha and beta variant expression is associated with ASF/SF2 splicing factor upregulation in HT-29 colon cancer and MCF-7 breast carcinoma cells. 2009 Arch. Med. Res. pmid:19427965
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Mavis CK et al. Expression level and DNA methylation status of glutathione-S-transferase genes in normal murine prostate and TRAMP tumors. 2009 Prostate pmid:19444856
Samuni Y et al. The inhibitors of histone deacetylase suberoylanilide hydroxamate and trichostatin A release nitric oxide upon oxidation. 2009 Free Radic. Biol. Med. pmid:19447172
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Woodfield GW et al. Interaction of TFAP2C with the estrogen receptor-alpha promoter is controlled by chromatin structure. 2009 Clin. Cancer Res. pmid:19458056
Hauswald S et al. Histone deacetylase inhibitors induce a very broad, pleiotropic anticancer drug resistance phenotype in acute myeloid leukemia cells by modulation of multiple ABC transporter genes. 2009 Clin. Cancer Res. pmid:19458058
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Chang J et al. The NIMA-family kinase Nek3 regulates microtubule acetylation in neurons. 2009 J. Cell. Sci. pmid:19509051
Nakajima S et al. Trichostatin A with adenovirus-mediated p53 gene transfer synergistically induces apoptosis in breast cancer cell line MDA-MB-231. 2009 Oncol. Rep. pmid:19513516
Takaya T et al. MicroRNA-1 and MicroRNA-133 in spontaneous myocardial differentiation of mouse embryonic stem cells. 2009 Circ. J. pmid:19521018
Sugimura S et al. Interspecies somatic cell nucleus transfer with porcine oocytes as recipients: A novel bioassay system for assessing the competence of canine somatic cells to develop into embryos. 2009 Theriogenology pmid:19524287
Nadasi E et al. Epigenetic modifiers exacerbate oxidative stress in renal proximal tubule cells. 2009 Anticancer Res. pmid:19528494
Link PA et al. Distinct roles for histone methyltransferases G9a and GLP in cancer germ-line antigen gene regulation in human cancer cells and murine embryonic stem cells. 2009 Mol. Cancer Res. pmid:19531572
Chen IH et al. Cytotoxic triterpenoids from the stems of Microtropis japonica. 2009 J. Nat. Prod. pmid:19534471
Casero RA and Woster PM Recent advances in the development of polyamine analogues as antitumor agents. 2009 J. Med. Chem. pmid:19534534
Dubois F et al. Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni. 2009 Mol. Biochem. Parasitol. pmid:19538992
Moon C et al. Use of epigenetic modification to induce FOXP3 expression in naïve T cells. 2009 Transplant. Proc. pmid:19545742
Hsu PY et al. Xenoestrogen-induced epigenetic repression of microRNA-9-3 in breast epithelial cells. 2009 Cancer Res. pmid:19549897
Noh H et al. Histone deacetylase-2 is a key regulator of diabetes- and transforming growth factor-beta1-induced renal injury. 2009 Am. J. Physiol. Renal Physiol. pmid:19553350
Jonsen MD et al. The 26-amino acid beta-motif of the Pit-1beta transcription factor is a dominant and independent repressor domain. 2009 Mol. Endocrinol. pmid:19556346
Tian F et al. NMDA receptor activation induces differential epigenetic modification of Bdnf promoters in hippocampal neurons. 2010 Amino Acids pmid:19565326
Ma XL et al. [Construction of anti-sense cDNA library of human breast cancer cells during apoptosis induced by trichostatin A and preliminary screening of essential genes]. 2009 Zhonghua Yi Xue Za Zhi pmid:19567099
Lee JH et al. Structural and functional studies of the yeast class II Hda1 histone deacetylase complex. 2009 J. Mol. Biol. pmid:19573535
Gan YH and Zhang S PTEN/AKT pathway involved in histone deacetylases inhibitor induced cell growth inhibition and apoptosis of oral squamous cell carcinoma cells. 2009 Oral Oncol. pmid:19574087
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Sawarkar R et al. Histone deacetylases regulate multicellular development in the social amoeba Dictyostelium discoideum. 2009 J. Mol. Biol. pmid:19576222
Watson JA et al. Hyperacetylation in prostate cancer induces cell cycle aberrations, chromatin reorganization and altered gene expression profiles. 2010 J. Cell. Mol. Med. pmid:19583812
Thiel A et al. 15-hydroxyprostaglandin dehydrogenase is down-regulated in gastric cancer. 2009 Clin. Cancer Res. pmid:19584167
Rahim R and Strobl JS Hydroxychloroquine, chloroquine, and all-trans retinoic acid regulate growth, survival, and histone acetylation in breast cancer cells. 2009 Anticancer Drugs pmid:19584707
Monks A et al. Gene expression-signature of belinostat in cell lines is specific for histone deacetylase inhibitor treatment, with a corresponding signature in xenografts. 2009 Anticancer Drugs pmid:19606018
Fujii K et al. Co-treatment with deoxycholic acid and azoxymethane accelerates secretion of HMGB1 in IEC6 intestinal epithelial cells. 2009 Cell Prolif. pmid:19614672
Ma GD et al. [Role of histone deacetylase in inhibiting invasion of human gastric carcinoma cell line SGC-7901 by PPARgamma-mediated pathway]. 2009 Ai Zheng pmid:19624894
Giustiniani J et al. Basal endothelial nitric oxide synthase (eNOS) phosphorylation on Ser(1177) occurs in a stable microtubule- and tubulin acetylation-dependent manner. 2009 Exp. Cell Res. pmid:19632222
Song S et al. Trichostatin A enhances proliferation and migration of vascular smooth muscle cells by downregulating thioredoxin 1. 2010 Cardiovasc. Res. pmid:19633316
Chandrasekaran S et al. Histone deacetylases facilitate sodium/calcium exchanger up-regulation in adult cardiomyocytes. 2009 FASEB J. pmid:19638401
Imesch P et al. MLH1 protects from resistance acquisition by the histone deacetylase inhibitor trichostatin A in colon tumor cells. 2009 Int. J. Oncol. pmid:19639184
Shiau RJ et al. Genistein and beta-carotene enhance the growth-inhibitory effect of trichostatin A in A549 cells. 2010 Eur J Nutr pmid:19639378
Pang M et al. Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy. 2009 Am. J. Physiol. Renal Physiol. pmid:19640900
Hong Z et al. Microarray study of mechanism of trichostatin a inducing apoptosis of Molt-4 cells. 2009 J. Huazhong Univ. Sci. Technol. Med. Sci. pmid:19662360
Dagtas AS et al. Histone deacetylase inhibitor uses p21(Cip1) to maintain anergy in CD4+ T cells. 2009 Int. Immunopharmacol. pmid:19664724
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Ma XX et al. Histone deacetylase inhibitor trichostatin A modulates cell cycles in A2780 human ovarian cancer cell lines. 2009 Eur. J. Gynaecol. Oncol. pmid:19697617
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Her S et al. Trichostatin A stimulates steroid 5alpha-reductase gene expression in rat C6 glioma cells via a mechanism involving Sp1 and Sp3 transcription factors. 2010 J. Mol. Neurosci. pmid:19728174
Kee HJ and Kook H Krüppel-like factor 4 mediates histone deacetylase inhibitor-induced prevention of cardiac hypertrophy. 2009 J. Mol. Cell. Cardiol. pmid:19729022
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Dombrowsky H et al. Conserved responses to trichostatin A in rodent lungs exposed to endotoxin or stretch. 2009 Pulm Pharmacol Ther pmid:19744573
Dandrea M et al. MeCP2/H3meK9 are involved in IL-6 gene silencing in pancreatic adenocarcinoma cell lines. 2009 Nucleic Acids Res. pmid:19745053
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Hirata H et al. Wnt antagonist gene DKK2 is epigenetically silenced and inhibits renal cancer progression through apoptotic and cell cycle pathways. 2009 Clin. Cancer Res. pmid:19755393
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Cervera RP et al. Trichostatin A affects histone acetylation and gene expression in porcine somatic cell nucleus transfer embryos. 2009 Theriogenology pmid:19765811
Kim HN et al. Trichostatin A inhibits osteoclastogenesis and bone resorption by suppressing the induction of c-Fos by RANKL. 2009 Eur. J. Pharmacol. pmid:19766111
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Beebe LF et al. Cytochalasin B and trichostatin a treatment postactivation improves in vitro development of porcine somatic cell nuclear transfer embryos. 2009 Cloning Stem Cells pmid:19780698
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Higashiyama R et al. Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis. 2010 Mod Rheumatol pmid:19784544
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Law AY and Wong CK Stanniocalcin-2 is a HIF-1 target gene that promotes cell proliferation in hypoxia. 2010 Exp. Cell Res. pmid:19786016
Meng CF et al. Promoter histone H3 lysine 9 di-methylation is associated with DNA methylation and aberrant expression of p16 in gastric cancer cells. 2009 Oncol. Rep. pmid:19787243
Iljin K et al. High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growth. 2009 Clin. Cancer Res. pmid:19789329