| MeSH term | MeSH ID | Detail |
|---|---|---|
| Osteosarcoma | D012516 | 50 associated lipids |
| Brain Neoplasms | D001932 | 15 associated lipids |
| Leukemia, Erythroblastic, Acute | D004915 | 41 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Muscular Dystrophies | D009136 | 10 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Intellectual Disability | D008607 | 13 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hypertension, Pulmonary | D006976 | 32 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Prostatic Hyperplasia | D011470 | 20 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ishimaru N et al. | Differential epigenetic regulation of BDNF and NT-3 genes by trichostatin A and 5-aza-2'-deoxycytidine in Neuro-2a cells. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20188708 |
| Popova AP et al. | Autocrine production of TGF-beta1 promotes myofibroblastic differentiation of neonatal lung mesenchymal stem cells. | 2010 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:20190033 |
| Calonge TM et al. | Transformation/transcription domain-associated protein (TRRAP)-mediated regulation of Wee1. | 2010 | Genetics | pmid:20194963 |
| Halili MA et al. | Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS. | 2010 | J. Leukoc. Biol. | pmid:20200406 |
| Reichrath S et al. | Notch- and vitamin D signaling in 1,25(OH)2D3-resistant glioblastoma multiforme (GBM) cell lines. | 2010 | J. Steroid Biochem. Mol. Biol. | pmid:20206691 |
| Bao BY et al. | Down-regulation of NF-kappaB signals is involved in loss of 1alpha,25-dihydroxyvitamin D3 responsiveness. | 2010 | J. Steroid Biochem. Mol. Biol. | pmid:20206692 |
| Wang G et al. | The effects of DNA methyltransferase inhibitors and histone deacetylase inhibitors on digit regeneration in mice. | 2010 | Regen Med | pmid:20210581 |
| Obier N et al. | Inhibition of histone deacetylases by Trichostatin A leads to a HoxB4-independent increase of hematopoietic progenitor/stem cell frequencies as a result of selective survival. | 2010 | Cytotherapy | pmid:20210674 |
| Bertrand P | Inside HDAC with HDAC inhibitors. | 2010 | Eur J Med Chem | pmid:20223566 |
| Gao A et al. | Methylation of PARP-1 promoter involved in the regulation of benzene-induced decrease of PARP-1 mRNA expression. | 2010 | Toxicol. Lett. | pmid:20230882 |
| Zhou Q et al. | TGFbeta mediated transition of corneal fibroblasts from a proinflammatory state to a profibrotic state through modulation of histone acetylation. | 2010 | J. Cell. Physiol. | pmid:20232294 |
| Chen WP et al. | Alleviation of osteoarthritis by Trichostatin A, a histone deacetylase inhibitor, in experimental osteoarthritis. | 2010 | Mol. Biol. Rep. | pmid:20237852 |
| Lu L et al. | Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cells. | 2010 | J. Immunol. | pmid:20304828 |
| Tokési N et al. | TPPP/p25 promotes tubulin acetylation by inhibiting histone deacetylase 6. | 2010 | J. Biol. Chem. | pmid:20308065 |
| Majid S et al. | Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer. | 2010 | Cancer Res. | pmid:20332239 |
| Khobta A et al. | Gene silencing induced by oxidative DNA base damage: association with local decrease of histone H4 acetylation in the promoter region. | 2010 | Nucleic Acids Res. | pmid:20338881 |
| Yuan GB et al. | Combined effects of all-trans-retinoic acid and trichostatin A on the induction of differentiation of thyroid carcinoma cells. | 2010 | Chin J Cancer | pmid:20346212 |
| Kongruttanachok N et al. | Replication independent DNA double-strand break retention may prevent genomic instability. | 2010 | Mol. Cancer | pmid:20356374 |
| Wang QH et al. | Opposite effects of Trichostatin A on activation of mast cells by different stimulants. | 2010 | FEBS Lett. | pmid:20371366 |
| Robertson DM et al. | C-terminal cleavage of DeltaNp63alpha is associated with TSA-induced apoptosis in immortalized corneal epithelial cells. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:20375332 |
| Terracciano S et al. | Synthesis and biological activity of cyclotetrapeptide analogues of the natural HDAC inhibitor FR235222. | 2010 | Bioorg. Med. Chem. | pmid:20381359 |
| Zhang LX et al. | Targeted deletion of NF-kappaB p50 diminishes the cardioprotection of histone deacetylase inhibition. | 2010 | Am. J. Physiol. Heart Circ. Physiol. | pmid:20382965 |
| Pan L et al. | HDAC4 inhibits the transcriptional activation of mda-7/IL-24 induced by Sp1. | 2010 | Cell. Mol. Immunol. | pmid:20383178 |
| Kim HB et al. | Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors. | 2010 | Mol. Cell. Biol. | pmid:20385772 |
| Varma A and Kwon-Chung KJ | Heteroresistance of Cryptococcus gattii to fluconazole. | 2010 | Antimicrob. Agents Chemother. | pmid:20385871 |
| Kim SH et al. | Trichostatin A enhances acetylation as well as protein stability of ERalpha through induction of p300 protein. | 2010 | Breast Cancer Res. | pmid:20388208 |
| Chen WP et al. | Trichostatin A inhibits expression of cathepsins in experimental osteoarthritis. | 2011 | Rheumatol. Int. | pmid:20390279 |
| Yang H et al. | Histone modification-mediated CYP2E1 gene expression and apoptosis of HepG2 cells. | 2010 | Exp. Biol. Med. (Maywood) | pmid:20404016 |
| Emonds E et al. | Molecular determinants of the antitumor effects of trichostatin A in pancreatic cancer cells. | 2010 | World J. Gastroenterol. | pmid:20419833 |
| Marshall H et al. | Deficiency of the dual ubiquitin/SUMO ligase Topors results in genetic instability and an increased rate of malignancy in mice. | 2010 | BMC Mol. Biol. | pmid:20429939 |
| Zhao TC et al. | gp-91 mediates histone deacetylase inhibition-induced cardioprotection. | 2010 | Biochim. Biophys. Acta | pmid:20433879 |
| Jeon HW and Lee YM | Inhibition of histone deacetylase attenuates hypoxia-induced migration and invasion of cancer cells via the restoration of RECK expression. | 2010 | Mol. Cancer Ther. | pmid:20442303 |
| Schuhmann NK et al. | Gene transfer into human cord blood-derived CD34(+) cells by adeno-associated viral vectors. | 2010 | Exp. Hematol. | pmid:20447441 |
| Zhang D et al. | [Effects of trichostatin A on human lung cancer cell strains A549]. | 2010 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:20450546 |
| Ju ZH et al. | [Effects of 5-Aza-2'-deoxycitydine and trichostatin A on expression and apoptosis of ALDH1a2 gene in human bladder cancer cell lines]. | 2010 | Zhonghua Wai Ke Za Zhi | pmid:20450613 |
| Kiyokawa S et al. | New orally bioavailable 2-aminobenzamide-type histone deacetylase inhibitor possessing a (2-hydroxyethyl)(4-(thiophen-2-yl)benzyl)amino group. | 2010 | Bioorg. Med. Chem. | pmid:20452226 |
| Barua S and Rege K | The influence of mediators of intracellular trafficking on transgene expression efficacy of polymer-plasmid DNA complexes. | 2010 | Biomaterials | pmid:20452664 |
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| Kobori A et al. | Butyrate stimulates IL-32alpha expression in human intestinal epithelial cell lines. | 2010 | World J. Gastroenterol. | pmid:20480520 |
| Sudo H and Baas PW | Acetylation of microtubules influences their sensitivity to severing by katanin in neurons and fibroblasts. | 2010 | J. Neurosci. | pmid:20505088 |
| Bui HT et al. | Effect of trichostatin A on chromatin remodeling, histone modifications, DNA replication, and transcriptional activity in cloned mouse embryos. | 2010 | Biol. Reprod. | pmid:20505166 |
| Kim IA et al. | HDAC inhibitor-mediated radiosensitization in human carcinoma cells: a general phenomenon? | 2010 | J. Radiat. Res. | pmid:20505264 |
| Chen J et al. | Interplay of bromodomain and histone acetylation in the regulation of p300-dependent genes. | 2010 | Epigenetics | pmid:20505343 |
| Liu YW et al. | Inhibition of LPS-induced C/EBP delta by trichostatin A has a positive effect on LPS-induced cyclooxygenase 2 expression in RAW264.7 cells. | 2010 | J. Cell. Biochem. | pmid:20506344 |
| Kitamoto S et al. | Promoter hypomethylation contributes to the expression of MUC3A in cancer cells. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20510874 |
| Tong JH et al. | Putative tumour-suppressor gene DAB2 is frequently down regulated by promoter hypermethylation in nasopharyngeal carcinoma. | 2010 | BMC Cancer | pmid:20525238 |
| Alamdari N et al. | Sepsis and glucocorticoids upregulate p300 and downregulate HDAC6 expression and activity in skeletal muscle. | 2010 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:20538901 |
| Li J et al. | Proteomic analysis revealed association of aberrant ROS signaling with suberoylanilide hydroxamic acid-induced autophagy in Jurkat T-leukemia cells. | 2010 | Autophagy | pmid:20543569 |
| Kaichi S et al. | Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice. | 2010 | Cardiovasc. Res. | pmid:20547733 |
| Hirata H et al. | Wnt antagonist DKK1 acts as a tumor suppressor gene that induces apoptosis and inhibits proliferation in human renal cell carcinoma. | 2011 | Int. J. Cancer | pmid:20549706 |
| Yoshikawa M et al. | Trichostatin a prevents TGF-beta1-induced apoptosis by inhibiting ERK activation in human renal tubular epithelial cells. | 2010 | Eur. J. Pharmacol. | pmid:20553909 |
| Russell SB et al. | Epigenetically altered wound healing in keloid fibroblasts. | 2010 | J. Invest. Dermatol. | pmid:20555348 |
| Repouskou A et al. | The circadian expression of c-MYC is modulated by the histone deacetylase inhibitor trichostatin A in synchronized murine neuroblastoma cells. | 2010 | Chronobiol. Int. | pmid:20560708 |
| Tessema M et al. | Re-expression of CXCL14, a common target for epigenetic silencing in lung cancer, induces tumor necrosis. | 2010 | Oncogene | pmid:20562917 |
| Kaimori A et al. | Histone deacetylase inhibition suppresses the transforming growth factor beta1-induced epithelial-to-mesenchymal transition in hepatocytes. | 2010 | Hepatology | pmid:20564330 |
| Dai X et al. | Somatic nucleus reprogramming is significantly improved by m-carboxycinnamic acid bishydroxamide, a histone deacetylase inhibitor. | 2010 | J. Biol. Chem. | pmid:20566633 |
| Han DS et al. | Transcription activation of myostatin by trichostatin A in differentiated C2C12 myocytes via ASK1-MKK3/4/6-JNK and p38 mitogen-activated protein kinase pathways. | 2010 | J. Cell. Biochem. | pmid:20568119 |
| Trtkova K et al. | Binding of AR to SMRT/N-CoR complex and its co-operation with PSA promoter in prostate cancer cells treated with natural histone deacetylase inhibitor NaB. | 2010 | Neoplasma | pmid:20568894 |
| Legartova S et al. | Expression of RAN, ZHX-2, and CHC1L genes in multiple myeloma patients and in myeloma cell lines treated with HDAC and Dnmts inhibitors. | 2010 | Neoplasma | pmid:20568903 |
| Bo F et al. | Effect of trichostatin A on transfected donor cells and subsequent development of porcine cloned embryos. | 2011 | Zygote | pmid:20569515 |
| Kim J et al. | PS-341 and histone deacetylase inhibitor synergistically induce apoptosis in head and neck squamous cell carcinoma cells. | 2010 | Mol. Cancer Ther. | pmid:20571067 |
| Salvi V et al. | Trichostatin A blocks type I interferon production by activated plasmacytoid dendritic cells. | 2010 Sep-Oct | Immunobiology | pmid:20573419 |
| Xue K et al. | Synchronous behaviors of CBP and acetylations of lysine 18 and lysine 23 on histone H3 during porcine oocyte first meiotic division. | 2010 | Mol. Reprod. Dev. | pmid:20575085 |
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| Oliveira CS et al. | Effects of histone hyperacetylation on the preimplantation development of male and female bovine embryos. | 2010 | Reprod. Fertil. Dev. | pmid:20591338 |
| Xia J et al. | Epigenetic modification of vomeronasal (V2r) precursor neurons by histone deacetylation. | 2010 | Neuroscience | pmid:20594945 |
| Urbinati G et al. | Liposomes loaded with histone deacetylase inhibitors for breast cancer therapy. | 2010 | Int J Pharm | pmid:20603204 |
| Sharma P et al. | Transcriptional regulation of human osteopontin promoter by histone deacetylase inhibitor, trichostatin A in cervical cancer cells. | 2010 | Mol. Cancer | pmid:20609221 |
| Mossman D et al. | Demethylation by 5-aza-2'-deoxycytidine in colorectal cancer cells targets genomic DNA whilst promoter CpG island methylation persists. | 2010 | BMC Cancer | pmid:20618997 |
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| Rössler R et al. | Differentiation of non-mesencephalic neural stem cells towards dopaminergic neurons. | 2010 | Neuroscience | pmid:20643196 |
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| Tamannai M et al. | The inhibitor of growth 1 (ING1) is involved in trichostatin A-induced apoptosis and caspase 3 signaling in p53-deficient glioblastoma cells. | 2010 | Oncol. Res. | pmid:20681406 |
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| Das ZC et al. | Lyophilized somatic cells direct embryonic development after whole cell intracytoplasmic injection into pig oocytes. | 2010 | Cryobiology | pmid:20691649 |
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| Jichan Nie SW et al. | Promoter hypermethylation of progesterone receptor isoform B (PR-B) in adenomyosis and its rectification by a histone deacetylase inhibitor and a demethylation agent. | 2010 | Reprod Sci | pmid:20697142 |
| Costa-Borges N et al. | Comparison between the effects of valproic acid and trichostatin A on the in vitro development, blastocyst quality, and full-term development of mouse somatic cell nuclear transfer embryos. | 2010 | Cell Reprogram | pmid:20698782 |
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| Tokoro M et al. | Deposition of acetylated histones by RNAP II promoter clearance may occur at onset of zygotic gene activation in preimplantation mouse embryos. | 2010 | J. Reprod. Dev. | pmid:20710121 |
| Yang F et al. | Trichostatin A and 5-azacytidine both cause an increase in global histone H4 acetylation and a decrease in global DNA and H3K9 methylation during mitosis in maize. | 2010 | BMC Plant Biol. | pmid:20718950 |
| Sanders YY et al. | Epigenetic regulation of thy-1 by histone deacetylase inhibitor in rat lung fibroblasts. | 2011 | Am. J. Respir. Cell Mol. Biol. | pmid:20724553 |
| Kim TH et al. | The histone deacetylase inhibitor, trichostatin A, inhibits the development of 2,4-dinitrofluorobenzene-induced dermatitis in NC/Nga mice. | 2010 | Int. Immunopharmacol. | pmid:20728595 |
| Liu Z et al. | Deacetylase inhibitor trichostatin A down-regulates Foxp3 expression and reduces CD4+CD25+ regulatory T cells. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20801101 |
| Torres J et al. | Biological effects of induced MYCN hyper-expression in MYCN-amplified neuroblastomas. | 2010 | Int. J. Oncol. | pmid:20811720 |
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