trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Osteosarcoma D012516 50 associated lipids
Brain Neoplasms D001932 15 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Melanoma D008545 69 associated lipids
Muscular Dystrophies D009136 10 associated lipids
Asthma D001249 52 associated lipids
Abnormalities, Multiple D000015 13 associated lipids
Intellectual Disability D008607 13 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Endometriosis D004715 29 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Prostatic Hyperplasia D011470 20 associated lipids
Alzheimer Disease D000544 76 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Leukemia D007938 74 associated lipids
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Per page 10 20 50 100 | Total 139

PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


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Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Zhang J et al. Inhibition of glyceroneogenesis by histone deacetylase 3 contributes to lipodystrophy in mice with adipose tissue inflammation. 2011 Endocrinology pmid:21406501
Kawasaki H et al. Mouse embryonic stem cells inhibit murine cytomegalovirus infection through a multi-step process. 2011 PLoS ONE pmid:21407806
Zhang Y et al. ERK1/2 activation plays important roles in the opposite effects of Trichostatin A in non-cancer and cancer cells. 2011 Toxicon pmid:21419152
WEI Q et al. [Trichostatin A inhibits the activation of CD(4)(+) T cells by suppressing CD(28) expression in mice]. 2011 Nan Fang Yi Ke Da Xue Xue Bao pmid:21421475
Jergil M et al. Short-time gene expression response to valproic acid and valproic acid analogs in mouse embryonic stem cells. 2011 Toxicol. Sci. pmid:21427059
Kadowaki M et al. DNA methylation-mediated silencing of nonsteroidal anti-inflammatory drug-activated gene (NAG-1/GDF15) in glioma cell lines. 2012 Int. J. Cancer pmid:21437897
Briggs B et al. Photosensitization by iodinated DNA minor groove binding ligands: Evaluation of DNA double-strand break induction and repair. 2011 J. Photochem. Photobiol. B, Biol. pmid:21440453
Agudelo M et al. Effects of alcohol on histone deacetylase 2 (HDAC2) and the neuroprotective role of trichostatin A (TSA). 2011 Alcohol. Clin. Exp. Res. pmid:21447001
Sun JY et al. Histone deacetylase inhibitors demonstrate significant preclinical activity as single agents, and in combination with bortezomib in Waldenström's macroglobulinemia. 2011 Clin Lymphoma Myeloma Leuk pmid:21454220
Min XJ et al. Dysfunction of volume-sensitive chloride channels contributes to cisplatin resistance in human lung adenocarcinoma cells. 2011 Exp. Biol. Med. (Maywood) pmid:21454376
Belakavadi M et al. Thyroid hormone suppression of β-amyloid precursor protein gene expression in the brain involves multiple epigenetic regulatory events. 2011 Mol. Cell. Endocrinol. pmid:21458529
Miller L et al. Histone deacetylase 1 (HDAC1) participates in the down-regulation of corticotropin releasing hormone gene (crh) expression. 2011 Physiol. Behav. pmid:21463644
Law AY et al. Sp1 is a transcription repressor to stanniocalcin-1 expression in TSA-treated human colon cancer cells, HT29. 2011 J. Cell. Biochem. pmid:21465530
Pang M et al. Histone deacetylase 1/2 mediates proliferation of renal interstitial fibroblasts and expression of cell cycle proteins. 2011 J. Cell. Biochem. pmid:21465537
Kimura T et al. Chromium (VI) inhibits mouse metallothionein-I gene transcription by modifying the transcription potential of the co-activator p300. 2011 J Toxicol Sci pmid:21467744
Zhang CZ et al. Trichostatin A sensitizes HBx-expressing liver cancer cells to etoposide treatment. 2011 Apoptosis pmid:21468663
Nagamine MK et al. In vitro inhibitory effect of trichostatin A on canine grade 3 mast cell tumor. 2011 Vet. Res. Commun. pmid:21472452
Yang J et al. [Study of RASSF1A expression and promoter demethylation in Hep-2 cell line]. 2011 Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi pmid:21473137
Cui XS et al. Trichostatin A modulates apoptotic-related gene expression and improves embryo viability in cloned bovine embryos. 2011 Cell Reprogram pmid:21473694
Wang Y et al. The effects of 5-aza-2'- deoxycytidine and trichostatin A on gene expression and DNA methylation status in cloned bovine blastocysts. 2011 Cell Reprogram pmid:21486115
Hattori N et al. Methylation silencing of angiopoietin-like 4 in rat and human mammary carcinomas. 2011 Cancer Sci. pmid:21489049
Chen MY et al. Decitabine and suberoylanilide hydroxamic acid (SAHA) inhibit growth of ovarian cancer cell lines and xenografts while inducing expression of imprinted tumor suppressor genes, apoptosis, G2/M arrest, and autophagy. 2011 Cancer pmid:21491416
Zelko IN et al. Histone acetylation regulates the cell-specific and interferon-γ-inducible expression of extracellular superoxide dismutase in human pulmonary arteries. 2011 Am. J. Respir. Cell Mol. Biol. pmid:21493784
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Park JW et al. Microbial transformation of trichostatin A to 2,3-dihydrotrichostatin A. 2011 J. Nat. Prod. pmid:21504214
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Fortson WS et al. Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells. 2011 Int. J. Oncol. pmid:21519790
Xiong H et al. Trichostatin A, a histone deacetylase inhibitor, suppresses JAK2/STAT3 signaling via inducing the promoter-associated histone acetylation of SOCS1 and SOCS3 in human colorectal cancer cells. 2012 Mol. Carcinog. pmid:21520296
Ramsey MR et al. Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma. 2011 Cancer Res. pmid:21527555
Qiu GH et al. Recognition and suppression of transfected plasmids by protein ZNF511-PRAP1, a potential molecular barrier to transgene expression. 2011 Mol. Ther. pmid:21540836
Kong Q et al. Effect of trichostatin A and 5-Aza-2'-deoxycytidine on transgene reactivation and epigenetic modification in transgenic pig fibroblast cells. 2011 Mol. Cell. Biochem. pmid:21541675
Shu G et al. Zac1 is a histone acetylation-regulated NF-κB suppressor that mediates histone deacetylase inhibitor-induced apoptosis. 2011 Cell Death Differ. pmid:21546906
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Meng Y et al. Epigenetic inactivation of the SFRP1 gene in esophageal squamous cell carcinoma. 2011 Dig. Dis. Sci. pmid:21567192
Hayashi-Takanaka Y et al. Tracking epigenetic histone modifications in single cells using Fab-based live endogenous modification labeling. 2011 Nucleic Acids Res. pmid:21576221
Bouquet F et al. A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia. 2011 J. Cell. Sci. pmid:21576354
Hawk JD et al. Post-training intrahippocampal inhibition of class I histone deacetylases enhances long-term object-location memory. 2011 Learn. Mem. pmid:21576516
Ververis K et al. Histone deacetylase inhibitors augment doxorubicin-induced DNA damage in cardiomyocytes. 2011 Cell. Mol. Life Sci. pmid:21584806
Misaki K et al. Histone deacetylase inhibition alters dendritic cells to assume a tolerogenic phenotype and ameliorates arthritis in SKG mice. 2011 Arthritis Res. Ther. pmid:21592365
Selinger CI et al. Loss of special AT-rich binding protein 1 expression is a marker of poor survival in lung cancer. 2011 J Thorac Oncol pmid:21597389
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Wong CY et al. Epigenetic regulation of phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 gene expression in prostate cancer cells. 2011 J. Biol. Chem. pmid:21636851
Xia B et al. Chromium(VI) causes down regulation of biotinidase in human bronchial epithelial cells by modifications of histone acetylation. 2011 Toxicol. Lett. pmid:21641978
Seo SK et al. Histone deacetylase inhibitors sensitize human non-small cell lung cancer cells to ionizing radiation through acetyl p53-mediated c-myc down-regulation. 2011 J Thorac Oncol pmid:21642861
Acun T et al. SIP1 is downregulated in hepatocellular carcinoma by promoter hypermethylation. 2011 BMC Cancer pmid:21645397
Cowell IG et al. Histone deacetylase inhibition redistributes topoisomerase IIβ from heterochromatin to euchromatin. 2011 Jan-Feb Nucleus pmid:21647300
Dávalos-Salas M et al. Gain of DNA methylation is enhanced in the absence of CTCF at the human retinoblastoma gene promoter. 2011 BMC Cancer pmid:21663659
Zhang L et al. ABA treatment of germinating maize seeds induces VP1 gene expression and selective promoter-associated histone acetylation. 2011 Physiol Plant pmid:21679193
Sar P et al. 3, 3'5 Triiodo L thyronine induces apoptosis in human breast cancer MCF-7 cells, repressing SMP30 expression through negative thyroid response elements. 2011 PLoS ONE pmid:21687737
Cosner CC and Helquist P Concise, convergent syntheses of (±)-trichostatin A utilizing a Pd-catalyzed ketone enolate α-alkenylation reaction. 2011 Org. Lett. pmid:21688856
Kojima S et al. Asymmetric leaves2 and Elongator, a histone acetyltransferase complex, mediate the establishment of polarity in leaves of Arabidopsis thaliana. 2011 Plant Cell Physiol. pmid:21700721
Chik CL et al. Histone modifications on the adrenergic induction of type II deiodinase in rat pinealocytes. 2011 Mol. Cell. Endocrinol. pmid:21704117
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Yoo YE and Ko CP Treatment with trichostatin A initiated after disease onset delays disease progression and increases survival in a mouse model of amyotrophic lateral sclerosis. 2011 Exp. Neurol. pmid:21712032
Gómez MC et al. Trichostatin A modified histone covalent pattern and enhanced expression of pluripotent genes in interspecies black-footed cat cloned embryos but did not improve in vitro and in vivo viability. 2011 Cell Reprogram pmid:21718106
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Crandall JE et al. Retinoic acid influences neuronal migration from the ganglionic eminence to the cerebral cortex. 2011 J. Neurochem. pmid:21895658
Atanackovic D et al. Cancer-testis antigen expression and its epigenetic modulation in acute myeloid leukemia. 2011 Am. J. Hematol. pmid:21898529
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