| MeSH term | MeSH ID | Detail |
|---|---|---|
| Osteosarcoma | D012516 | 50 associated lipids |
| Brain Neoplasms | D001932 | 15 associated lipids |
| Leukemia, Erythroblastic, Acute | D004915 | 41 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Muscular Dystrophies | D009136 | 10 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Intellectual Disability | D008607 | 13 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hypertension, Pulmonary | D006976 | 32 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Prostatic Hyperplasia | D011470 | 20 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sugita K et al. | Morphological reversion of sis-transformed NIH3T3 cells by trichostatin A. | 1992 | Cancer Res. | pmid:1727377 |
| Kim SH et al. | Regulation of the HIF-1alpha stability by histone deacetylases. | 2007 | Oncol. Rep. | pmid:17273746 |
| Han S et al. | HDAC inhibitors TSA and sodium butyrate enhanced the human IL-5 expression by altering histone acetylation status at its promoter region. | 2007 | Immunol. Lett. | pmid:17270283 |
| Sakuma M et al. | Promoter methylation status of the Cyclin D2 gene is associated with poor prognosis in human epithelial ovarian cancer. | 2007 | Cancer Sci. | pmid:17270028 |
| Nagashima T et al. | Histone acetylation and subcellular localization of chromosomal protein BRD4 during mouse oocyte meiosis and mitosis. | 2007 | Mol. Hum. Reprod. | pmid:17267518 |
| Oyama T et al. | Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes in vitro and in vivo. | 2007 | J. Cell Biol. | pmid:17261849 |
| Janowski BA et al. | Activating gene expression in mammalian cells with promoter-targeted duplex RNAs. | 2007 | Nat. Chem. Biol. | pmid:17259978 |
| Ishihara K et al. | Differentiation of eosinophilic leukemia EoL-1 cells into eosinophils induced by histone deacetylase inhibitors. | 2007 | Life Sci. | pmid:17258775 |
| Scott SA et al. | Zebularine inhibits human acute myeloid leukemia cell growth in vitro in association with p15INK4B demethylation and reexpression. | 2007 | Exp. Hematol. | pmid:17258075 |
| Suzuki T et al. | Identification of a potent and stable antiproliferative agent by the prodrug formation of a thiolate histone deacetylase inhibitor. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17257837 |
| Li Y et al. | Regulation of neuronal nitric oxide synthase exon 1f gene expression by nuclear factor-kappaB acetylation in human neuroblastoma cells. | 2007 | J. Neurochem. | pmid:17250678 |
| Ghosh AK et al. | Trichostatin A blocks TGF-beta-induced collagen gene expression in skin fibroblasts: involvement of Sp1. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17234156 |
| Karam JA et al. | The use of histone deacetylase inhibitor FK228 and DNA hypomethylation agent 5-azacytidine in human bladder cancer therapy. | 2007 | Int. J. Cancer | pmid:17230511 |
| Feng W et al. | Multiple histone deacetylases repress tumor suppressor gene ARHI in breast cancer. | 2007 | Int. J. Cancer | pmid:17230502 |
| Ting CH et al. | Stat5 constitutive activation rescues defects in spinal muscular atrophy. | 2007 | Hum. Mol. Genet. | pmid:17220171 |
| Sun C et al. | Anticancer activities of trichostatin A on maligant lymphoid cells. | 2006 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:17219961 |
| Liu H et al. | Trichostatin A regulates hGCN5 expression and cell cycle on Daudi cells in vitro. | 2006 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:17219960 |
| He J et al. | Effects of trichostatin A on HDAC8 expression, proliferation and cell cycle of Molt-4 cells. | 2006 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:17219959 |
| Kozłowska A and Jagodziński PP | Effect of Trichostatin A on CD4 surface density in peripheral blood T cells. | 2006 | Folia Histochem. Cytobiol. | pmid:17219719 |
| Elaut G et al. | A metabolic screening study of trichostatin A (TSA) and TSA-like histone deacetylase inhibitors in rat and human primary hepatocyte cultures. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17218485 |
| Karagiannis TC et al. | Disparity of histone deacetylase inhibition on repair of radiation-induced DNA damage on euchromatin and constitutive heterochromatin compartments. | 2007 | Oncogene | pmid:17213813 |
| Cras A et al. | Epigenetic patterns of the retinoic acid receptor beta2 promoter in retinoic acid-resistant thyroid cancer cells. | 2007 | Oncogene | pmid:17213810 |
| Kuang PP et al. | Activation of elastin transcription by transforming growth factor-beta in human lung fibroblasts. | 2007 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:17209135 |
| Bártová E et al. | Differentiation-specific association of HP1alpha and HP1beta with chromocentres is correlated with clustering of TIF1beta at these sites. | 2007 | Histochem. Cell Biol. | pmid:17205308 |
| McCool KW et al. | The role of histone acetylation in regulating early gene expression patterns during early embryonic stem cell differentiation. | 2007 | J. Biol. Chem. | pmid:17204470 |
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| Katz RA et al. | High-frequency epigenetic repression and silencing of retroviruses can be antagonized by histone deacetylase inhibitors and transcriptional activators, but uniform reactivation in cell clones is restricted by additional mechanisms. | 2007 | J. Virol. | pmid:17202206 |
| Fujita Y et al. | Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1. | 2007 | Dev. Cell | pmid:17199038 |
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| Koh E et al. | Trichostatin A and 5-aza-2'-deoxycytidine switch S1P from an inhibitor to a stimulator of motility through epigenetic regulation of S1P receptors. | 2007 | Cancer Lett. | pmid:17189669 |
| Lee EL et al. | Impaired activity of volume-sensitive Cl- channel is involved in cisplatin resistance of cancer cells. | 2007 | J. Cell. Physiol. | pmid:17186499 |
| Araki H et al. | Chromatin-modifying agents permit human hematopoietic stem cells to undergo multiple cell divisions while retaining their repopulating potential. | 2007 | Blood | pmid:17185465 |
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| Shimazu T et al. | Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing. | 2007 | J. Biol. Chem. | pmid:17172643 |
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| Liu TX et al. | Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation. | 2007 | Nat. Med. | pmid:17159988 |
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| Fang S et al. | Coordinated recruitment of histone methyltransferase G9a and other chromatin-modifying enzymes in SHP-mediated regulation of hepatic bile acid metabolism. | 2007 | Mol. Cell. Biol. | pmid:17145766 |
| Reddy RM et al. | Rapid and profound potentiation of Apo2L/TRAIL-mediated cytotoxicity and apoptosis in thoracic cancer cells by the histone deacetylase inhibitor Trichostatin A: the essential role of the mitochondria-mediated caspase activation cascade. | 2007 | Apoptosis | pmid:17136498 |
| Yoshikawa M et al. | Inhibition of histone deacetylase activity suppresses epithelial-to-mesenchymal transition induced by TGF-beta1 in human renal epithelial cells. | 2007 | J. Am. Soc. Nephrol. | pmid:17135397 |
| Henkens T et al. | Trichostatin A, a critical factor in maintaining the functional differentiation of primary cultured rat hepatocytes. | 2007 | Toxicol. Appl. Pharmacol. | pmid:17125810 |
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| Kishigami S et al. | Successful mouse cloning of an outbred strain by trichostatin A treatment after somatic nuclear transfer. | 2007 | J. Reprod. Dev. | pmid:17077581 |
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| Berg T et al. | Reversal of p15/INK4b hypermethylation in AML1/ETO-positive and -negative myeloid leukemia cell lines. | 2007 | Leuk. Res. | pmid:17056112 |
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| Tyson-Capper AJ et al. | Characterization of cellular retinoid-binding proteins in human myometrium during pregnancy. | 2006 | Mol. Hum. Reprod. | pmid:16959971 |
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| Zhang Y et al. | Phosphatidylinositol 3-kinase/protein kinase Czeta-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated derepression [corrected] of transcription of the luteinizing hormone receptor gene. | 2006 | Mol. Cell. Biol. | pmid:16943418 |
| Yamamura K et al. | Pleiotropic role of histone deacetylases in the regulation of human adult erythropoiesis. | 2006 | Br. J. Haematol. | pmid:16939493 |
| Dokras A et al. | Epigenetic regulation of maspin expression in the human placenta. | 2006 | Mol. Hum. Reprod. | pmid:16936308 |
| Zaveri NT et al. | Regulation of the prepronociceptin gene and its effect on neuronal differentiation. | 2006 | Gene | pmid:16935438 |
| Ondrousková E et al. | A proteomic analysis of protein variations during differentiation of v-myb-transformed monoblasts. | 2007 | Leuk. Res. | pmid:16930693 |
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| Kim MY et al. | A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16924111 |
| Wang LG et al. | Dual action on promoter demethylation and chromatin by an isothiocyanate restored GSTP1 silenced in prostate cancer. | 2007 | Mol. Carcinog. | pmid:16921492 |
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| Malone CS et al. | B29 gene silencing in pituitary cells is regulated by its 3' enhancer. | 2006 | J. Mol. Biol. | pmid:16920149 |
| Okamoto H et al. | Trichostatin A, an inhibitor of histone deacetylase, inhibits smooth muscle cell proliferation via induction of p21(WAF1). | 2006 | J. Atheroscler. Thromb. | pmid:16908950 |
| Charrier C et al. | Synthesis of rigid trichostatin A analogs as HDAC inhibitors. | 2006 | Bioorg. Med. Chem. Lett. | pmid:16904890 |
| Bai J et al. | Histone deacetylase inhibitor trichostatin A and proteasome inhibitor PS-341 synergistically induce apoptosis in pancreatic cancer cells. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16904634 |
| Meisel A et al. | Inhibition of histone deacetylation protects wild-type but not gelsolin-deficient neurons from oxygen/glucose deprivation. | 2006 | J. Neurochem. | pmid:16895577 |
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