| MeSH term | MeSH ID | Detail |
|---|---|---|
| Osteosarcoma | D012516 | 50 associated lipids |
| Brain Neoplasms | D001932 | 15 associated lipids |
| Leukemia, Erythroblastic, Acute | D004915 | 41 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Muscular Dystrophies | D009136 | 10 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Intellectual Disability | D008607 | 13 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hypertension, Pulmonary | D006976 | 32 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Prostatic Hyperplasia | D011470 | 20 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Oliveira CS et al. | Effects of histone hyperacetylation on the preimplantation development of male and female bovine embryos. | 2010 | Reprod. Fertil. Dev. | pmid:20591338 |
| Suo L et al. | Changes in acetylation on lysine 12 of histone H4 (acH4K12) of murine oocytes during maternal aging may affect fertilization and subsequent embryo development. | 2010 | Fertil. Steril. | pmid:19285668 |
| Xia J et al. | Epigenetic modification of vomeronasal (V2r) precursor neurons by histone deacetylation. | 2010 | Neuroscience | pmid:20594945 |
| Tian F et al. | Effects of histone deacetylase inhibitor Trichostatin A on epigenetic changes and transcriptional activation of Bdnf promoter 1 by rat hippocampal neurons. | 2010 | Ann. N. Y. Acad. Sci. | pmid:20633124 |
| Rössler R et al. | Differentiation of non-mesencephalic neural stem cells towards dopaminergic neurons. | 2010 | Neuroscience | pmid:20643196 |
| Hajji N et al. | Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the sensitivity to the topoisomerase II inhibitor etoposide. | 2010 | Oncogene | pmid:20118981 |
| Suh HS et al. | Histone deacetylase inhibitors suppress the expression of inflammatory and innate immune response genes in human microglia and astrocytes. | 2010 | J Neuroimmune Pharmacol | pmid:20157787 |
| Crosson CE et al. | Inhibition of histone deacetylase protects the retina from ischemic injury. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:20164449 |
| Ajiro K et al. | Reciprocal epigenetic modification of histone H2B occurs in chromatin during apoptosis in vitro and in vivo. | 2010 | Cell Death Differ. | pmid:20057502 |
| Auzzas L et al. | Non-natural macrocyclic inhibitors of histone deacetylases: design, synthesis, and activity. | 2010 | J. Med. Chem. | pmid:21073160 |
| Choi YS et al. | Differentiation of human adipose-derived stem cells into beating cardiomyocytes. | 2010 | J. Cell. Mol. Med. | pmid:20070436 |
| Lee KJ et al. | Downregulation of a tumor suppressor RECK by hypoxia through recruitment of HDAC1 and HIF-1alpha to reverse HRE site in the promoter. | 2010 | Biochim. Biophys. Acta | pmid:20080132 |
| Li Y et al. | Synergistic epigenetic reactivation of estrogen receptor-α (ERα) by combined green tea polyphenol and histone deacetylase inhibitor in ERα-negative breast cancer cells. | 2010 | Mol. Cancer | pmid:20946668 |
| Gupta PK et al. | Inhibitors selective for HDAC6 in enzymes and cells. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20947351 |
| Halili MA et al. | Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS. | 2010 | J. Leukoc. Biol. | pmid:20200406 |
| Karagiannis TC et al. | Trichostatin A accentuates doxorubicin-induced hypertrophy in cardiac myocytes. | 2010 | Aging (Albany NY) | pmid:20930262 |
| Reichrath S et al. | Notch- and vitamin D signaling in 1,25(OH)2D3-resistant glioblastoma multiforme (GBM) cell lines. | 2010 | J. Steroid Biochem. Mol. Biol. | pmid:20206691 |
| Milagre I et al. | Chromatin-modifying agents increase transcription of CYP46A1, a key player in brain cholesterol elimination. | 2010 | J. Alzheimers Dis. | pmid:20930312 |
| Bertrand P | Inside HDAC with HDAC inhibitors. | 2010 | Eur J Med Chem | pmid:20223566 |
| Kitano A et al. | Therapeutic potential of trichostatin A to control inflammatory and fibrogenic disorders of the ocular surface. | 2010 | Mol. Vis. | pmid:21203344 |
| Sponziello M et al. | Regulation of sodium/iodide symporter and lactoperoxidase expression in four human breast cancer cell lines. | 2010 | J. Endocrinol. Invest. | pmid:19794300 |
| Wu P et al. | Ubiquitin B: an essential mediator of trichostatin A-induced tumor-selective killing in human cancer cells. | 2010 | Cell Death Differ. | pmid:19798105 |
| Law AY and Wong CK | Stanniocalcin-2 is a HIF-1 target gene that promotes cell proliferation in hypoxia. | 2010 | Exp. Cell Res. | pmid:19786016 |
| Pollack BP et al. | Ultraviolet radiation-induced transcription is associated with gene-specific histone acetylation. | 2009 May-Jun | Photochem. Photobiol. | pmid:19076306 |
| Chen Z et al. | BCL11A represses HBG transcription in K562 cells. | 2009 Mar-Apr | Blood Cells Mol. Dis. | pmid:19153051 |
| Wang L et al. | Using histone deacetylase inhibitors to enhance Foxp3(+) regulatory T-cell function and induce allograft tolerance. | 2009 Mar-Apr | Immunol. Cell Biol. | pmid:19172156 |
| Allritz C et al. | Endothelin-1 reverses the histone deacetylase inhibitor-induced increase in glial glutamate transporter transcription without affecting histone acetylation levels. | 2009 Jul-Aug | Neurochem. Int. | pmid:19428803 |
| Deng G et al. | Unique methylation pattern of oncostatin m receptor gene in cancers of colorectum and other digestive organs. | 2009 | Clin. Cancer Res. | pmid:19223499 |
| Sterthaus O et al. | Evaluation of in vitro cultured rat oocytes, from different strains, by spindle morphology and maturation-promoting-factor activity combined with nuclear-transfer experiments. | 2009 | Cloning Stem Cells | pmid:19751114 |
| Wang X et al. | Correction of the abnormal trafficking of primary myelofibrosis CD34+ cells by treatment with chromatin-modifying agents. | 2009 | Cancer Res. | pmid:19752087 |
| Hirata H et al. | Wnt antagonist gene DKK2 is epigenetically silenced and inhibits renal cancer progression through apoptotic and cell cycle pathways. | 2009 | Clin. Cancer Res. | pmid:19755393 |
| Noh EJ et al. | An HDAC inhibitor, trichostatin A, induces a delay at G2/M transition, slippage of spindle checkpoint, and cell death in a transcription-dependent manner. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19038231 |
| Kong X et al. | HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cells. | 2009 | J. Mol. Cell. Cardiol. | pmid:19041327 |
| Rossi M et al. | Caspase cleavage of Itch in chronic lymphocytic leukemia cells. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19073138 |
| Kishigami S and Wakayama T | Somatic cell nuclear transfer in the mouse. | 2009 | Methods Mol. Biol. | pmid:19085136 |
| Sibinga NE | Stable protein, unstable plaque? | 2009 | J. Mol. Cell. Cardiol. | pmid:19101562 |
| Niu F et al. | Trichostatin A enhances OGD-astrocyte viability by inhibiting inflammatory reaction mediated by NF-kappaB. | 2009 | Brain Res. Bull. | pmid:19103266 |
| Santiago A et al. | Identification of two independent SUMO-interacting motifs in Daxx: evolutionary conservation from Drosophila to humans and their biochemical functions. | 2009 | Cell Cycle | pmid:19106612 |
| Nakajima S et al. | Trichostatin A with adenovirus-mediated p53 gene transfer synergistically induces apoptosis in breast cancer cell line MDA-MB-231. | 2009 | Oncol. Rep. | pmid:19513516 |
| Takaya T et al. | MicroRNA-1 and MicroRNA-133 in spontaneous myocardial differentiation of mouse embryonic stem cells. | 2009 | Circ. J. | pmid:19521018 |
| Sugimura S et al. | Interspecies somatic cell nucleus transfer with porcine oocytes as recipients: A novel bioassay system for assessing the competence of canine somatic cells to develop into embryos. | 2009 | Theriogenology | pmid:19524287 |
| Gregorie CJ et al. | Restoration of immune response gene induction in trophoblast tumor cells associated with cellular senescence. | 2009 | J. Reprod. Immunol. | pmid:19493573 |
| Soriano FX et al. | Role of histone acetylation in the activity-dependent regulation of sulfiredoxin and sestrin 2. | 2009 | Epigenetics | pmid:19430206 |
| Dagtas AS et al. | Histone deacetylase inhibitor uses p21(Cip1) to maintain anergy in CD4+ T cells. | 2009 | Int. Immunopharmacol. | pmid:19664724 |
| Carambula SF et al. | Repression of induced apoptosis in the 2-cell bovine embryo involves DNA methylation and histone deacetylation. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19665989 |
| Fujii K et al. | Co-treatment with deoxycholic acid and azoxymethane accelerates secretion of HMGB1 in IEC6 intestinal epithelial cells. | 2009 | Cell Prolif. | pmid:19614672 |
| Ai J et al. | HDAC6 regulates androgen receptor hypersensitivity and nuclear localization via modulating Hsp90 acetylation in castration-resistant prostate cancer. | 2009 | Mol. Endocrinol. | pmid:19855091 |
| Peng DF et al. | DNA hypermethylation regulates the expression of members of the Mu-class glutathione S-transferases and glutathione peroxidases in Barrett's adenocarcinoma. | 2009 | Gut | pmid:18664505 |
| Fraczek J et al. | Screening of amide analogues of Trichostatin A in cultures of primary rat hepatocytes: search for potent and safe HDAC inhibitors. | 2009 | Invest New Drugs | pmid:18825314 |
| Demircan B et al. | Comparative epigenomics of human and mouse mammary tumors. | 2009 | Genes Chromosomes Cancer | pmid:18836996 |