Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Huang W et al. | Trichostatin A induces transforming growth factor beta type II receptor promoter activity and acetylation of Sp1 by recruitment of PCAF/p300 to a Sp1.NF-Y complex. | 2005 | J. Biol. Chem. | pmid:15647279 |
Choi JH et al. | Trichostatin A attenuates airway inflammation in mouse asthma model. | 2005 | Clin. Exp. Allergy | pmid:15649272 |
Varshochi R et al. | ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line. | 2005 | J. Biol. Chem. | pmid:15557281 |
Goeman F et al. | Growth inhibition by the tumor suppressor p33ING1 in immortalized and primary cells: involvement of two silencing domains and effect of Ras. | 2005 | Mol. Cell. Biol. | pmid:15601862 |
Tai HH et al. | Dynamic histone acetylation of late embryonic genes during seed germination. | 2005 | Plant Mol. Biol. | pmid:16307366 |
Marchion DC et al. | Synergistic interaction between histone deacetylase and topoisomerase II inhibitors is mediated through topoisomerase IIbeta. | 2005 | Clin. Cancer Res. | pmid:16322310 |
Farrajota K et al. | Inhibition of interleukin-1beta-induced cyclooxygenase 2 expression in human synovial fibroblasts by 15-deoxy-Delta12,14-prostaglandin J2 through a histone deacetylase-independent mechanism. | 2005 | Arthritis Rheum. | pmid:15641079 |
Noh EJ et al. | Methyl CpG-binding domain protein 3 mediates cancer-selective cytotoxicity by histone deacetylase inhibitors via differential transcriptional reprogramming in lung cancer cells. | 2005 | Cancer Res. | pmid:16357148 |
Wetzel M et al. | Effect of trichostatin A, a histone deacetylase inhibitor, on glioma proliferation in vitro by inducing cell cycle arrest and apoptosis. | 2005 | J. Neurosurg. | pmid:16383255 |
Place RF et al. | HDACs and the senescent phenotype of WI-38 cells. | 2005 | BMC Cell Biol. | pmid:16250917 |
Lee JH et al. | Interactions with p300 enhance transcriptional activation by the PDZ-domain coactivator Bridge-1. | 2005 | J. Endocrinol. | pmid:16293776 |
Hazzalin CA and Mahadevan LC | Dynamic acetylation of all lysine 4-methylated histone H3 in the mouse nucleus: analysis at c-fos and c-jun. | 2005 | PLoS Biol. | pmid:16262446 |
Hohl M and Thiel G | Cell type-specific regulation of RE-1 silencing transcription factor (REST) target genes. | 2005 | Eur. J. Neurosci. | pmid:16262660 |
Bernes S et al. | Epigenetic and classical activation of Entamoeba histolytica heat shock protein 100 (EHsp100) expression. | 2005 | FEBS Lett. | pmid:16263115 |
Gao S et al. | CpG methylation of the PAI-1 gene 5'-flanking region is inversely correlated with PAI-1 mRNA levels in human cell lines. | 2005 | Thromb. Haemost. | pmid:16268485 |
Li XX et al. | Function of c-Fos-like and c-Jun-like proteins on trichostatin A-induced G2/M arrest in Physarum polycephalum. | 2005 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:16270156 |
Francia G et al. | Down-regulation of DNA mismatch repair proteins in human and murine tumor spheroids: implications for multicellular resistance to alkylating agents. | 2005 | Mol. Cancer Ther. | pmid:16227397 |
Chou SD et al. | Histone acetylation regulates the cell type specific CIITA promoters, MHC class II expression and antigen presentation in tumor cells. | 2005 | Int. Immunol. | pmid:16210330 |
Bai Y et al. | Protein acetylation regulates both PU.1 transactivation and Ig kappa 3' enhancer activity. | 2005 | J. Immunol. | pmid:16210620 |
Chen G et al. | [Enhancive effect of histone deacetylase inhibitor trichostatin a on transfection efficiency of adenovirus in ovarian carcinoma cell line A2780]. | 2005 | Ai Zheng | pmid:16219132 |
Chang S and Pikaard CS | Transcript profiling in Arabidopsis reveals complex responses to global inhibition of DNA methylation and histone deacetylation. | 2005 | J. Biol. Chem. | pmid:15516340 |
Osada H et al. | Histone modification in the TGFbetaRII gene promoter and its significance for responsiveness to HDAC inhibitor in lung cancer cell lines. | 2005 | Mol. Carcinog. | pmid:16163707 |
Rogier E et al. | A novel biological assay to detect the active form of TGF-beta in urine to monitor renal allograft rejection. | 2005 | Kidney Int. | pmid:16164666 |
Di-Poï N et al. | Transcriptional repression of peroxisome proliferator-activated receptor beta/delta in murine keratinocytes by CCAAT/enhancer-binding proteins. | 2005 | J. Biol. Chem. | pmid:16166081 |
Spengler ML et al. | Sumoylation of internally initiated Sp3 isoforms regulates transcriptional repression via a Trichostatin A-insensitive mechanism. | 2005 | Cell. Signal. | pmid:15494207 |
Valenzuela-Fernández A et al. | Histone deacetylase 6 regulates human immunodeficiency virus type 1 infection. | 2005 | Mol. Biol. Cell | pmid:16148047 |
Davis FJ et al. | Concurrent opposite effects of trichostatin A, an inhibitor of histone deacetylases, on expression of alpha-MHC and cardiac tubulins: implication for gain in cardiac muscle contractility. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15388503 |
Curtin BF et al. | Histone acetylase inhibitor trichostatin A induces acetylcholinesterase expression and protects against organophosphate exposure. | 2005 | J. Cell. Biochem. | pmid:16149071 |
Chen JS and Faller DV | Histone deacetylase inhibition-mediated post-translational elevation of p27KIP1 protein levels is required for G1 arrest in fibroblasts. | 2005 | J. Cell. Physiol. | pmid:15389542 |
Medugno L et al. | The Krüppel-like zinc-finger protein ZNF224 represses aldolase A gene transcription by interacting with the KAP-1 co-repressor protein. | 2005 | Gene | pmid:16150558 |
Frønsdal K and Saatcioglu F | Histone deacetylase inhibitors differentially mediate apoptosis in prostate cancer cells. | 2005 | Prostate | pmid:15389787 |
Lin KT et al. | Epigenetic activation of alpha4, beta2 and beta6 integrins involved in cell migration in trichostatin A-treated Hep3B cells. | 2005 | J. Biomed. Sci. | pmid:16132114 |
Smardová J et al. | CBP sensitizes v-myb-transformed monoblasts to differentiation inducers. | 2005 | Differentiation | pmid:16026544 |
Fandy TE et al. | Interactive effects of HDAC inhibitors and TRAIL on apoptosis are associated with changes in mitochondrial functions and expressions of cell cycle regulatory genes in multiple myeloma. | 2005 | Neoplasia | pmid:16026644 |
Korutla L et al. | The POZ/BTB protein NAC1 interacts with two different histone deacetylases in neuronal-like cultures. | 2005 | J. Neurochem. | pmid:16033423 |
Shindo N et al. | The ESC-E(Z) complex participates in the hedgehog signaling pathway. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15652519 |
Kemp MG et al. | The histone deacetylase inhibitor trichostatin A alters the pattern of DNA replication origin activity in human cells. | 2005 | Nucleic Acids Res. | pmid:15653633 |
Huang H et al. | MEIS C termini harbor transcriptional activation domains that respond to cell signaling. | 2005 | J. Biol. Chem. | pmid:15654074 |
Danam RP et al. | Epigenetic regulation of O6-methylguanine-DNA methyltransferase gene expression by histone acetylation and methyl-CpG binding proteins. | 2005 | Mol. Cancer Ther. | pmid:15657354 |
Li Y et al. | Histone deacetylation is required for progression through mitosis in tobacco cells. | 2005 | Plant J. | pmid:15659094 |
Zhao Y et al. | Lifespan extension and elevated hsp gene expression in Drosophila caused by histone deacetylase inhibitors. | 2005 | J. Exp. Biol. | pmid:15695762 |
Hooven LA et al. | Effects of suberoylanilide hydroxamic acid and trichostatin A on induction of cytochrome P450 enzymes and benzo[a]pyrene DNA adduct formation in human cells. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15713371 |
Chen B et al. | Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15713393 |
Duan H et al. | Histone deacetylase inhibitors down-regulate bcl-2 expression and induce apoptosis in t(14;18) lymphomas. | 2005 | Mol. Cell. Biol. | pmid:15713621 |
Tong X et al. | Cyclooxygenase-2 regulation in colon cancer cells: modulation of RNA polymerase II elongation by histone deacetylase inhibitors. | 2005 | J. Biol. Chem. | pmid:15713675 |
Galfi P et al. | Divergent effects of resveratrol, a polyphenolic phytostilbene, on free radical levels and type of cell death induced by the histone deacetylase inhibitors butyrate and trichostatin A. | 2005 | J. Steroid Biochem. Mol. Biol. | pmid:15862948 |
Choi KH et al. | Activation of CMV promoter-controlled glycosyltransferase and beta -galactosidase glycogenes by butyrate, tricostatin A, and 5-aza-2'-deoxycytidine. | 2005 | Glycoconj. J. | pmid:15864436 |
Touma SE et al. | Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model. | 2005 | Clin. Cancer Res. | pmid:15867260 |
Fish JE et al. | The expression of endothelial nitric-oxide synthase is controlled by a cell-specific histone code. | 2005 | J. Biol. Chem. | pmid:15870070 |
Dyson MH et al. | MAP kinase-mediated phosphorylation of distinct pools of histone H3 at S10 or S28 via mitogen- and stress-activated kinase 1/2. | 2005 | J. Cell. Sci. | pmid:15870105 |
Reid G et al. | Multiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor alpha, in response to deacetylase inhibition by valproic acid and trichostatin A. | 2005 | Oncogene | pmid:15870696 |
Kim MS et al. | Sensitization to UV-induced apoptosis by the histone deacetylase inhibitor trichostatin A (TSA). | 2005 | Exp. Cell Res. | pmid:15878336 |
Rosenqvist N et al. | Inhibition of chromatin condensation prevents transgene silencing in a neural progenitor cell line transplanted to the rat brain. | 2005 | Cell Transplant | pmid:15881422 |
Gonçalves J et al. | Modulation of translation factor's gene expression by histone deacetylase inhibitors in breast cancer cells. | 2005 | Clin. Chem. Lab. Med. | pmid:15843208 |
Robbins AR et al. | Inhibitors of histone deacetylases alter kinetochore assembly by disrupting pericentromeric heterochromatin. | 2005 | Cell Cycle | pmid:15846093 |
Taghiyev AF et al. | Trichostatin A (TSA) sensitizes the human prostatic cancer cell line DU145 to death receptor ligands treatment. | 2005 | Cancer Biol. Ther. | pmid:15846101 |
Barki-Celli L et al. | Differences in nuclear positioning of 1q12 pericentric heterochromatin in normal and tumor B lymphocytes with 1q rearrangements. | 2005 | Genes Chromosomes Cancer | pmid:15846776 |
Wooten LG and Ogretmen B | Sp1/Sp3-dependent regulation of human telomerase reverse transcriptase promoter activity by the bioactive sphingolipid ceramide. | 2005 | J. Biol. Chem. | pmid:15951564 |
Malago JJ et al. | Anti-inflammatory properties of heat shock protein 70 and butyrate on Salmonella-induced interleukin-8 secretion in enterocyte-like Caco-2 cells. | 2005 | Clin. Exp. Immunol. | pmid:15958071 |
Whang YM et al. | Hyperacetylation enhances the growth-inhibitory effect of all-trans retinoic acid by the restoration of retinoic acid receptor beta expression in head and neck squamous carcinoma (HNSCC) cells. | 2005 | Cancer Chemother. Pharmacol. | pmid:15959780 |
Gunin AG et al. | Effects of histone deacetylase inhibitors on estradiol-induced proliferation and hyperplasia formation in the mouse uterus. | 2005 | J. Endocrinol. | pmid:15930180 |
Wittich S et al. | Effect of inhibitors of histone deacetylase on the induction of cell differentiation in murine and human erythroleukemia cell lines. | 2005 | Anticancer Drugs | pmid:15930892 |
Kaneda R et al. | Genome-wide screening for target regions of histone deacetylases in cardiomyocytes. | 2005 | Circ. Res. | pmid:16002748 |
Kusy S et al. | Promoter characterization of Semaphorin SEMA3F, a tumor suppressor gene. | 2005 | Biochim. Biophys. Acta | pmid:16005989 |
Rho JH et al. | Doxorubicin induces apoptosis with profile of large-scale DNA fragmentation and without DNA ladder in anaplastic thyroid carcinoma cells via histone hyperacetylation. | 2005 | Int. J. Oncol. | pmid:16010429 |
Choi YH | Induction of apoptosis by trichostatin A, a histone deacetylase inhibitor, is associated with inhibition of cyclooxygenase-2 activity in human non-small cell lung cancer cells. | 2005 | Int. J. Oncol. | pmid:16010430 |
Taddei A et al. | The effects of histone deacetylase inhibitors on heterochromatin: implications for anticancer therapy? | 2005 | EMBO Rep. | pmid:15940285 |
Gray SG et al. | Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein. | 2005 | J. Biol. Chem. | pmid:15927959 |
Fishel ML et al. | Effect of cell cycle inhibition on Cisplatin-induced cytotoxicity. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15304523 |
Wagner S and Roemer K | Retinoblastoma protein is required for efficient colorectal carcinoma cell apoptosis by histone deacetylase inhibitors in the absence of p21Waf. | 2005 | Biochem. Pharmacol. | pmid:15763542 |
Kawamura T et al. | Acetylation of GATA-4 is involved in the differentiation of embryonic stem cells into cardiac myocytes. | 2005 | J. Biol. Chem. | pmid:15764815 |
Xiong Y et al. | Histone deacetylase inhibitors decrease DNA methyltransferase-3B messenger RNA stability and down-regulate de novo DNA methyltransferase activity in human endometrial cells. | 2005 | Cancer Res. | pmid:15805266 |
Kumakura S et al. | Reversible conversion of immortal human cells from telomerase-positive to telomerase-negative cells. | 2005 | Cancer Res. | pmid:15805278 |
Zhao W et al. | The essential role of histone H3 Lys9 di-methylation and MeCP2 binding in MGMT silencing with poor DNA methylation of the promoter CpG island. | 2005 | J. Biochem. | pmid:15809347 |
Subramanian C et al. | Ku70 acetylation mediates neuroblastoma cell death induced by histone deacetylase inhibitors. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15778293 |
Lu ZP et al. | Histone deacetylase inhibitor Trichostatin A reduces anti-DNA autoantibody production and represses IgH gene transcription. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15781251 |
Nishigaki M et al. | Discovery of aberrant expression of R-RAS by cancer-linked DNA hypomethylation in gastric cancer using microarrays. | 2005 | Cancer Res. | pmid:15781621 |
Bai J et al. | Predominant Bcl-XL knockdown disables antiapoptotic mechanisms: tumor necrosis factor-related apoptosis-inducing ligand-based triple chemotherapy overcomes chemoresistance in pancreatic cancer cells in vitro. | 2005 | Cancer Res. | pmid:15781649 |
Rahmani M et al. | Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species. | 2005 | Cancer Res. | pmid:15781658 |
Frescas D et al. | Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes. | 2005 | J. Biol. Chem. | pmid:15788402 |
Kang J et al. | Curcumin-induced histone hypoacetylation: the role of reactive oxygen species. | 2005 | Biochem. Pharmacol. | pmid:15794941 |
Narayanan R et al. | Human progesterone receptor displays cell cycle-dependent changes in transcriptional activity. | 2005 | Mol. Cell. Biol. | pmid:15798179 |
Fujisawa K et al. | Epigenetic status and aberrant expression of the maspin gene in human hepato-biliary tract carcinomas. | 2005 | Lab. Invest. | pmid:15608662 |
Bottardi S et al. | Onset and inheritance of abnormal epigenetic regulation in hematopoietic cells. | 2005 | Hum. Mol. Genet. | pmid:15615768 |
Ezzat S et al. | The zinc finger Ikaros transcription factor regulates pituitary growth hormone and prolactin gene expression through distinct effects on chromatin accessibility. | 2005 | Mol. Endocrinol. | pmid:15618287 |
Cecconi D et al. | Proteomic analysis of pancreatic ductal carcinoma cells after combined treatment with gemcitabine and trichostatin A. | 2005 Nov-Dec | J. Proteome Res. | pmid:16335935 |
Garcia BA et al. | Resetting the epigenetic histone code in the MRL-lpr/lpr mouse model of lupus by histone deacetylase inhibition. | 2005 Nov-Dec | J. Proteome Res. | pmid:16335948 |
Suzuki M et al. | Site-specific DNA methylation by a complex of PU.1 and Dnmt3a/b. | 2006 | Oncogene | pmid:16331260 |
Topark-Ngarm A et al. | CTIP2 associates with the NuRD complex on the promoter of p57KIP2, a newly identified CTIP2 target gene. | 2006 | J. Biol. Chem. | pmid:16950772 |
Akiyama T et al. | Inadequate histone deacetylation during oocyte meiosis causes aneuploidy and embryo death in mice. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16651529 |
Hernandez M et al. | A histone deacetylation-dependent mechanism for transcriptional repression of the gap junction gene cx43 in prostate cancer cells. | 2006 | Prostate | pmid:16652385 |
Iacomino G et al. | Effects of histone deacetylase inhibitors on p55CDC/Cdc20 expression in HT29 cell line. | 2006 | J. Cell. Biochem. | pmid:16795040 |
Vanniasinkam T et al. | Trichostatin-A enhances adaptive immune responses to DNA vaccination. | 2006 | J. Clin. Virol. | pmid:16765083 |
Yu Z and Kone BC | Targeted histone H4 acetylation via phosphoinositide 3-kinase- and p70s6-kinase-dependent pathways inhibits iNOS induction in mesangial cells. | 2006 | Am. J. Physiol. Renal Physiol. | pmid:16174862 |
Kozłowska A and Jagodziński PP | Effect of Trichostatin A on CD4 surface density in peripheral blood T cells. | 2006 | Folia Histochem. Cytobiol. | pmid:17219719 |
He J et al. | Effects of trichostatin A on HDAC8 expression, proliferation and cell cycle of Molt-4 cells. | 2006 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:17219959 |
Wagner S et al. | SET-mediated promoter hypoacetylation is a prerequisite for coactivation of the estrogen-responsive pS2 gene by PRMT1. | 2006 | J. Biol. Chem. | pmid:16861234 |
Zhang X et al. | Histone deacetylase inhibitor, trichostatin A, increases the chemosensitivity of anticancer drugs in gastric cancer cell lines. | 2006 | Oncol. Rep. | pmid:16865256 |
Hellebrekers DM et al. | Angiostatic activity of DNA methyltransferase inhibitors. | 2006 | Mol. Cancer Ther. | pmid:16505122 |
Kong X et al. | Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha. | 2006 | Mol. Cell. Biol. | pmid:16507982 |