trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Meester-Smoor MA et al. | The ETS family member TEL binds to nuclear receptors RAR and RXR and represses gene activation. | 2011 | PLoS ONE | pmid:21949683 |
| Halder SK et al. | Elucidating the mechanism of regulation of transforming growth factor β Type II receptor expression in human lung cancer cell lines. | 2011 | Neoplasia | pmid:22028617 |
| Bo F et al. | Effect of trichostatin A on transfected donor cells and subsequent development of porcine cloned embryos. | 2011 | Zygote | pmid:20569515 |
| Hutt DM et al. | Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides that Restore Trafficking and Activity of ΔF508-CFTR. | 2011 | ACS Med Chem Lett | pmid:21984958 |
| Majumdar G et al. | Panhistone deacetylase inhibitors inhibit proinflammatory signaling pathways to ameliorate interleukin-18-induced cardiac hypertrophy. | 2011 | Physiol. Genomics | pmid:21954451 |
| Tsai KW et al. | Epigenetic regulation of miR-34b and miR-129 expression in gastric cancer. | 2011 | Int. J. Cancer | pmid:21960261 |
| Ohtani K et al. | Epigenetic regulation of endothelial lineage committed genes in pro-angiogenic hematopoietic and endothelial progenitor cells. | 2011 | Circ. Res. | pmid:21980126 |
| Kaichi S et al. | Cyclin-dependent kinase 9 forms a complex with GATA4 and is involved in the differentiation of mouse ES cells into cardiomyocytes. | 2011 | J. Cell. Physiol. | pmid:20665673 |
| Pichugin A et al. | Ring-like distribution of constitutive heterochromatin in bovine senescent cells. | 2011 | PLoS ONE | pmid:22132080 |
| Wang JP et al. | Trichostatin A inhibits TGF-β1 induced in vitro chondrogenesis of hMSCs through Sp1 suppression. | 2011 | Differentiation | pmid:21074928 |
| Oyer JA et al. | Aberrantly silenced promoters retain a persistent memory of the silenced state after long-term reactivation. | 2011 | Mutat. Res. | pmid:21035468 |
| Pabba C et al. | Design and synthesis of aryl ether and sulfone hydroxamic acids as potent histone deacetylase (HDAC) inhibitors. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21109435 |
| Vrzal R et al. | Valproic acid augments vitamin D receptor-mediated induction of CYP24 by vitamin D3: a possible cause of valproic acid-induced osteomalacia? | 2011 | Toxicol. Lett. | pmid:21115105 |
| Coleman SL et al. | Unsaturated fatty acids repress the expression of adipocyte fatty acid binding protein via the modulation of histone deacetylation in RAW 264.7 macrophages. | 2011 | Eur J Nutr | pmid:21046125 |
| Marrazzo A et al. | Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells. | 2011 | Eur J Med Chem | pmid:21055848 |
| Gao A et al. | Epigenetic modification involved in benzene-induced apoptosis through regulating apoptosis-related genes expression. | 2011 | Cell Biol. Int. | pmid:21143203 |
| Wang YS et al. | Production of cloned calves by combination treatment of both donor cells and early cloned embryos with 5-aza-2/-deoxycytidine and trichostatin A. | 2011 | Theriogenology | pmid:21144561 |
| Shiratsuki S et al. | Trichostatin A-treated eight-cell bovine embryos had increased histone acetylation and gene expression, with increased cell numbers at the blastocyst stage. | 2011 | Theriogenology | pmid:21144563 |
| Poljakova J et al. | Anticancer agent ellipticine combined with histone deacetylase inhibitors, valproic acid and trichostatin A, is an effective DNA damage strategy in human neuroblastoma. | 2011 | Neuro Endocrinol. Lett. | pmid:22167207 |
| Williams PJ et al. | HDAC inhibitor trichostatin A suppresses osteoclastogenesis by upregulating the expression of C/EBP-β and MKP-1. | 2011 | Ann. N. Y. Acad. Sci. | pmid:22172035 |
| Xia B et al. | Chromium(VI) causes down regulation of biotinidase in human bronchial epithelial cells by modifications of histone acetylation. | 2011 | Toxicol. Lett. | pmid:21641978 |
| Johansson AS et al. | Valproic acid phase shifts the rhythmic expression of Period2::Luciferase. | 2011 | J. Biol. Rhythms | pmid:22215612 |
| Bouquet F et al. | A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia. | 2011 | J. Cell. Sci. | pmid:21576354 |
| Hawk JD et al. | Post-training intrahippocampal inhibition of class I histone deacetylases enhances long-term object-location memory. | 2011 | Learn. Mem. | pmid:21576516 |
| Dong X et al. | Histone deacetylase inhibitors upregulate Rap1GAP and inhibit Rap activity in thyroid tumor cells. | 2011 | Endocr. Relat. Cancer | pmid:21367844 |
| Zhu QY et al. | C6-ceramide synergistically potentiates the anti-tumor effects of histone deacetylase inhibitors via AKT dephosphorylation and α-tubulin hyperacetylation both in vitro and in vivo. | 2011 | Cell Death Dis | pmid:21368888 |
| Hsu YF et al. | p53 in trichostatin A induced C6 glioma cell death. | 2011 | Biochim. Biophys. Acta | pmid:21376104 |
| Ryhänen T et al. | Influence of Hsp90 and HDAC inhibition and tubulin acetylation on perinuclear protein aggregation in human retinal pigment epithelial cells. | 2011 | J. Biomed. Biotechnol. | pmid:20981255 |
| Briggs B et al. | Photosensitization by iodinated DNA minor groove binding ligands: Evaluation of DNA double-strand break induction and repair. | 2011 | J. Photochem. Photobiol. B, Biol. | pmid:21440453 |
| Seitz V et al. | Classical Hodgkin's lymphoma shows epigenetic features of abortive plasma cell differentiation. | 2011 | Haematologica | pmid:21393330 |
| Agudelo M et al. | Effects of alcohol on histone deacetylase 2 (HDAC2) and the neuroprotective role of trichostatin A (TSA). | 2011 | Alcohol. Clin. Exp. Res. | pmid:21447001 |
| Zhang Y et al. | ERK1/2 activation plays important roles in the opposite effects of Trichostatin A in non-cancer and cancer cells. | 2011 | Toxicon | pmid:21419152 |
| WEI Q et al. | [Trichostatin A inhibits the activation of CD(4)(+) T cells by suppressing CD(28) expression in mice]. | 2011 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:21421475 |
| Jergil M et al. | Short-time gene expression response to valproic acid and valproic acid analogs in mouse embryonic stem cells. | 2011 | Toxicol. Sci. | pmid:21427059 |
| Diao JS et al. | Trichostatin A inhibits collagen synthesis and induces apoptosis in keloid fibroblasts. | 2011 | Arch. Dermatol. Res. | pmid:21400246 |
| Zhang J et al. | Inhibition of glyceroneogenesis by histone deacetylase 3 contributes to lipodystrophy in mice with adipose tissue inflammation. | 2011 | Endocrinology | pmid:21406501 |
| Kawasaki H et al. | Mouse embryonic stem cells inhibit murine cytomegalovirus infection through a multi-step process. | 2011 | PLoS ONE | pmid:21407806 |
| Li Z et al. | Epigenetic inactivation of PCDH10 in human prostate cancer cell lines. | 2011 | Cell Biol. Int. | pmid:21314642 |
| Kretzner L et al. | Combining histone deacetylase inhibitor vorinostat with aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and microRNA levels. | 2011 | Cancer Res. | pmid:21502403 |
| Poplineau M et al. | Raman microspectroscopy detects epigenetic modifications in living Jurkat leukemic cells. | 2011 | Epigenomics | pmid:22126296 |
| Qiu GH et al. | Recognition and suppression of transfected plasmids by protein ZNF511-PRAP1, a potential molecular barrier to transgene expression. | 2011 | Mol. Ther. | pmid:21540836 |
| Kong Q et al. | Effect of trichostatin A and 5-Aza-2'-deoxycytidine on transgene reactivation and epigenetic modification in transgenic pig fibroblast cells. | 2011 | Mol. Cell. Biochem. | pmid:21541675 |
| Wang QS et al. | [Silence mechanism of WT1 gene in leukemic cell line U937]. | 2011 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:22040952 |
| Park JW et al. | Microbial transformation of trichostatin A to 2,3-dihydrotrichostatin A. | 2011 | J. Nat. Prod. | pmid:21504214 |
| Matoba S et al. | RNAi-mediated knockdown of Xist can rescue the impaired postimplantation development of cloned mouse embryos. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22065773 |
| Bolleyn J et al. | Effect of Trichostatin A on miRNA expression in cultures of primary rat hepatocytes. | 2011 | Toxicol In Vitro | pmid:21513791 |
| Rajasingh J et al. | Improvement of cardiac function in mouse myocardial infarction after transplantation of epigenetically-modified bone marrow progenitor cells. | 2011 | PLoS ONE | pmid:21799893 |
| Ramsey MR et al. | Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma. | 2011 | Cancer Res. | pmid:21527555 |
| Klawitter M et al. | Human MMP28 expression is unresponsive to inflammatory stimuli and does not correlate to the grade of intervertebral disc degeneration. | 2011 | J Negat Results Biomed | pmid:21801383 |
| Nishikata I et al. | Sumoylation of MEL1S at lysine 568 and its interaction with CtBP facilitates its repressor activity and the blockade of G-CSF-induced myeloid differentiation. | 2011 | Oncogene | pmid:21516122 |
| Tong Y et al. | PTTG1 attenuates drug-induced cellular senescence. | 2011 | PLoS ONE | pmid:21858218 |
| Crump NT et al. | Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21518915 |
| Bui HT et al. | Histone deacetylase inhibition improves activation of ribosomal RNA genes and embryonic nucleolar reprogramming in cloned mouse embryos. | 2011 | Biol. Reprod. | pmid:21753193 |
| Fortson WS et al. | Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells. | 2011 | Int. J. Oncol. | pmid:21519790 |
| Huang KT et al. | Aberrant DNA methylation but not mutation of CITED4 is associated with alteration of HIF-regulated genes in breast cancer. | 2011 | Breast Cancer Res. Treat. | pmid:21755341 |
| Inoue H et al. | Analysis of expression and structure of the rat GH-secretagogue/ghrelin receptor (Ghsr) gene: roles of epigenetic modifications in transcriptional regulation. | 2011 | Mol. Cell. Endocrinol. | pmid:21756973 |
| Wang Y et al. | The effects of 5-aza-2'- deoxycytidine and trichostatin A on gene expression and DNA methylation status in cloned bovine blastocysts. | 2011 | Cell Reprogram | pmid:21486115 |
| Watanabe Y and Tanaka M | p62/SQSTM1 in autophagic clearance of a non-ubiquitylated substrate. | 2011 | J. Cell. Sci. | pmid:21771882 |
| Hattori N et al. | Methylation silencing of angiopoietin-like 4 in rat and human mammary carcinomas. | 2011 | Cancer Sci. | pmid:21489049 |
| Miller L et al. | Histone deacetylase 1 (HDAC1) participates in the down-regulation of corticotropin releasing hormone gene (crh) expression. | 2011 | Physiol. Behav. | pmid:21463644 |
| Tost J et al. | Methylation of specific CpG sites in the P2 promoter of parathyroid hormone-related protein determines the invasive potential of breast cancer cell lines. | 2011 | Epigenetics | pmid:21775817 |
| Law AY et al. | Sp1 is a transcription repressor to stanniocalcin-1 expression in TSA-treated human colon cancer cells, HT29. | 2011 | J. Cell. Biochem. | pmid:21465530 |
| Blanquart C et al. | Pharmacological characterization of histone deacetylase inhibitor and tumor cell-growth inhibition properties of new benzofuranone compounds. | 2011 | Curr Cancer Drug Targets | pmid:21762083 |
| Pang M et al. | Histone deacetylase 1/2 mediates proliferation of renal interstitial fibroblasts and expression of cell cycle proteins. | 2011 | J. Cell. Biochem. | pmid:21465537 |
| Wan Y et al. | Transcriptome profiling reveals a novel role for trichostatin A in antagonizing histone chaperone Chz1 mediated telomere anti-silencing. | 2011 | FEBS Lett. | pmid:21763693 |
| Kimura T et al. | Chromium (VI) inhibits mouse metallothionein-I gene transcription by modifying the transcription potential of the co-activator p300. | 2011 | J Toxicol Sci | pmid:21467744 |
| Hu Y et al. | Trichostatin A selectively suppresses the cold-induced transcription of the ZmDREB1 gene in maize. | 2011 | PLoS ONE | pmid:21811564 |
| Nakaya Y et al. | Epigenetic regulation on the 5'-proximal CpG island of human porcine endogenous retrovirus subgroup A receptor 2/GPR172B. | 2011 | Microbes Infect. | pmid:20951222 |
| Robers MB et al. | Measurement of the cellular deacetylase activity of SIRT1 on p53 via LanthaScreen® technology. | 2011 | Mol Biosyst | pmid:20931131 |
| Hsu YF et al. | MAPK phosphatase-1 contributes to trichostatin A inhibition of cyclooxygenase-2 expression in human umbilical vascular endothelial cells exposed to lipopolysaccharide. | 2011 | Biochim. Biophys. Acta | pmid:21911040 |
| Crandall JE et al. | Retinoic acid influences neuronal migration from the ganglionic eminence to the cerebral cortex. | 2011 | J. Neurochem. | pmid:21895658 |
| Bogaard HJ et al. | Suppression of histone deacetylases worsens right ventricular dysfunction after pulmonary artery banding in rats. | 2011 | Am. J. Respir. Crit. Care Med. | pmid:21297075 |
| Jafarpour F et al. | Somatic cell-induced hyperacetylation, but not hypomethylation, positively and reversibly affects the efficiency of in vitro cloned blastocyst production in cattle. | 2011 | Cell Reprogram | pmid:21919704 |
| Furumai R et al. | Histone deacetylase inhibitors block nuclear factor-κB-dependent transcription by interfering with RNA polymerase II recruitment. | 2011 | Cancer Sci. | pmid:21299717 |
| Chen S et al. | [Effect of trichostatin alone and combination with imatinb on the proliferation and apoptosis of the K562R cells]. | 2011 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:21937807 |
| Cai HH et al. | Aberrant methylation frequency of TNFRSF10C promoter in pancreatic cancer cell lines. | 2011 | HBPD INT | pmid:21269942 |
| Lee SC et al. | HDAC activity is required for efficient core promoter function at the mouse mammary tumor virus promoter. | 2011 | J. Biomed. Biotechnol. | pmid:21253530 |
| Chen WP et al. | Trichostatin A inhibits expression of cathepsins in experimental osteoarthritis. | 2011 | Rheumatol. Int. | pmid:20390279 |
| Yoon CY et al. | The histone deacetylase inhibitor trichostatin A synergistically resensitizes a cisplatin resistant human bladder cancer cell line. | 2011 | J. Urol. | pmid:21255805 |
| Choi E et al. | Structure and property based design, synthesis and biological evaluation of γ-lactam based HDAC inhibitors. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21256006 |
| Mizuno S et al. | Inhibition of histone deacetylase causes emphysema. | 2011 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:21224215 |
| Hai T et al. | Pluripotency maintenance in mouse somatic cell nuclear transfer embryos and its improvement by treatment with the histone deacetylase inhibitor TSA. | 2011 | Cell Reprogram | pmid:21241188 |
| Zou CF et al. | Re-expression of ARHI (DIRAS3) induces autophagy in breast cancer cells and enhances the inhibitory effect of paclitaxel. | 2011 | BMC Cancer | pmid:21244707 |
| Chen MY et al. | Decitabine and suberoylanilide hydroxamic acid (SAHA) inhibit growth of ovarian cancer cell lines and xenografts while inducing expression of imprinted tumor suppressor genes, apoptosis, G2/M arrest, and autophagy. | 2011 | Cancer | pmid:21491416 |
| Mitmaker EJ et al. | Modulation of matrix metalloproteinase activity in human thyroid cancer cell lines using demethylating agents and histone deacetylase inhibitors. | 2011 | Surgery | pmid:21193210 |
| Liao M et al. | Coactivator function of positive cofactor 4 (PC4) in Sp1-directed luteinizing hormone receptor (LHR) gene transcription. | 2011 | J. Biol. Chem. | pmid:21193408 |
| Erb TM et al. | Paracrine and epigenetic control of trophectoderm differentiation from human embryonic stem cells: the role of bone morphogenic protein 4 and histone deacetylases. | 2011 | Stem Cells Dev. | pmid:21204619 |
| Farinas B and Mas P | Functional implication of the MYB transcription factor RVE8/LCL5 in the circadian control of histone acetylation. | 2011 | Plant J. | pmid:21205033 |
| Host L et al. | Cocaine self-administration alters the expression of chromatin-remodelling proteins; modulation by histone deacetylase inhibition. | 2011 | J. Psychopharmacol. (Oxford) | pmid:19939859 |
| Muralidhar SA et al. | Histone deacetylase 9 activates gamma-globin gene expression in primary erythroid cells. | 2011 | J. Biol. Chem. | pmid:21078662 |
| Chakravarty G et al. | Cytoplasmic compartmentalization of SOX9 abrogates the growth arrest response of breast cancer cells that can be rescued by trichostatin A treatment. | 2011 | Cancer Biol. Ther. | pmid:21084857 |
| Meng Y et al. | Epigenetic inactivation of the SFRP1 gene in esophageal squamous cell carcinoma. | 2011 | Dig. Dis. Sci. | pmid:21567192 |
| Puppin C et al. | Histone deacetylase inhibitors induce thymidine phosphorylase expression in cultured breast cancer cell lines. | 2011 | Oncol. Rep. | pmid:21617864 |
| Shu G et al. | Zac1 is a histone acetylation-regulated NF-κB suppressor that mediates histone deacetylase inhibitor-induced apoptosis. | 2011 | Cell Death Differ. | pmid:21546906 |
| Vojdani Z et al. | Cardiomyocyte marker expression in a human lymphocyte cell line using mouse cardiomyocyte extract. | 2011 | Hum. Cell | pmid:21547694 |
| Neelarapu R et al. | Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes. | 2011 | J. Med. Chem. | pmid:21548582 |
| Vassiliev I et al. | Isolation and in vitro characterization of putative porcine embryonic stem cells from cloned embryos treated with trichostatin A. | 2011 | Cell Reprogram | pmid:21548828 |
| Ververis K et al. | Histone deacetylase inhibitors augment doxorubicin-induced DNA damage in cardiomyocytes. | 2011 | Cell. Mol. Life Sci. | pmid:21584806 |
| Misaki K et al. | Histone deacetylase inhibition alters dendritic cells to assume a tolerogenic phenotype and ameliorates arthritis in SKG mice. | 2011 | Arthritis Res. Ther. | pmid:21592365 |
| Selinger CI et al. | Loss of special AT-rich binding protein 1 expression is a marker of poor survival in lung cancer. | 2011 | J Thorac Oncol | pmid:21597389 |