Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Federman N et al. | Histone acetylation is recruited in consolidation as a molecular feature of stronger memories. | 2009 | Learn. Mem. | pmid:19794185 |
Sponziello M et al. | Regulation of sodium/iodide symporter and lactoperoxidase expression in four human breast cancer cell lines. | 2010 | J. Endocrinol. Invest. | pmid:19794300 |
Wu P et al. | Ubiquitin B: an essential mediator of trichostatin A-induced tumor-selective killing in human cancer cells. | 2010 | Cell Death Differ. | pmid:19798105 |
Liberatore RA et al. | NF-kappaB activity is constitutively elevated in c-Abl null fibroblasts. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19805123 |
Sasaki K et al. | Real-time imaging of histone H4 hyperacetylation in living cells. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19805290 |
Gibbs A et al. | Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19805354 |
Li X et al. | Gene silencing of MIR22 in acute lymphoblastic leukaemia involves histone modifications independent of promoter DNA methylation. | 2010 | Br. J. Haematol. | pmid:19807731 |
Lee JH et al. | Notch signal activates hypoxia pathway through HES1-dependent SRC/signal transducers and activators of transcription 3 pathway. | 2009 | Mol. Cancer Res. | pmid:19808903 |
Hui KF and Chiang AK | Suberoylanilide hydroxamic acid induces viral lytic cycle in Epstein-Barr virus-positive epithelial malignancies and mediates enhanced cell death. | 2010 | Int. J. Cancer | pmid:19816947 |
Gray SG et al. | Regulation of EP receptors in non-small cell lung cancer by epigenetic modifications. | 2009 | Eur. J. Cancer | pmid:19818596 |
Hara D et al. | Persistent BDNF exon I-IX mRNA expression following the withdrawal of neuronal activity in neurons. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19818730 |
Li C et al. | Induction of myelogenous leukemia cells with histone deacetylase inhibitors through down-regulating the Daxx protein expression. | 2009 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:19821084 |
Puca R et al. | HIPK2 modulates p53 activity towards pro-apoptotic transcription. | 2009 | Mol. Cancer | pmid:19828042 |
Röhrs S et al. | Hypomethylation and expression of BEX2, IGSF4 and TIMP3 indicative of MLL translocations in acute myeloid leukemia. | 2009 | Mol. Cancer | pmid:19835597 |
Wang Y et al. | HDAC inhibitor trichostatin A-inhibited survival of dopaminergic neuronal cells. | 2009 | Neurosci. Lett. | pmid:19835929 |
Di Renzo F et al. | VPA-related axial skeletal defects and apoptosis: a proposed event cascade. | 2010 | Reprod. Toxicol. | pmid:19850124 |
Ai J et al. | HDAC6 regulates androgen receptor hypersensitivity and nuclear localization via modulating Hsp90 acetylation in castration-resistant prostate cancer. | 2009 | Mol. Endocrinol. | pmid:19855091 |
Meng CF et al. | Role of histone modifications and DNA methylation in the regulation of O6-methylguanine-DNA methyltransferase gene expression in human stomach cancer cells. | 2010 | Cancer Invest. | pmid:19857042 |
Li X et al. | Mta3-NuRD complex is a master regulator for initiation of primitive hematopoiesis in vertebrate embryos. | 2009 | Blood | pmid:19864643 |
Kusakabe M et al. | Impact of DNA demethylation of the G0S2 gene on the transcription of G0S2 in squamous lung cancer cell lines with or without nuclear receptor agonists. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19878646 |
Krishnan M et al. | HDAC inhibitors regulate claudin-1 expression in colon cancer cells through modulation of mRNA stability. | 2010 | Oncogene | pmid:19881542 |
Ninios YP et al. | Histone H1 subtype preferences of DFF40 and possible nuclear localization of DFF40/45 in normal and trichostatin A-treated NB4 leukemic cells. | 2010 | Apoptosis | pmid:19882353 |
Ma X et al. | Identification of LIV1, a putative zinc transporter gene responsible for HDACi-induced apoptosis, using a functional gene screen approach. | 2009 | Mol. Cancer Ther. | pmid:19887557 |
Dong G et al. | Inhibitors of histone deacetylases suppress cisplatin-induced p53 activation and apoptosis in renal tubular cells. | 2010 | Am. J. Physiol. Renal Physiol. | pmid:19889954 |
Bhuiyan MM et al. | Production of Sei whale (Balaenoptera borealis) cloned embryos by inter- and intra-species somatic cell nuclear transfer. | 2010 | J. Reprod. Dev. | pmid:19893277 |
Ellis JK et al. | Effect of the histone deacetylase inhibitor trichostatin a on the metabolome of cultured primary hepatocytes. | 2010 | J. Proteome Res. | pmid:19894772 |
Mastitskaya S and Denecke B | Human spongiosa mesenchymal stem cells fail to generate cardiomyocytes in vitro. | 2009 | J Negat Results Biomed | pmid:19903342 |
Marumo T et al. | Histone deacetylase modulates the proinflammatory and -fibrotic changes in tubulointerstitial injury. | 2010 | Am. J. Physiol. Renal Physiol. | pmid:19906951 |
Yakovlev A et al. | Epigenetic regulation of caspase-3 gene expression in rat brain development. | 2010 | Gene | pmid:19909801 |
Patil V et al. | Antimalarial and antileishmanial activities of histone deacetylase inhibitors with triazole-linked cap group. | 2010 | Bioorg. Med. Chem. | pmid:19914074 |
Choi JH et al. | TSA-induced DNMT1 down-regulation represses hTERT expression via recruiting CTCF into demethylated core promoter region of hTERT in HCT116. | 2010 | Biochem. Biophys. Res. Commun. | pmid:19914212 |
Freidkin I et al. | Effects of histone deacetylase inhibitors on rat mesangial cells. | 2010 | Am. J. Physiol. Renal Physiol. | pmid:19923417 |
Perisic T et al. | Valproate and amitriptyline exert common and divergent influences on global and gene promoter-specific chromatin modifications in rat primary astrocytes. | 2010 | Neuropsychopharmacology | pmid:19924110 |
Sun F et al. | Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells. | 2009 | Mol. Cancer Ther. | pmid:19934278 |
Koh HS et al. | Twist2 regulates CD7 expression and galectin-1-induced apoptosis in mature T-cells. | 2009 | Mol. Cells | pmid:19937140 |
Host L et al. | Cocaine self-administration alters the expression of chromatin-remodelling proteins; modulation by histone deacetylase inhibition. | 2011 | J. Psychopharmacol. (Oxford) | pmid:19939859 |
Kuribayashi T et al. | Scriptaid, a novel histone deacetylase inhibitor, enhances the response of human tumor cells to radiation. | 2010 | Int. J. Mol. Med. | pmid:19956898 |
Zhang D et al. | [Synergistic cytotoxicity effect of histone deacetylase inhibitor combined with paclitaxel on lung cancer cell lines and its mechanism]. | 2009 | Ai Zheng | pmid:19958621 |
Cao Y et al. | Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19966229 |
Hutt DM et al. | Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis. | 2010 | Nat. Chem. Biol. | pmid:19966789 |
Aoyama M et al. | Butyrate and propionate induced activated or non-activated neutrophil apoptosis via HDAC inhibitor activity but without activating GPR-41/GPR-43 pathways. | 2010 | Nutrition | pmid:20004081 |
von Dassow G et al. | Action at a distance during cytokinesis. | 2009 | J. Cell Biol. | pmid:20008563 |
Wang N and Tilly JL | Epigenetic status determines germ cell meiotic commitment in embryonic and postnatal mammalian gonads. | 2010 | Cell Cycle | pmid:20009537 |
Kakihana M et al. | Induction of E-cadherin in lung cancer and interaction with growth suppression by histone deacetylase inhibition. | 2009 | J Thorac Oncol | pmid:20009910 |
Wang L et al. | Chronic cocaine-induced H3 acetylation and transcriptional activation of CaMKIIalpha in the nucleus accumbens is critical for motivation for drug reinforcement. | 2010 | Neuropsychopharmacology | pmid:20010550 |
O'Leary DA et al. | Identification of small molecule and genetic modulators of AON-induced dystrophin exon skipping by high-throughput screening. | 2009 | PLoS ONE | pmid:20020055 |
Lee CS et al. | Casein kinase 2 inhibition differentially modulates apoptotic effect of trichostatin A against epithelial ovarian carcinoma cell lines. | 2010 | Mol. Cell. Biochem. | pmid:20020183 |
Ibanez de Caceres I et al. | IGFBP-3 hypermethylation-derived deficiency mediates cisplatin resistance in non-small-cell lung cancer. | 2010 | Oncogene | pmid:20023704 |
Huber K et al. | Novel 3-arylideneindolin-2-ones as inhibitors of NAD+ -dependent histone deacetylases (sirtuins). | 2010 | J. Med. Chem. | pmid:20030343 |
Kroening S et al. | Characterization of connective tissue growth factor expression in primary cultures of human tubular epithelial cells: modulation by hypoxia. | 2010 | Am. J. Physiol. Renal Physiol. | pmid:20032117 |
Benny Klimek ME et al. | Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20036643 |
Peng CY et al. | Growth-inhibiting effects of arsenic trioxide plus epigenetic therapeutic agents on leukemia cell lines. | 2010 | Leuk. Lymphoma | pmid:20038232 |
Li RJ et al. | Down-regulation of mitochondrial ATPase by hypermethylation mechanism in chronic myeloid leukemia is associated with multidrug resistance. | 2010 | Ann. Oncol. | pmid:20038517 |
Nordén R et al. | Inhibition of protein deacetylation augments herpes simplex virus type 1-activated transcription of host fucosyltransferase genes associated with virus-induced sLex expression. | 2010 | Arch. Virol. | pmid:20039087 |
Sayan BS et al. | Induction of TAp63 by histone deacetylase inhibitors. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20043870 |
Islam NM et al. | Bicyclic peptides as potent inhibitors of histone deacetylases: optimization of alkyl loop length. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20045316 |
Wu J et al. | Trichostatin A sensitizes cisplatin-resistant A549 cells to apoptosis by up-regulating death-associated protein kinase. | 2010 | Acta Pharmacol. Sin. | pmid:20048748 |
Hebbel RP et al. | The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice. | 2010 | Blood | pmid:20053759 |
He R et al. | Synthesis and biological evaluation of triazol-4-ylphenyl-bearing histone deacetylase inhibitors as anticancer agents. | 2010 | J. Med. Chem. | pmid:20055418 |
Ajiro K et al. | Reciprocal epigenetic modification of histone H2B occurs in chromatin during apoptosis in vitro and in vivo. | 2010 | Cell Death Differ. | pmid:20057502 |
Taura A et al. | Histone deacetylase inhibition enhances adenoviral vector transduction in inner ear tissue. | 2010 | Neuroscience | pmid:20060033 |
Chou JL et al. | Promoter hypermethylation of FBXO32, a novel TGF-beta/SMAD4 target gene and tumor suppressor, is associated with poor prognosis in human ovarian cancer. | 2010 | Lab. Invest. | pmid:20065949 |
Chang J et al. | Hepatopoietin Cn suppresses apoptosis of human hepatocellular carcinoma cells by up-regulating myeloid cell leukemia-1. | 2010 | World J. Gastroenterol. | pmid:20066738 |
Choi YS et al. | Differentiation of human adipose-derived stem cells into beating cardiomyocytes. | 2010 | J. Cell. Mol. Med. | pmid:20070436 |
Lee KJ et al. | Downregulation of a tumor suppressor RECK by hypoxia through recruitment of HDAC1 and HIF-1alpha to reverse HRE site in the promoter. | 2010 | Biochim. Biophys. Acta | pmid:20080132 |
Bracha AL et al. | Carbon metabolism-mediated myogenic differentiation. | 2010 | Nat. Chem. Biol. | pmid:20081855 |
Pan L et al. | Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate-induced and 5-aza-2'-deoxycytidine-induced PTEN upregulation. | 2010 | FEBS J. | pmid:20089040 |
Wang J et al. | Effect of EGF-induced HDAC6 activation on corneal epithelial wound healing. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:20089874 |
Nunes MJ et al. | Sp proteins play a critical role in histone deacetylase inhibitor-mediated derepression of CYP46A1 gene transcription. | 2010 | J. Neurochem. | pmid:20096088 |
Aizawa S and Yamamuro Y | Involvement of histone acetylation in the regulation of choline acetyltransferase gene in NG108-15 neuronal cells. | 2010 | Neurochem. Int. | pmid:20100532 |
Grabiec AM et al. | Histone deacetylase inhibitors suppress inflammatory activation of rheumatoid arthritis patient synovial macrophages and tissue. | 2010 | J. Immunol. | pmid:20100935 |
Chatterjee A et al. | An efficient synthesis of (+/-)-trichostatic Acid and analogues: a new route to (+/-)-trichostatin A. | 2010 | Org. Lett. | pmid:20104892 |
Kicic A et al. | Decreased fibronectin production significantly contributes to dysregulated repair of asthmatic epithelium. | 2010 | Am. J. Respir. Crit. Care Med. | pmid:20110557 |
Liang Q et al. | The novel human endogenous retrovirus-related gene, psiTPTE22-HERV, is silenced by DNA methylation in cancers. | 2010 | Int. J. Cancer | pmid:20112338 |
Beedanagari SR et al. | Differential regulation of the dioxin-induced Cyp1a1 and Cyp1b1 genes in mouse hepatoma and fibroblast cell lines. | 2010 | Toxicol. Lett. | pmid:20116417 |
Lu Y et al. | Trichostatin A, a histone deacetylase inhibitor, reduces lesion growth and hyperalgesia in experimentally induced endometriosis in mice. | 2010 | Hum. Reprod. | pmid:20118114 |
Izawa M et al. | Inhibition of histone deacetylase causes reduction of appressorium formation in the rice blast fungus Magnaporthe oryzae. | 2009 | J. Gen. Appl. Microbiol. | pmid:20118613 |
Hajji N et al. | Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the sensitivity to the topoisomerase II inhibitor etoposide. | 2010 | Oncogene | pmid:20118981 |
Wu Y et al. | Constitutive and tumor necrosis factor-alpha-stimulated activation of nuclear factor-kappaB in immortalized endometriotic cells and their suppression by trichostatin A. | 2010 | Gynecol. Obstet. Invest. | pmid:20130413 |
Zhao J et al. | Histone deacetylase inhibitors improve in vitro and in vivo developmental competence of somatic cell nuclear transfer porcine embryos. | 2010 | Cell Reprogram | pmid:20132015 |
Martinez-Diaz MA et al. | Pre- and postimplantation development of swine-cloned embryos derived from fibroblasts and bone marrow cells after inhibition of histone deacetylases. | 2010 | Cell Reprogram | pmid:20132016 |
Host L et al. | Inhibition of histone deacetylases in rats self-administering cocaine regulates lissencephaly gene-1 and reelin gene expression, as revealed by microarray technique. | 2010 | J. Neurochem. | pmid:20132486 |
Wu Y et al. | Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation. | 2010 | BMC Cancer | pmid:20132554 |
Mercer TR et al. | Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation. | 2010 | BMC Neurosci | pmid:20137068 |
Hodges SJ et al. | The effect of epigenetic therapy on congenital neurogenic bladders--a pilot study. | 2010 | Urology | pmid:20138341 |
Bradner JE et al. | Chemical phylogenetics of histone deacetylases. | 2010 | Nat. Chem. Biol. | pmid:20139990 |
Okada T et al. | TWIST1 hypermethylation is observed frequently in colorectal tumors and its overexpression is associated with unfavorable outcomes in patients with colorectal cancer. | 2010 | Genes Chromosomes Cancer | pmid:20140954 |
Wessels I et al. | Changes in chromatin structure and methylation of the human interleukin-1beta gene during monopoiesis. | 2010 | Immunology | pmid:20141541 |
Swingler TE et al. | MMP28 gene expression is regulated by Sp1 transcription factor acetylation. | 2010 | Biochem. J. | pmid:20144149 |
Liu TY et al. | EBV-positive Hodgkin lymphoma is associated with suppression of p21cip1/waf1 and a worse prognosis. | 2010 | Mol. Cancer | pmid:20144199 |
Suh HS et al. | Histone deacetylase inhibitors suppress the expression of inflammatory and innate immune response genes in human microglia and astrocytes. | 2010 | J Neuroimmune Pharmacol | pmid:20157787 |
Crosson CE et al. | Inhibition of histone deacetylase protects the retina from ischemic injury. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:20164449 |
Jang ER et al. | ATM modulates transcription in response to histone deacetylase inhibition as part of its DNA damage response. | 2010 | Exp. Mol. Med. | pmid:20164679 |
Desai D et al. | SelSA, selenium analogs of SAHA as potent histone deacetylase inhibitors. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20167479 |
Awe S and Renkawitz-Pohl R | Histone H4 acetylation is essential to proceed from a histone- to a protamine-based chromatin structure in spermatid nuclei of Drosophila melanogaster. | 2010 | Syst Biol Reprod Med | pmid:20170286 |
Akiba Y et al. | Histone deacetylase inhibitors de-repress tyrosine hydroxylase expression in the olfactory bulb and rostral migratory stream. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20170631 |
Angst E et al. | Epigenetic regulation affects N-myc downstream-regulated gene 1 expression indirectly in pancreatic cancer cells. | 2010 | Pancreas | pmid:20173668 |
Zhang L et al. | Histone deacetylase inhibitors attenuate acute lung injury during cecal ligation and puncture-induced polymicrobial sepsis. | 2010 | World J Surg | pmid:20177680 |
Fakhry H et al. | Immunohistochemical detection of histone deacetylases in endometrial carcinoma: involvement of histone deacetylase 2 in the proliferation of endometrial carcinoma cells. | 2010 | Hum. Pathol. | pmid:20178884 |
Wood JP et al. | A comparison of differentiation protocols for RGC-5 cells. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:20181845 |