trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Huisman C et al. | Prolonged re-expression of the hypermethylated gene EPB41L3 using artificial transcription factors and epigenetic drugs. | 2015 | Epigenetics | pmid:25830725 |
| Fujii K et al. | Lactogenic hormone stimulation and epigenetic control of L-amino acid oxidase expression in lactating mammary glands. | 2015 | J. Cell. Physiol. | pmid:25820447 |
| Hartman H et al. | Histone deacetylase regulates trypsin activation, inflammation, and tissue damage in acute pancreatitis in mice. | 2015 | Dig. Dis. Sci. | pmid:25492506 |
| Fukui T et al. | Histone deacetylase inhibitor attenuates neurotoxicity of clioquinol in PC12 cells. | 2015 | Toxicology | pmid:25758465 |
| Wang Y et al. | Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases. | 2015 | Chem. Biol. | pmid:25699604 |
| Rodrigues MF et al. | Reciprocal modulation of histone deacetylase inhibitors sodium butyrate and trichostatin A on the energy metabolism of breast cancer cells. | 2015 | J. Cell. Biochem. | pmid:25510910 |
| Uchida H et al. | Histone deacetylase inhibitors relieve morphine resistance in neuropathic pain after peripheral nerve injury. | 2015 | J. Pharmacol. Sci. | pmid:26318673 |
| Zhang P et al. | Histone Deacetylase Inhibitors Inhibit the Proliferation of Gallbladder Carcinoma Cells by Suppressing AKT/mTOR Signaling. | 2015 | PLoS ONE | pmid:26287365 |
| Huan Y et al. | Epigenetic Modification Agents Improve Gene-Specific Methylation Reprogramming in Porcine Cloned Embryos. | 2015 | PLoS ONE | pmid:26068219 |
| Huan Y et al. | Epigenetic Modification of Cloned Embryos Improves Nanog Reprogramming in Pigs. | 2015 | Cell Reprogram | pmid:26053519 |
| Sharifulina SA et al. | Epigenetic regulation of death of crayfish glial cells but not neurons induced by photodynamic impact. | 2014 | Brain Res. Bull. | pmid:24502940 |
| Nieto-Pelegrin E et al. | Nck adaptors, besides promoting N-WASP mediated actin-nucleation activity at pedestals, influence the cellular levels of enteropathogenic Escherichia coli Tir effector. | 2014 | Cell Adh Migr | pmid:25482634 |
| Lu HG et al. | TET1 partially mediates HDAC inhibitor-induced suppression of breast cancer invasion. | 2014 | Mol Med Rep | pmid:25175940 |
| Zohre S et al. | Trichostatin A-induced apoptosis is mediated by Kruppel-like factor 4 in ovarian and lung cancer. | 2014 | Asian Pac. J. Cancer Prev. | pmid:25169491 |
| Yang DH et al. | Dynamic rearrangement of F-actin is required to maintain the antitumor effect of trichostatin A. | 2014 | PLoS ONE | pmid:24846135 |
| Kumafuji M et al. | Mediator MED18 subunit plays a negative role in transcription via the CDK/cyclin module. | 2014 | Genes Cells | pmid:24840924 |
| Deng Y et al. | [Expression of neprilysin gene is associated with methylation and histone modification on promoter in mouse neuroblastoma Neuro-2a cells]. | 2014 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:25108432 |
| Liu J et al. | DNA promoter and histone H3 methylation downregulate NGX6 in gastric cancer cells. | 2014 | Med. Oncol. | pmid:24338274 |
| Al-Rayyan N et al. | 5-Aza-2-deoxycytidine and trichostatin A increase COUP-TFII expression in antiestrogen-resistant breast cancer cell lines. | 2014 | Cancer Lett. | pmid:24513177 |
| Alsarraf O et al. | Acetylation: a lysine modification with neuroprotective effects in ischemic retinal degeneration. | 2014 | Exp. Eye Res. | pmid:25064603 |