Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Takahashi K et al. | Homozygous deletion and reduced expression of the DOCK8 gene in human lung cancer. | 2006 | Int. J. Oncol. | pmid:16391785 |
Bai T et al. | A novel mechanism for acquired cisplatin-resistance: suppressed translation of death-associated protein kinase mRNA is insensitive to 5-aza-2'-deoxycitidine and trichostatin in cisplatin-resistant cervical squamous cancer cells. | 2006 | Int. J. Oncol. | pmid:16391806 |
Pazmany T and Tomasi TB | The major histocompatibility complex class II transactivator is differentially regulated by interferon-gamma and transforming growth factor-beta in microglial cells. | 2006 | J. Neuroimmunol. | pmid:16360884 |
Lee KY et al. | NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcription. | 2006 | J. Immunol. | pmid:16365456 |
Ohnishi K | [Therapeutic strategies for patients with relapsed acute promyelocytic leukemia]. | 2006 | Rinsho Ketsueki | pmid:16986710 |
Hansen KR et al. | Evolutionary-conserved telomere-linked helicase genes of fission yeast are repressed by silencing factors, RNAi components and the telomere-binding protein Taz1. | 2006 | Nucleic Acids Res. | pmid:16407326 |
Dowdy SC et al. | Histone deacetylase inhibitors and paclitaxel cause synergistic effects on apoptosis and microtubule stabilization in papillary serous endometrial cancer cells. | 2006 | Mol. Cancer Ther. | pmid:17121923 |
Fischer S et al. | Histone acetylation dependent allelic expression imbalance of BAPX1 in patients with the oculo-auriculo-vertebral spectrum. | 2006 | Hum. Mol. Genet. | pmid:16407370 |
Saunders LR and Verdin E | Ornithine decarboxylase activity in tumor cell lines correlates with sensitivity to cell death induced by histone deacetylase inhibitors. | 2006 | Mol. Cancer Ther. | pmid:17121924 |
Bieler A et al. | Novel three-pronged strategy to enhance cancer cell killing in glioblastoma cell lines: histone deacetylase inhibitor, chemotherapy, and oncolytic adenovirus dl520. | 2006 | Hum. Gene Ther. | pmid:16409125 |
Lo PK et al. | Epigenetic suppression of secreted frizzled related protein 1 (SFRP1) expression in human breast cancer. | 2006 | Cancer Biol. Ther. | pmid:16410723 |
Williams SA et al. | NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. | 2006 | EMBO J. | pmid:16319923 |
ChuÄkin IA et al. | [Anti-proliferative effect of histone deacetylase inhibitors on murine embryonic stem cells]. | 2006 | Tsitologiia | pmid:17147260 |
Zou B et al. | Correlation between the single-site CpG methylation and expression silencing of the XAF1 gene in human gastric and colon cancers. | 2006 | Gastroenterology | pmid:17087954 |
Anderson I | Deacetylase inhibitors aid recovery in muscular dystrophy. | 2006 | Lancet Neurol | pmid:17089447 |
Kiefer J et al. | Mixtures of SCFA, composed according to physiologically available concentrations in the gut lumen, modulate histone acetylation in human HT29 colon cancer cells. | 2006 | Br. J. Nutr. | pmid:17092367 |
Stefanovsky V and Moss T | Regulation of rRNA synthesis in human and mouse cells is not determined by changes in active gene count. | 2006 | Cell Cycle | pmid:16582637 |
Wang Q et al. | Histone deacetylation is required for orderly meiosis. | 2006 | Cell Cycle | pmid:16582639 |
Magnaghi-Jaulin L and Jaulin C | Histone deacetylase activity is necessary for chromosome condensation during meiotic maturation in Xenopus laevis. | 2006 | Chromosome Res. | pmid:16628502 |
Pavan Kumar P et al. | Phosphorylation of SATB1, a global gene regulator, acts as a molecular switch regulating its transcriptional activity in vivo. | 2006 | Mol. Cell | pmid:16630892 |
Vinken M et al. | Trichostatin a enhances gap junctional intercellular communication in primary cultures of adult rat hepatocytes. | 2006 | Toxicol. Sci. | pmid:16531468 |
Gastaldi T et al. | Plakoglobin is differentially expressed in alveolar and embryonal rhabdomyosarcoma and is regulated by DNA methylation and histone acetylation. | 2006 | Carcinogenesis | pmid:16537559 |
Tada Y et al. | Epigenetic modulation of tumor suppressor CCAAT/enhancer binding protein alpha activity in lung cancer. | 2006 | J. Natl. Cancer Inst. | pmid:16537832 |
Bishop CL et al. | Role for centromeric heterochromatin and PML nuclear bodies in the cellular response to foreign DNA. | 2006 | Mol. Cell. Biol. | pmid:16537904 |
Gagnon JF et al. | Irinotecan inactivation is modulated by epigenetic silencing of UGT1A1 in colon cancer. | 2006 | Clin. Cancer Res. | pmid:16551870 |
Rebbaa A et al. | The role of histone acetylation versus DNA damage in drug-induced senescence and apoptosis. | 2006 | Cell Death Differ. | pmid:16557274 |
Suuronen T et al. | Characterization of the pro-inflammatory signaling induced by protein acetylation in microglia. | 2006 | Neurochem. Int. | pmid:16797784 |
Wallace DM et al. | Histone deacetylase activity regulates apaf-1 and caspase 3 expression in the developing mouse retina. | 2006 | Invest. Ophthalmol. Vis. Sci. | pmid:16799012 |
Jüngel A et al. | Trichostatin A sensitises rheumatoid arthritis synovial fibroblasts for TRAIL-induced apoptosis. | 2006 | Ann. Rheum. Dis. | pmid:16284094 |
Nygård M et al. | Thyroid hormone-mediated negative transcriptional regulation of Necdin expression. | 2006 | J. Mol. Endocrinol. | pmid:16720720 |
Armstrong K et al. | NF-kappaB activation upregulates fibroblast growth factor 8 expression in prostate cancer cells. | 2006 | Prostate | pmid:16683270 |
Wischnewski F et al. | Promoter demethylation and histone acetylation mediate gene expression of MAGE-A1, -A2, -A3, and -A12 in human cancer cells. | 2006 | Mol. Cancer Res. | pmid:16687489 |
Yamada N et al. | MUC2 expression is regulated by histone H3 modification and DNA methylation in pancreatic cancer. | 2006 | Int. J. Cancer | pmid:16721789 |
Kim Y et al. | Effects of acetylation, polymerase phosphorylation, and DNA unwinding in glucocorticoid receptor transactivation. | 2006 | J. Steroid Biochem. Mol. Biol. | pmid:16723222 |
Santander VS et al. | Tubulin must be acetylated in order to form a complex with membrane Na(+),K (+)-ATPase and to inhibit its enzyme activity. | 2006 | Mol. Cell. Biochem. | pmid:16733802 |
Kong Y et al. | Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy. | 2006 | Circulation | pmid:16735673 |
Dannenberg LO et al. | Differential regulation of the alcohol dehydrogenase 1B (ADH1B) and ADH1C genes by DNA methylation and histone deacetylation. | 2006 | Alcohol. Clin. Exp. Res. | pmid:16737450 |
Cabrero JR et al. | Lymphocyte chemotaxis is regulated by histone deacetylase 6, independently of its deacetylase activity. | 2006 | Mol. Biol. Cell | pmid:16738306 |
Vulcano F et al. | HDAC inhibition is associated to valproic acid induction of early megakaryocytic markers. | 2006 | Exp. Cell Res. | pmid:16739251 |
Balasubramaniyan V et al. | Effects of histone deacetylation inhibition on neuronal differentiation of embryonic mouse neural stem cells. | 2006 | Neuroscience | pmid:17084985 |
Zhang Y et al. | Phosphatidylinositol 3-kinase/protein kinase Czeta-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated derepression [corrected] of transcription of the luteinizing hormone receptor gene. | 2006 | Mol. Cell. Biol. | pmid:16943418 |
Stewart MD et al. | Dynamic regulation of histone modifications in Xenopus oocytes through histone exchange. | 2006 | Mol. Cell. Biol. | pmid:16943430 |
Mühlisch J et al. | Epigenetic repression of RASSF1A but not CASP8 in supratentorial PNET (sPNET) and atypical teratoid/rhabdoid tumors (AT/RT) of childhood. | 2006 | Oncogene | pmid:16186793 |
Hirsch CL et al. | Src family kinase members have a common response to histone deacetylase inhibitors in human colon cancer cells. | 2006 | Int. J. Cancer | pmid:16094635 |
Scott SA et al. | 5-Aza-2'-deoxycytidine (decitabine) can relieve p21WAF1 repression in human acute myeloid leukemia by a mechanism involving release of histone deacetylase 1 (HDAC1) without requiring p21WAF1 promoter demethylation. | 2006 | Leuk. Res. | pmid:16043219 |
Hofmann A et al. | Epigenetic regulation of lentiviral transgene vectors in a large animal model. | 2006 | Mol. Ther. | pmid:16140581 |
Clem BF and Clark BJ | Association of the mSin3A-histone deacetylase 1/2 corepressor complex with the mouse steroidogenic acute regulatory protein gene. | 2006 | Mol. Endocrinol. | pmid:16109738 |
Kim HR et al. | Trichostatin A induces apoptosis in lung cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathway? | 2006 | Exp. Mol. Med. | pmid:17202837 |
Mai A et al. | Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors. | 2006 | J. Med. Chem. | pmid:17004718 |
Yao J et al. | NF-kappaB signaling pathway is involved in growth inhibition, G2/M arrest and apoptosis induced by Trichostatin A in human tongue carcinoma cells. | 2006 | Pharmacol. Res. | pmid:17005413 |
Inoue K et al. | Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression. | 2006 | Arterioscler. Thromb. Vasc. Biol. | pmid:17008592 |
Baqir S and Smith LC | Inhibitors of histone deacetylases and DNA methyltransferases alter imprinted gene regulation in embryonic stem cells. | 2006 | Cloning Stem Cells | pmid:17009896 |
Jung JW et al. | Effects of the histone deacetylases inhibitors sodium butyrate and trichostatin A on the inhibition of gap junctional intercellular communication by H2O2- and 12-O-tetradecanoylphorbol-13-acetate in rat liver epithelial cells. | 2006 | Cancer Lett. | pmid:16337085 |
Bai J et al. | Histone deacetylase inhibitor trichostatin A and proteasome inhibitor PS-341 synergistically induce apoptosis in pancreatic cancer cells. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16904634 |
Charrier C et al. | Synthesis of rigid trichostatin A analogs as HDAC inhibitors. | 2006 | Bioorg. Med. Chem. Lett. | pmid:16904890 |
Okamoto H et al. | Trichostatin A, an inhibitor of histone deacetylase, inhibits smooth muscle cell proliferation via induction of p21(WAF1). | 2006 | J. Atheroscler. Thromb. | pmid:16908950 |
Claus R et al. | Inhibitors of DNA methylation and histone deacetylation independently relieve AML1/ETO-mediated lysozyme repression. | 2006 | J. Leukoc. Biol. | pmid:17000900 |
Kogai T et al. | Enhancement of sodium/iodide symporter expression in thyroid and breast cancer. | 2006 | Endocr. Relat. Cancer | pmid:16954431 |
Tyson-Capper AJ et al. | Characterization of cellular retinoid-binding proteins in human myometrium during pregnancy. | 2006 | Mol. Hum. Reprod. | pmid:16959971 |
Chen J et al. | Trichostatin A improves the anticancer activity of low concentrations of curcumin in human leukemia cells. | 2006 | Pharmazie | pmid:16964716 |
Kim MY et al. | A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16924111 |
Mühlethaler-Mottet A et al. | Histone deacetylase inhibitors strongly sensitise neuroblastoma cells to TRAIL-induced apoptosis by a caspases-dependent increase of the pro- to anti-apoptotic proteins ratio. | 2006 | BMC Cancer | pmid:16930472 |
Suzuki T et al. | Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate. | 2006 | J. Med. Chem. | pmid:16884291 |
Seo H et al. | An ex vivo method for rapid generation of monoclonal antibodies (ADLib system). | 2006 | Nat Protoc | pmid:17406441 |
Pedram M et al. | Telomere position effect and silencing of transgenes near telomeres in the mouse. | 2006 | Mol. Cell. Biol. | pmid:16479005 |
Rybouchkin A et al. | Role of histone acetylation in reprogramming of somatic nuclei following nuclear transfer. | 2006 | Biol. Reprod. | pmid:16481594 |
Banchio C et al. | Role of histone deacetylase in the expression of CTP:phosphocholine cytidylyltransferase alpha. | 2006 | J. Biol. Chem. | pmid:16484221 |
Weaver IC et al. | Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16484373 |
Fandy TE and Srivastava RK | Trichostatin A sensitizes TRAIL-resistant myeloma cells by downregulation of the antiapoptotic Bcl-2 proteins. | 2006 | Cancer Chemother. Pharmacol. | pmid:16435155 |
Deng G et al. | Regional hypermethylation and global hypomethylation are associated with altered chromatin conformation and histone acetylation in colorectal cancer. | 2006 | Int. J. Cancer | pmid:16425274 |
Huang L et al. | Activation of ATP-sensitive K channels protects hippocampal CA1 neurons from hypoxia by suppressing p53 expression. | 2006 | Neurosci. Lett. | pmid:16426753 |
Kim IA et al. | Histone deacetylase inhibitor-mediated radiosensitization of human cancer cells: class differences and the potential influence of p53. | 2006 | Clin. Cancer Res. | pmid:16467109 |
Osborn NK et al. | Aberrant methylation of the eyes absent 4 gene in ulcerative colitis-associated dysplasia. | 2006 | Clin. Gastroenterol. Hepatol. | pmid:16469682 |
Baraz L et al. | Tumor suppressor p53 regulates heparanase gene expression. | 2006 | Oncogene | pmid:16474844 |
Gialitakis M et al. | Coordinated changes of histone modifications and HDAC mobilization regulate the induction of MHC class II genes by Trichostatin A. | 2006 | Nucleic Acids Res. | pmid:16452299 |
Kwon HS et al. | Retinoic acids and trichostatin A (TSA), a histone deacetylase inhibitor, induce human pyruvate dehydrogenase kinase 4 (PDK4) gene expression. | 2006 Mar-Apr | Biochim. Biophys. Acta | pmid:16757381 |
Sakuma M et al. | Promoter methylation status of the Cyclin D2 gene is associated with poor prognosis in human epithelial ovarian cancer. | 2007 | Cancer Sci. | pmid:17270028 |
Kim SH et al. | Regulation of the HIF-1alpha stability by histone deacetylases. | 2007 | Oncol. Rep. | pmid:17273746 |
Ou JN et al. | Histone deacetylase inhibitor Trichostatin A induces global and gene-specific DNA demethylation in human cancer cell lines. | 2007 | Biochem. Pharmacol. | pmid:17276411 |
Yoshikawa M et al. | Inhibition of histone deacetylase activity suppresses epithelial-to-mesenchymal transition induced by TGF-beta1 in human renal epithelial cells. | 2007 | J. Am. Soc. Nephrol. | pmid:17135397 |
Reddy RM et al. | Rapid and profound potentiation of Apo2L/TRAIL-mediated cytotoxicity and apoptosis in thoracic cancer cells by the histone deacetylase inhibitor Trichostatin A: the essential role of the mitochondria-mediated caspase activation cascade. | 2007 | Apoptosis | pmid:17136498 |
Tuncel M et al. | The comparative effects of gene modulators on thyroid-specific genes and radioiodine uptake. | 2007 | Cancer Biother. Radiopharm. | pmid:17679169 |
Sun DF et al. | [The relationship of mTOR signaling pathway and histone acetylation in human gastric cancer cell lines]. | 2007 | Zhonghua Yi Xue Yi Chuan Xue Za Zhi | pmid:17680526 |
Wu Y et al. | Trichostatin A, a histone deacetylase inhibitor, attenuates invasiveness and reactivates E-cadherin expression in immortalized endometriotic cells. | 2007 | Reprod Sci | pmid:17644810 |
Wang CT and Meng M | [Experimental study on the effect of trichostatin A on differentiation of human lung carcinoma cell]. | 2007 | Zhonghua Yi Xue Za Zhi | pmid:17650409 |
Janowski BA et al. | Activating gene expression in mammalian cells with promoter-targeted duplex RNAs. | 2007 | Nat. Chem. Biol. | pmid:17259978 |
Woo HJ et al. | Induction of apoptosis and inhibition of telomerase activity by trichostatin A, a histone deacetylase inhibitor, in human leukemic U937 cells. | 2007 | Exp. Mol. Pathol. | pmid:16574101 |
Januchowski R et al. | Trichostatin A down-regulate DNA methyltransferase 1 in Jurkat T cells. | 2007 | Cancer Lett. | pmid:16624484 |
Frye M et al. | Epidermal stem cells are defined by global histone modifications that are altered by Myc-induced differentiation. | 2007 | PLoS ONE | pmid:17712411 |
Adcock IM et al. | Epigenetic regulation of airway inflammation. | 2007 | Curr. Opin. Immunol. | pmid:17720468 |
Zhang Y et al. | Attenuated DNA damage repair by trichostatin A through BRCA1 suppression. | 2007 | Radiat. Res. | pmid:17722998 |
Zhong S et al. | Pharmacologic inhibition of epigenetic modifications, coupled with gene expression profiling, reveals novel targets of aberrant DNA methylation and histone deacetylation in lung cancer. | 2007 | Oncogene | pmid:17043644 |
Katz RA et al. | High-frequency epigenetic repression and silencing of retroviruses can be antagonized by histone deacetylase inhibitors and transcriptional activators, but uniform reactivation in cell clones is restricted by additional mechanisms. | 2007 | J. Virol. | pmid:17202206 |
Pourebrahim R et al. | ZIC1 gene expression is controlled by DNA and histone methylation in mesenchymal proliferations. | 2007 | FEBS Lett. | pmid:17936758 |
Sichtig N et al. | Papillomavirus binding factor binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex. | 2007 | Arch. Biochem. Biophys. | pmid:17897615 |
Charrier C et al. | Antiproliferative activities of a library of hybrids between indanones and HDAC inhibitor SAHA and MS-275 analogues. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17897824 |
Barr H et al. | Mbd2 contributes to DNA methylation-directed repression of the Xist gene. | 2007 | Mol. Cell. Biol. | pmid:17353271 |
Li B et al. | FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17360565 |
Vandergeeten C et al. | HIV-1 protease inhibitors do not interfere with provirus transcription and host cell apoptosis induced by combined treatment TNF-alpha + TSA. | 2007 | Biochem. Pharmacol. | pmid:17386923 |
Rohner A et al. | Differentiation-promoting drugs up-regulate NKG2D ligand expression and enhance the susceptibility of acute myeloid leukemia cells to natural killer cell-mediated lysis. | 2007 | Leuk. Res. | pmid:17391757 |