Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Hizume K et al. | Nano-scale analyses of the chromatin decompaction induced by histone acetylation. | 2010 | Arch. Histol. Cytol. | pmid:22572182 |
Wang XH et al. | S100A6 overexpression is associated with poor prognosis and is epigenetically up-regulated in gastric cancer. | 2010 | Am. J. Pathol. | pmid:20581057 |
Terhune SS et al. | Human cytomegalovirus UL29/28 protein interacts with components of the NuRD complex which promote accumulation of immediate-early RNA. | 2010 | PLoS Pathog. | pmid:20585571 |
Luo W et al. | Epigenetic regulation of vitamin D 24-hydroxylase/CYP24A1 in human prostate cancer. | 2010 | Cancer Res. | pmid:20587525 |
Zaman MS et al. | The functional significance of microRNA-145 in prostate cancer. | 2010 | Br. J. Cancer | pmid:20588276 |
Bui HT et al. | Effect of trichostatin A on chromatin remodeling, histone modifications, DNA replication, and transcriptional activity in cloned mouse embryos. | 2010 | Biol. Reprod. | pmid:20505166 |
Kim IA et al. | HDAC inhibitor-mediated radiosensitization in human carcinoma cells: a general phenomenon? | 2010 | J. Radiat. Res. | pmid:20505264 |
Chen J et al. | Interplay of bromodomain and histone acetylation in the regulation of p300-dependent genes. | 2010 | Epigenetics | pmid:20505343 |
Liu YW et al. | Inhibition of LPS-induced C/EBP delta by trichostatin A has a positive effect on LPS-induced cyclooxygenase 2 expression in RAW264.7 cells. | 2010 | J. Cell. Biochem. | pmid:20506344 |
Martinez-Diaz MA et al. | Pre- and postimplantation development of swine-cloned embryos derived from fibroblasts and bone marrow cells after inhibition of histone deacetylases. | 2010 | Cell Reprogram | pmid:20132016 |
Yang F et al. | Trichostatin A and 5-azacytidine both cause an increase in global histone H4 acetylation and a decrease in global DNA and H3K9 methylation during mitosis in maize. | 2010 | BMC Plant Biol. | pmid:20718950 |
Host L et al. | Inhibition of histone deacetylases in rats self-administering cocaine regulates lissencephaly gene-1 and reelin gene expression, as revealed by microarray technique. | 2010 | J. Neurochem. | pmid:20132486 |
Wu Y et al. | Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation. | 2010 | BMC Cancer | pmid:20132554 |
Kim TH et al. | The histone deacetylase inhibitor, trichostatin A, inhibits the development of 2,4-dinitrofluorobenzene-induced dermatitis in NC/Nga mice. | 2010 | Int. Immunopharmacol. | pmid:20728595 |
Aoyama M et al. | Butyrate and propionate induced activated or non-activated neutrophil apoptosis via HDAC inhibitor activity but without activating GPR-41/GPR-43 pathways. | 2010 | Nutrition | pmid:20004081 |
Ji P et al. | Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal erythroblasts. | 2010 | Haematologica | pmid:20823130 |
Xu J et al. | CpG island methylation affects accessibility of the proximal BRCA1 promoter to transcription factors. | 2010 | Breast Cancer Res. Treat. | pmid:19466541 |
Watson JA et al. | Hyperacetylation in prostate cancer induces cell cycle aberrations, chromatin reorganization and altered gene expression profiles. | 2010 | J. Cell. Mol. Med. | pmid:19583812 |
McKenzie L et al. | p53-dependent repression of polo-like kinase-1 (PLK1). | 2010 | Cell Cycle | pmid:20962589 |
Mittal MK et al. | Mode of action of the retrogene product SNAI1P, a SNAIL homolog, in human breast cancer cells. | 2010 | Mol. Biol. Rep. | pmid:19277896 |
Zein S et al. | Identification of fetal hemoglobin-inducing agents using the human leukemia KU812 cell line. | 2010 | Exp. Biol. Med. (Maywood) | pmid:20975082 |
Marumo T et al. | Histone deacetylase modulates the proinflammatory and -fibrotic changes in tubulointerstitial injury. | 2010 | Am. J. Physiol. Renal Physiol. | pmid:19906951 |
Yakovlev A et al. | Epigenetic regulation of caspase-3 gene expression in rat brain development. | 2010 | Gene | pmid:19909801 |
Pollack BP et al. | Ultraviolet radiation-induced transcription is associated with gene-specific histone acetylation. | 2009 May-Jun | Photochem. Photobiol. | pmid:19076306 |
Chen Z et al. | BCL11A represses HBG transcription in K562 cells. | 2009 Mar-Apr | Blood Cells Mol. Dis. | pmid:19153051 |
Wang L et al. | Using histone deacetylase inhibitors to enhance Foxp3(+) regulatory T-cell function and induce allograft tolerance. | 2009 Mar-Apr | Immunol. Cell Biol. | pmid:19172156 |
Allritz C et al. | Endothelin-1 reverses the histone deacetylase inhibitor-induced increase in glial glutamate transporter transcription without affecting histone acetylation levels. | 2009 Jul-Aug | Neurochem. Int. | pmid:19428803 |
Vilar E et al. | Gene expression patterns in mismatch repair-deficient colorectal cancers highlight the potential therapeutic role of inhibitors of the phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway. | 2009 | Clin. Cancer Res. | pmid:19351759 |
Lu SC et al. | The essential role of Oct-2 in LPS-induced expression of iNOS in RAW 264.7 macrophages and its regulation by trichostatin A. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19279235 |
Luo SF et al. | Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells. | 2009 | Toxicol. Appl. Pharmacol. | pmid:19281832 |
Giannini G et al. | N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19285395 |
Ueda JY et al. | JBIR-17, a novel trichostatin analog from Streptomyces sp. 26634. | 2009 | J. Antibiot. | pmid:19300468 |
Noro R et al. | The anticancer effect of histone deacetylase inhibitors and combination with the cytotoxic agents in lung cancer cells: biological analyses for future clinical application. | 2009 | J Nippon Med Sch | pmid:19305113 |
Glenn DJ et al. | Endothelin-stimulated human B-type natriuretic peptide gene expression is mediated by Yin Yang 1 in association with histone deacetylase 2. | 2009 | Hypertension | pmid:19139378 |
Deng G et al. | Unique methylation pattern of oncostatin m receptor gene in cancers of colorectum and other digestive organs. | 2009 | Clin. Cancer Res. | pmid:19223499 |
Sterthaus O et al. | Evaluation of in vitro cultured rat oocytes, from different strains, by spindle morphology and maturation-promoting-factor activity combined with nuclear-transfer experiments. | 2009 | Cloning Stem Cells | pmid:19751114 |
Wang X et al. | Correction of the abnormal trafficking of primary myelofibrosis CD34+ cells by treatment with chromatin-modifying agents. | 2009 | Cancer Res. | pmid:19752087 |
Hirata H et al. | Wnt antagonist gene DKK2 is epigenetically silenced and inhibits renal cancer progression through apoptotic and cell cycle pathways. | 2009 | Clin. Cancer Res. | pmid:19755393 |
Chiou SK and Hoa N | Up-regulation of GADD45alpha expression by NSAIDs leads to apoptotic and necrotic colon cancer cell deaths. | 2009 | Apoptosis | pmid:19757064 |
Diplas AI et al. | Demonstration of all-or-none loss of imprinting in mRNA expression in single cells. | 2009 | Nucleic Acids Res. | pmid:19767614 |
Ma XX et al. | Histone deacetylase inhibitor trichostatin A modulates cell cycles in A2780 human ovarian cancer cell lines. | 2009 | Eur. J. Gynaecol. Oncol. | pmid:19697617 |
Izawa M et al. | Inhibition of histone deacetylase causes reduction of appressorium formation in the rice blast fungus Magnaporthe oryzae. | 2009 | J. Gen. Appl. Microbiol. | pmid:20118613 |
Guo W et al. | Abrogation of TGF-beta1-induced fibroblast-myofibroblast differentiation by histone deacetylase inhibition. | 2009 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:19700647 |
Yamanaka K et al. | Acetylation level of histone H3 in early embryonic stages affects subsequent development of miniature pig somatic cell nuclear transfer embryos. | 2009 | J. Reprod. Dev. | pmid:19700928 |
McCulloch MW et al. | Psammaplin A as a general activator of cell-based signaling assays via HDAC inhibition and studies on some bromotyrosine derivatives. | 2009 | Bioorg. Med. Chem. | pmid:19022675 |
Gao J et al. | Loss of NECL1, a novel tumor suppressor, can be restored in glioma by HDAC inhibitor-Trichostatin A through Sp1 binding site. | 2009 | Glia | pmid:19062177 |
Noh EJ et al. | An HDAC inhibitor, trichostatin A, induces a delay at G2/M transition, slippage of spindle checkpoint, and cell death in a transcription-dependent manner. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19038231 |
Kong X et al. | HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cells. | 2009 | J. Mol. Cell. Cardiol. | pmid:19041327 |
Rossi M et al. | Caspase cleavage of Itch in chronic lymphocytic leukemia cells. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19073138 |
Wiesen JL and Tomasi TB | Dicer is regulated by cellular stresses and interferons. | 2009 | Mol. Immunol. | pmid:19118902 |
Togi S et al. | HDAC3 influences phosphorylation of STAT3 at serine 727 by interacting with PP2A. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19121623 |
Dje N'Guessan P et al. | Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells. | 2009 | Arterioscler. Thromb. Vasc. Biol. | pmid:19122173 |
Yamada N et al. | Promoter CpG methylation in cancer cells contributes to the regulation of MUC4. | 2009 | Br. J. Cancer | pmid:19127263 |
Kishigami S and Wakayama T | Somatic cell nuclear transfer in the mouse. | 2009 | Methods Mol. Biol. | pmid:19085136 |
Sibinga NE | Stable protein, unstable plaque? | 2009 | J. Mol. Cell. Cardiol. | pmid:19101562 |
Niu F et al. | Trichostatin A enhances OGD-astrocyte viability by inhibiting inflammatory reaction mediated by NF-kappaB. | 2009 | Brain Res. Bull. | pmid:19103266 |
Santiago A et al. | Identification of two independent SUMO-interacting motifs in Daxx: evolutionary conservation from Drosophila to humans and their biochemical functions. | 2009 | Cell Cycle | pmid:19106612 |
Kim HN et al. | Trichostatin A inhibits osteoclastogenesis and bone resorption by suppressing the induction of c-Fos by RANKL. | 2009 | Eur. J. Pharmacol. | pmid:19766111 |
Woodfield GW et al. | Interaction of TFAP2C with the estrogen receptor-alpha promoter is controlled by chromatin structure. | 2009 | Clin. Cancer Res. | pmid:19458056 |
Hauswald S et al. | Histone deacetylase inhibitors induce a very broad, pleiotropic anticancer drug resistance phenotype in acute myeloid leukemia cells by modulation of multiple ABC transporter genes. | 2009 | Clin. Cancer Res. | pmid:19458058 |
Arce L et al. | Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression. | 2009 | BMC Cancer | pmid:19460168 |
Petr J et al. | Histone deacetylase inhibition improves meiotic competence but not developmental competence in growing pig oocytes. | 2009 | Zygote | pmid:19460191 |
Ku WC et al. | Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2. | 2009 | Mol. Cell Proteomics | pmid:19505873 |
Kondo T et al. | Epigenetic silencing of TTF-1/NKX2-1 through DNA hypermethylation and histone H3 modulation in thyroid carcinomas. | 2009 | Lab. Invest. | pmid:19506552 |
Bonetto A et al. | Deacetylase inhibitors modulate the myostatin/follistatin axis without improving cachexia in tumor-bearing mice. | 2009 | Curr Cancer Drug Targets | pmid:19508174 |
Chang J et al. | The NIMA-family kinase Nek3 regulates microtubule acetylation in neurons. | 2009 | J. Cell. Sci. | pmid:19509051 |
Nakajima S et al. | Trichostatin A with adenovirus-mediated p53 gene transfer synergistically induces apoptosis in breast cancer cell line MDA-MB-231. | 2009 | Oncol. Rep. | pmid:19513516 |
Takaya T et al. | MicroRNA-1 and MicroRNA-133 in spontaneous myocardial differentiation of mouse embryonic stem cells. | 2009 | Circ. J. | pmid:19521018 |
Sugimura S et al. | Interspecies somatic cell nucleus transfer with porcine oocytes as recipients: A novel bioassay system for assessing the competence of canine somatic cells to develop into embryos. | 2009 | Theriogenology | pmid:19524287 |
Gregorie CJ et al. | Restoration of immune response gene induction in trophoblast tumor cells associated with cellular senescence. | 2009 | J. Reprod. Immunol. | pmid:19493573 |
Araki H et al. | Cord blood stem cell expansion is permissive to epigenetic regulation and environmental cues. | 2009 | Exp. Hematol. | pmid:19501128 |
Rahim R and Strobl JS | Hydroxychloroquine, chloroquine, and all-trans retinoic acid regulate growth, survival, and histone acetylation in breast cancer cells. | 2009 | Anticancer Drugs | pmid:19584707 |
Nadasi E et al. | Epigenetic modifiers exacerbate oxidative stress in renal proximal tubule cells. | 2009 | Anticancer Res. | pmid:19528494 |
Giustiniani J et al. | Basal endothelial nitric oxide synthase (eNOS) phosphorylation on Ser(1177) occurs in a stable microtubule- and tubulin acetylation-dependent manner. | 2009 | Exp. Cell Res. | pmid:19632222 |
Chandrasekaran S et al. | Histone deacetylases facilitate sodium/calcium exchanger up-regulation in adult cardiomyocytes. | 2009 | FASEB J. | pmid:19638401 |
Imesch P et al. | MLH1 protects from resistance acquisition by the histone deacetylase inhibitor trichostatin A in colon tumor cells. | 2009 | Int. J. Oncol. | pmid:19639184 |
Ma GD et al. | [Role of histone deacetylase in inhibiting invasion of human gastric carcinoma cell line SGC-7901 by PPARgamma-mediated pathway]. | 2009 | Ai Zheng | pmid:19624894 |
Hong Z et al. | Microarray study of mechanism of trichostatin a inducing apoptosis of Molt-4 cells. | 2009 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:19662360 |
Dagtas AS et al. | Histone deacetylase inhibitor uses p21(Cip1) to maintain anergy in CD4+ T cells. | 2009 | Int. Immunopharmacol. | pmid:19664724 |
Carambula SF et al. | Repression of induced apoptosis in the 2-cell bovine embryo involves DNA methylation and histone deacetylation. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19665989 |
Fujii K et al. | Co-treatment with deoxycholic acid and azoxymethane accelerates secretion of HMGB1 in IEC6 intestinal epithelial cells. | 2009 | Cell Prolif. | pmid:19614672 |
Pang M et al. | Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy. | 2009 | Am. J. Physiol. Renal Physiol. | pmid:19640900 |
Charrier C et al. | Synthesis and modeling of new benzofuranone histone deacetylase inhibitors that stimulate tumor suppressor gene expression. | 2009 | J. Med. Chem. | pmid:19385600 |
Yap OW et al. | Epigenetic modifications of the Estrogen receptor beta gene in epithelial ovarian cancer cells. | 2009 | Anticancer Res. | pmid:19331143 |
Sun F et al. | Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells. | 2009 | Mol. Cancer Ther. | pmid:19934278 |
Koh HS et al. | Twist2 regulates CD7 expression and galectin-1-induced apoptosis in mature T-cells. | 2009 | Mol. Cells | pmid:19937140 |
Federman N et al. | Histone acetylation is recruited in consolidation as a molecular feature of stronger memories. | 2009 | Learn. Mem. | pmid:19794185 |
Ai J et al. | HDAC6 regulates androgen receptor hypersensitivity and nuclear localization via modulating Hsp90 acetylation in castration-resistant prostate cancer. | 2009 | Mol. Endocrinol. | pmid:19855091 |
Codd R et al. | Zn(II)-dependent histone deacetylase inhibitors: suberoylanilide hydroxamic acid and trichostatin A. | 2009 | Int. J. Biochem. Cell Biol. | pmid:18725319 |
Peng DF et al. | DNA hypermethylation regulates the expression of members of the Mu-class glutathione S-transferases and glutathione peroxidases in Barrett's adenocarcinoma. | 2009 | Gut | pmid:18664505 |
Popova EY et al. | Chromatin condensation in terminally differentiating mouse erythroblasts does not involve special architectural proteins but depends on histone deacetylation. | 2009 | Chromosome Res. | pmid:19172406 |
Tsuji Y et al. | The developmental potential of mouse somatic cell nuclear-transferred oocytes treated with trichostatin A and 5-aza-2'-deoxycytidine. | 2009 | Zygote | pmid:19175955 |
Lee JH et al. | Notch signal activates hypoxia pathway through HES1-dependent SRC/signal transducers and activators of transcription 3 pathway. | 2009 | Mol. Cancer Res. | pmid:19808903 |
Bao Y et al. | Identification of trichostatin A as a novel transcriptional up-regulator of scavenger receptor BI both in HepG2 and RAW 264.7 cells. | 2009 | Atherosclerosis | pmid:18930459 |
Chen CZ et al. | The Scar-in-a-Jar: studying potential antifibrotic compounds from the epigenetic to extracellular level in a single well. | 2009 | Br. J. Pharmacol. | pmid:19785660 |
Bonazzi VF et al. | Identification of candidate tumor suppressor genes inactivated by promoter methylation in melanoma. | 2009 | Genes Chromosomes Cancer | pmid:18803327 |
Meng CF et al. | Promoter histone H3 lysine 9 di-methylation is associated with DNA methylation and aberrant expression of p16 in gastric cancer cells. | 2009 | Oncol. Rep. | pmid:19787243 |
Iljin K et al. | High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growth. | 2009 | Clin. Cancer Res. | pmid:19789329 |
Fraczek J et al. | Screening of amide analogues of Trichostatin A in cultures of primary rat hepatocytes: search for potent and safe HDAC inhibitors. | 2009 | Invest New Drugs | pmid:18825314 |
Demircan B et al. | Comparative epigenomics of human and mouse mammary tumors. | 2009 | Genes Chromosomes Cancer | pmid:18836996 |