Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Pile LA et al. | The histone deacetylase inhibitor trichostatin A influences the development of Drosophila melanogaster. | 2001 | Cell. Mol. Life Sci. | pmid:11706997 |
Chen Lf W et al. | Duration of nuclear NF-kappaB action regulated by reversible acetylation. | 2001 | Science | pmid:11533489 |
Grande A et al. | A functionally active RARalpha nuclear receptor is expressed in retinoic acid non responsive early myeloblastic cell lines. | 2001 | Cell Death Differ. | pmid:11313705 |
Wu Y et al. | Negative regulation of bcl-2 expression by p53 in hematopoietic cells. | 2001 | Oncogene | pmid:11313951 |
Arthur JL et al. | Herpes simplex virus type 1 promoter activity during latency establishment, maintenance, and reactivation in primary dorsal root neurons in vitro. | 2001 | J. Virol. | pmid:11264377 |
Steinbac OC et al. | Histone deacetylase activity is required for the induction of the MyoD muscle cell lineage in Xenopus. | 2000 Sep-Oct | Biol. Chem. | pmid:11076034 |
Dressel U et al. | Promoter specific sensitivity to inhibition of histone deacetylases: implications for hormonal gene control, cellular differentiation and cancer. | 2000 Mar-Apr | Anticancer Res. | pmid:10810390 |
Liou JS et al. | Oncogenic ras mediates apoptosis in response to protein kinase C inhibition through the generation of reactive oxygen species. | 2000 | J. Biol. Chem. | pmid:10967125 |
McInerney JM et al. | Long-term silencing of retroviral vectors is resistant to reversal by trichostatin A and 5-azacytidine. | 2000 | Gene Ther. | pmid:10800088 |
McBlane F and Boyes J | Stimulation of V(D)J recombination by histone acetylation. | 2000 | Curr. Biol. | pmid:10801420 |
Hobbs CA and Gilmour SK | High levels of intracellular polyamines promote histone acetyltransferase activity resulting in chromatin hyperacetylation. | 2000 | J. Cell. Biochem. | pmid:10760944 |
Yoshida M and Horinouchi S | [Histone deacetylase inhibitors--new anticancer agents?]. | 2000 | Tanpakushitsu Kakusan Koso | pmid:10771678 |
Diamond SE and Gutierrez-Hartmann A | The Pit-1beta domain dictates active repression and alteration of histone acetylation of the proximal prolactin promoter. | 2000 | J. Biol. Chem. | pmid:10921928 |
Andoh A et al. | Modulation of complement component (C3 and factor B) biosynthesis by a histone deacetylase inhibitor in human intestinal epithelial cells. | 2000 | Int. J. Mol. Med. | pmid:10851266 |
Siavoshian S et al. | Butyrate and trichostatin A effects on the proliferation/differentiation of human intestinal epithelial cells: induction of cyclin D3 and p21 expression. | 2000 | Gut | pmid:10716680 |
Hemavathy K et al. | Human Slug is a repressor that localizes to sites of active transcription. | 2000 | Mol. Cell. Biol. | pmid:10866665 |
Jin S et al. | Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10841572 |
Claassen GF and Hann SR | A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta -induced cell-cycle arrest. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10920185 |
Mao C and Shapiro DJ | A histone deacetylase inhibitor potentiates estrogen receptor activation of a stably integrated vitellogenin promoter in HepG2 cells. | 2000 | Endocrinology | pmid:10875235 |
Eickhoff B et al. | Trichostatin A-mediated regulation of gene expression and protein kinase activities: reprogramming tumor cells for ribotoxic stress-induced apoptosis. | 2000 | Biol. Chem. | pmid:11154071 |