trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nielsen AL et al. | Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family. | 1999 | EMBO J. | pmid:10562550 |
| Habeck M | Gelsolin: a new marker for breast cancer? | 1999 | Mol Med Today | pmid:10562712 |
| O'Neill LP et al. | A developmental switch in H4 acetylation upstream of Xist plays a role in X chromosome inactivation. | 1999 | EMBO J. | pmid:10329635 |
| Strouboulis J et al. | Transcriptional repression by XPc1, a new Polycomb homolog in Xenopus laevis embryos, is independent of histone deacetylase. | 1999 | Mol. Cell. Biol. | pmid:10330136 |
| Verdel A and Khochbin S | Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers. | 1999 | J. Biol. Chem. | pmid:9891014 |
| Coffee B et al. | Acetylated histones are associated with FMR1 in normal but not fragile X-syndrome cells. | 1999 | Nat. Genet. | pmid:10319871 |
| Xiao H et al. | Both Sp1 and Sp3 are responsible for p21waf1 promoter activity induced by histone deacetylase inhibitor in NIH3T3 cells. | 1999 | J. Cell. Biochem. | pmid:10321829 |
| Mielnicki LM et al. | Epigenetic regulation of gelsolin expression in human breast cancer cells. | 1999 | Exp. Cell Res. | pmid:10328963 |
| Krajewski WA | Effect of in vivo histone hyperacetylation on the state of chromatin fibers. | 1999 | J. Biomol. Struct. Dyn. | pmid:10333179 |
| Yoshida M | [Discovery of cell cycle inhibitors and their application to molecular biology]. | 1999 | Jpn J Antibiot | pmid:10221182 |
| Feng YQ et al. | Enhancer-dependent transcriptional oscillations in mouse erythroleukemia cells. | 1999 | Mol. Cell. Biol. | pmid:10373540 |
| Böger H and Gruss P | Functional determinants for the tetracycline-dependent transactivator tTA in transgenic mouse embryos. | 1999 | Mech. Dev. | pmid:10381574 |
| Ng HH et al. | MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. | 1999 | Nat. Genet. | pmid:10471499 |
| Sowa Y et al. | Sp3, but not Sp1, mediates the transcriptional activation of the p21/WAF1/Cip1 gene promoter by histone deacetylase inhibitor. | 1999 | Cancer Res. | pmid:10485470 |
| Finnin MS et al. | Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors. | 1999 | Nature | pmid:10490031 |
| Huang Y et al. | Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes. | 1999 | Nat. Neurosci. | pmid:10491605 |
| List HJ et al. | Inhibition of histone deacetylation augments dihydrotestosterone induction of androgen receptor levels: an explanation for trichostatin A effects on androgen-induced chromatin remodeling and transcription of the mouse mammary tumor virus promoter. | 1999 | Exp. Cell Res. | pmid:10527637 |
| Bordonaro M et al. | Butyrate-induced apoptotic cascade in colonic carcinoma cells: modulation of the beta-catenin-Tcf pathway and concordance with effects of sulindac and trichostatin A but not curcumin. | 1999 | Cell Growth Differ. | pmid:10547075 |
| KraevskiÄ VA and Prasolov VS | [Comparative analysis of higher levels of organization of normal and hyperacetylated chromatin]. | 1999 | Dokl. Akad. Nauk. | pmid:10439916 |
| Zabel MD et al. | Lymphoid transcription of the murine CD21 gene is positively regulated by histone acetylation. | 1999 | J. Immunol. | pmid:10453011 |