Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Fetahu IS et al. | Calcium-sensing receptor silencing in colorectal cancer is associated with promoter hypermethylation and loss of acetylation on histone 3. | 2014 | Int. J. Cancer | pmid:24691920 |
Zhang YW et al. | Integrated analysis of DNA methylation and mRNA expression profiling reveals candidate genes associated with cisplatin resistance in non-small cell lung cancer. | 2014 | Epigenetics | pmid:24699858 |
Tu CY et al. | Trichostatin A suppresses EGFR expression through induction of microRNA-7 in an HDAC-independent manner in lapatinib-treated cells. | 2014 | Biomed Res Int | pmid:24707474 |
Yan YE et al. | Prenatal nicotinic exposure suppresses fetal adrenal steroidogenesis via steroidogenic factor 1 (SF-1) deacetylation. | 2014 | Toxicol. Appl. Pharmacol. | pmid:24709674 |
Zhu XJ et al. | Novel tumor-suppressor gene epidermal growth factor-containing fibulin-like extracellular matrix protein 1 is epigenetically silenced and associated with invasion and metastasis in human gastric cancer. | 2014 | Mol Med Rep | pmid:24718752 |
Drela K et al. | Low oxygen atmosphere facilitates proliferation and maintains undifferentiated state of umbilical cord mesenchymal stem cells in an hypoxia inducible factor-dependent manner. | 2014 | Cytotherapy | pmid:24726658 |
Hassan MK et al. | Histone deacetylase inhibitors sensitize lung cancer cells to hyperthermia: involvement of Ku70/SirT-1 in thermo-protection. | 2014 | PLoS ONE | pmid:24728004 |
Ma XH et al. | Neuroprotective capabilities of TSA against cerebral ischemia/reperfusion injury via PI3K/Akt signaling pathway in rats. | 2015 | Int. J. Neurosci. | pmid:24730998 |
Rafehi H et al. | Vascular histone deacetylation by pharmacological HDAC inhibition. | 2014 | Genome Res. | pmid:24732587 |
Poplutz MK et al. | Regulation of the Interleukin-6 gene expression during monocytic differentiation of HL-60 cells by chromatin remodeling and methylation. | 2014 | Immunobiology | pmid:24746556 |
Herr MJ et al. | Tetraspanin CD9 modulates human lymphoma cellular proliferation via histone deacetylase activity. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24747564 |
Cheng X et al. | Generation and characterization of gsuα:EGFP transgenic zebrafish for evaluating endocrine-disrupting effects. | 2014 | Toxicol. Appl. Pharmacol. | pmid:24747804 |
Guo J et al. | Effect of 5-aza-2'-deoxycytidine combined with trichostatin A on RPMI-8226 cell proliferation, apoptosis and DLC-1 gene expression. | 2014 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:24763005 |
Soler E and Grosveld F | Targeting epigenetics to speed up repair. | 2014 | Cell Stem Cell | pmid:24792110 |
Palii CG et al. | Trichostatin A enhances vascular repair by injected human endothelial progenitors through increasing the expression of TAL1-dependent genes. | 2014 | Cell Stem Cell | pmid:24792117 |
Peiffer L et al. | Trichostatin A effectively induces apoptosis in chronic lymphocytic leukemia cells via inhibition of Wnt signaling and histone deacetylation. | 2014 | J. Cancer Res. Clin. Oncol. | pmid:24793644 |
Guo W et al. | Aberrant methylation and decreased expression of the TGF-β/Smad target gene FBXO32 in esophageal squamous cell carcinoma. | 2014 | Cancer | pmid:24798237 |
Motevalli A et al. | The effect of chemotherapeutic agents on telomere length maintenance in breast cancer cell lines. | 2014 | Breast Cancer Res. Treat. | pmid:24807106 |
Meier BC and Wagner BK | Inhibition of HDAC3 as a strategy for developing novel diabetes therapeutics. | 2014 | Epigenomics | pmid:24811789 |
Skoge RH et al. | Regulation of SIRT2-dependent α-tubulin deacetylation by cellular NAD levels. | 2014 | DNA Repair (Amst.) | pmid:24814981 |
Wang Y et al. | Inhibition of histone deacetylase in the basolateral amygdala facilitates morphine context-associated memory formation in rats. | 2015 | J. Mol. Neurosci. | pmid:24829091 |
Bezecny P | Histone deacetylase inhibitors in glioblastoma: pre-clinical and clinical experience. | 2014 | Med. Oncol. | pmid:24838514 |
Zhang Y et al. | Autophagy in pulmonary macrophages mediates lung inflammatory injury via NLRP3 inflammasome activation during mechanical ventilation. | 2014 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:24838752 |
Kumafuji M et al. | Mediator MED18 subunit plays a negative role in transcription via the CDK/cyclin module. | 2014 | Genes Cells | pmid:24840924 |
Yang DH et al. | Dynamic rearrangement of F-actin is required to maintain the antitumor effect of trichostatin A. | 2014 | PLoS ONE | pmid:24846135 |
Kiliccioglu I et al. | Apoptotic effects of proteasome and histone deacetylase inhibitors in prostate cancer cell lines. | 2014 | Genet. Mol. Res. | pmid:24854658 |
Chan ST et al. | Oral and intraperitoneal administration of quercetin decreased lymphocyte DNA damage and plasma lipid peroxidation induced by TSA in vivo. | 2014 | Biomed Res Int | pmid:24868531 |
Alvarez AA et al. | The effects of histone deacetylase inhibitors on glioblastoma-derived stem cells. | 2015 | J. Mol. Neurosci. | pmid:24874578 |
Wang Y et al. | Effects of histone deacetylase inhibition on the survival, proliferation and migration of Schwann cells, as well as on the expression of neurotrophic factors and genes associated with myelination. | 2014 | Int. J. Mol. Med. | pmid:24888454 |
Smirnova L et al. | MicroRNA profiling as tool for in vitro developmental neurotoxicity testing: the case of sodium valproate. | 2014 | PLoS ONE | pmid:24896083 |
Ononye SN et al. | Tropolones as lead-like natural products: the development of potent and selective histone deacetylase inhibitors. | 2013 | ACS Med Chem Lett | pmid:24900743 |
Maleszewska M et al. | The effects of selected inhibitors of histone modifying enzyme on C6 glioma cells. | 2014 | Pharmacol Rep | pmid:24905315 |
Srirattana K et al. | Effects of trichostatin A on In vitro development and DNA methylation level of the satellite I region of swamp buffalo (Bubalus bubalis) cloned embryos. | 2014 | J. Reprod. Dev. | pmid:24909601 |
Felisbino MB et al. | Changes in chromatin structure in NIH 3T3 cells induced by valproic acid and trichostatin A. | 2014 | J. Cell. Biochem. | pmid:24913611 |
Thangavel J et al. | Combinatorial therapy with acetylation and methylation modifiers attenuates lung vascular hyperpermeability in endotoxemia-induced mouse inflammatory lung injury. | 2014 | Am. J. Pathol. | pmid:24929240 |
Balmer NV et al. | From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. | 2014 | Arch. Toxicol. | pmid:24935251 |
Ma H et al. | HSPC117 is regulated by epigenetic modification and is involved in the migration of JEG-3 cells. | 2014 | Int J Mol Sci | pmid:24941254 |
Hu Z and Wang J | Histone deacetylase inhibitor induces the expression of select epithelial genes in mouse utricle sensory epithelia-derived progenitor cells. | 2014 | Cell Reprogram | pmid:24945595 |
Yang XL et al. | Effect of trichostatin A on CNE2 nasopharyngeal carcinoma cells--genome-wide DNA methylation alteration. | 2014 | Asian Pac. J. Cancer Prev. | pmid:24969901 |
Wilson-Edell KA et al. | RPL24: a potential therapeutic target whose depletion or acetylation inhibits polysome assembly and cancer cell growth. | 2014 | Oncotarget | pmid:24970821 |
Bartling TR et al. | Redox-sensitive gene-regulatory events controlling aberrant matrix metalloproteinase-1 expression. | 2014 | Free Radic. Biol. Med. | pmid:24973648 |
Maldonado L et al. | An epigenetic marker panel for recurrence risk prediction of low grade papillary urothelial cell carcinoma (LGPUCC) and its potential use for surveillance after transurethral resection using urine. | 2014 | Oncotarget | pmid:24980822 |
Liu H et al. | The Smn-independent beneficial effects of trichostatin A on an intermediate mouse model of spinal muscular atrophy. | 2014 | PLoS ONE | pmid:24984019 |
Ishihara K | Eosinophil cell lines. | 2014 | Methods Mol. Biol. | pmid:24986606 |
Xie L et al. | Histone deacetylase inhibitors trichostatin A and vorinostat inhibit TGFβ2-induced lens epithelial-to-mesenchymal cell transition. | 2014 | Invest. Ophthalmol. Vis. Sci. | pmid:24994865 |
Lee J et al. | Therapeutic targeting of epigenetic components in amyotrophic lateral sclerosis (ALS). | 2014 | Curr. Med. Chem. | pmid:25005187 |
Reeves ME et al. | Evidence that RASSF1C stimulation of lung cancer cell proliferation depends on IGFBP-5 and PIWIL1 expression levels. | 2014 | PLoS ONE | pmid:25007054 |
Scholpa NE et al. | Epigenetic changes in p21 expression in renal cells after exposure to bromate. | 2014 | Toxicol. Sci. | pmid:25015661 |
Uhlenbrock F et al. | The NKG2D ligand ULBP2 is specifically regulated through an invariant chain-dependent endosomal pathway. | 2014 | J. Immunol. | pmid:25024379 |
Ji Z et al. | Integrating genomics and proteomics data to predict drug effects using binary linear programming. | 2014 | PLoS ONE | pmid:25036040 |
Sun G et al. | Insights into the lysine acetylproteome of human sperm. | 2014 | J Proteomics | pmid:25038526 |
Huan YJ et al. | Epigenetic modification agents improve genomic methylation reprogramming in porcine cloned embryos. | 2014 | J. Reprod. Dev. | pmid:25047549 |
Tsuji M et al. | Epigenetic regulation of resistance to emotional stress: possible involvement of 5-HT1A receptor-mediated histone acetylation. | 2014 | J. Pharmacol. Sci. | pmid:25048113 |
Shi Q et al. | [Inhibitory effect of trichostatin A on HepG2 cell proliferation and the mechanisms]. | 2014 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:25057056 |
Alsarraf O et al. | Acetylation: a lysine modification with neuroprotective effects in ischemic retinal degeneration. | 2014 | Exp. Eye Res. | pmid:25064603 |
Kondo Y et al. | Histone deacetylase inhibitor valproic acid promotes the differentiation of human induced pluripotent stem cells into hepatocyte-like cells. | 2014 | PLoS ONE | pmid:25084468 |
Wu TH et al. | Melatonin prevents neonatal dexamethasone induced programmed hypertension: histone deacetylase inhibition. | 2014 | J. Steroid Biochem. Mol. Biol. | pmid:25090636 |
Dubois-Pot-Schneider H et al. | Inflammatory cytokines promote the retrodifferentiation of tumor-derived hepatocyte-like cells to progenitor cells. | 2014 | Hepatology | pmid:25098666 |
Yoshida T et al. | Kruppel-like factor 4 protein regulates isoproterenol-induced cardiac hypertrophy by modulating myocardin expression and activity. | 2014 | J. Biol. Chem. | pmid:25100730 |
Helm D et al. | Ion mobility tandem mass spectrometry enhances performance of bottom-up proteomics. | 2014 | Mol. Cell Proteomics | pmid:25106551 |
Deng Y et al. | [Expression of neprilysin gene is associated with methylation and histone modification on promoter in mouse neuroblastoma Neuro-2a cells]. | 2014 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:25108432 |
Zhang Q et al. | Interferon regulatory factor 8 functions as a tumor suppressor in renal cell carcinoma and its promoter methylation is associated with patient poor prognosis. | 2014 | Cancer Lett. | pmid:25109451 |
Vorrink SU et al. | Epigenetic determinants of CYP1A1 induction by the aryl hydrocarbon receptor agonist 3,3',4,4',5-pentachlorobiphenyl (PCB 126). | 2014 | Int J Mol Sci | pmid:25116688 |
Tomioka T et al. | The histone deacetylase inhibitor trichostatin A induces neurite outgrowth in PC12 cells via the epigenetically regulated expression of the nur77 gene. | 2014 | Neurosci. Res. | pmid:25128386 |
Kanski R et al. | Histone acetylation in astrocytes suppresses GFAP and stimulates a reorganization of the intermediate filament network. | 2014 | J. Cell. Sci. | pmid:25128567 |
Wei G et al. | [Functional analysis of Oct4 promoter in Xuhuai goat]. | 2014 | Yi Chuan | pmid:25143277 |
Saini M et al. | Trichostatin A alters the expression of cell cycle controlling genes and microRNAs in donor cells and subsequently improves the yield and quality of cloned bovine embryos in vitro. | 2014 | Theriogenology | pmid:25151601 |
Zohre S et al. | Trichostatin A-induced apoptosis is mediated by Kruppel-like factor 4 in ovarian and lung cancer. | 2014 | Asian Pac. J. Cancer Prev. | pmid:25169491 |
Lu HG et al. | TET1 partially mediates HDAC inhibitor-induced suppression of breast cancer invasion. | 2014 | Mol Med Rep | pmid:25175940 |
Svegliati S et al. | Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis. | 2014 | Sci Signal | pmid:25185156 |
Wang B et al. | Reversion of trichostatin A resistance via inhibition of the Wnt signaling pathway in human pancreatic cancer cells. | 2014 | Oncol. Rep. | pmid:25224651 |
Choi DC et al. | MicroRNA-7 protects against 1-methyl-4-phenylpyridinium-induced cell death by targeting RelA. | 2014 | J. Neurosci. | pmid:25232110 |
Wang BY et al. | Epigenetic suppression of hippocampal BDNF mediates the memory deficiency induced by amyloid fibrils. | 2014 | Pharmacol. Biochem. Behav. | pmid:25242807 |
Boucher J et al. | Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25246545 |
Han RF et al. | Trichostatin A induces mesenchymal-like morphological change and gene expression but inhibits migration and colony formation in human cancer cells. | 2014 | Mol Med Rep | pmid:25269990 |
Charni Chaabane S et al. | PDGF-D expression is down-regulated by TGFβ in fibroblasts. | 2014 | PLoS ONE | pmid:25280005 |
An JH et al. | The expression of p21 is upregulated by forkhead box A1/2 in p53-null H1299 cells. | 2014 | FEBS Lett. | pmid:25281925 |
Wei N et al. | Oxidative stress diverts tRNA synthetase to nucleus for protection against DNA damage. | 2014 | Mol. Cell | pmid:25284223 |
Shi QQ et al. | Effect of trichostatin A on anti HepG2 liver carcinoma cells: inhibition of HDAC activity and activation of Wnt/β-Catenin signaling. | 2014 | Asian Pac. J. Cancer Prev. | pmid:25292076 |
Toscano MG et al. | SCL/TAL1-mediated transcriptional network enhances megakaryocytic specification of human embryonic stem cells. | 2015 | Mol. Ther. | pmid:25292191 |
Tiernan AR et al. | Trichostatin A affects the secretion pathways of beta and intestinal endocrine cells. | 2015 | Exp. Cell Res. | pmid:25305500 |
Hou X et al. | Histone deacetylase inhibitor regulates the balance of Th17/Treg in allergic asthma. | 2016 | Clin Respir J | pmid:25307458 |
Mousai M et al. | Effect of epigenetic modification with trichostatin A and S-adenosylhomocysteine on developmental competence and POU5F1-EGFP expression of interspecies cloned embryos in dog. | 2015 | Zygote | pmid:25314965 |
Li G et al. | Short-chain fatty acids enhance adipocyte differentiation in the stromal vascular fraction of porcine adipose tissue. | 2014 | J. Nutr. | pmid:25320182 |
Xiong J et al. | USP22 transcriptional activity is negatively regulated by the histone deacetylase inhibitor trichostatin A. | 2014 | Mol Med Rep | pmid:25323692 |
Chahine MN et al. | Nuclear pore rearrangements and nuclear trafficking in cardiomyocytes from rat and human failing hearts. | 2015 | Cardiovasc. Res. | pmid:25341891 |
Xie M et al. | Effects of 5-aza-2'-deoxycytidine and trichostatin A on high glucose- and interleukin-1β-induced secretory mediators from human retinal endothelial cells and retinal pigment epithelial cells. | 2014 | Mol. Vis. | pmid:25352747 |
Saraf S et al. | Ex vivo expansion of human mobilized peripheral blood stem cells using epigenetic modifiers. | 2015 | Transfusion | pmid:25363624 |
Hao ZF et al. | Activating transcription factor 3 interferes with p21 activation in histone deacetylase inhibitor-induced growth inhibition of epidermoid carcinoma cells. | 2015 | Tumour Biol. | pmid:25371069 |
Nishida N et al. | Identification of epigenetically inactivated genes in human hepatocellular carcinoma by integrative analyses of methylation profiling and pharmacological unmasking. | 2014 | Dig Dis | pmid:25376292 |
Ying H et al. | Pressure overload-induced cardiac hypertrophy response requires janus kinase 2-histone deacetylase 2 signaling. | 2014 | Int J Mol Sci | pmid:25380525 |
Yang W et al. | Effect of trichostatin A on gelsolin levels, proteolysis of amyloid precursor protein, and amyloid beta-protein load in the brain of transgenic mouse model of Alzheimer's disease. | 2014 | Curr Alzheimer Res | pmid:25387339 |
Sharma S et al. | Histone deacetylase inhibitor, trichostatin A, improves learning and memory in high-fat diet-induced cognitive deficits in mice. | 2015 | J. Mol. Neurosci. | pmid:25391764 |
Shao A et al. | Enhancement of Autophagy by Histone Deacetylase Inhibitor Trichostatin A Ameliorates Neuronal Apoptosis After Subarachnoid Hemorrhage in Rats. | 2016 | Mol. Neurobiol. | pmid:25399954 |
Lu HK et al. | Ex vivo response to histone deacetylase (HDAC) inhibitors of the HIV long terminal repeat (LTR) derived from HIV-infected patients on antiretroviral therapy. | 2014 | PLoS ONE | pmid:25409334 |
Saini M et al. | Treatment of buffalo (Bubalus bubalis) donor cells with trichostatin A and 5-aza-2'-deoxycytidine alters their growth characteristics, gene expression and epigenetic status and improves the in vitro developmental competence, quality and epigenetic status of cloned embryos. | 2016 | Reprod. Fertil. Dev. | pmid:25409339 |
Lv W et al. | Histone deacetylase 1 and 3 regulate the mesodermal lineage commitment of mouse embryonic stem cells. | 2014 | PLoS ONE | pmid:25412078 |
Ma X et al. | Effect of LIV1 on the sensitivity of ovarian cancer cells to trichostatin A. | 2015 | Oncol. Rep. | pmid:25420545 |
Wang X et al. | Trichostatin A, a histone deacetylase inhibitor, reverses epithelial-mesenchymal transition in colorectal cancer SW480 and prostate cancer PC3 cells. | 2015 | Biochem. Biophys. Res. Commun. | pmid:25434997 |
Wang J et al. | Fungal metabolite myriocin promotes human herpes simplex virus-2 infection. | 2015 | Life Sci. | pmid:25447452 |