Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Deng Y et al. | [Expression of neprilysin gene is associated with methylation and histone modification on promoter in mouse neuroblastoma Neuro-2a cells]. | 2014 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:25108432 |
Wang YG et al. | Mechanisms of trichostatin A inhibiting AGS proliferation and identification of lysine-acetylated proteins. | 2013 | World J. Gastroenterol. | pmid:23745024 |
Chang J et al. | Hepatopoietin Cn suppresses apoptosis of human hepatocellular carcinoma cells by up-regulating myeloid cell leukemia-1. | 2010 | World J. Gastroenterol. | pmid:20066738 |
Emonds E et al. | Molecular determinants of the antitumor effects of trichostatin A in pancreatic cancer cells. | 2010 | World J. Gastroenterol. | pmid:20419833 |
Meng CF et al. | Re-expression of methylation-induced tumor suppressor gene silencing is associated with the state of histone modification in gastric cancer cell lines. | 2007 | World J. Gastroenterol. | pmid:18069755 |
Chen YX et al. | Histone acetylation regulates p21WAF1 expression in human colon cancer cell lines. | 2004 | World J. Gastroenterol. | pmid:15309711 |
Xu LN et al. | Effect of histone deacetylase inhibitor on proliferation of biliary tract cancer cell lines. | 2008 | World J. Gastroenterol. | pmid:18442209 |
Wei ZQ et al. | Curcumin inhibits hepatitis B virus infection by down-regulating cccDNA-bound histone acetylation. | 2017 | World J. Gastroenterol. | pmid:28974891 |
Zou XM et al. | Gastric cancer cell lines induced by trichostatin A. | 2008 | World J. Gastroenterol. | pmid:18720545 |
Kobori A et al. | Butyrate stimulates IL-32alpha expression in human intestinal epithelial cell lines. | 2010 | World J. Gastroenterol. | pmid:20480520 |
Zhang L et al. | Histone deacetylase inhibitors attenuate acute lung injury during cecal ligation and puncture-induced polymicrobial sepsis. | 2010 | World J Surg | pmid:20177680 |
Nishikawa J et al. | Upregulation of LMP1 expression by histone deacetylase inhibitors in an EBV carrying NPC cell line. | 2004 | Virus Genes | pmid:14739656 |
Brandão FA et al. | Histone deacetylases inhibitors effects on Cryptococcus neoformans major virulence phenotypes. | 2015 | Virulence | pmid:26103530 |
Hatama S et al. | Reactivation of feline foamy virus from a chronically infected feline renal cell line by trichostatin A. | 2001 | Virology | pmid:11336556 |
Dion LD et al. | Amplification of recombinant adenoviral transgene products occurs by inhibition of histone deacetylase. | 1997 | Virology | pmid:9168882 |
Preston CM and McFarlane M | Cytodifferentiating agents affect the replication of herpes simplex virus type 1 in the absence of functional VP16. | 1998 | Virology | pmid:9791032 |
Arbuckle JH et al. | Mapping the telomere integrated genome of human herpesvirus 6A and 6B. | 2013 | Virology | pmid:23648233 |
Pinnoji RC et al. | Repressor element-1 silencing transcription factor/neuronal restrictive silencer factor (REST/NRSF) can regulate HSV-1 immediate-early transcription via histone modification. | 2007 | Virol. J. | pmid:17555596 |
Jaalouk DE et al. | Inhibition of histone deacetylation in 293GPG packaging cell line improves the production of self-inactivating MLV-derived retroviral vectors. | 2006 | Virol. J. | pmid:16603064 |
Balakrishnan L and Milavetz B | HDAC inhibitors stimulate viral transcription by multiple mechanisms. | 2008 | Virol. J. | pmid:18353181 |
Sahu GK and Cloyd MW | Latent HIV in primary T lymphocytes is unresponsive to histone deacetylase inhibitors. | 2011 | Virol. J. | pmid:21838863 |
Fernandez G and Zeichner SL | Cell line-dependent variability in HIV activation employing DNMT inhibitors. | 2010 | Virol. J. | pmid:20942961 |
Yamamoto G et al. | Correlation of invasion and metastasis of cancer cells, and expression of the RAD21 gene in oral squamous cell carcinoma. | 2006 | Virchows Arch. | pmid:16416296 |
Piacentini P et al. | Trichostatin A enhances the response of chemotherapeutic agents in inhibiting pancreatic cancer cell proliferation. | 2006 | Virchows Arch. | pmid:16568310 |
Nagamine MK et al. | In vitro inhibitory effect of trichostatin A on canine grade 3 mast cell tumor. | 2011 | Vet. Res. Commun. | pmid:21472452 |
Doherty R et al. | Epigenetic regulation of the innate immune response to LPS in bovine peripheral blood mononuclear cells (PBMC). | 2013 | Vet. Immunol. Immunopathol. | pmid:23764468 |
Green BB and Kerr DE | Epigenetic contribution to individual variation in response to lipopolysaccharide in bovine dermal fibroblasts. | 2014 | Vet. Immunol. Immunopathol. | pmid:24268632 |
Kee HJ et al. | Trichostatin A prevents neointimal hyperplasia via activation of Krüppel like factor 4. | 2011 Nov-Dec | Vascul. Pharmacol. | pmid:21763782 |
Hodges SJ et al. | The effect of epigenetic therapy on congenital neurogenic bladders--a pilot study. | 2010 | Urology | pmid:20138341 |
Dhawan D et al. | DNMT1: an emerging target in the treatment of invasive urinary bladder cancer. | 2013 | Urol. Oncol. | pmid:22609058 |
Hao ZF et al. | Activating transcription factor 3 interferes with p21 activation in histone deacetylase inhibitor-induced growth inhibition of epidermoid carcinoma cells. | 2015 | Tumour Biol. | pmid:25371069 |
He G et al. | Inhibition of autophagy induced by TSA sensitizes colon cancer cell to radiation. | 2014 | Tumour Biol. | pmid:24122231 |
Kilinc V et al. | Do iron chelators increase the antiproliferative effect of trichostatin A through a glucose-regulated protein 78 mediated mechanism? | 2014 | Tumour Biol. | pmid:24622883 |
Wisnieski F et al. | Differential expression of histone deacetylase and acetyltransferase genes in gastric cancer and their modulation by trichostatin A. | 2014 | Tumour Biol. | pmid:24668547 |
Li L et al. | Trichostatin A potentiates TRAIL-induced antitumor effects via inhibition of ERK/FOXM1 pathway in gastric cancer. | 2016 | Tumour Biol. | pmid:26831669 |
Pang X et al. | Knockdown of Rad9A enhanced DNA damage induced by trichostatin A in esophageal cancer cells. | 2016 | Tumour Biol. | pmid:26264615 |
Tavakoli-Yaraki M et al. | Induction of apoptosis by Trichostatin A in human breast cancer cell lines: involvement of 15-Lox-1. | 2013 | Tumour Biol. | pmid:23055198 |
ChuÄkin IA et al. | [Anti-proliferative effect of histone deacetylase inhibitors on murine embryonic stem cells]. | 2006 | Tsitologiia | pmid:17147260 |
Golyshev SA et al. | [The role of DNA methylation and histone modifications in structural maintainance of heterochromatin domains (chromocenters)]. | 2008 | Tsitologiia | pmid:19140344 |
ChuÄkin IA et al. | [Transcription of c-fos gene and DNA binding activity of transcription factor AP-1 increase upon differentiation of mouse F9 teratocarcinoma cells]. | 2004 | Tsitologiia | pmid:15747838 |
Bobkov DE et al. | [Isolation of tropomyosin particles from the cytosol of cultured cells and their protein composition analysis]. | 2012 | Tsitologiia | pmid:22567898 |
Goldman MA | Executive decision: chromatin structure and gene regulation. | 1997 | Trends Genet. | pmid:9351338 |
Xia X et al. | Effects of trichostatin A in a rat model of acute graft-versus-host disease after liver transplantation. | 2013 | Transplantation | pmid:23694951 |
Moon C et al. | Use of epigenetic modification to induce FOXP3 expression in naïve T cells. | 2009 | Transplant. Proc. | pmid:19545742 |
Sugimoto K et al. | Improving allogeneic islet transplantation by suppressing Th17 and enhancing Treg with histone deacetylase inhibitors. | 2014 | Transpl. Int. | pmid:24410777 |
Saraf S et al. | Ex vivo expansion of human mobilized peripheral blood stem cells using epigenetic modifiers. | 2015 | Transfusion | pmid:25363624 |
Zutz C et al. | Small chemical chromatin effectors alter secondary metabolite production in Aspergillus clavatus. | 2013 | Toxins (Basel) | pmid:24105402 |
Zhang Y et al. | ERK1/2 activation plays important roles in the opposite effects of Trichostatin A in non-cancer and cancer cells. | 2011 | Toxicon | pmid:21419152 |
Liu M et al. | Decreased H3K9ac level of StAR mediated testicular dysplasia induced by prenatal dexamethasone exposure in male offspring rats. | 2018 | Toxicology | pmid:29902490 |
Fukui T et al. | Histone deacetylase inhibitor attenuates neurotoxicity of clioquinol in PC12 cells. | 2015 | Toxicology | pmid:25758465 |