trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Amin HM et al. | Histone deacetylase inhibitors induce caspase-dependent apoptosis and downregulation of daxx in acute promyelocytic leukaemia with t(15;17). | 2001 | Br. J. Haematol. | pmid:11703323 |
| Pile LA et al. | The histone deacetylase inhibitor trichostatin A influences the development of Drosophila melanogaster. | 2001 | Cell. Mol. Life Sci. | pmid:11706997 |
| Sachs LM et al. | An essential role of histone deacetylases in postembryonic organ transformations in Xenopus laevis. | 2001 | Int. J. Mol. Med. | pmid:11712071 |
| Marianna P et al. | Valproic acid, trichostatin and their combination with hemin preferentially enhance gamma-globin gene expression in human erythroid liquid cultures. | 2001 | Haematologica | pmid:11454524 |
| Cho JH et al. | DNA methylation regulates placental lactogen I gene expression. | 2001 | Endocrinology | pmid:11459782 |
| Walker GE et al. | Butyrate, a histone deacetylase inhibitor, activates the human IGF binding protein-3 promoter in breast cancer cells: molecular mechanism involves an Sp1/Sp3 multiprotein complex. | 2001 | Endocrinology | pmid:11517158 |
| Jorgensen JS and Nilson JH | AR suppresses transcription of the alpha glycoprotein hormone subunit gene through protein-protein interactions with cJun and activation transcription factor 2. | 2001 | Mol. Endocrinol. | pmid:11518798 |
| Phiel CJ et al. | Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. | 2001 | J. Biol. Chem. | pmid:11473107 |
| Sundqvist A et al. | Functional knockout of the corepressor CtBP by the second exon of adenovirus E1a relieves repression of transcription. | 2001 | Exp. Cell Res. | pmid:11478854 |
| Jacob AL et al. | Acetylation of steroidogenic factor 1 protein regulates its transcriptional activity and recruits the coactivator GCN5. | 2001 | J. Biol. Chem. | pmid:11479297 |
| Benjamin D and Jost JP | Reversal of methylation-mediated repression with short-chain fatty acids: evidence for an additional mechanism to histone deacetylation. | 2001 | Nucleic Acids Res. | pmid:11522830 |
| Li J et al. | Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation. | 2001 | Mol. Cell. Biol. | pmid:11689710 |
| Rashid SF et al. | Synergistic growth inhibition of prostate cancer cells by 1 alpha,25 Dihydroxyvitamin D(3) and its 19-nor-hexafluoride analogs in combination with either sodium butyrate or trichostatin A. | 2001 | Oncogene | pmid:11313934 |
| Maës J et al. | Chromatin remodeling at the Ig loci prior to V(D)J recombination. | 2001 | J. Immunol. | pmid:11441093 |
| Wang H et al. | Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. | 2001 | Science | pmid:11387442 |
| Klar AJ et al. | A histone deacetylation inhibitor and mutant promote colony-type switching of the human pathogen Candida albicans. | 2001 | Genetics | pmid:11404352 |
| Massa S et al. | 3-(4-aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors. | 2001 | J. Med. Chem. | pmid:11405644 |
| Setlow JK et al. | Evidence for gene silencing in Haemophilus influenzae. | 2001 | Mutat. Res. | pmid:11406170 |
| Feng YQ et al. | Position effects are influenced by the orientation of a transgene with respect to flanking chromatin. | 2001 | Mol. Cell. Biol. | pmid:11113204 |
| Mehra-Chaudhary R et al. | Msx3 protein recruits histone deacetylase to down-regulate the Msx1 promoter. | 2001 | Biochem. J. | pmid:11115394 |
| Osborne A et al. | Histone deacetylase activity represses gamma interferon-inducible HLA-DR gene expression following the establishment of a DNase I-hypersensitive chromatin conformation. | 2001 | Mol. Cell. Biol. | pmid:11533238 |
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| Furumai R et al. | Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11134513 |
| Johnson CA et al. | Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis. | 2001 | J. Biol. Chem. | pmid:11136718 |
| Yoshioka H et al. | A novel in vitro system for analyzing parental allele-specific histone acetylation in genomic imprinting. | 2001 | J. Hum. Genet. | pmid:11721881 |
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| Rombouts K et al. | Trichostatin A, lead compound for development of antifibrogenic drugs. | 2001 Jul-Sep | Acta Gastroenterol. Belg. | pmid:11680040 |
| McGuinness MC et al. | Evaluation of pharmacological induction of fatty acid beta-oxidation in X-linked adrenoleukodystrophy. | 2001 Sep-Oct | Mol. Genet. Metab. | pmid:11592822 |
| López-Solache I et al. | Regulation of uncoupling protein-2 mRNA in L6 myotubules: II: Thyroid hormone amplifies stimulation of uncoupling protein-2 gene by thiazolidinediones and other peroxisome proliferator-activated receptor ligands in L6 myotubules: evidence for a priming effect. | 2002 | Endocrine | pmid:12588052 |
| Stimson KM and Vertino PM | Methylation-mediated silencing of TMS1/ASC is accompanied by histone hypoacetylation and CpG island-localized changes in chromatin architecture. | 2002 | J. Biol. Chem. | pmid:11733524 |
| Sawa H et al. | Histone deacetylase inhibitors such as sodium butyrate and trichostatin A inhibit vascular endothelial growth factor (VEGF) secretion from human glioblastoma cells. | 2002 | Brain Tumor Pathol | pmid:12622137 |
| Suzuki-Mizushima Y et al. | Enhancement of NGF- and cholera toxin-induced neurite outgrowth by butyrate in PC12 cells. | 2002 | Brain Res. | pmid:12270499 |
| Boutillier AL et al. | Constitutive repression of E2F1 transcriptional activity through HDAC proteins is essential for neuronal survival. | 2002 | Ann. N. Y. Acad. Sci. | pmid:12485907 |
| Zarnegar R et al. | Increasing the effectiveness of radioactive iodine therapy in the treatment of thyroid cancer using Trichostatin A, a histone deacetylase inhibitor. | 2002 | Surgery | pmid:12490845 |
| Chen T et al. | Histone acetylation is involved in hsp70 gene transcription regulation in Drosophila melanogaster. | 2002 | Arch. Biochem. Biophys. | pmid:12464268 |
| Drewell RA et al. | Methylation-dependent silencing at the H19 imprinting control region by MeCP2. | 2002 | Nucleic Acids Res. | pmid:11861904 |
| Murphy JC et al. | Control of cytomegalovirus lytic gene expression by histone acetylation. | 2002 | EMBO J. | pmid:11867539 |
| Gregory RI et al. | Inhibition of histone deacetylases alters allelic chromatin conformation at the imprinted U2af1-rs1 locus in mouse embryonic stem cells. | 2002 | J. Biol. Chem. | pmid:11821379 |
| Elaut G et al. | Major phase I biotransformation pathways of Trichostatin a in rat hepatocytes and in rat and human liver microsomes. | 2002 | Drug Metab. Dispos. | pmid:12433798 |
| Lim Y et al. | Trichostatin A-induced detransformation correlates with decreased focal adhesion kinase phosphorylation at tyrosine 861 in ras-transformed fibroblasts. | 2002 | J. Biol. Chem. | pmid:11821402 |
| Yáñez RJ and Porter AC | A chromosomal position effect on gene targeting in human cells. | 2002 | Nucleic Acids Res. | pmid:12433992 |
| Wilson MA et al. | The histone deacetylase inhibitor trichostatin A blocks progesterone receptor-mediated transactivation of the mouse mammary tumor virus promoter in vivo. | 2002 | J. Biol. Chem. | pmid:11821430 |
| Takechi S et al. | Chicken HDAC2 down-regulates IgM light chain gene promoter activity. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12437980 |
| Deroanne CF et al. | Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling. | 2002 | Oncogene | pmid:11821955 |
| Ego T et al. | The interaction of HTLV-1 Tax with HDAC1 negatively regulates the viral gene expression. | 2002 | Oncogene | pmid:12370815 |
| Zhang W and Kone BC | NF-kappaB inhibits transcription of the H(+)-K(+)-ATPase alpha(2)-subunit gene: role of histone deacetylases. | 2002 | Am. J. Physiol. Renal Physiol. | pmid:12372765 |
| Handumrongkul C et al. | Distinct sets of cellular genes control the expression of transfected, nuclear-localized genes. | 2002 | Mol. Ther. | pmid:11829526 |
| Ailenberg M and Silverman M | Trichostatin A-histone deacetylase inhibitor with clinical therapeutic potential-is also a selective and potent inhibitor of gelatinase A expression. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12379227 |
| Herold C et al. | The histone-deacetylase inhibitor Trichostatin A blocks proliferation and triggers apoptotic programs in hepatoma cells. | 2002 | J. Hepatol. | pmid:11830335 |
| Yamashita K et al. | Pharmacologic unmasking of epigenetically silenced tumor suppressor genes in esophageal squamous cell carcinoma. | 2002 | Cancer Cell | pmid:12498717 |
| Zhou DC et al. | Frequent mutations in the ligand-binding domain of PML-RARalpha after multiple relapses of acute promyelocytic leukemia: analysis for functional relationship to response to all-trans retinoic acid and histone deacetylase inhibitors in vitro and in vivo. | 2002 | Blood | pmid:11830487 |
| Fahrner JA et al. | Dependence of histone modifications and gene expression on DNA hypermethylation in cancer. | 2002 | Cancer Res. | pmid:12499261 |
| Valapour M et al. | Histone deacetylation inhibits IL4 gene expression in T cells. | 2002 | J. Allergy Clin. Immunol. | pmid:11842291 |
| McBurney MW et al. | Evidence for repeat-induced gene silencing in cultured Mammalian cells: inactivation of tandem repeats of transfected genes. | 2002 | Exp. Cell Res. | pmid:11855851 |
| Hou M et al. | The histone deacetylase inhibitor trichostatin A derepresses the telomerase reverse transcriptase (hTERT) gene in human cells. | 2002 | Exp. Cell Res. | pmid:11855854 |
| Remiszewski SW et al. | Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. | 2002 | J. Med. Chem. | pmid:11831887 |
| Kiefer SM et al. | Murine Sall1 represses transcription by recruiting a histone deacetylase complex. | 2002 | J. Biol. Chem. | pmid:11836251 |
| Roddie PH et al. | Primary acute myeloid leukaemia blasts resistant to cytokine-induced differentiation to dendritic-like leukaemia cells can be forced to differentiate by the addition of bryostatin-1. | 2002 | Leukemia | pmid:11840267 |
| Bordonaro M et al. | Cell type- and promoter-dependent modulation of the Wnt signaling pathway by sodium butyrate. | 2002 | Int. J. Cancer | pmid:11774242 |
| Kikuchi T et al. | Aberrant methylation and histone deacetylation of cyclooxygenase 2 in gastric cancer. | 2002 | Int. J. Cancer | pmid:11774276 |
| Rombouts K et al. | Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesis in skin fibroblasts. | 2002 | Exp. Cell Res. | pmid:12169274 |
| Waterborg JH and Kapros T | Kinetic analysis of histone acetylation turnover and Trichostatin A induced hyper- and hypoacetylation in alfalfa. | 2002 | Biochem. Cell Biol. | pmid:12123281 |
| Mikkelsen IM et al. | Activation of the gamma-glutamyltransferase promoter 2 in the rat colon carcinoma cell line CC531 by histone deacetylase inhibitors is mediated through the Sp1 binding motif. | 2002 | Biochem. Pharmacol. | pmid:12123752 |
| Petti MC et al. | Complete remission through blast cell differentiation in PLZF/RARalpha-positive acute promyelocytic leukemia: in vitro and in vivo studies. | 2002 | Blood | pmid:12130525 |
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| Wittich S et al. | Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in Friend leukemic cells. | 2002 | J. Med. Chem. | pmid:12109913 |
| Toyooka S et al. | Differential expression of FEZ1/LZTS1 gene in lung cancers and their cell cultures. | 2002 | Clin. Cancer Res. | pmid:12114433 |
| Choi HS et al. | Trichostatin A, a histone deacetylase inhibitor, activates the IGFBP-3 promoter by upregulating Sp1 activity in hepatoma cells: alteration of the Sp1/Sp3/HDAC1 multiprotein complex. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12200149 |
| Maecker HL et al. | Epigenetic changes in tumor Fas levels determine immune escape and response to therapy. | 2002 | Cancer Cell | pmid:12204534 |
| Fang D et al. | Selective down-regulation of tyrosinase family gene TYRP1 by inhibition of the activity of melanocyte transcription factor, MITF. | 2002 | Nucleic Acids Res. | pmid:12136092 |
| Huang HC et al. | Geldanamycin inhibits trichostatin A-induced cell death and histone H4 hyperacetylation in COS-7 cells. | 2002 | Life Sci. | pmid:12002521 |
| Chiocca S et al. | Histone deacetylase 1 inactivation by an adenovirus early gene product. | 2002 | Curr. Biol. | pmid:11937030 |
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| Koyama N et al. | Differential effects of histone deacetylase inhibitors on interleukin-18 gene expression in myeloid cells. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11944905 |
| Nair RR et al. | Enhancement of transgene expression by combining glucocorticoids and anti-mitotic agents during transient transfection using DNA-cationic liposomes. | 2002 | Mol. Ther. | pmid:11945073 |
| Qiu P and Li L | Histone acetylation and recruitment of serum responsive factor and CREB-binding protein onto SM22 promoter during SM22 gene expression. | 2002 | Circ. Res. | pmid:11988486 |
| Mai A et al. | Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation. | 2002 | J. Med. Chem. | pmid:11960489 |
| Merezak C et al. | Inhibition of histone deacetylases induces bovine leukemia virus expression in vitro and in vivo. | 2002 | J. Virol. | pmid:11967319 |
| Weston AD et al. | Requirement for RAR-mediated gene repression in skeletal progenitor differentiation. | 2002 | J. Cell Biol. | pmid:12105181 |
| Toyooka S et al. | Progressive aberrant methylation of the RASSF1A gene in simian virus 40 infected human mesothelial cells. | 2002 | Oncogene | pmid:12082623 |
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| Iezzi S et al. | Stage-specific modulation of skeletal myogenesis by inhibitors of nuclear deacetylases. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12032356 |
| Nielsen J | Combinatorial synthesis of natural products. | 2002 | Curr Opin Chem Biol | pmid:12023109 |
| Mikkelsen IM et al. | The expression of gamma-glutamyltransferase in rat colon carcinoma cells is distinctly regulated during differentiation and oxidative stress. | 2002 | Mol. Cell. Biochem. | pmid:12030384 |
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| Lynch CA et al. | Reactivation of a silenced H19 gene in human rhabdomyosarcoma by demethylation of DNA but not by histone hyperacetylation. | 2002 | Mol. Cancer | pmid:12234381 |
| Bereshchenko OR et al. | Acetylation inactivates the transcriptional repressor BCL6. | 2002 | Nat. Genet. | pmid:12402037 |
| Chen Z et al. | Induction and superinduction of growth arrest and DNA damage gene 45 (GADD45) alpha and beta messenger RNAs by histone deacetylase inhibitors trichostatin A (TSA) and butyrate in SW620 human colon carcinoma cells. | 2002 | Cancer Lett. | pmid:12406558 |
| Gálfi P et al. | Apoptosis sensitivity is not correlated with sensitivity to proliferation inhibition by the histone deacetylase inhibitors butyrate and TSA. | 2002 | Cancer Lett. | pmid:12406559 |
| Travers H et al. | Human CD34+ hematopoietic progenitor cells hyperacetylate core histones in response to sodium butyrate, but not trichostatin A. | 2002 | Exp. Cell Res. | pmid:12413881 |
| Wilson AJ et al. | Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention. | 2002 | Cancer Res. | pmid:12414619 |
| Choy JS and Kron SJ | NuA4 subunit Yng2 function in intra-S-phase DNA damage response. | 2002 | Mol. Cell. Biol. | pmid:12417725 |
| Ghoshal K et al. | Inhibitors of histone deacetylase and DNA methyltransferase synergistically activate the methylated metallothionein I promoter by activating the transcription factor MTF-1 and forming an open chromatin structure. | 2002 | Mol. Cell. Biol. | pmid:12417732 |
| Hauser C et al. | Activation of the mouse histone deacetylase 1 gene by cooperative histone phosphorylation and acetylation. | 2002 | Mol. Cell. Biol. | pmid:12391151 |
| Westendorf JJ et al. | Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter. | 2002 | Mol. Cell. Biol. | pmid:12391164 |