trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Reperfusion Injury D015427 65 associated lipids
Supratentorial Neoplasms D015173 1 associated lipids
Uveal Neoplasms D014604 3 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Ureteral Obstruction D014517 10 associated lipids
Translocation, Genetic D014178 20 associated lipids
Tongue Neoplasms D014062 15 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Osteosarcoma D012516 50 associated lipids
Mast-Cell Sarcoma D012515 9 associated lipids
Rubinstein-Taybi Syndrome D012415 1 associated lipids
Retinoblastoma D012175 12 associated lipids
Radiation Injuries D011832 14 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Prostatic Hyperplasia D011470 20 associated lipids
Progeria D011371 3 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Osteomalacia D010018 5 associated lipids
Neuroblastoma D009447 66 associated lipids
Nerve Degeneration D009410 53 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Neoplasms D009369 13 associated lipids
Nasopharyngeal Neoplasms D009303 4 associated lipids
Nasal Polyps D009298 26 associated lipids
Opioid-Related Disorders D009293 5 associated lipids
Myeloproliferative Disorders D009196 5 associated lipids
Muscular Dystrophies D009136 10 associated lipids
Intellectual Disability D008607 13 associated lipids
Melanoma D008545 69 associated lipids
Medulloblastoma D008527 22 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Lymphoma, Follicular D008224 3 associated lipids
Lymphatic Metastasis D008207 10 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lupus Vulgaris D008177 1 associated lipids
Lung Neoplasms D008175 171 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Leukemia D007938 74 associated lipids
Leishmaniasis D007896 19 associated lipids
Keloid D007627 12 associated lipids
Chromosome Inversion D007446 1 associated lipids
Inflammation D007249 119 associated lipids
Immunologic Deficiency Syndromes D007153 8 associated lipids
Hypesthesia D006987 1 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Hypertension D006973 115 associated lipids
Hypersensitivity D006967 22 associated lipids
Per page 10 20 50 100 | Total 139

PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Srirattana K et al. Full-term development of gaur-bovine interspecies somatic cell nuclear transfer embryos: effect of trichostatin A treatment. 2012 Cell Reprogram pmid:22578161
Wang HF et al. Transcription levels of sirtuin family in neural stem cells and brain tissues of adult mice. 2012 Cell. Mol. Biol. (Noisy-le-grand) pmid:22992439
Ma J et al. Coxsackievirus and adenovirus receptor promotes antitumor activity of oncolytic adenovirus H101 in esophageal cancer. 2012 Int. J. Mol. Med. pmid:22992863
Zhai FX et al. RUNX3 is involved in caspase-3-dependent apoptosis induced by a combination of 5-aza-CdR and TSA in leukaemia cell lines. 2012 J. Cancer Res. Clin. Oncol. pmid:22179198
Sangalli JR et al. Treatment of nuclear-donor cells or cloned zygotes with chromatin-modifying agents increases histone acetylation but does not improve full-term development of cloned cattle. 2012 Cell Reprogram pmid:22468998
Zhang S et al. [Effect of trichostatin A and paclitaxel on the growth and apoptosis of lung adenocarcinoma cell lines]. 2012 Zhonghua Zhong Liu Za Zhi pmid:22967465
Yamamura N and Kishimoto T Epigenetic regulation of GATA4 expression by histone modification in AFP-producing gastric adenocarcinoma. 2012 Exp. Mol. Pathol. pmid:22472323
Xiong H et al. Trichostatin A, a histone deacetylase inhibitor, suppresses JAK2/STAT3 signaling via inducing the promoter-associated histone acetylation of SOCS1 and SOCS3 in human colorectal cancer cells. 2012 Mol. Carcinog. pmid:21520296
Zhu K et al. Expression characterization and the promoter activity analysis of zebrafish hdac4. 2012 Fish Physiol. Biochem. pmid:21773810
Ikehata M et al. Different involvement of DNA methylation and histone deacetylation in the expression of solute-carrier transporters in 4 colon cancer cell lines. 2012 Biol. Pharm. Bull. pmid:22382314
Andrews KT et al. Comparative gene expression profiling of P. falciparum malaria parasites exposed to three different histone deacetylase inhibitors. 2012 PLoS ONE pmid:22384084
Gupta K et al. Green tea polyphenols induce p53-dependent and p53-independent apoptosis in prostate cancer cells through two distinct mechanisms. 2012 PLoS ONE pmid:23285096
Mehdi O et al. HDAC gene expression in pancreatic tumor cell lines following treatment with the HDAC inhibitors panobinostat (LBH589) and trichostatine (TSA). 2012 Mar-Apr Pancreatology pmid:22487525
Guo X et al. Histone deacetylase inhibitors promote mice corneal allograft survival through alteration of CD4+ effector T cells and induction of Foxp3+ regulatory T cells. 2012 May-Jun Cell. Immunol. pmid:22776176
Hou W et al. Hypoxia-induced deacetylation is required for tetraploid differentiation in response to testicular ischemia-reperfusion (IR) injury. 2012 Nov-Dec J. Androl. pmid:22556385
Darlyuk-Saadon I et al. The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members to the ATF3 promoter. 2012 Nov-Dec Biochim. Biophys. Acta pmid:22989952
Tang X et al. Protocadherin 10 is frequently downregulated by promoter methylation and functions as a tumor suppressor gene in non-small cell lung cancer. 2012-2013 Cancer Biomark pmid:23321465
Dhawan D et al. DNMT1: an emerging target in the treatment of invasive urinary bladder cancer. 2013 Urol. Oncol. pmid:22609058
Fernandez G et al. Targeting IκB proteins for HIV latency activation: the role of individual IκB and NF-κB proteins. 2013 J. Virol. pmid:23365428
Meng F et al. Anticancer efficacy of cisplatin and trichostatin A or 5-aza-2'-deoxycytidine on ovarian cancer. 2013 Br. J. Cancer pmid:23370212
Wang Z et al. Arabidopsis paired amphipathic helix proteins SNL1 and SNL2 redundantly regulate primary seed dormancy via abscisic acid-ethylene antagonism mediated by histone deacetylation. 2013 Plant Cell pmid:23371947
Horvat T et al. Reversibility of membrane N-glycome of HeLa cells upon treatment with epigenetic inhibitors. 2013 PLoS ONE pmid:23336012
Li H et al. Epigenetic regulation of CXCR4 expression by the ocular microenvironment. 2013 Invest. Ophthalmol. Vis. Sci. pmid:23188729
Guo SW et al. Dysmenorrhea and its severity are associated with increased uterine contractility and overexpression of oxytocin receptor (OTR) in women with symptomatic adenomyosis. 2013 Fertil. Steril. pmid:22999795
Pitta CA et al. Reversal of ER-β silencing by chromatin modifying agents overrides acquired tamoxifen resistance. 2013 Cancer Lett. pmid:23752064
Zhang C et al. Decreased PADI4 mRNA association with global hypomethylation in hepatocellular carcinoma during HBV exposure. 2013 Cell Biochem. Biophys. pmid:22907585
Van Beneden K et al. Comparison of trichostatin A and valproic acid treatment regimens in a mouse model of kidney fibrosis. 2013 Toxicol. Appl. Pharmacol. pmid:23707763
Meng F et al. Inhibition of DNA methyltransferases, histone deacetylases and lysine-specific demethylase-1 suppresses the tumorigenicity of the ovarian cancer ascites cell line SKOV3. 2013 Int. J. Oncol. pmid:23709006
Liu Y et al. MCM-2 is a therapeutic target of Trichostatin A in colon cancer cells. 2013 Toxicol. Lett. pmid:23770000
Spallotta F et al. A nitric oxide-dependent cross-talk between class I and III histone deacetylases accelerates skin repair. 2013 J. Biol. Chem. pmid:23463510
Wu DS et al. Epigallocatechin-3-gallate and trichostatin A synergistically inhibit human lymphoma cell proliferation through epigenetic modification of p16INK4a. 2013 Oncol. Rep. pmid:24064951
Al-Nakhle H et al. Regulation of estrogen receptor β1 expression in breast cancer by epigenetic modification of the 5' regulatory region. 2013 Int. J. Oncol. pmid:24068253
Yu CW et al. Quinazolin-4-one derivatives as selective histone deacetylase-6 inhibitors for the treatment of Alzheimer's disease. 2013 J. Med. Chem. pmid:23905680
Fujiki R et al. A proapoptotic effect of valproic acid on progenitors of embryonic stem cell-derived glutamatergic neurons. 2013 Cell Death Dis pmid:23788034
Li KK et al. MiR-383 is downregulated in medulloblastoma and targets peroxiredoxin 3 (PRDX3). 2013 Brain Pathol. pmid:23227829
Matsubara K et al. Dynamics and regulation of lysine-acetylation during one-cell stage mouse embryos. 2013 Biochem. Biophys. Res. Commun. pmid:23567968
Contreras AU et al. Deacetylation of p53 induces autophagy by suppressing Bmf expression. 2013 J. Cell Biol. pmid:23629966
Duo J et al. Metformin synergistically enhances antitumor activity of histone deacetylase inhibitor trichostatin a against osteosarcoma cell line. 2013 DNA Cell Biol. pmid:23451817
Chen CQ et al. Pure curcumin increases the expression of SOCS1 and SOCS3 in myeloproliferative neoplasms through suppressing class I histone deacetylases. 2013 Carcinogenesis pmid:23430957
Wang P et al. Trichostatin A protects against cisplatin-induced ototoxicity by regulating expression of genes related to apoptosis and synaptic function. 2013 Neurotoxicology pmid:23558232
Guo LH et al. The Tumor Suppressor Roles of miR-433 and miR-127 in Gastric Cancer. 2013 Int J Mol Sci pmid:23880861
Jo SJ et al. Valproic acid promotes human hair growth in in vitro culture model. 2013 J. Dermatol. Sci. pmid:23810771
Keuser B et al. Influences of histone deacetylase inhibitors and resveratrol on DNA repair and chromatin compaction. 2013 Mutagenesis pmid:23814181
Lim SY et al. Trichostatin A enhances differentiation of human induced pluripotent stem cells to cardiogenic cells for cardiac tissue engineering. 2013 Stem Cells Transl Med pmid:23884641
Shim SH et al. Histone deacetylase inhibitors suppress coxsackievirus B3 growth in vitro and myocarditis induced in mice. 2013 Acta Virol. pmid:24294962
Zhang S et al. Effect of trichostatin A and paclitaxel on the proliferation and apoptosis of lung adenocarcinoma cells. 2013 Chin. Med. J. pmid:23286491
Gao C et al. Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex. 2013 Blood pmid:23287862
Marek L et al. Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells. 2013 J. Med. Chem. pmid:23252603
Li KK et al. MIR-137 suppresses growth and invasion, is downregulated in oligodendroglial tumors and targets CSE1L. 2013 Brain Pathol. pmid:23252729
Chen CQ et al. Histone deacetylases inhibitor trichostatin A increases the expression of Dleu2/miR-15a/16-1 via HDAC3 in non-small cell lung cancer. 2013 Mol. Cell. Biochem. pmid:23867991