Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Inoue H et al. | Histone deacetylase inhibitors sensitize human colonic adenocarcinoma cell lines to TNF-related apoptosis inducing ligand-mediated apoptosis. | 2002 | Int. J. Mol. Med. | pmid:11956660 |
Sawa H et al. | Histone deacetylase inhibitors such as sodium butyrate and trichostatin A inhibit vascular endothelial growth factor (VEGF) secretion from human glioblastoma cells. | 2002 | Brain Tumor Pathol | pmid:12622137 |
Suzuki-Mizushima Y et al. | Enhancement of NGF- and cholera toxin-induced neurite outgrowth by butyrate in PC12 cells. | 2002 | Brain Res. | pmid:12270499 |
Boutillier AL et al. | Constitutive repression of E2F1 transcriptional activity through HDAC proteins is essential for neuronal survival. | 2002 | Ann. N. Y. Acad. Sci. | pmid:12485907 |
Zarnegar R et al. | Increasing the effectiveness of radioactive iodine therapy in the treatment of thyroid cancer using Trichostatin A, a histone deacetylase inhibitor. | 2002 | Surgery | pmid:12490845 |
Chen T et al. | Histone acetylation is involved in hsp70 gene transcription regulation in Drosophila melanogaster. | 2002 | Arch. Biochem. Biophys. | pmid:12464268 |
Rombouts K et al. | Actin filament formation, reorganization and migration are impaired in hepatic stellate cells under influence of trichostatin A, a histone deacetylase inhibitor. | 2002 | J. Hepatol. | pmid:12445420 |
Guo WH et al. | Inhibition of growth of mouse gastric cancer cells by Runx3, a novel tumor suppressor. | 2002 | Oncogene | pmid:12447699 |
Marin-Husstege M et al. | Histone deacetylase activity is necessary for oligodendrocyte lineage progression. | 2002 | J. Neurosci. | pmid:12451133 |
Wang ZM et al. | Trichostatin A inhibits proliferation and induces expression of p21WAF and p27 in human brain tumor cell lines. | 2002 | Ai Zheng | pmid:12508652 |
Zhou DC et al. | Frequent mutations in the ligand-binding domain of PML-RARalpha after multiple relapses of acute promyelocytic leukemia: analysis for functional relationship to response to all-trans retinoic acid and histone deacetylase inhibitors in vitro and in vivo. | 2002 | Blood | pmid:11830487 |
Valapour M et al. | Histone deacetylation inhibits IL4 gene expression in T cells. | 2002 | J. Allergy Clin. Immunol. | pmid:11842291 |
McBurney MW et al. | Evidence for repeat-induced gene silencing in cultured Mammalian cells: inactivation of tandem repeats of transfected genes. | 2002 | Exp. Cell Res. | pmid:11855851 |
Hou M et al. | The histone deacetylase inhibitor trichostatin A derepresses the telomerase reverse transcriptase (hTERT) gene in human cells. | 2002 | Exp. Cell Res. | pmid:11855854 |
Remiszewski SW et al. | Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. | 2002 | J. Med. Chem. | pmid:11831887 |
Kiefer SM et al. | Murine Sall1 represses transcription by recruiting a histone deacetylase complex. | 2002 | J. Biol. Chem. | pmid:11836251 |
Roddie PH et al. | Primary acute myeloid leukaemia blasts resistant to cytokine-induced differentiation to dendritic-like leukaemia cells can be forced to differentiate by the addition of bryostatin-1. | 2002 | Leukemia | pmid:11840267 |
Taniura S et al. | Transcriptional regulation of cyclooxygenase-1 by histone deacetylase inhibitors in normal human astrocyte cells. | 2002 | J. Biol. Chem. | pmid:11877441 |
Heltweg B and Jung M | A microplate reader-based nonisotopic histone deacetylase activity assay. | 2002 | Anal. Biochem. | pmid:11878795 |
Kamitani H et al. | Histone acetylation may suppress human glioma cell proliferation when p21 WAF/Cip1 and gelsolin are induced. | 2002 | Neuro-oncology | pmid:11916500 |
Kishikawa S et al. | Roles of histone acetylation in the Dnmt1 gene expression. | 2002 | Nucleic Acids Res. Suppl. | pmid:12903179 |
Ginjala V et al. | Multiple cis elements within the Igf2/H19 insulator domain organize a distance-dependent silencer. A cautionary note. | 2002 | J. Biol. Chem. | pmid:11777900 |
Avram D et al. | COUP-TF (chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding protein. | 2002 | Biochem. J. | pmid:12196208 |
Guo Y et al. | Regulation of DNA methylation in human breast cancer. Effect on the urokinase-type plasminogen activator gene production and tumor invasion. | 2002 | J. Biol. Chem. | pmid:12198113 |
Wittich S et al. | Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in Friend leukemic cells. | 2002 | J. Med. Chem. | pmid:12109913 |
Toyooka S et al. | Differential expression of FEZ1/LZTS1 gene in lung cancers and their cell cultures. | 2002 | Clin. Cancer Res. | pmid:12114433 |
Choi HS et al. | Trichostatin A, a histone deacetylase inhibitor, activates the IGFBP-3 promoter by upregulating Sp1 activity in hepatoma cells: alteration of the Sp1/Sp3/HDAC1 multiprotein complex. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12200149 |
Maecker HL et al. | Epigenetic changes in tumor Fas levels determine immune escape and response to therapy. | 2002 | Cancer Cell | pmid:12204534 |
Fang D et al. | Selective down-regulation of tyrosinase family gene TYRP1 by inhibition of the activity of melanocyte transcription factor, MITF. | 2002 | Nucleic Acids Res. | pmid:12136092 |
Zschocke J et al. | Estrogen receptor alpha-mediated silencing of caveolin gene expression in neuronal cells. | 2002 | J. Biol. Chem. | pmid:12138116 |
Yu Z et al. | Histone deacetylases augment cytokine induction of the iNOS gene. | 2002 | J. Am. Soc. Nephrol. | pmid:12138131 |
Li J et al. | Involvement of histone methylation and phosphorylation in regulation of transcription by thyroid hormone receptor. | 2002 | Mol. Cell. Biol. | pmid:12138181 |
Aapola U et al. | Imprinting regulator DNMT3L is a transcriptional repressor associated with histone deacetylase activity. | 2002 | Nucleic Acids Res. | pmid:12177302 |
Chang TH and Szabo E | Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung. | 2002 | Clin. Cancer Res. | pmid:11948134 |
Ventura A et al. | The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter. | 2002 | J. Biol. Chem. | pmid:11948181 |
Weston AD et al. | Requirement for RAR-mediated gene repression in skeletal progenitor differentiation. | 2002 | J. Cell Biol. | pmid:12105181 |
Toyooka S et al. | Progressive aberrant methylation of the RASSF1A gene in simian virus 40 infected human mesothelial cells. | 2002 | Oncogene | pmid:12082623 |
Maehara K et al. | Effects of histone acetylation on transcriptional regulation of manganese superoxide dismutase gene. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12083788 |
Iezzi S et al. | Stage-specific modulation of skeletal myogenesis by inhibitors of nuclear deacetylases. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12032356 |
Nielsen J | Combinatorial synthesis of natural products. | 2002 | Curr Opin Chem Biol | pmid:12023109 |
Mikkelsen IM et al. | The expression of gamma-glutamyltransferase in rat colon carcinoma cells is distinctly regulated during differentiation and oxidative stress. | 2002 | Mol. Cell. Biochem. | pmid:12030384 |
Bharadwaj S and Prasad GL | Tropomyosin-1, a novel suppressor of cellular transformation is downregulated by promoter methylation in cancer cells. | 2002 | Cancer Lett. | pmid:12065096 |
Ito K et al. | A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12070353 |
Katula KS et al. | Cell cycle specific changes in the human cyclin B1 gene regulatory region as revealed by response to trichostatin A. | 2002 | Arch. Biochem. Biophys. | pmid:12054478 |
Wang XQ et al. | Histone deacetylase inhibition results in decreased macrophage CD9 expression. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12056820 |
Rahmani M et al. | The histone deacetylase inhibitor sodium butyrate interacts synergistically with phorbol myristate acetate (PMA) to induce mitochondrial damage and apoptosis in human myeloid leukemia cells through a tumor necrosis factor-alpha-mediated process. | 2002 | Exp. Cell Res. | pmid:12061815 |
Woo SH et al. | Structurally simple trichostatin A-like straight chain hydroxamates as potent histone deacetylase inhibitors. | 2002 | J. Med. Chem. | pmid:12061890 |
Chen Y et al. | On the epigenetic regulation of the human reelin promoter. | 2002 | Nucleic Acids Res. | pmid:12087179 |
Zhang Y and Dufau ML | Silencing of transcription of the human luteinizing hormone receptor gene by histone deacetylase-mSin3A complex. | 2002 | J. Biol. Chem. | pmid:12091390 |
Danbara M et al. | DNA methylation dominates transcriptional silencing of Pax5 in terminally differentiated B cell lines. | 2002 | Mol. Immunol. | pmid:12044782 |
Im H et al. | Histone deacetylase-dependent establishment and maintenance of broad low-level histone acetylation within a tissue-specific chromatin domain. | 2002 | Biochemistry | pmid:12484752 |
Gong XQ and Li L | Dermo-1, a multifunctional basic helix-loop-helix protein, represses MyoD transactivation via the HLH domain, MEF2 interaction, and chromatin deacetylation. | 2002 | J. Biol. Chem. | pmid:11809751 |
Rössig L et al. | Inhibitors of histone deacetylation downregulate the expression of endothelial nitric oxide synthase and compromise endothelial cell function in vasorelaxation and angiogenesis. | 2002 | Circ. Res. | pmid:12411399 |
Westendorf JJ et al. | Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter. | 2002 | Mol. Cell. Biol. | pmid:12391164 |
Hoshimoto A et al. | Caprylic acid and medium-chain triglycerides inhibit IL-8 gene transcription in Caco-2 cells: comparison with the potent histone deacetylase inhibitor trichostatin A. | 2002 | Br. J. Pharmacol. | pmid:12010777 |
Sourlingas TG et al. | The effect of the histone deacetylase inhibitor, trichostatin A, on total histone synthesis, H1(0) synthesis and histone H4 acetylation in peripheral blood lymphocytes increases as a function of increasing age: a model study. | 2002 Jan-Mar | Exp. Gerontol. | pmid:11772521 |
Iwata K et al. | Trichostatin A, a histone deacetylase inhibitor, down-regulates interleukin-12 transcription in SV-40-transformed lung epithelial cells. | 2002 Jul-Aug | Cell. Immunol. | pmid:12470611 |
Noss KR et al. | Methylation state of the prostate specific membrane antigen (PSMA) CpG island in prostate cancer cell lines. | 2002 May-Jun | Anticancer Res. | pmid:12168830 |
Rahman I et al. | Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB/AP-1 activation in alveolar epithelial cells: potential mechanism in gene transcription in lung inflammation. | 2002 May-Jun | Mol. Cell. Biochem. | pmid:12162440 |
Henderson C et al. | Role of caspases, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA). | 2003 | J. Biol. Chem. | pmid:12556448 |
Palazzo A et al. | Cell biology: Tubulin acetylation and cell motility. | 2003 | Nature | pmid:12529632 |
Fernandes I et al. | Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms. | 2003 | Mol. Cell | pmid:12535528 |
Cheutin T et al. | Maintenance of stable heterochromatin domains by dynamic HP1 binding. | 2003 | Science | pmid:12560555 |
Boutillier AL et al. | Selective E2F-dependent gene transcription is controlled by histone deacetylase activity during neuronal apoptosis. | 2003 | J. Neurochem. | pmid:12562525 |
Tomita K et al. | The effect of oxidative stress on histone acetylation and IL-8 release. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12565901 |
Musikacharoen T et al. | Histone acetylation and activation of cAMP-response element-binding protein regulate transcriptional activation of MKP-M in lipopolysaccharide-stimulated macrophages. | 2003 | J. Biol. Chem. | pmid:12511574 |
Gusterson RJ et al. | The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity. | 2003 | J. Biol. Chem. | pmid:12477714 |
Kondo Y et al. | Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer. | 2003 | Mol. Cell. Biol. | pmid:12482974 |
James SY et al. | Regulation of retinoic acid receptor beta expression by peroxisome proliferator-activated receptor gamma ligands in cancer cells. | 2003 | Cancer Res. | pmid:12839938 |
Ding Z et al. | Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain. | 2003 | Mol. Cell. Biol. | pmid:12482978 |
Kim DK et al. | Synthesis and biological evaluation of 3-(4-substituted-phenyl)-N-hydroxy-2-propenamides, a new class of histone deacetylase inhibitors. | 2003 | J. Med. Chem. | pmid:14667227 |
Obata T et al. | Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer. | 2003 | Clin. Cancer Res. | pmid:14695142 |
Terui T et al. | Induction of PIG3 and NOXA through acetylation of p53 at 320 and 373 lysine residues as a mechanism for apoptotic cell death by histone deacetylase inhibitors. | 2003 | Cancer Res. | pmid:14695212 |
Le Masson I et al. | Yaf9, a novel NuA4 histone acetyltransferase subunit, is required for the cellular response to spindle stress in yeast. | 2003 | Mol. Cell. Biol. | pmid:12917332 |
Zhong S et al. | Phosphorylation at serine 28 and acetylation at lysine 9 of histone H3 induced by trichostatin A. | 2003 | Oncogene | pmid:12917630 |
Condon JC et al. | A decline in the levels of progesterone receptor coactivators in the pregnant uterus at term may antagonize progesterone receptor function and contribute to the initiation of parturition. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12886011 |
Ryu JR and Arnosti DN | Functional similarity of Knirps CtBP-dependent and CtBP-independent transcriptional repressor activities. | 2003 | Nucleic Acids Res. | pmid:12888527 |
Pivot-Pajot C et al. | Acetylation-dependent chromatin reorganization by BRDT, a testis-specific bromodomain-containing protein. | 2003 | Mol. Cell. Biol. | pmid:12861021 |
Grassi G et al. | Inhibitors of DNA methylation and histone deacetylation activate cytomegalovirus promoter-controlled reporter gene expression in human glioblastoma cell line U87. | 2003 | Carcinogenesis | pmid:12869421 |
Ammanamanchi S et al. | Acetylated sp3 is a transcriptional activator. | 2003 | J. Biol. Chem. | pmid:12837748 |
Kishikawa S et al. | Control elements of Dnmt1 gene are regulated in cell-cycle dependent manner. | 2003 | Nucleic Acids Res. Suppl. | pmid:14510503 |
Liu LT et al. | Histone deacetylase inhibitor up-regulates RECK to inhibit MMP-2 activation and cancer cell invasion. | 2003 | Cancer Res. | pmid:12810630 |
Shin HJ et al. | Inhibition of histone deacetylase activity increases chromosomal instability by the aberrant regulation of mitotic checkpoint activation. | 2003 | Oncogene | pmid:12813458 |
Kim TY et al. | Transcriptional silencing of the DLC-1 tumor suppressor gene by epigenetic mechanism in gastric cancer cells. | 2003 | Oncogene | pmid:12813468 |
Kim JM et al. | Changes in histone acetylation during mouse oocyte meiosis. | 2003 | J. Cell Biol. | pmid:12835313 |
Camarero N et al. | Histone deacetylase inhibitors stimulate mitochondrial HMG-CoA synthase gene expression via a promoter proximal Sp1 site. | 2003 | Nucleic Acids Res. | pmid:12626711 |
Park KK et al. | Modulation of Sp1-dependent transcription by a cis-acting E2F element in dhfr promoter. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12788094 |
Marks J et al. | Two functionally divergent p53-responsive elements in the rat bradykinin B2 receptor promoter. | 2003 | J. Biol. Chem. | pmid:12791684 |
Valls E et al. | The SV40 T antigen modulates CBP histone acetyltransferase activity. | 2003 | Nucleic Acids Res. | pmid:12799439 |
Ferguson M et al. | Histone deacetylase inhibition is associated with transcriptional repression of the Hmga2 gene. | 2003 | Nucleic Acids Res. | pmid:12799440 |
Cimini D et al. | Histone hyperacetylation in mitosis prevents sister chromatid separation and produces chromosome segregation defects. | 2003 | Mol. Biol. Cell | pmid:12972566 |
Schuettengruber B et al. | Autoregulation of mouse histone deacetylase 1 expression. | 2003 | Mol. Cell. Biol. | pmid:12972616 |
Yang Y et al. | The histone code regulating expression of the imprinted mouse Igf2r gene. | 2003 | Endocrinology | pmid:12975326 |
Hu E et al. | Identification of novel isoform-selective inhibitors within class I histone deacetylases. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12975486 |
Craig JM et al. | Centromeric chromatin pliability and memory at a human neocentromere. | 2003 | EMBO J. | pmid:12743043 |
Enright BP et al. | Epigenetic characteristics and development of embryos cloned from donor cells treated by trichostatin A or 5-aza-2'-deoxycytidine. | 2003 | Biol. Reprod. | pmid:12748129 |
Van Ommeslaeghe K et al. | Amide analogues of TSA: synthesis, binding mode analysis and HDAC inhibition. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12749885 |
Zhao S et al. | Requirement of a specific Sp1 site for histone deacetylase-mediated repression of transforming growth factor beta Type II receptor expression in human pancreatic cancer cells. | 2003 | Cancer Res. | pmid:12750289 |
Castro-Galache MD et al. | Susceptibility of multidrug resistance tumor cells to apoptosis induction by histone deacetylase inhibitors. | 2003 | Int. J. Cancer | pmid:12594812 |
Teyssier C et al. | Receptor-interacting protein 140 binds c-Jun and inhibits estradiol-induced activator protein-1 activity by reversing glucocorticoid receptor-interacting protein 1 effect. | 2003 | Mol. Endocrinol. | pmid:12554755 |