trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Toscano MG et al. | SCL/TAL1-mediated transcriptional network enhances megakaryocytic specification of human embryonic stem cells. | 2015 | Mol. Ther. | pmid:25292191 |
| Hou H et al. | Influence of intra-articular administration of trichostatin a on autologous osteochondral transplantation in a rabbit model. | 2015 | Biomed Res Int | pmid:25866784 |
| Guo W et al. | RASSF5A, a candidate tumor suppressor, is epigenetically inactivated in esophageal squamous cell carcinoma. | 2015 | Clin. Exp. Metastasis | pmid:25579665 |
| Kitchen MO et al. | Epidrug mediated re-expression of miRNA targeting the HMGA transcripts in pituitary cells. | 2015 | Pituitary | pmid:25557289 |
| Tiernan AR et al. | Trichostatin A affects the secretion pathways of beta and intestinal endocrine cells. | 2015 | Exp. Cell Res. | pmid:25305500 |
| Schlörmann W et al. | Influence of miRNA-106b and miRNA-135a on butyrate-regulated expression of p21 and Cyclin D2 in human colon adenoma cells. | 2015 | Genes Nutr | pmid:26559563 |
| Sugimoto H et al. | Production of somatic cell nuclear transfer embryos using in vitro-grown and in vitro-matured oocytes in rabbits. | 2015 | Zygote | pmid:24666637 |
| Singh AK et al. | Evaluation of Epigenetic Drug Targeting of Heterogenous Tumor Cell Fractions Using Potential Biomarkers of Response in Ovarian Cancer. | 2015 | Clin. Cancer Res. | pmid:26130461 |
| Lee YR et al. | Extracellularly secreted APE1/Ref-1 triggers apoptosis in triple-negative breast cancer cells via RAGE binding, which is mediated through acetylation. | 2015 | Oncotarget | pmid:26125438 |
| Lim SY et al. | Enhancing Human Cardiomyocyte Differentiation from Induced Pluripotent Stem Cells with Trichostatin A. | 2016 | Methods Mol. Biol. | pmid:25520285 |
| Dai Q et al. | Histone deacetylase inhibitors attenuate P-aIgA1-induced cell proliferation and extracellular matrix synthesis in human renal mesangial cells in vitro. | 2016 | Acta Pharmacol. Sin. | pmid:26775659 |
| Rong X et al. | Effects of histone acetylation on superoxide dismutase 1 gene expression in the pathogenesis of senile cataract. | 2016 | Sci Rep | pmid:27703255 |
| Zhang Y and Zhang B | Trichostatin A, an Inhibitor of Histone Deacetylase, Inhibits the Viability and Invasiveness of Hypoxic Rheumatoid Arthritis Fibroblast-Like Synoviocytes via PI3K/Akt Signaling. | 2016 | J. Biochem. Mol. Toxicol. | pmid:26509796 |
| Contreras-Leal E et al. | Histone deacetylase inhibitors promote the expression of ATP2A3 gene in breast cancer cell lines. | 2016 | Mol. Carcinog. | pmid:26331238 |
| Bricambert J et al. | Impaired histone deacetylases 5 and 6 expression mimics the effects of obesity and hypoxia on adipocyte function. | 2016 | Mol Metab | pmid:27900262 |
| Kim HR et al. | Aberrant Expression of TIMP-2 and PBEF Genes in the Placentae of Cloned Mice Due to Epigenetic Reprogramming Error. | 2016 | PLoS ONE | pmid:27855185 |
| Tombolan L et al. | Global DNA methylation profiling uncovers distinct methylation patterns of protocadherin alpha4 in metastatic and non-metastatic rhabdomyosarcoma. | 2016 | BMC Cancer | pmid:27842508 |
| Tao W et al. | Histone deacetylase inhibitor-induced emergence of synaptic δ-opioid receptors and behavioral antinociception in persistent neuropathic pain. | 2016 | Neuroscience | pmid:27646288 |
| Chen W et al. | MicroRNA-455-3p modulates cartilage development and degeneration through modification of histone H3 acetylation. | 2016 | Biochim. Biophys. Acta | pmid:27638301 |
| Bauer I et al. | A Class 1 Histone Deacetylase with Potential as an Antifungal Target. | 2016 | MBio | pmid:27803184 |
| Xu Q et al. | Changes in cardiac Nav1.5 expression, function, and acetylation by pan-histone deacetylase inhibitors. | 2016 | Am. J. Physiol. Heart Circ. Physiol. | pmid:27638876 |
| Nadanaka S et al. | Histone deacetylase-mediated regulation of chondroitin 4-O-sulfotransferase-1 (Chst11) gene expression by Wnt/β-catenin signaling. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27751852 |
| Tiper IV and Webb TJ | Histone deacetylase inhibitors enhance CD1d-dependent NKT cell responses to lymphoma. | 2016 | Cancer Immunol. Immunother. | pmid:27614429 |
| Morinobu A et al. | Expression and Functions of Immediate Early Response Gene X-1 (IEX-1) in Rheumatoid Arthritis Synovial Fibroblasts. | 2016 | PLoS ONE | pmid:27736946 |
| Li C et al. | PU.1-Bim axis is involved in Trichostatin A-induced apoptosis in murine pro-B lymphoma FL5.12 cells. | 2016 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:27451443 |
| Igaz N et al. | Modulating chromatin structure and DNA accessibility by deacetylase inhibition enhances the anti-cancer activity of silver nanoparticles. | 2016 | Colloids Surf B Biointerfaces | pmid:27434153 |
| Qu H et al. | Trichostatin A increases the TIMP-1/MMP ratio to protect against osteoarthritis in an animal model of the disease. | 2016 | Mol Med Rep | pmid:27431944 |
| Choi SY et al. | Class I HDACs specifically regulate E-cadherin expression in human renal epithelial cells. | 2016 | J. Cell. Mol. Med. | pmid:27420561 |
| Dhoke NR et al. | Histone deacetylases differentially regulate the proliferative phenotype of mouse bone marrow stromal and hematopoietic stem/progenitor cells. | 2016 | Stem Cell Res | pmid:27394013 |
| Drzewiecka H et al. | Decreased expression of connective tissue growth factor in non-small cell lung cancer is associated with clinicopathological variables and can be restored by epigenetic modifiers. | 2016 | J. Cancer Res. Clin. Oncol. | pmid:27393180 |
| Zhang NH et al. | Rejection of adenovirus infection is independent of coxsackie and adenovirus receptor expression in cisplatin-resistant human lung cancer cells. | 2016 | Oncol. Rep. | pmid:27373420 |
| Chang I and Wang CY | Inhibition of HDAC6 Protein Enhances Bortezomib-induced Apoptosis in Head and Neck Squamous Cell Carcinoma (HNSCC) by Reducing Autophagy. | 2016 | J. Biol. Chem. | pmid:27369083 |
| Yagi K et al. | Histone Deacetylase Inhibition Protects Mice Against Lethal Postinfluenza Pneumococcal Infection. | 2016 | Crit. Care Med. | pmid:27352127 |
| Wei L et al. | Microinjection of histone deacetylase inhibitor into the ventrolateral orbital cortex potentiates morphine induced behavioral sensitization. | 2016 | Brain Res. | pmid:27312092 |
| Hakami NY et al. | Trichostatin A, a histone deacetylase inhibitor suppresses NADPH Oxidase 4-Derived Redox Signalling and Angiogenesis. | 2016 | J. Cell. Mol. Med. | pmid:27297729 |
| Raju I et al. | Epigenetic regulation of KLK7 gene expression in pancreatic and cervical cancer cells. | 2016 | Biol. Chem. | pmid:27279059 |
| Cui W et al. | A SUMO-acetyl switch in PXR biology. | 2016 | Biochim. Biophys. Acta | pmid:26883953 |
| Ma X et al. | Identification of genes regulated by histone acetylation during root development in Populus trichocarpa. | 2016 | BMC Genomics | pmid:26847576 |
| Li L et al. | Trichostatin A potentiates TRAIL-induced antitumor effects via inhibition of ERK/FOXM1 pathway in gastric cancer. | 2016 | Tumour Biol. | pmid:26831669 |
| Rios EC et al. | The role of nitric oxide in the epigenetic regulation of THP-1 induced by lipopolysaccharide. | 2016 | Life Sci. | pmid:26826317 |
| Wang X et al. | The synergistic effect of 5Azadc and TSA on maintenance of pluripotency of chicken ESCs by overexpression of NANOG gene. | 2016 | In Vitro Cell. Dev. Biol. Anim. | pmid:26822431 |
| Kuan CS et al. | Sp1 and Sp3 Are the Transcription Activators of Human ek1 Promoter in TSA-Treated Human Colon Carcinoma Cells. | 2016 | PLoS ONE | pmid:26807725 |
| Noh H et al. | Trichostatin A enhances estrogen receptor-alpha repression in MCF-7 breast cancer cells under hypoxia. | 2016 | Biochem. Biophys. Res. Commun. | pmid:26768368 |
| Hosseini SM et al. | Epigenetic modification with trichostatin A does not correct specific errors of somatic cell nuclear transfer at the transcriptomic level; highlighting the non-random nature of oocyte-mediated reprogramming errors. | 2016 | BMC Genomics | pmid:26725231 |
| Lee K et al. | Histone deacetylation-mediated cellular dedifferentiation in Arabidopsis. | 2016 | J. Plant Physiol. | pmid:26724747 |
| Calvert S et al. | A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. | 2016 | Aging Cell | pmid:26676933 |
| Saini M et al. | Treatment of buffalo (Bubalus bubalis) donor cells with trichostatin A and 5-aza-2'-deoxycytidine alters their growth characteristics, gene expression and epigenetic status and improves the in vitro developmental competence, quality and epigenetic status of cloned embryos. | 2016 | Reprod. Fertil. Dev. | pmid:25409339 |
| Trifunović D et al. | HDAC inhibition in the cpfl1 mouse protects degenerating cone photoreceptors in vivo. | 2016 | Hum. Mol. Genet. | pmid:28172811 |
| Kim HJ et al. | Enhancement of human mesenchymal stem cell differentiation by combination treatment with 5-azacytidine and trichostatin A. | 2016 | Biotechnol. Lett. | pmid:26341652 |
| Meng Z et al. | PTEN activation through K163 acetylation by inhibiting HDAC6 contributes to tumour inhibition. | 2016 | Oncogene | pmid:26279303 |