trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Reperfusion Injury D015427 65 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Carcinoma D002277 18 associated lipids
Ureteral Obstruction D014517 10 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypersensitivity D006967 22 associated lipids
Per page 10 20 50 100 | Total 139

PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with trichostatin A?

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Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


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Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Takamatsu G et al. Tescalcin is a potential target of class I histone deacetylase inhibitors in neurons. 2017 Biochem. Biophys. Res. Commun. pmid:27939885
Song Y et al. Trichostatin A and 5-Aza-2'-Deoxycytidine influence the expression of cold-induced genes in Arabidopsis. 2017 Plant Signal Behav pmid:29027833
Jia L et al. Trichostatin A increases radiosensitization of tongue squamous cell carcinoma via miR‑375. 2017 Oncol. Rep. pmid:27878285
Huynh NC et al. Histone deacetylase inhibition enhances in-vivo bone regeneration induced by human periodontal ligament cells. 2017 Bone pmid:27871909
Anantharaju PG et al. Induction of colon and cervical cancer cell death by cinnamic acid derivatives is mediated through the inhibition of Histone Deacetylases (HDAC). 2017 PLoS ONE pmid:29190639
Ngwa CJ et al. Transcriptional Profiling Defines Histone Acetylation as a Regulator of Gene Expression during Human-to-Mosquito Transmission of the Malaria Parasite . 2017 Front Cell Infect Microbiol pmid:28791254
Wang SC et al. Trichostatin A induces bladder cancer cell death via intrinsic apoptosis at the early phase and Sp1‑survivin downregulation at the late phase of treatment. 2017 Oncol. Rep. pmid:28713892
Pérez-Garrastachu M et al. Nucleoporins redistribute inside the nucleus after cell cycle arrest induced by histone deacetylases inhibition. 2017 Nucleus pmid:28696859
Opiela J et al. In vitro development and cytological quality of inter-species (porcine→bovine) cloned embryos are affected by trichostatin A-dependent epigenomic modulation of adult mesenchymal stem cells. 2017 Theriogenology pmid:28583605
Hou X et al. HDAC inhibitor TSA ameliorates mechanical hypersensitivity and potentiates analgesic effect of morphine in a rat model of bone cancer pain by restoring μ-opioid receptor in spinal cord. 2017 Brain Res. pmid:28559159
Ma T et al. Suppression of BMP-7 by histone deacetylase 2 promoted apoptosis of renal tubular epithelial cells in acute kidney injury. 2017 Cell Death Dis pmid:29072686
Androutsopoulos VP and Spandidos DA Antiproliferative effects of TSA, PXD‑101 and MS‑275 in A2780 and MCF7 cells: Acetylated histone H4 and acetylated tubulin as markers for HDACi potency and selectivity. 2017 Oncol. Rep. pmid:29039546
Anantharaju PG et al. Naturally occurring benzoic acid derivatives retard cancer cell growth by inhibiting histone deacetylases (HDAC). 2017 Cancer Biol. Ther. pmid:28506198
Kotantaki P and Mosialos G The expression of tumor suppressor gene Cyld is upregulated by histone deacetylace inhibitors in human hepatocellular carcinoma cell lines. 2016 Cell Biochem. Funct. pmid:27570065
Lim SY et al. Enhancing Human Cardiomyocyte Differentiation from Induced Pluripotent Stem Cells with Trichostatin A. 2016 Methods Mol. Biol. pmid:25520285
Dai Q et al. Histone deacetylase inhibitors attenuate P-aIgA1-induced cell proliferation and extracellular matrix synthesis in human renal mesangial cells in vitro. 2016 Acta Pharmacol. Sin. pmid:26775659
Shao A et al. Enhancement of Autophagy by Histone Deacetylase Inhibitor Trichostatin A Ameliorates Neuronal Apoptosis After Subarachnoid Hemorrhage in Rats. 2016 Mol. Neurobiol. pmid:25399954
Rong X et al. Effects of histone acetylation on superoxide dismutase 1 gene expression in the pathogenesis of senile cataract. 2016 Sci Rep pmid:27703255
Li X et al. Role of histone deacetylases(HDACs) in progression and reversal of liver fibrosis. 2016 Toxicol. Appl. Pharmacol. pmid:27396813
Robert C et al. Histone deacetylase inhibitors decrease NHEJ both by acetylation of repair factors and trapping of PARP1 at DNA double-strand breaks in chromatin. 2016 Leuk. Res. pmid:27064363
Mohammadi-Bardbori A et al. Chromatin remodeling by curcumin alters endogenous aryl hydrocarbon receptor signaling. 2016 Chem. Biol. Interact. pmid:27041069
Li W et al. Epigenetics Reactivation of Nrf2 in Prostate TRAMP C1 Cells by Curcumin Analogue FN1. 2016 Chem. Res. Toxicol. pmid:26991801
Wu TC et al. The enhancing effect of genistein on apoptosis induced by trichostatin A in lung cancer cells with wild type p53 genes is associated with upregulation of histone acetyltransferase. 2016 Toxicol. Appl. Pharmacol. pmid:26768552
Contreras-Leal E et al. Histone deacetylase inhibitors promote the expression of ATP2A3 gene in breast cancer cell lines. 2016 Mol. Carcinog. pmid:26331238
Díaz-Núñez M et al. Histone deacetylase inhibitors induce invasion of human melanoma cells in vitro via differential regulation of N-cadherin expression and RhoA activity. 2016 BMC Cancer pmid:27549189
Bricambert J et al. Impaired histone deacetylases 5 and 6 expression mimics the effects of obesity and hypoxia on adipocyte function. 2016 Mol Metab pmid:27900262
Adachi T et al. Histone deacetylase inhibitors stimulate the susceptibility of A549 cells to a plasma-activated medium treatment. 2016 Arch. Biochem. Biophys. pmid:27470189
Tombolan L et al. Global DNA methylation profiling uncovers distinct methylation patterns of protocadherin alpha4 in metastatic and non-metastatic rhabdomyosarcoma. 2016 BMC Cancer pmid:27842508
Tao W et al. Histone deacetylase inhibitor-induced emergence of synaptic δ-opioid receptors and behavioral antinociception in persistent neuropathic pain. 2016 Neuroscience pmid:27646288
Chen W et al. MicroRNA-455-3p modulates cartilage development and degeneration through modification of histone H3 acetylation. 2016 Biochim. Biophys. Acta pmid:27638301
Duffy S et al. Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer. 2016 Proc. Natl. Acad. Sci. U.S.A. pmid:27551064
Bauer I et al. A Class 1 Histone Deacetylase with Potential as an Antifungal Target. 2016 MBio pmid:27803184
Xu Q et al. Changes in cardiac Nav1.5 expression, function, and acetylation by pan-histone deacetylase inhibitors. 2016 Am. J. Physiol. Heart Circ. Physiol. pmid:27638876
Nadanaka S et al. Histone deacetylase-mediated regulation of chondroitin 4-O-sulfotransferase-1 (Chst11) gene expression by Wnt/β-catenin signaling. 2016 Biochem. Biophys. Res. Commun. pmid:27751852
Tiper IV and Webb TJ Histone deacetylase inhibitors enhance CD1d-dependent NKT cell responses to lymphoma. 2016 Cancer Immunol. Immunother. pmid:27614429
Morinobu A et al. Expression and Functions of Immediate Early Response Gene X-1 (IEX-1) in Rheumatoid Arthritis Synovial Fibroblasts. 2016 PLoS ONE pmid:27736946
Hrgovic I et al. The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways. 2016 BMC Cancer pmid:27716272
Sobue S et al. Mechanism of paclitaxel resistance in a human prostate cancer cell line, PC3-PR, and its sensitization by cabazitaxel. 2016 Biochem. Biophys. Res. Commun. pmid:27687545
Zhang Q et al. Trichostatin A protects against intestinal injury in rats with acute liver failure. 2016 J. Surg. Res. pmid:27620992
Desjardins D et al. Histone Deacetylase Inhibition Restores Retinal Pigment Epithelium Function in Hyperglycemia. 2016 PLoS ONE pmid:27617745
Park IH et al. Trichostatin A Inhibits Epithelial Mesenchymal Transition Induced by TGF-β1 in Airway Epithelium. 2016 PLoS ONE pmid:27571418
Sugiyama KI et al. Epigenetic mutagen as histone modulator can be detected by yeast flocculation. 2016 Mutagenesis pmid:27549112
Zhang XF et al. Trichostatin A Enhances the Apoptotic Potential of Palladium Nanoparticles in Human Cervical Cancer Cells. 2016 Int J Mol Sci pmid:27548148
Scholpa NE et al. Nephrotoxicity of epigenetic inhibitors used for the treatment of cancer. 2016 Chem. Biol. Interact. pmid:27543423
Hou Y et al. Expression Profiles of SIRT1 and APP Genes in Human Neuroblastoma SK-N-SH Cells Treated with Two Epigenetic Agents. 2016 Neurosci Bull pmid:27522594
Huang H et al. Regulation of TWIK-related potassium channel-1 (Trek1) restitutes intestinal epithelial barrier function. 2016 Cell. Mol. Immunol. pmid:25683610
Wang S et al. Sex steroid-induced DNA methylation changes and inflammation response in prostate cancer. 2016 Cytokine pmid:27500645
Por ED et al. Trichostatin A Inhibits Retinal Pigmented Epithelium Activation in an In Vitro Model of Proliferative Vitreoretinopathy. 2016 J Ocul Pharmacol Ther pmid:27494828
Qu H et al. Trichostatin A increases the TIMP-1/MMP ratio to protect against osteoarthritis in an animal model of the disease. 2016 Mol Med Rep pmid:27431944
Choi SY et al. Class I HDACs specifically regulate E-cadherin expression in human renal epithelial cells. 2016 J. Cell. Mol. Med. pmid:27420561
Dhoke NR et al. Histone deacetylases differentially regulate the proliferative phenotype of mouse bone marrow stromal and hematopoietic stem/progenitor cells. 2016 Stem Cell Res pmid:27394013
Drzewiecka H et al. Decreased expression of connective tissue growth factor in non-small cell lung cancer is associated with clinicopathological variables and can be restored by epigenetic modifiers. 2016 J. Cancer Res. Clin. Oncol. pmid:27393180
Zhang NH et al. Rejection of adenovirus infection is independent of coxsackie and adenovirus receptor expression in cisplatin-resistant human lung cancer cells. 2016 Oncol. Rep. pmid:27373420
Chang I and Wang CY Inhibition of HDAC6 Protein Enhances Bortezomib-induced Apoptosis in Head and Neck Squamous Cell Carcinoma (HNSCC) by Reducing Autophagy. 2016 J. Biol. Chem. pmid:27369083
Yagi K et al. Histone Deacetylase Inhibition Protects Mice Against Lethal Postinfluenza Pneumococcal Infection. 2016 Crit. Care Med. pmid:27352127
Wei L et al. Microinjection of histone deacetylase inhibitor into the ventrolateral orbital cortex potentiates morphine induced behavioral sensitization. 2016 Brain Res. pmid:27312092
Hakami NY et al. Trichostatin A, a histone deacetylase inhibitor suppresses NADPH Oxidase 4-Derived Redox Signalling and Angiogenesis. 2016 J. Cell. Mol. Med. pmid:27297729
Raju I et al. Epigenetic regulation of KLK7 gene expression in pancreatic and cervical cancer cells. 2016 Biol. Chem. pmid:27279059
Somanna NK et al. Histone deacetyltransferase inhibitors Trichostatin A and Mocetinostat differentially regulate MMP9, IL-18 and RECK expression, and attenuate Angiotensin II-induced cardiac fibroblast migration and proliferation. 2016 Hypertens. Res. pmid:27278287
Kang HR et al. Butyrate-mediated acquisition of chemoresistance by human colon cancer cells. 2016 Oncol. Rep. pmid:27277338
Agudelo M et al. Profile of Class I Histone Deacetylases (HDAC) by Human Dendritic Cells after Alcohol Consumption and In Vitro Alcohol Treatment and Their Implication in Oxidative Stress: Role of HDAC Inhibitors Trichostatin A and Mocetinostat. 2016 PLoS ONE pmid:27249803
Allgayer J et al. Widespread transcriptional gene inactivation initiated by a repair intermediate of 8-oxoguanine. 2016 Nucleic Acids Res. pmid:27220469
Du R et al. Trichostatin A potentiates genistein-induced apoptosis and reverses EMT in HEp2 cells. 2016 Mol Med Rep pmid:27121018
Wang H et al. [Effect of trichostatin A on the osteogenic differentiation potential of periodontal ligament stem cells in inflammatory microenvironment induced by tumor necrosis factor-α stimulation]. 2016 Zhonghua Kou Qiang Yi Xue Za Zhi pmid:27117217
Gehring KB et al. Involvement of phosphorylated Apis mellifera CREB in gating a honeybee's behavioral response to an external stimulus. 2016 Learn. Mem. pmid:27084927
Li QQ et al. Histone deacetylase inhibitor-induced cell death in bladder cancer is associated with chromatin modification and modifying protein expression: A proteomic approach. 2016 Int. J. Oncol. pmid:27082124
Duclot F et al. Trichostatin A (TSA) facilitates formation of partner preference in male prairie voles (Microtus ochrogaster). 2016 Horm Behav pmid:27074037
Toki S et al. The histone deacetylase inhibitor trichostatin A suppresses murine innate allergic inflammation by blocking group 2 innate lymphoid cell (ILC2) activation. 2016 Thorax pmid:27071418
Chen J et al. Histone Deacetylase Inhibitors Trichostatin A and MCP30 Relieve Benzene-Induced Hematotoxicity via Restoring Topoisomerase IIα. 2016 PLoS ONE pmid:27058040
Zhang F et al. Histone Acetylation Induced Transformation of B-DNA to Z-DNA in Cells Probed through FT-IR Spectroscopy. 2016 Anal. Chem. pmid:27046421
Huynh NC et al. Inhibition of Histone Deacetylases Enhances the Osteogenic Differentiation of Human Periodontal Ligament Cells. 2016 J. Cell. Biochem. pmid:27043246
Gupta DK et al. DNA damage regulation and its role in drug-related phenotypes in the malaria parasites. 2016 Sci Rep pmid:27033103
Clarke CJ et al. ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation. 2016 J. Lipid Res. pmid:27013100
Zhang HP et al. Association between histone hyperacetylation status in memory T lymphocytes and allergen-induced eosinophilic airway inflammation. 2016 Respirology pmid:26991676
Sharma K et al. Constitutive hyperactivity of histone deacetylases enhances radioresistance in Lepidopteran Sf9 insect cells. 2016 Biochim. Biophys. Acta pmid:26968462
Ho TT et al. Transient resistance to DNA damaging agents is associated with expression of microRNAs-135b and -196b in human leukemia cell lines. 2016 Int J Biochem Mol Biol pmid:27570640
Li L et al. Trichostatin A potentiates TRAIL-induced antitumor effects via inhibition of ERK/FOXM1 pathway in gastric cancer. 2016 Tumour Biol. pmid:26831669
Rios EC et al. The role of nitric oxide in the epigenetic regulation of THP-1 induced by lipopolysaccharide. 2016 Life Sci. pmid:26826317
Deguise MO et al. Differential induction of muscle atrophy pathways in two mouse models of spinal muscular atrophy. 2016 Sci Rep pmid:27349908
Wang X et al. The synergistic effect of 5Azadc and TSA on maintenance of pluripotency of chicken ESCs by overexpression of NANOG gene. 2016 In Vitro Cell. Dev. Biol. Anim. pmid:26822431
Kuan CS et al. Sp1 and Sp3 Are the Transcription Activators of Human ek1 Promoter in TSA-Treated Human Colon Carcinoma Cells. 2016 PLoS ONE pmid:26807725
Noh H et al. Trichostatin A enhances estrogen receptor-alpha repression in MCF-7 breast cancer cells under hypoxia. 2016 Biochem. Biophys. Res. Commun. pmid:26768368
Hosseini SM et al. Epigenetic modification with trichostatin A does not correct specific errors of somatic cell nuclear transfer at the transcriptomic level; highlighting the non-random nature of oocyte-mediated reprogramming errors. 2016 BMC Genomics pmid:26725231
Lee K et al. Histone deacetylation-mediated cellular dedifferentiation in Arabidopsis. 2016 J. Plant Physiol. pmid:26724747
Calvert S et al. A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. 2016 Aging Cell pmid:26676933
Zhang Q et al. Trichostatin A inhibits inflammation in phorbol myristate acetate‑induced macrophages by regulating the acetylation of histone and/or non‑histone proteins. 2016 Mol Med Rep pmid:26647731
Kikuchi M et al. Epigenetic regulation of ZEB1-RAB25/ESRP1 axis plays a critical role in phenylbutyrate treatment-resistant breast cancer. 2016 Oncotarget pmid:26646320
Sheng Y et al. Methylation of tumor suppressor gene CDH13 and SHP1 promoters and their epigenetic regulation by the UHRF1/PRMT5 complex in endometrial carcinoma. 2016 Gynecol. Oncol. pmid:26597461
Yeh BW et al. Histone deacetylase inhibitor trichostatin A resensitizes gemcitabine resistant urothelial carcinoma cells via suppression of TG-interacting factor. 2016 Toxicol. Appl. Pharmacol. pmid:26589485
Asgar MA et al. Synergistic anticancer effects of cisplatin and histone deacetylase inhibitors (SAHA and TSA) on cholangiocarcinoma cell lines. 2016 Int. J. Oncol. pmid:26575528
Ranganathan P et al. Histone deacetylase–mediated silencing of AMWAP expression contributes to cisplatin nephrotoxicity. 2016 Kidney Int. pmid:26509586
Selokar NL et al. Buffalo (Bubalus bubalis) SCNT embryos produced from somatic cells isolated from frozen-thawed semen: effect of trichostatin A on the in vitro and in vivo developmental potential, quality and epigenetic status. 2016 Zygote pmid:26503476
Trifunović D et al. HDAC inhibition in the cpfl1 mouse protects degenerating cone photoreceptors in vivo. 2016 Hum. Mol. Genet. pmid:28172811
Vargas-López V et al. Histone deacetylase inhibition abolishes stress-induced spatial memory impairment. 2016 Neurobiol Learn Mem pmid:27544851
Piao J et al. Superior efficacy of co-treatment with the dual PI3K/mTOR inhibitor BEZ235 and histone deacetylase inhibitor Trichostatin A against NSCLC. 2016 Oncotarget pmid:27507059
Kim HJ et al. Enhancement of human mesenchymal stem cell differentiation by combination treatment with 5-azacytidine and trichostatin A. 2016 Biotechnol. Lett. pmid:26341652
Meng Z et al. PTEN activation through K163 acetylation by inhibiting HDAC6 contributes to tumour inhibition. 2016 Oncogene pmid:26279303
Pang X et al. Knockdown of Rad9A enhanced DNA damage induced by trichostatin A in esophageal cancer cells. 2016 Tumour Biol. pmid:26264615
Kim SH et al. The heat shock protein 90 inhibitor SNX5422 has a synergistic activity with histone deacetylase inhibitors in induction of death of anaplastic thyroid carcinoma cells. 2016 Endocrine pmid:26219406
Tan CS et al. Epigenetic Regulation of Cytosolic Phospholipase A2 in SH-SY5Y Human Neuroblastoma Cells. 2016 Mol. Neurobiol. pmid:26162318