trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Reperfusion Injury D015427 65 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Carcinoma D002277 18 associated lipids
Ureteral Obstruction D014517 10 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypersensitivity D006967 22 associated lipids
Per page 10 20 50 100 | Total 139

PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

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Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


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Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Li L et al. In Vivo Screening Using Transgenic Zebrafish Embryos Reveals New Effects of HDAC Inhibitors Trichostatin A and Valproic Acid on Organogenesis. 2016 PLoS ONE pmid:26900852
Lim SY et al. Enhancing Human Cardiomyocyte Differentiation from Induced Pluripotent Stem Cells with Trichostatin A. 2016 Methods Mol. Biol. pmid:25520285
Zhang Y and Zhang B Trichostatin A, an Inhibitor of Histone Deacetylase, Inhibits the Viability and Invasiveness of Hypoxic Rheumatoid Arthritis Fibroblast-Like Synoviocytes via PI3K/Akt Signaling. 2016 J. Biochem. Mol. Toxicol. pmid:26509796
Kim HR et al. Aberrant Expression of TIMP-2 and PBEF Genes in the Placentae of Cloned Mice Due to Epigenetic Reprogramming Error. 2016 PLoS ONE pmid:27855185
Tombolan L et al. Global DNA methylation profiling uncovers distinct methylation patterns of protocadherin alpha4 in metastatic and non-metastatic rhabdomyosarcoma. 2016 BMC Cancer pmid:27842508
Tao W et al. Histone deacetylase inhibitor-induced emergence of synaptic δ-opioid receptors and behavioral antinociception in persistent neuropathic pain. 2016 Neuroscience pmid:27646288
Miyake Y et al. Structural insights into HDAC6 tubulin deacetylation and its selective inhibition. 2016 Nat. Chem. Biol. pmid:27454931
Li C et al. PU.1-Bim axis is involved in Trichostatin A-induced apoptosis in murine pro-B lymphoma FL5.12 cells. 2016 Acta Biochim. Biophys. Sin. (Shanghai) pmid:27451443
Igaz N et al. Modulating chromatin structure and DNA accessibility by deacetylase inhibition enhances the anti-cancer activity of silver nanoparticles. 2016 Colloids Surf B Biointerfaces pmid:27434153
Qu H et al. Trichostatin A increases the TIMP-1/MMP ratio to protect against osteoarthritis in an animal model of the disease. 2016 Mol Med Rep pmid:27431944
Choi SY et al. Class I HDACs specifically regulate E-cadherin expression in human renal epithelial cells. 2016 J. Cell. Mol. Med. pmid:27420561
Cui W et al. A SUMO-acetyl switch in PXR biology. 2016 Biochim. Biophys. Acta pmid:26883953
Ma X et al. Identification of genes regulated by histone acetylation during root development in Populus trichocarpa. 2016 BMC Genomics pmid:26847576
Li L et al. Trichostatin A potentiates TRAIL-induced antitumor effects via inhibition of ERK/FOXM1 pathway in gastric cancer. 2016 Tumour Biol. pmid:26831669
Rios EC et al. The role of nitric oxide in the epigenetic regulation of THP-1 induced by lipopolysaccharide. 2016 Life Sci. pmid:26826317
Saini M et al. Treatment of buffalo (Bubalus bubalis) donor cells with trichostatin A and 5-aza-2'-deoxycytidine alters their growth characteristics, gene expression and epigenetic status and improves the in vitro developmental competence, quality and epigenetic status of cloned embryos. 2016 Reprod. Fertil. Dev. pmid:25409339
Kim HJ et al. Enhancement of human mesenchymal stem cell differentiation by combination treatment with 5-azacytidine and trichostatin A. 2016 Biotechnol. Lett. pmid:26341652
Nayak S et al. Superior Versus Inferior Vestibular Neuritis: Are There Intrinsic Differences in Infection, Reactivation, or Production of Infectious Particles Between the Vestibular Ganglia? 2015 Otol. Neurotol. pmid:25978655
Chen MH et al. A new trichostatin analog from Streptomyces sp. CPCC 203909. 2015 J Asian Nat Prod Res pmid:25977996
Inoue K et al. Trichostatin A specifically improves the aberrant expression of transcription factor genes in embryos produced by somatic cell nuclear transfer. 2015 Sci Rep pmid:25974394
El-Awady RA et al. Epigenetics and miRNA as predictive markers and targets for lung cancer chemotherapy. 2015 Cancer Biol. Ther. pmid:25962089
Huan Y et al. Trichostatin A rescues the disrupted imprinting induced by somatic cell nuclear transfer in pigs. 2015 PLoS ONE pmid:25962071
Koumbadinga GA et al. Increased stability of heterogeneous ribonucleoproteins by a deacetylase inhibitor. 2015 Biochim. Biophys. Acta pmid:25959059
Meschini R et al. Role of chromatin structure modulation by the histone deacetylase inhibitor trichostatin A on the radio-sensitivity of ataxia telangiectasia. 2015 Mutat. Res. pmid:25942615
Ooi JY et al. HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes. 2015 Epigenetics pmid:25941940
Marquardt JU et al. Curcumin effectively inhibits oncogenic NF-κB signaling and restrains stemness features in liver cancer. 2015 J. Hepatol. pmid:25937435
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Acun T et al. PTPRD is homozygously deleted and epigenetically downregulated in human hepatocellular carcinomas. 2015 OMICS pmid:25831062
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Pandey SC et al. Potential role of adolescent alcohol exposure-induced amygdaloid histone modifications in anxiety and alcohol intake during adulthood. 2015 Neurobiol. Dis. pmid:25814047
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Asaoka N et al. Inhibition of histone deacetylases enhances the function of serotoninergic neurons in organotypic raphe slice cultures. 2015 Neurosci. Lett. pmid:25796177
Martini M et al. Postmitotic Expression of SOD1(G93A) Gene Affects the Identity of Myogenic Cells and Inhibits Myoblasts Differentiation. 2015 Mediators Inflamm. pmid:26491230
Butler PL et al. Acetylation stimulates the epithelial sodium channel by reducing its ubiquitination and degradation. 2015 J. Biol. Chem. pmid:25787079
Zelko IN and Folz RJ Regulation of Oxidative Stress in Pulmonary Artery Endothelium. Modulation of Extracellular Superoxide Dismutase and NOX4 Expression Using Histone Deacetylase Class I Inhibitors. 2015 Am. J. Respir. Cell Mol. Biol. pmid:25749103
Cao K et al. Histone deacetylase inhibitors prevent activation-induced cell death and promote anti-tumor immunity. 2015 Oncogene pmid:25745993
Mostafavi-Pour Z et al. Methylation of Integrin α4 and E-Cadherin Genes in Human Prostate Cancer. 2015 Pathol. Oncol. Res. pmid:25743258
Hsu HH et al. Protection against reperfusion lung injury via aborgating multiple signaling cascades by trichostatin A. 2015 Int. Immunopharmacol. pmid:25698558
Meng J et al. Ku70 is essential for histone deacetylase inhibitor trichostatin A-induced apoptosis. 2015 Mol Med Rep pmid:25695595
Wang P et al. Epigenetic Changes are Associated with Programmed Cell Death Induced by Heat Stress in Seedling Leaves of Zea mays. 2015 Plant Cell Physiol. pmid:25670712
Mataki H et al. Downregulation of the microRNA-1/133a cluster enhances cancer cell migration and invasion in lung-squamous cell carcinoma via regulation of Coronin1C. 2015 J. Hum. Genet. pmid:25518741
Jeong SG and Cho GW Trichostatin A modulates intracellular reactive oxygen species through SOD2 and FOXO1 in human bone marrow-mesenchymal stem cells. 2015 Cell Biochem. Funct. pmid:25515622
Hartman H et al. Histone deacetylase regulates trypsin activation, inflammation, and tissue damage in acute pancreatitis in mice. 2015 Dig. Dis. Sci. pmid:25492506
Jiang H et al. Changes of spontaneous parthenogenetic activation and development potential of golden hamster oocytes during the aging process. 2015 Acta Histochem. pmid:25480399
Du J et al. HDAC4 degradation mediates HDAC inhibition-induced protective effects against hypoxia/reoxygenation injury. 2015 J. Cell. Physiol. pmid:25475100
Xu T and Hu X Copper-catalyzed 1,2-addition of α-carbonyl iodides to alkynes. 2015 Angew. Chem. Int. Ed. Engl. pmid:25470461
Rabineau M et al. Cell guidance into quiescent state through chromatin remodeling induced by elastic modulus of substrate. 2015 Biomaterials pmid:25453945
Wang J et al. Fungal metabolite myriocin promotes human herpes simplex virus-2 infection. 2015 Life Sci. pmid:25447452
Wang X et al. Trichostatin A, a histone deacetylase inhibitor, reverses epithelial-mesenchymal transition in colorectal cancer SW480 and prostate cancer PC3 cells. 2015 Biochem. Biophys. Res. Commun. pmid:25434997
Ma X et al. Effect of LIV1 on the sensitivity of ovarian cancer cells to trichostatin A. 2015 Oncol. Rep. pmid:25420545
Cui Y et al. Interference of the Histone Deacetylase Inhibits Pollen Germination and Pollen Tube Growth in Picea wilsonii Mast. 2015 PLoS ONE pmid:26710276
Sharma S et al. Histone deacetylase inhibitor, trichostatin A, improves learning and memory in high-fat diet-induced cognitive deficits in mice. 2015 J. Mol. Neurosci. pmid:25391764
Hao ZF et al. Activating transcription factor 3 interferes with p21 activation in histone deacetylase inhibitor-induced growth inhibition of epidermoid carcinoma cells. 2015 Tumour Biol. pmid:25371069
Singh RD et al. Arsenic exposure causes epigenetic dysregulation of IL-8 expression leading to proneoplastic changes in kidney cells. 2015 Toxicol. Lett. pmid:26008221
Fukui T et al. Histone deacetylase inhibitor attenuates neurotoxicity of clioquinol in PC12 cells. 2015 Toxicology pmid:25758465
Pinz S et al. Deacetylase inhibitors repress STAT5-mediated transcription by interfering with bromodomain and extra-terminal (BET) protein function. 2015 Nucleic Acids Res. pmid:25769527
Wang Y et al. Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases. 2015 Chem. Biol. pmid:25699604
Chahine MN et al. Nuclear pore rearrangements and nuclear trafficking in cardiomyocytes from rat and human failing hearts. 2015 Cardiovasc. Res. pmid:25341891
Ji M et al. HDAC inhibitors induce epithelial-mesenchymal transition in colon carcinoma cells. 2015 Oncol. Rep. pmid:25813246
Tao Y et al. HDAC1 regulates the proliferation of radial glial cells in the developing Xenopus tectum. 2015 PLoS ONE pmid:25789466
Wang Y et al. Inhibition of histone deacetylase in the basolateral amygdala facilitates morphine context-associated memory formation in rats. 2015 J. Mol. Neurosci. pmid:24829091
Yamanegi K et al. Sodium valproate, a histone deacetylase inhibitor, modulates the vascular endothelial growth inhibitor-mediated cell death in human osteosarcoma and vascular endothelial cells. 2015 Int. J. Oncol. pmid:25778932
Ma XH et al. Neuroprotective capabilities of TSA against cerebral ischemia/reperfusion injury via PI3K/Akt signaling pathway in rats. 2015 Int. J. Neurosci. pmid:24730998
Li Z et al. DNA methylation downregulated mir-10b acts as a tumor suppressor in gastric cancer. 2015 Gastric Cancer pmid:24481854
Cao QF et al. TRPM2 mediates histone deacetylase inhibition-induced apoptosis in bladder cancer cells. 2015 Cancer Biother. Radiopharm. pmid:25760728
Mackmull MT et al. Histone Deacetylase Inhibitors (HDACi) Cause the Selective Depletion of Bromodomain Containing Proteins (BCPs). 2015 Mol. Cell Proteomics pmid:25755299
Alvarez AA et al. The effects of histone deacetylase inhibitors on glioblastoma-derived stem cells. 2015 J. Mol. Neurosci. pmid:24874578
Rodrigues MF et al. Reciprocal modulation of histone deacetylase inhibitors sodium butyrate and trichostatin A on the energy metabolism of breast cancer cells. 2015 J. Cell. Biochem. pmid:25510910
Uchida H et al. Histone deacetylase inhibitors relieve morphine resistance in neuropathic pain after peripheral nerve injury. 2015 J. Pharmacol. Sci. pmid:26318673
Zhang Y et al. Effect of histone deacetylase on prostate carcinoma. 2015 Int J Clin Exp Pathol pmid:26823840
Passeri E et al. Enhanced conversion of induced neuronal cells (iN cells) from human fibroblasts: Utility in uncovering cellular deficits in mental illness-associated chromosomal abnormalities. 2015 Neurosci. Res. pmid:26260244
Cavalieri V and Spinelli G Ectopic hbox12 Expression Evoked by Histone Deacetylase Inhibition Disrupts Axial Specification of the Sea Urchin Embryo. 2015 PLoS ONE pmid:26618749
Zhang Y et al. The Induction Effect of Am80 and TSA on ESC Differentiation via Regulation of Stra8 in Chicken. 2015 PLoS ONE pmid:26606052
Nakada Y et al. Inhibitory effects of trichostatin A on adrenocorticotropic hormone production and proliferation of corticotroph tumor AtT-20 cells. 2015 Endocr. J. pmid:26497760
Kotze AC et al. Histone deacetylase enzymes as drug targets for the control of the sheep blowfly, Lucilia cuprina. 2015 Int J Parasitol Drugs Drug Resist pmid:27120067
Li YL et al. Downregulation of growth differentiation factor-15 in trichostatin A-induced apoptosis could play a role in progression of gastric cancer. 2015 Int J Clin Exp Pathol pmid:26339382
Zhang P et al. Histone Deacetylase Inhibitors Inhibit the Proliferation of Gallbladder Carcinoma Cells by Suppressing AKT/mTOR Signaling. 2015 PLoS ONE pmid:26287365
Perez-Janices N et al. Differential involvement of RASSF2 hypermethylation in breast cancer subtypes and their prognosis. 2015 Oncotarget pmid:26284587
Keil KP et al. Histone acetylation regulates prostate ductal morphogenesis through a bone morphogenetic protein-dependent mechanism. 2015 Dev. Dyn. pmid:26283270
Hsing CH et al. Histone Deacetylase Inhibitor Trichostatin A Ameliorated Endotoxin-Induced Neuroinflammation and Cognitive Dysfunction. 2015 Mediators Inflamm. pmid:26273133
Zhou L et al. Inhibition of Histone Deacetylase Activity Aggravates Coxsackievirus B3-Induced Myocarditis by Promoting Viral Replication and Myocardial Apoptosis. 2015 J. Virol. pmid:26269170
Zheng J et al. Gain-of-function STAT1 mutations impair STAT3 activity in patients with chronic mucocutaneous candidiasis (CMC). 2015 Eur. J. Immunol. pmid:26255980
Mehta A et al. HDAC inhibitor prevents LPS mediated inhibition of CYP19A1 expression and 17β-estradiol production in granulosa cells. 2015 Mol. Cell. Endocrinol. pmid:26213324
Sancak D and Ozden S Global histone modifications in Fumonisin B1 exposure in rat kidney epithelial cells. 2015 Toxicol In Vitro pmid:26208285
Cabanel M et al. Epigenetic Control of Macrophage Shape Transition towards an Atypical Elongated Phenotype by Histone Deacetylase Activity. 2015 PLoS ONE pmid:26196676
Suo H et al. NRSF is an essential mediator for the neuroprotection of trichostatin A in the MPTP mouse model of Parkinson's disease. 2015 Neuropharmacology pmid:26188143
Gutiérrez J et al. Human papillomavirus type 16 E7 oncoprotein upregulates the retinoic acid receptor-beta expression in cervical cancer cell lines and K14E7 transgenic mice. 2015 Mol. Cell. Biochem. pmid:26173416
Liu J et al. Trichostatin A suppresses lung adenocarcinoma development in Grg1 overexpressing transgenic mice. 2015 Biochem. Biophys. Res. Commun. pmid:26086099
Huang J et al. Trichostatin A reduces cisplatin-induced ototoxicity through the STAT6 signaling pathway. 2015 Int. J. Mol. Med. pmid:26080623
Huan Y et al. Epigenetic Modification Agents Improve Gene-Specific Methylation Reprogramming in Porcine Cloned Embryos. 2015 PLoS ONE pmid:26068219
Huan Y et al. Epigenetic Modification of Cloned Embryos Improves Nanog Reprogramming in Pigs. 2015 Cell Reprogram pmid:26053519
Kaldre D et al. Optimization of histone deacetylase inhibitor activity in non-secosteroidal vitamin D-receptor agonist hybrids. 2015 Bioorg. Med. Chem. pmid:26048026
Liu Y and Li S A Cell Culture Model of Latent and Lytic Herpes Simplex Virus Type 1 Infection in Spiral Ganglion. 2015 ORL J. Otorhinolaryngol. Relat. Spec. pmid:26022499
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Koppaka V et al. Effect of HDAC Inhibitors on Corneal Keratocyte Mechanical Phenotypes in 3-D Collagen Matrices. 2015 Mol. Vis. pmid:25999677
Ukaegbu UE et al. A Unique Virulence Gene Occupies a Principal Position in Immune Evasion by the Malaria Parasite Plasmodium falciparum. 2015 PLoS Genet. pmid:25993442
Chen Z et al. Promotion of Metastasis-associated Gene Expression in Survived PANC-1 Cells Following Trichostatin A Treatment. 2015 Anticancer Agents Med Chem pmid:25991546