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Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. |
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Down-regulation of HLA class I antigens in prostate cancer tissues and up-regulation by histone deacetylase inhibition. |
2007 |
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Repressor element-1 silencing transcription factor/neuronal restrictive silencer factor (REST/NRSF) can regulate HSV-1 immediate-early transcription via histone modification. |
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HDAC inhibition amplifies gap junction communication in neural progenitors: potential for cell-mediated enzyme prodrug therapy. |
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Synergistic inhibition of pancreatic adenocarcinoma cell growth by trichostatin A and gemcitabine. |
2007 |
Biochim. Biophys. Acta |
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Epigenetic modulation of endogenous tumor suppressor expression in lung cancer xenografts suppresses tumorigenicity. |
2007 |
Int. J. Cancer |
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Prostaglandin F2alpha inhibits adipocyte differentiation via a G alpha q-calcium-calcineurin-dependent signaling pathway. |
2007 |
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Trichostatin A-mediated upregulation of p21(WAF1) contributes to osteoclast apoptosis. |
2007 |
Exp. Mol. Med. |
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Tissue factor pathway inhibitor-2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma. |
2007 |
Hepatology |
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Homeobox gene HOP has a potential tumor suppressive activity in human lung cancer. |
2007 |
Int. J. Cancer |
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Design and synthesis of a potent histone deacetylase inhibitor. |
2007 |
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Evidence of endogenous mu opioid receptor regulation by epigenetic control of the promoters. |
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Trichostatin A, sodium butyrate, and 5-aza-2'-deoxycytidine alter the expression of glucocorticoid receptor alpha and beta isoforms in Hut-78 T- and Raji B-lymphoma cell lines. |
2007 |
Biomed. Pharmacother. |
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Reversal of p15/INK4b hypermethylation in AML1/ETO-positive and -negative myeloid leukemia cell lines. |
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Leuk. Res. |
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Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention. |
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RhoB is frequently downregulated in non-small-cell lung cancer and resides in the 2p24 homozygous deletion region of a lung cancer cell line. |
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Int. J. Cancer |
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HP1 proteins are essential for a dynamic nuclear response that rescues the function of perturbed heterochromatin in primary human cells. |
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Mol. Cell. Biol. |
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The zinc finger repressor, ZBP-89, recruits histone deacetylase 1 to repress vimentin gene expression. |
2007 |
Genes Cells |
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HDAC3 is linked to cell cycle machinery in MiaPaCa2 cells by regulating transcription of skp2. |
2007 |
Cell Prolif. |
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Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment. |
2007 |
Immunology |
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Inhibition of histone deacetylase activates side population cells in kidney and partially reverses chronic renal injury. |
2007 |
Stem Cells |
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Global epiproteomic signatures distinguish embryonic stem cells from differentiated cells. |
2007 |
Stem Cells |
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Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA. |
2007 |
Nat. Chem. Biol. |
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Inhibition of trichostatin A-induced antiangiogenesis by small-interfering RNA for thrombospondin-1. |
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Exp. Mol. Med. |
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Functional interaction of the human cytomegalovirus IE2 protein with histone deacetylase 2 in infected human fibroblasts. |
2007 |
J. Gen. Virol. |
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Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells. |
2007 |
Mol. Cancer Ther. |
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Histone deacetylase inhibitors promote the tumoricidal effect of HAMLET. |
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Cancer Res. |
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Effect of the histone deacetylase inhibitor trichostatin a in human peripheral blood lymphocytes as a function of donor age. |
2007 |
Ann. N. Y. Acad. Sci. |
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Trichostatin A effects on gene expression in the protozoan parasite Entamoeba histolytica. |
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BMC Genomics |
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Multiple histone deacetylases repress tumor suppressor gene ARHI in breast cancer. |
2007 |
Int. J. Cancer |
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Histone deacetylase inhibitor trichostatin A induced caspase-independent apoptosis in human gastric cancer cell. |
2007 |
Chin. Med. J. |
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The use of histone deacetylase inhibitor FK228 and DNA hypomethylation agent 5-azacytidine in human bladder cancer therapy. |
2007 |
Int. J. Cancer |
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Trichostatin A blocks TGF-beta-induced collagen gene expression in skin fibroblasts: involvement of Sp1. |
2007 |
Biochem. Biophys. Res. Commun. |
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Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing. |
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Trichostatin A down-regulates ZAP-70, LAT and SLP-76 content in Jurkat T cells. |
2007 |
Int. Immunopharmacol. |
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Epigenetic patterns of the retinoic acid receptor beta2 promoter in retinoic acid-resistant thyroid cancer cells. |
2007 |
Oncogene |
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HDAC inhibitors TSA and sodium butyrate enhanced the human IL-5 expression by altering histone acetylation status at its promoter region. |
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[Hypermethylation and regulation of expression of secreted frizzled-related protein genes in colorectal tumor]. |
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Inhibition of histone deacetylase activity promotes invasion of human cancer cells through activation of urokinase plasminogen activator. |
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Functional characteristics and gene expression profiles of primary acute myeloid leukaemia cells identify patient subgroups that differ in susceptibility to histone deacetylase inhibitors. |
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Regulation of the CLDN3 gene in ovarian cancer cells. |
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Cancer Biol. Ther. |
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Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. |
2007 |
Neuron |
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Genetic and epigenetic changes in the common 1p36 deletion in neuroblastoma tumours. |
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Br. J. Cancer |
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Epigenetic alteration of the donor cells does not recapitulate the reprogramming of DNA methylation in cloned embryos. |
2007 |
Reproduction |
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Retinoic acids and trichostatin A (TSA), a histone deacetylase inhibitor, induce human pyruvate dehydrogenase kinase 4 (PDK4) gene expression. |
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Biochim. Biophys. Acta |
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Epigenetic regulation of metallothionein-i gene expression: differential regulation of methylated and unmethylated promoters by DNA methyltransferases and methyl CpG binding proteins. |
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Neuron restrictive silencer factor NRSF/REST is a transcriptional repressor of neuropilin-1 and diminishes the ability of semaphorin 3A to inhibit keratinocyte migration. |
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Oncogene |
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Inhibition of histone acetylation as a tool in bone tissue engineering. |
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Tissue Eng. |
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Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. |
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Nat. Chem. Biol. |
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CTIP2 associates with the NuRD complex on the promoter of p57KIP2, a newly identified CTIP2 target gene. |
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A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity. |
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Genes Dev. |
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Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors. |
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Nat. Med. |
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[Therapeutic strategies for patients with relapsed acute promyelocytic leukemia]. |
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Correlation of invasion and metastasis of cancer cells, and expression of the RAD21 gene in oral squamous cell carcinoma. |
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Virchows Arch. |
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Inhibition of hypoxia-induced angiogenesis by trichostatin A via suppression of HIF-1a activity in human osteosarcoma. |
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J. Exp. Clin. Cancer Res. |
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Protein kinase C theta co-operates with calcineurin in the activation of slow muscle genes in cultured myogenic cells. |
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J. Cell. Physiol. |
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Inadequate histone deacetylation during oocyte meiosis causes aneuploidy and embryo death in mice. |
2006 |
Proc. Natl. Acad. Sci. U.S.A. |
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A histone deacetylation-dependent mechanism for transcriptional repression of the gap junction gene cx43 in prostate cancer cells. |
2006 |
Prostate |
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Human endometrial cytodifferentiation by histone deacetylase inhibitors. |
2006 |
Hum. Cell |
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Stefanovsky V and Moss T |
Regulation of rRNA synthesis in human and mouse cells is not determined by changes in active gene count. |
2006 |
Cell Cycle |
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Sharma D et al. |
Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctive corepressor complexes. |
2006 |
Cancer Res. |
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Molecular inhibition of histone deacetylation results in major enhancement of the production of IL-1beta in response to LPS. |
2006 |
Am. J. Physiol. Endocrinol. Metab. |
pmid:16234266
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Wu Y and Guo SW |
Inhibition of proliferation of endometrial stromal cells by trichostatin A, RU486, CDB-2914, N-acetylcysteine, and ICI 182780. |
2006 |
Gynecol. Obstet. Invest. |
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Effects of histone deacetylase inhibitors on p55CDC/Cdc20 expression in HT29 cell line. |
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J. Cell. Biochem. |
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Trichostatin-A enhances adaptive immune responses to DNA vaccination. |
2006 |
J. Clin. Virol. |
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Histone deacetylase inhibitor trichostatin A inhibits the growth of bladder cancer cells through induction of p21WAF1 and G1 cell cycle arrest. |
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Int. J. Urol. |
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Inhibition of EGFR/PI3K/AKT cell survival pathway promotes TSA's effect on cell death and migration in human ovarian cancer cells. |
2006 |
Int. J. Oncol. |
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TLR4 expression in mouse embryonic stem cells and in stem cell-derived vascular cells is regulated by epigenetic modifications. |
2006 |
Biochem. Biophys. Res. Commun. |
pmid:16814255
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Jüngel A et al. |
Trichostatin A sensitises rheumatoid arthritis synovial fibroblasts for TRAIL-induced apoptosis. |
2006 |
Ann. Rheum. Dis. |
pmid:16284094
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Sestáková B and Vachtenheim J |
Distinct co-regulation of endogenous versus transfected MITF-dependent tyrosinase promoter. |
2006 |
Folia Biol. (Praha) |
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Effects of histone deacetylation inhibition on neuronal differentiation of embryonic mouse neural stem cells. |
2006 |
Neuroscience |
pmid:17084985
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El-Zawahry A et al. |
In vitro efficacy of AdTRAIL gene therapy of bladder cancer is enhanced by trichostatin A-mediated restoration of CAR expression and downregulation of cFLIP and Bcl-XL. |
2006 |
Cancer Gene Ther. |
pmid:16167063
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Yu Z and Kone BC |
Targeted histone H4 acetylation via phosphoinositide 3-kinase- and p70s6-kinase-dependent pathways inhibits iNOS induction in mesangial cells. |
2006 |
Am. J. Physiol. Renal Physiol. |
pmid:16174862
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Kozłowska A and Jagodziński PP |
Effect of Trichostatin A on CD4 surface density in peripheral blood T cells. |
2006 |
Folia Histochem. Cytobiol. |
pmid:17219719
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Effects of trichostatin A on HDAC8 expression, proliferation and cell cycle of Molt-4 cells. |
2006 |
J. Huazhong Univ. Sci. Technol. Med. Sci. |
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Trichostatin A regulates hGCN5 expression and cell cycle on Daudi cells in vitro. |
2006 |
J. Huazhong Univ. Sci. Technol. Med. Sci. |
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Anticancer activities of trichostatin A on maligant lymphoid cells. |
2006 |
J. Huazhong Univ. Sci. Technol. Med. Sci. |
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Androgen receptor regulates nuclear trafficking and nuclear domain residency of corepressor HDAC7 in a ligand-dependent fashion. |
2006 |
Exp. Cell Res. |
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Wagner S et al. |
SET-mediated promoter hypoacetylation is a prerequisite for coactivation of the estrogen-responsive pS2 gene by PRMT1. |
2006 |
J. Biol. Chem. |
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Histone deacetylase inhibitor, trichostatin A, increases the chemosensitivity of anticancer drugs in gastric cancer cell lines. |
2006 |
Oncol. Rep. |
pmid:16865256
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Histone deacetylase 3 represses HTLV-1 tax transcription. |
2006 |
Oncol. Rep. |
pmid:16865259
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van den Boom J et al. |
Identification of novel genes associated with astrocytoma progression using suppression subtractive hybridization and real-time reverse transcription-polymerase chain reaction. |
2006 |
Int. J. Cancer |
pmid:16865689
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Bai J et al. |
Histone deacetylase inhibitor trichostatin A and proteasome inhibitor PS-341 synergistically induce apoptosis in pancreatic cancer cells. |
2006 |
Biochem. Biophys. Res. Commun. |
pmid:16904634
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Alao JP et al. |
Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells. |
2006 |
Mol. Cancer |
pmid:16504004
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Ostapkowicz A et al. |
Lipid rafts remodeling in estrogen receptor-negative breast cancer is reversed by histone deacetylase inhibitor. |
2006 |
Mol. Cancer Ther. |
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Angiostatic activity of DNA methyltransferase inhibitors. |
2006 |
Mol. Cancer Ther. |
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Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha. |
2006 |
Mol. Cell. Biol. |
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Expansion of human umbilical cord blood SCID-repopulating cells using chromatin-modifying agents. |
2006 |
Exp. Hematol. |
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Histone deacetylase inhibitors induce cell death and enhance the susceptibility to ionizing radiation, etoposide, and TRAIL in medulloblastoma cells. |
2006 |
Int. J. Oncol. |
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Telomere position effect and silencing of transgenes near telomeres in the mouse. |
2006 |
Mol. Cell. Biol. |
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