| MeSH term | MeSH ID | Detail |
|---|---|---|
| Myopathy, Central Core | D020512 | 1 associated lipids |
| Roseolovirus Infections | D019349 | 1 associated lipids |
| Cystadenocarcinoma, Serous | D018284 | 2 associated lipids |
| Fibromatosis, Aggressive | D018222 | 2 associated lipids |
| Rhabdomyosarcoma, Alveolar | D018232 | 2 associated lipids |
| Small Cell Lung Carcinoma | D055752 | 2 associated lipids |
| Bone Marrow Neoplasms | D019046 | 2 associated lipids |
| Adenocarcinoma, Papillary | D000231 | 2 associated lipids |
| Inflammatory Breast Neoplasms | D058922 | 2 associated lipids |
| Ganglioneuroma | D005729 | 2 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ahmed S et al. | A novel protein with similarities to Rb binding protein 2 compensates for loss of Chk1 function and affects histone modification in fission yeast. | 2004 | Mol. Cell. Biol. | pmid:15082762 |
| Amor DJ et al. | Human centromere repositioning "in progress". | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15084747 |
| Tani M et al. | Correlation between histone acetylation and expression of the MYO18B gene in human lung cancer cells. | 2004 | Genes Chromosomes Cancer | pmid:15101048 |
| Lasa A et al. | MEIS 1 expression is downregulated through promoter hypermethylation in AML1-ETO acute myeloid leukemias. | 2004 | Leukemia | pmid:15103390 |
| Yokota T et al. | Histone deacetylase inhibitors activate INK4d gene through Sp1 site in its promoter. | 2004 | Oncogene | pmid:15107822 |
| McGarry LC et al. | Invasion of v-Fos(FBR)-transformed cells is dependent upon histone deacetylase activity and suppression of histone deacetylase regulated genes. | 2004 | Oncogene | pmid:15107823 |
| Chen YX et al. | [Regulation of histone acetylation on the expression of cell cycle-associated genes in human colon cancer cell lines]. | 2004 | Zhonghua Yi Xue Za Zhi | pmid:15059516 |
| Hildmann C et al. | A new amidohydrolase from Bordetella or Alcaligenes strain FB188 with similarities to histone deacetylases. | 2004 | J. Bacteriol. | pmid:15060035 |
| Vorontsova M et al. | Effect of 5-azacytidine and trichostatin A on somatic centromere association in wheat. | 2004 | Genome | pmid:15060593 |
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| Leu TH et al. | Participation of p97Eps8 in Src-mediated transformation. | 2004 | J. Biol. Chem. | pmid:14699156 |
| Pagans S et al. | Repression by TTK69 of GAGA-mediated activation occurs in the absence of TTK69 binding to DNA and solely requires the contribution of the POZ/BTB domain of TTK69. | 2004 | J. Biol. Chem. | pmid:14701830 |
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| Brush MH et al. | Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases. | 2004 | J. Biol. Chem. | pmid:14670976 |
| Gray SG et al. | Microarray profiling of the effects of histone deacetylase inhibitors on gene expression in cancer cell lines. | 2004 | Int. J. Oncol. | pmid:15010814 |
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| Aapola U et al. | Epigenetic modifications affect Dnmt3L expression. | 2004 | Biochem. J. | pmid:15015937 |
| Burton GR et al. | Microarray analysis of differentiation-specific gene expression during 3T3-L1 adipogenesis. | 2004 | Gene | pmid:15033539 |
| David GL et al. | MDR1 promoter hypermethylation in MCF-7 human breast cancer cells: changes in chromatin structure induced by treatment with 5-Aza-cytidine. | 2004 | Cancer Biol. Ther. | pmid:15034303 |
| Liu X et al. | Nuclear factor Y regulation and promoter transactivation of human ribonucleotide reductase subunit M2 gene in a Gemcitabine resistant KB clone. | 2004 | Biochem. Pharmacol. | pmid:15041467 |
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| Emmans VC et al. | Regulation of cellular processes by PPARgamma ligands in neuroblastoma cells is modulated by the level of retinoblastoma protein expression. | 2004 | Biochem. Soc. Trans. | pmid:15494029 |
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| Glenn MP et al. | Antiproliferative and phenotype-transforming antitumor agents derived from cysteine. | 2004 | J. Med. Chem. | pmid:15163181 |
| Ronai D et al. | The epigenetic stability of the locus control region-deficient IgH locus in mouse hybridoma cells is a clonally varying, heritable feature. | 2004 | Genetics | pmid:15166165 |
| Zhang X et al. | Activation of the growth-differentiation factor 11 gene by the histone deacetylase (HDAC) inhibitor trichostatin A and repression by HDAC3. | 2004 | Mol. Cell. Biol. | pmid:15169878 |
| Chaturvedi V et al. | Resistance to UV-induced apoptosis in human keratinocytes during accelerated senescence is associated with functional inactivation of p53. | 2004 | J. Cell. Physiol. | pmid:14584049 |
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| Kim MK and Carroll WL | Autoregulation of the N-myc gene is operative in neuroblastoma and involves histone deacetylase 2. | 2004 | Cancer | pmid:15382088 |
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| Yokota T et al. | Trichostatin A activates p18INK4c gene: differential activation and cooperation with p19INK4d gene. | 2004 | FEBS Lett. | pmid:15358560 |
| Jansen MS et al. | Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15103026 |
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| Sanderson L et al. | Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice. | 2004 | Drug Metab. Dispos. | pmid:15269190 |
| Levenson JM et al. | Regulation of histone acetylation during memory formation in the hippocampus. | 2004 | J. Biol. Chem. | pmid:15273246 |
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| Marengo E et al. | Identification of the regulatory proteins in human pancreatic cancers treated with Trichostatin A by 2D-PAGE maps and multivariate statistical analysis. | 2004 | Anal Bioanal Chem | pmid:15257427 |
| Swank RA et al. | The histone deacetylase inhibitor, trichostatin A, reactivates the developmentally silenced gamma globin expression in somatic cell hybrids and induces gamma gene expression in adult BFUe cultures. | 2003 May-Jun | Blood Cells Mol. Dis. | pmid:12737942 |