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Inhibition of histone deacetylase activity by trichostatin A modulates gene expression during mouse embryogenesis without apparent toxicity. |
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Association of deletions and translocation of the reduced folate carrier gene with profound loss of gene expression in methotrexate-resistant K562 human erythroleukemia cells. |
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Biochem. Pharmacol. |
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Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells. |
2001 |
Proc. Natl. Acad. Sci. U.S.A. |
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Repressor element silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) can act as an enhancer as well as a repressor of corticotropin-releasing hormone gene transcription. |
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J. Biol. Chem. |
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Targeting of Krüppel-associated box-containing zinc finger proteins to centromeric heterochromatin. Implication for the gene silencing mechanisms. |
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The site of HIV-1 integration in the human genome determines basal transcriptional activity and response to Tat transactivation. |
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Paradoxical effects of trichostatin A: inhibition of NF-Y-associated histone acetyltransferase activity, phosphorylation of hGCN5 and downregulation of cyclin A and B1 mRNA. |
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Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo. |
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Magdinier F and Wolffe AP |
Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia. |
2001 |
Proc. Natl. Acad. Sci. U.S.A. |
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A functionally active RARalpha nuclear receptor is expressed in retinoic acid non responsive early myeloblastic cell lines. |
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Synergistic growth inhibition of prostate cancer cells by 1 alpha,25 Dihydroxyvitamin D(3) and its 19-nor-hexafluoride analogs in combination with either sodium butyrate or trichostatin A. |
2001 |
Oncogene |
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Negative regulation of bcl-2 expression by p53 in hematopoietic cells. |
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Oncogene |
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Reduction of telomerase activity in human liver cancer cells by a histone deacetylase inhibitor. |
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Reactivation of feline foamy virus from a chronically infected feline renal cell line by trichostatin A. |
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Virology |
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