Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Golyshev SA et al. | [The role of DNA methylation and histone modifications in structural maintainance of heterochromatin domains (chromocenters)]. | 2008 | Tsitologiia | pmid:19140344 |
Khan AN et al. | Histone deacetylase inhibitors induce TAP, LMP, Tapasin genes and MHC class I antigen presentation by melanoma cells. | 2008 | Cancer Immunol. Immunother. | pmid:18046553 |
Domingo-Domènech J et al. | Inactivation of NF-kappaB by proteasome inhibition contributes to increased apoptosis induced by histone deacetylase inhibitors in human breast cancer cells. | 2008 | Breast Cancer Res. Treat. | pmid:18064564 |
Li X et al. | The effects of trichostatin A on mRNA expression of chromatin structure-, DNA methylation-, and development-related genes in cloned mouse blastocysts. | 2008 | Cloning Stem Cells | pmid:18241125 |
Chou SD and Tomasi TB | Spatial distribution of histone methylation during MHC class II expression. | 2008 | Mol. Immunol. | pmid:17850872 |
Ragno R et al. | Class II-selective histone deacetylase inhibitors. Part 2: alignment-independent GRIND 3-D QSAR, homology and docking studies. | 2008 | Eur J Med Chem | pmid:17698257 |
Lin W et al. | Modulation of immunoglobulin gene conversion frequency and distribution by the histone deacetylase HDAC2 in chicken DT40. | 2008 | Genes Cells | pmid:18298800 |
Fan J et al. | ER alpha negative breast cancer cells restore response to endocrine therapy by combination treatment with both HDAC inhibitor and DNMT inhibitor. | 2008 | J. Cancer Res. Clin. Oncol. | pmid:18264725 |
Shi LH et al. | Trichostatin A (TSA) improves the development of rabbit-rabbit intraspecies cloned embryos, but not rabbit-human interspecies cloned embryos. | 2008 | Dev. Dyn. | pmid:18265023 |
Sasaki K et al. | Histone deacetylase inhibitors trichostatin A and valproic acid circumvent apoptosis in human leukemic cells expressing the RUNX1 chimera. | 2008 | Cancer Sci. | pmid:18271940 |
Moynihan AT et al. | Histone deacetylase inhibitors and a functional potent inhibitory effect on human uterine contractility. | 2008 | Am. J. Obstet. Gynecol. | pmid:18455134 |
Brown CR et al. | Global histone acetylation induces functional genomic reorganization at mammalian nuclear pore complexes. | 2008 | Genes Dev. | pmid:18316479 |
Mackay CL et al. | Sensitive, specific, and quantitative FTICR mass spectrometry of combinatorial post-translational modifications in intact histone H4. | 2008 | Anal. Chem. | pmid:18457408 |
Fleury L et al. | Eliminating epigenetic barriers induces transient hormone-regulated gene expression in estrogen receptor negative breast cancer cells. | 2008 | Oncogene | pmid:18317449 |
Muscolini M et al. | Trichostatin A up-regulates p73 and induces Bax-dependent apoptosis in cisplatin-resistant ovarian cancer cells. | 2008 | Mol. Cancer Ther. | pmid:18566213 |
Bieliauskas AV and Pflum MK | Isoform-selective histone deacetylase inhibitors. | 2008 | Chem Soc Rev | pmid:18568166 |
Zhang Y et al. | Unlocking repression of the human luteinizing hormone receptor gene by trichostatin A-induced cell-specific phosphatase release. | 2008 | J. Biol. Chem. | pmid:18596044 |
Xu LN et al. | Effect of histone deacetylase inhibitor on proliferation of biliary tract cancer cell lines. | 2008 | World J. Gastroenterol. | pmid:18442209 |
Pandey SC et al. | Brain chromatin remodeling: a novel mechanism of alcoholism. | 2008 | J. Neurosci. | pmid:18385331 |
Rebbaa A et al. | Novel function of the thyroid hormone analog tetraiodothyroacetic acid: a cancer chemosensitizing and anti-cancer agent. | 2008 | Angiogenesis | pmid:18386142 |
Henkens T et al. | Differential effects of hydroxamate histone deacetylase inhibitors on cellular functionality and gap junctions in primary cultures of mitogen-stimulated hepatocytes. | 2008 | Toxicol. Lett. | pmid:18358644 |
Wei Q et al. | [Effect of trichostatin A on proliferation and interleukin-2 expression of mouse T cells in mixed lymphocyte culture]. | 2008 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:18359716 |
Hämäläinen M et al. | Inhibition of iNOS expression and NO production by anti-inflammatory steroids. Reversal by histone deacetylase inhibitors. | 2008 | Pulm Pharmacol Ther | pmid:17913526 |
Svechnikova I et al. | HDAC inhibitors effectively induce cell type-specific differentiation in human glioblastoma cell lines of different origin. | 2008 | Int. J. Oncol. | pmid:18360709 |
Fontán-Lozano A et al. | Histone deacetylase inhibitors improve learning consolidation in young and in KA-induced-neurodegeneration and SAMP-8-mutant mice. | 2008 | Mol. Cell. Neurosci. | pmid:18638560 |
Mukherjee P et al. | Structural insights into the Plasmodium falciparum histone deacetylase 1 (PfHDAC-1): A novel target for the development of antimalarial therapy. | 2008 | Bioorg. Med. Chem. | pmid:18362073 |
Fabre C et al. | A novel effect of DNA methyltransferase and histone deacetylase inhibitors: NFkappaB inhibition in malignant myeloblasts. | 2008 | Cell Cycle | pmid:18641459 |
Brown SL et al. | Histone deacetylase inhibitors protect against and mitigate the lethality of total-body irradiation in mice. | 2008 | Radiat. Res. | pmid:18363436 |
Kozikowski AP et al. | Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6. | 2008 | J. Med. Chem. | pmid:18642892 |
Dow GS et al. | Antimalarial activity of phenylthiazolyl-bearing hydroxamate-based histone deacetylase inhibitors. | 2008 | Antimicrob. Agents Chemother. | pmid:18644969 |
Liu PY et al. | Modulation of the cyclin-dependent kinase inhibitor p21(WAF1/Cip1) gene by Zac1 through the antagonistic regulators p53 and histone deacetylase 1 in HeLa Cells. | 2008 | Mol. Cancer Res. | pmid:18644983 |
Roy S et al. | Array-based analysis of the effects of trichostatin A and CG-1521 on cell cycle and cell death in LNCaP prostate cancer cells. | 2008 | Mol. Cancer Ther. | pmid:18645003 |
Cheli Y et al. | Transcriptional and epigenetic regulation of the integrin collagen receptor locus ITGA1-PELO-ITGA2. | 2007 Sep-Oct | Biochim. Biophys. Acta | pmid:17669516 |
Yasuda K et al. | ERas oncogene expression and epigenetic regulation by histone acetylation in human cancer cells. | 2007 Nov-Dec | Anticancer Res. | pmid:18225573 |
Kuwajima A et al. | The histone deacetylase inhibitor butyrate inhibits melanoma cell invasion of Matrigel. | 2007 Nov-Dec | Anticancer Res. | pmid:18225587 |
Royo H et al. | Bsr, a nuclear-retained RNA with monoallelic expression. | 2007 | Mol. Biol. Cell | pmid:17507654 |
Lin T et al. | Histone deacetylase as therapeutic target in a rodent model of hemorrhagic shock: effect of different resuscitation strategies on lung and liver. | 2007 | Surgery | pmid:17560255 |
Bai L and Merchant JL | ATM phosphorylates ZBP-89 at Ser202 to potentiate p21waf1 induction by butyrate. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17560543 |
Rigamonti D et al. | Loss of huntingtin function complemented by small molecules acting as repressor element 1/neuron restrictive silencer element silencer modulators. | 2007 | J. Biol. Chem. | pmid:17565993 |
Huang JC et al. | Changes in histone acetylation during postovulatory aging of mouse oocyte. | 2007 | Biol. Reprod. | pmid:17582009 |
Lee S et al. | Design, synthesis, and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17588744 |
Castro-Galache MD et al. | Protein kinase C-alpha antagonizes apoptosis induction by histone deacetylase inhibitors in multidrug resistant leukaemia cells. | 2007 | Int. J. Biochem. Cell Biol. | pmid:17588800 |
Henkens T et al. | Trichostatin A, a critical factor in maintaining the functional differentiation of primary cultured rat hepatocytes. | 2007 | Toxicol. Appl. Pharmacol. | pmid:17125810 |
Nagashima T et al. | Histone acetylation and subcellular localization of chromosomal protein BRD4 during mouse oocyte meiosis and mitosis. | 2007 | Mol. Hum. Reprod. | pmid:17267518 |
Fang S et al. | Coordinated recruitment of histone methyltransferase G9a and other chromatin-modifying enzymes in SHP-mediated regulation of hepatic bile acid metabolism. | 2007 | Mol. Cell. Biol. | pmid:17145766 |
Sakuma M et al. | Promoter methylation status of the Cyclin D2 gene is associated with poor prognosis in human epithelial ovarian cancer. | 2007 | Cancer Sci. | pmid:17270028 |
Liu TX et al. | Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation. | 2007 | Nat. Med. | pmid:17159988 |
Yoshikawa M et al. | Inhibition of histone deacetylase activity suppresses epithelial-to-mesenchymal transition induced by TGF-beta1 in human renal epithelial cells. | 2007 | J. Am. Soc. Nephrol. | pmid:17135397 |
Ryningen A et al. | Clonogenic acute myelogenous leukemia cells are heterogeneous with regard to regulation of differentiation and effect of epigenetic pharmacological targeting. | 2007 | Leuk. Res. | pmid:17416413 |
Loudni L et al. | Design, synthesis and biological evaluation of 1,4-benzodiazepine-2,5-dione-based HDAC inhibitors. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17624773 |
Kato N et al. | Regulation of the expression of MHC class I-related chain A, B (MICA, MICB) via chromatin remodeling and its impact on the susceptibility of leukemic cells to the cytotoxicity of NKG2D-expressing cells. | 2007 | Leukemia | pmid:17625602 |
Bu Y and Gelman IH | v-Src-mediated down-regulation of SSeCKS metastasis suppressor gene promoter by the recruitment of HDAC1 into a USF1-Sp1-Sp3 complex. | 2007 | J. Biol. Chem. | pmid:17626016 |
Dombrowsky H and Uhlig S | Steroids and histone deacetylase in ventilation-induced gene transcription. | 2007 | Eur. Respir. J. | pmid:17626110 |
Zampetaki A et al. | Lacking cytokine production in ES cells and ES-cell-derived vascular cells stimulated by TNF-alpha is rescued by HDAC inhibitor trichostatin A. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17626239 |
Strobl JS et al. | Scriptaid and suberoylanilide hydroxamic acid are histone deacetylase inhibitors with potent anti-Toxoplasma gondii activity in vitro. | 2007 | J. Parasitol. | pmid:17626366 |
Ho AK et al. | Acetylation of histone H3 and adrenergic-regulated gene transcription in rat pinealocytes. | 2007 | Endocrinology | pmid:17628002 |
Tuncel M et al. | The comparative effects of gene modulators on thyroid-specific genes and radioiodine uptake. | 2007 | Cancer Biother. Radiopharm. | pmid:17679169 |
Gahr S et al. | The combination of the histone-deacetylase inhibitor trichostatin A and gemcitabine induces inhibition of proliferation and increased apoptosis in pancreatic carcinoma cells. | 2007 | Int. J. Oncol. | pmid:17671683 |
Tomita A et al. | Epigenetic regulation of CD20 protein expression in a novel B-cell lymphoma cell line, RRBL1, established from a patient treated repeatedly with rituximab-containing chemotherapy. | 2007 | Int. J. Hematol. | pmid:17675267 |
Wang J et al. | Histone deacetylase inhibitors suppress TF-kappaB-dependent agonist-driven tissue factor expression in endothelial cells and monocytes. | 2007 | J. Biol. Chem. | pmid:17675290 |
Di Renzo F et al. | Boric acid inhibits embryonic histone deacetylases: a suggested mechanism to explain boric acid-related teratogenicity. | 2007 | Toxicol. Appl. Pharmacol. | pmid:17320131 |
Xin C et al. | FTY720 suppresses interleukin-1beta-induced secretory phospholipase A2 expression in renal mesangial cells by a transcriptional mechanism. | 2007 | Br. J. Pharmacol. | pmid:17325654 |
Hishiki T et al. | BCL3 acts as a negative regulator of transcription from the human T-cell leukemia virus type 1 long terminal repeat through interactions with TORC3. | 2007 | J. Biol. Chem. | pmid:17644518 |
Wu Y et al. | Trichostatin A, a histone deacetylase inhibitor, attenuates invasiveness and reactivates E-cadherin expression in immortalized endometriotic cells. | 2007 | Reprod Sci | pmid:17644810 |
Mogal AP et al. | Haploinsufficient prostate tumor suppression by Nkx3.1: a role for chromatin accessibility in dosage-sensitive gene regulation. | 2007 | J. Biol. Chem. | pmid:17602165 |
Huber LC et al. | Trichostatin A prevents the accumulation of extracellular matrix in a mouse model of bleomycin-induced skin fibrosis. | 2007 | Arthritis Rheum. | pmid:17665426 |
Ishihara K et al. | Differentiation of eosinophilic leukemia EoL-1 cells into eosinophils induced by histone deacetylase inhibitors. | 2007 | Life Sci. | pmid:17258775 |
Putignano E et al. | Developmental downregulation of histone posttranslational modifications regulates visual cortical plasticity. | 2007 | Neuron | pmid:17329213 |
Vibhakar R et al. | Dickkopf-1 is an epigenetically silenced candidate tumor suppressor gene in medulloblastoma. | 2007 | Neuro-oncology | pmid:17329407 |
Pan L et al. | Histone deacetylase inhibitor trichostatin a potentiates doxorubicin-induced apoptosis by up-regulating PTEN expression. | 2007 | Cancer | pmid:17330857 |
Jamaluddin MD et al. | Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin A gene. | 2007 | Blood | pmid:17698632 |
Hong S et al. | Differential regulation of thrombospondin-1 expression and antiangiogenesis of ECV304 cells by trichostatin A and helixor A. | 2007 | Anticancer Drugs | pmid:17704650 |
Robertson DM et al. | Insulin-like Growth Factor Binding Protein-3 expression in the human corneal epithelium. | 2007 | Exp. Eye Res. | pmid:17709104 |
Chen WY et al. | Histone deacetylase inhibitors reduce steroidogenesis through SCF-mediated ubiquitination and degradation of steroidogenic factor 1 (NR5A1). | 2007 | Mol. Cell. Biol. | pmid:17709382 |
Kuang PP et al. | Activation of elastin transcription by transforming growth factor-beta in human lung fibroblasts. | 2007 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:17209135 |
D'Alessio AC et al. | Acetylation-induced transcription is required for active DNA demethylation in methylation-silenced genes. | 2007 | Mol. Cell. Biol. | pmid:17709385 |
Bazhin AV et al. | Expression of GAGE family proteins in malignant melanoma. | 2007 | Cancer Lett. | pmid:17194529 |
Tsaprouni LG et al. | Suppression of lipopolysaccharide- and tumour necrosis factor-alpha-induced interleukin (IL)-8 expression by glucocorticoids involves changes in IL-8 promoter acetylation. | 2007 | Clin. Exp. Immunol. | pmid:17711487 |
Markova NG et al. | Inhibition of histone deacetylation promotes abnormal epidermal differentiation and specifically suppresses the expression of the late differentiation marker profilaggrin. | 2007 | J. Invest. Dermatol. | pmid:17195011 |
Yasukawa K et al. | Histone deacetylase inhibitors preferentially augment transient transgene expression in human dermal fibroblasts. | 2007 | Br. J. Dermatol. | pmid:17711521 |
Fujita Y et al. | Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1. | 2007 | Dev. Cell | pmid:17199038 |
Frye M et al. | Epidermal stem cells are defined by global histone modifications that are altered by Myc-induced differentiation. | 2007 | PLoS ONE | pmid:17712411 |
Kovács P et al. | Effect of histone deacetylase inhibitor trichostatin A (TSA) on the microtubular system of Tetrahymena. | 2007 | Acta. Biol. Hung. | pmid:18277464 |
Wu P et al. | [Role of human telomerase reverse transcriptase in apoptosis of human umbilical vein endothelial cells induced by trichostatin A]. | 2007 | Zhonghua Zhong Liu Za Zhi | pmid:17892126 |
Akao Y et al. | Downregulation of microRNAs-143 and -145 in B-cell malignancies. | 2007 | Cancer Sci. | pmid:17892514 |
Murga M et al. | Global chromatin compaction limits the strength of the DNA damage response. | 2007 | J. Cell Biol. | pmid:17893239 |
Schnur N et al. | The histone deacetylase inhibitor trichostatin A mediates upregulation of 5-lipoxygenase promoter activity by recruitment of Sp1 to distinct GC-boxes. | 2007 | Biochim. Biophys. Acta | pmid:17894944 |
Oshima M et al. | Molecular mechanism of transcriptional repression of AhR repressor involving ANKRA2, HDAC4, and HDAC5. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17949687 |
Itoh Y et al. | Design, synthesis, structure--selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors. | 2007 | J. Med. Chem. | pmid:17929798 |
Pourebrahim R et al. | ZIC1 gene expression is controlled by DNA and histone methylation in mesenchymal proliferations. | 2007 | FEBS Lett. | pmid:17936758 |
Ondrousková E et al. | A proteomic analysis of protein variations during differentiation of v-myb-transformed monoblasts. | 2007 | Leuk. Res. | pmid:16930693 |
Li Y et al. | Regulation of neuronal nitric oxide synthase exon 1f gene expression by nuclear factor-kappaB acetylation in human neuroblastoma cells. | 2007 | J. Neurochem. | pmid:17250678 |
Suzuki T et al. | Identification of a potent and stable antiproliferative agent by the prodrug formation of a thiolate histone deacetylase inhibitor. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17257837 |
Scott SA et al. | Zebularine inhibits human acute myeloid leukemia cell growth in vitro in association with p15INK4B demethylation and reexpression. | 2007 | Exp. Hematol. | pmid:17258075 |
Hummel M et al. | Transcriptional reactivation of murine cytomegalovirus ie gene expression by 5-aza-2'-deoxycytidine and trichostatin A in latently infected cells despite lack of methylation of the major immediate-early promoter. | 2007 | J. Gen. Virol. | pmid:17374752 |
Appanah R et al. | An unmethylated 3' promoter-proximal region is required for efficient transcription initiation. | 2007 | PLoS Genet. | pmid:17305432 |
Bui HT et al. | Regulation of chromatin and chromosome morphology by histone H3 modifications in pig oocytes. | 2007 | Reproduction | pmid:17307905 |
Hattori N et al. | Epigenetic regulation of Nanog gene in embryonic stem and trophoblast stem cells. | 2007 | Genes Cells | pmid:17352742 |
Barr H et al. | Mbd2 contributes to DNA methylation-directed repression of the Xist gene. | 2007 | Mol. Cell. Biol. | pmid:17353271 |
Li B et al. | FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17360565 |