trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Hypertension D006973 115 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Hypesthesia D006987 1 associated lipids
Immunologic Deficiency Syndromes D007153 8 associated lipids
Inflammation D007249 119 associated lipids
Chromosome Inversion D007446 1 associated lipids
Keloid D007627 12 associated lipids
Leishmaniasis D007896 19 associated lipids
Leukemia D007938 74 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lupus Vulgaris D008177 1 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lymphatic Metastasis D008207 10 associated lipids
Lymphoma, Follicular D008224 3 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Medulloblastoma D008527 22 associated lipids
Melanoma D008545 69 associated lipids
Intellectual Disability D008607 13 associated lipids
Per page 10 20 50 100 | Total 139

PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


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Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Rosborough BR et al. Histone deacetylase inhibition facilitates GM-CSF-mediated expansion of myeloid-derived suppressor cells in vitro and in vivo. 2012 J. Leukoc. Biol. pmid:22028329
Tsuboi H et al. Epigenetic memory of DNAi associated with cytosine methylation and histone modification in fern. 2012 Plant Signal Behav pmid:22990449
Kerr JB et al. The primordial follicle reserve is not renewed after chemical or γ-irradiation mediated depletion. 2012 Reproduction pmid:22301887
Li H et al. Sodium butyrate stimulates expression of fibroblast growth factor 21 in liver by inhibition of histone deacetylase 3. 2012 Diabetes pmid:22338096
Bebenek IG et al. CYP2S1 is negatively regulated by corticosteroids in human cell lines. 2012 Toxicol. Lett. pmid:22155357
Sakuma Y et al. WZ4002, a third-generation EGFR inhibitor, can overcome anoikis resistance in EGFR-mutant lung adenocarcinomas more efficiently than Src inhibitors. 2012 Lab. Invest. pmid:22157722
Schor IE et al. Perturbation of chromatin structure globally affects localization and recruitment of splicing factors. 2012 PLoS ONE pmid:23152763
Jasek E et al. Effect of histone deacetylase inhibitors trichostatin A and valproic acid on etoposide-induced apoptosis in leukemia cells. 2012 Anticancer Res. pmid:22753739
Gan L et al. Histone deacetylases regulate gonadotropin-releasing hormone I gene expression via modulating Otx2-driven transcriptional activity. 2012 PLoS ONE pmid:22761896
Buurman R et al. Histone deacetylases activate hepatocyte growth factor signaling by repressing microRNA-449 in hepatocellular carcinoma cells. 2012 Gastroenterology pmid:22641068
Orlova DY et al. Arrangement of nuclear structures is not transmitted through mitosis but is identical in sister cells. 2012 J. Cell. Biochem. pmid:22644811
Pufahl L et al. Trichostatin A induces 5-lipoxygenase promoter activity and mRNA expression via inhibition of histone deacetylase 2 and 3. 2012 J. Cell. Mol. Med. pmid:21883892
Mehdi O et al. HDAC gene expression in pancreatic tumor cell lines following treatment with the HDAC inhibitors panobinostat (LBH589) and trichostatine (TSA). 2012 Mar-Apr Pancreatology pmid:22487525
Guo X et al. Histone deacetylase inhibitors promote mice corneal allograft survival through alteration of CD4+ effector T cells and induction of Foxp3+ regulatory T cells. 2012 May-Jun Cell. Immunol. pmid:22776176
Hou W et al. Hypoxia-induced deacetylation is required for tetraploid differentiation in response to testicular ischemia-reperfusion (IR) injury. 2012 Nov-Dec J. Androl. pmid:22556385
Darlyuk-Saadon I et al. The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members to the ATF3 promoter. 2012 Nov-Dec Biochim. Biophys. Acta pmid:22989952
Tang X et al. Protocadherin 10 is frequently downregulated by promoter methylation and functions as a tumor suppressor gene in non-small cell lung cancer. 2012-2013 Cancer Biomark pmid:23321465
Wilson DW et al. Defining the timing of action of antimalarial drugs against Plasmodium falciparum. 2013 Antimicrob. Agents Chemother. pmid:23318799
Wolf G et al. Epigenetic marking and repression of porcine endogenous retroviruses. 2013 J. Gen. Virol. pmid:23324470
Laska MJ et al. (Some) cellular mechanisms influencing the transcription of human endogenous retrovirus, HERV-Fc1. 2013 PLoS ONE pmid:23382858
Bhargavan B et al. Epigenetic repression of LEDGF during UVB exposure by recruitment of SUV39H1 and HDAC1 to the Sp1-responsive elements within LEDGF promoter CpG island. 2013 Epigenetics pmid:23386123
Peng L et al. Epigenetic inactivation of ADAMTS9 via promoter methylation in multiple myeloma. 2013 Mol Med Rep pmid:23358566
Corvetta D et al. Physical interaction between MYCN oncogene and polycomb repressive complex 2 (PRC2) in neuroblastoma: functional and therapeutic implications. 2013 J. Biol. Chem. pmid:23362253
Dhawan D et al. DNMT1: an emerging target in the treatment of invasive urinary bladder cancer. 2013 Urol. Oncol. pmid:22609058
Oikawa M et al. RNAi-mediated knockdown of Xist does not rescue the impaired development of female cloned mouse embryos. 2013 J. Reprod. Dev. pmid:23363561
Dagnas M et al. HDAC inhibition facilitates the switch between memory systems in young but not aged mice. 2013 J. Neurosci. pmid:23365234
Fernandez G et al. Targeting IκB proteins for HIV latency activation: the role of individual IκB and NF-κB proteins. 2013 J. Virol. pmid:23365428
Meng F et al. Anticancer efficacy of cisplatin and trichostatin A or 5-aza-2'-deoxycytidine on ovarian cancer. 2013 Br. J. Cancer pmid:23370212
Wang Z et al. Arabidopsis paired amphipathic helix proteins SNL1 and SNL2 redundantly regulate primary seed dormancy via abscisic acid-ethylene antagonism mediated by histone deacetylation. 2013 Plant Cell pmid:23371947
Tran L et al. Importance of epigenetic mechanisms in visceral pain induced by chronic water avoidance stress. 2013 Psychoneuroendocrinology pmid:23084728
Su SF et al. miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer. 2013 Oncogene pmid:23085757
Ziesché E et al. The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB. 2013 Nucleic Acids Res. pmid:23087373
Eriksson I et al. The histone deacetylase inhibitor trichostatin A reduces lysosomal pH and enhances cisplatin-induced apoptosis. 2013 Exp. Cell Res. pmid:23063877
Seuter S et al. Chromatin acetylation at transcription start sites and vitamin D receptor binding regions relates to effects of 1α,25-dihydroxyvitamin D3 and histone deacetylase inhibitors on gene expression. 2013 Nucleic Acids Res. pmid:23093607
Jin H et al. HDAC inhibitor trichostatin A promotes proliferation and odontoblast differentiation of human dental pulp stem cells. 2013 Tissue Eng Part A pmid:23013422
Duncan HF et al. Histone deacetylase inhibitors epigenetically promote reparative events in primary dental pulp cells. 2013 Exp. Cell Res. pmid:23562654
Wang Y et al. Role of histone deacetylase inhibitors in the aging of human umbilical cord mesenchymal stem cells. 2013 J. Cell. Biochem. pmid:23564418
Höring E et al. The histone deacetylase inhibitor trichostatin a promotes apoptosis and antitumor immunity in glioblastoma cells. 2013 Anticancer Res. pmid:23564772
Chen CH et al. Synergistic effect of trichostatin A and scriptaid on the development of cloned rabbit embryos. 2013 Theriogenology pmid:23566670
Sato A et al. Suppressive effect of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) on hepatitis C virus replication. 2013 J. Cell. Biochem. pmid:23519646
Wang Y et al. Nuclear factor κB mediates suppression of canonical transient receptor potential 6 expression by reactive oxygen species and protein kinase C in kidney cells. 2013 J. Biol. Chem. pmid:23525112
Sato T et al. Enhancement of inflammatory protein expression and nuclear factor Κb (NF-Κb) activity by trichostatin A (TSA) in OP9 preadipocytes. 2013 PLoS ONE pmid:23555753
Mateen S et al. Silibinin synergizes with histone deacetylase and DNA methyltransferase inhibitors in upregulating E-cadherin expression together with inhibition of migration and invasion of human non-small cell lung cancer cells. 2013 J. Pharmacol. Exp. Ther. pmid:23461975
Chambliss AB et al. Simultaneously defining cell phenotypes, cell cycle, and chromatin modifications at single-cell resolution. 2013 FASEB J. pmid:23538711
Wang YG et al. Mechanisms of trichostatin A inhibiting AGS proliferation and identification of lysine-acetylated proteins. 2013 World J. Gastroenterol. pmid:23745024
Guo SW et al. Dysmenorrhea and its severity are associated with increased uterine contractility and overexpression of oxytocin receptor (OTR) in women with symptomatic adenomyosis. 2013 Fertil. Steril. pmid:22999795
Pitta CA et al. Reversal of ER-β silencing by chromatin modifying agents overrides acquired tamoxifen resistance. 2013 Cancer Lett. pmid:23752064
Zhang C et al. Decreased PADI4 mRNA association with global hypomethylation in hepatocellular carcinoma during HBV exposure. 2013 Cell Biochem. Biophys. pmid:22907585
Van Beneden K et al. Comparison of trichostatin A and valproic acid treatment regimens in a mouse model of kidney fibrosis. 2013 Toxicol. Appl. Pharmacol. pmid:23707763
Meng F et al. Inhibition of DNA methyltransferases, histone deacetylases and lysine-specific demethylase-1 suppresses the tumorigenicity of the ovarian cancer ascites cell line SKOV3. 2013 Int. J. Oncol. pmid:23709006
Jang SM et al. Transcription factor Sox4 is required for PUMA-mediated apoptosis induced by histone deacetylase inhibitor, TSA. 2013 Biochem. Biophys. Res. Commun. pmid:23916609
Luo C et al. Treatment of donor cells with trichostatin A improves in vitro development and reprogramming of buffalo (Bubalus bubalis) nucleus transfer embryos. 2013 Theriogenology pmid:24007823
Lauffer BE et al. Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability. 2013 J. Biol. Chem. pmid:23897821
Lu JC et al. Trichostatin A modulates thiazolidinedione-mediated suppression of tumor necrosis factor α-induced lipolysis in 3T3-L1 adipocytes. 2013 PLoS ONE pmid:23951179
Seo J et al. Trichostatin A epigenetically increases calpastatin expression and inhibits calpain activity and calcium-induced SH-SY5Y neuronal cell toxicity. 2013 FEBS J. pmid:24200051
Chandwani S et al. Induction of DARPP-32 by brain-derived neurotrophic factor in striatal neurons in vitro is modified by histone deacetylase inhibitors and Nab2. 2013 PLoS ONE pmid:24204683
Liesz A et al. Boosting regulatory T cells limits neuroinflammation in permanent cortical stroke. 2013 J. Neurosci. pmid:24174668
Wu DS et al. Epigallocatechin-3-gallate and trichostatin A synergistically inhibit human lymphoma cell proliferation through epigenetic modification of p16INK4a. 2013 Oncol. Rep. pmid:24064951
Feng L et al. Histone deacetylase 3 inhibits expression of PUMA in gastric cancer cells. 2013 J. Mol. Med. pmid:22763818
Kadiyala V et al. Class I lysine deacetylases facilitate glucocorticoid-induced transcription. 2013 J. Biol. Chem. pmid:23946490
Itoh M et al. Trichostatin A enhances glutamate transporter GLT-1 mRNA levels in C6 glioma cells via neurosteroid-mediated cell differentiation. 2013 J. Mol. Neurosci. pmid:22711563
Fujiki R et al. A proapoptotic effect of valproic acid on progenitors of embryonic stem cell-derived glutamatergic neurons. 2013 Cell Death Dis pmid:23788034
Chang X et al. DNA methylation of NDRG2 in gastric cancer and its clinical significance. 2013 Dig. Dis. Sci. pmid:23010743
Li KK et al. MiR-383 is downregulated in medulloblastoma and targets peroxiredoxin 3 (PRDX3). 2013 Brain Pathol. pmid:23227829
Matsubara K et al. Dynamics and regulation of lysine-acetylation during one-cell stage mouse embryos. 2013 Biochem. Biophys. Res. Commun. pmid:23567968
Duo J et al. Metformin synergistically enhances antitumor activity of histone deacetylase inhibitor trichostatin a against osteosarcoma cell line. 2013 DNA Cell Biol. pmid:23451817
Han B et al. Trichostatin A stabilizes the expression of pluripotent genes in human mesenchymal stem cells during ex vivo expansion. 2013 PLoS ONE pmid:24312356
Katsuno M et al. [Dysfunction of dynactin 1 in motor neuron degeneration]. 2013 Rinsho Shinkeigaku pmid:24291886
Ning SF et al. Methylation characteristics and developmental potential of Guangxi Bama minipig (Sus scrofa domestica) cloned embryos from donor cells treated with trichostatin A and 5-aza-2'-deoxycytidine. 2013 Zygote pmid:22355002
Wang P et al. Trichostatin A protects against cisplatin-induced ototoxicity by regulating expression of genes related to apoptosis and synaptic function. 2013 Neurotoxicology pmid:23558232
Yeo M et al. Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23440186
Zhang L et al. Effect of histone deacetylase inhibitors on cell apoptosis and expression of the tumor suppressor genes RUNX3 and ARHI in ovarian tumors. 2013 Mol Med Rep pmid:23504001
Tran HT et al. Improved therapeutic effect against leukemia by a combination of the histone methyltransferase inhibitor chaetocin and the histone deacetylase inhibitor trichostatin A. 2013 J. Korean Med. Sci. pmid:23400519
Cho JS et al. Effects of histone deacetylase inhibitor on extracellular matrix production in human nasal polyp organ cultures. 2013 Am J Rhinol Allergy pmid:23406592
Miyatake Y et al. Protective roles of epithelial cells in the survival of adult T-cell leukemia/lymphoma cells. 2013 Am. J. Pathol. pmid:23474084
Hansberg-Pastor V et al. The role of DNA methylation and histone acetylation in the regulation of progesterone receptor isoforms expression in human astrocytoma cell lines. 2013 Steroids pmid:23474171
Biernacka KM et al. Hyperglycaemia-induced chemoresistance of prostate cancer cells due to IGFBP2. 2013 Endocr. Relat. Cancer pmid:23959956
Arora DS et al. Hyposensitivity to gamma-aminobutyric acid in the ventral tegmental area during alcohol withdrawal: reversal by histone deacetylase inhibitors. 2013 Neuropsychopharmacology pmid:23474591
Lee AR et al. Nicotinamide: a class III HDACi delays in vitro aging of mouse oocytes. 2013 J. Reprod. Dev. pmid:23474603
Chatterjee N et al. Histone deacetylase inhibitors modulate miRNA and mRNA expression, block metaphase, and induce apoptosis in inflammatory breast cancer cells. 2013 Cancer Biol. Ther. pmid:23792638
Zych J et al. The epigenetic modifiers 5-aza-2'-deoxycytidine and trichostatin A influence adipocyte differentiation in human mesenchymal stem cells. 2013 Braz. J. Med. Biol. Res. pmid:23797495
Guo LH et al. The Tumor Suppressor Roles of miR-433 and miR-127 in Gastric Cancer. 2013 Int J Mol Sci pmid:23880861
Jo SJ et al. Valproic acid promotes human hair growth in in vitro culture model. 2013 J. Dermatol. Sci. pmid:23810771
Huang L et al. Down-regulation of miR-301a suppresses pro-inflammatory cytokines in Toll-like receptor-triggered macrophages. 2013 Immunology pmid:23808420
Keuser B et al. Influences of histone deacetylase inhibitors and resveratrol on DNA repair and chromatin compaction. 2013 Mutagenesis pmid:23814181
Shim SH et al. Histone deacetylase inhibitors suppress coxsackievirus B3 growth in vitro and myocarditis induced in mice. 2013 Acta Virol. pmid:24294962
Oleksiewicz U et al. Cytoglobin has bimodal: tumour suppressor and oncogene functions in lung cancer cell lines. 2013 Hum. Mol. Genet. pmid:23591990
Breuzard G et al. Molecular mechanisms of Tau binding to microtubules and its role in microtubule dynamics in live cells. 2013 J. Cell. Sci. pmid:23659998
Matteucci E et al. Epigenetic control of endothelin-1 axis affects invasiveness of breast carcinoma cells with bone tropism. 2013 Exp. Cell Res. pmid:23660387
Ignatius MS et al. Distinct functional and temporal requirements for zebrafish Hdac1 during neural crest-derived craniofacial and peripheral neuron development. 2013 PLoS ONE pmid:23667588
Webster SJ et al. Regulation of GTP-binding protein (Gαs) expression in human myometrial cells: a role for tumor necrosis factor in modulating Gαs promoter acetylation by transcriptional complexes. 2013 J. Biol. Chem. pmid:23297421
Lee MS et al. Stabilization of p21 (Cip1/WAF1) following Tip60-dependent acetylation is required for p21-mediated DNA damage response. 2013 Cell Death Differ. pmid:23238566
Kamiya H et al. Enhanced transgene expression from chromatinized plasmid DNA in mouse liver. 2013 Int J Pharm pmid:23247018
Yang L et al. Trichostatin A inhibits transforming growth factor-β-induced reactive oxygen species accumulation and myofibroblast differentiation via enhanced NF-E2-related factor 2-antioxidant response element signaling. 2013 Mol. Pharmacol. pmid:23284002
Zhang S et al. Effect of trichostatin A and paclitaxel on the proliferation and apoptosis of lung adenocarcinoma cells. 2013 Chin. Med. J. pmid:23286491
Gao C et al. Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex. 2013 Blood pmid:23287862
Marek L et al. Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells. 2013 J. Med. Chem. pmid:23252603
Li KK et al. MIR-137 suppresses growth and invasion, is downregulated in oligodendroglial tumors and targets CSE1L. 2013 Brain Pathol. pmid:23252729
Chen CQ et al. Histone deacetylases inhibitor trichostatin A increases the expression of Dleu2/miR-15a/16-1 via HDAC3 in non-small cell lung cancer. 2013 Mol. Cell. Biochem. pmid:23867991
Chan ST et al. Quercetin enhances the antitumor activity of trichostatin A through upregulation of p53 protein expression in vitro and in vivo. 2013 PLoS ONE pmid:23342112