Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Viñuelas J et al. | Towards experimental manipulation of stochasticity in gene expression. | 2012 | Prog. Biophys. Mol. Biol. | pmid:22609563 |
Zhao ZN et al. | TSA suppresses miR-106b-93-25 cluster expression through downregulation of MYC and inhibits proliferation and induces apoptosis in human EMC. | 2012 | PLoS ONE | pmid:23028803 |
Tomosugi M et al. | Retinoblastoma gene-independent G1 phase arrest by flavone, phosphatidylinositol 3-kinase inhibitor, and histone deacetylase inhibitor. | 2012 | Cancer Sci. | pmid:22957647 |
Vadnal J et al. | Transcriptional signatures mediated by acetylation overlap with early-stage Alzheimer's disease. | 2012 | Exp Brain Res | pmid:22811216 |
Lin KT et al. | HDAC inhibitors augmented cell migration and metastasis through induction of PKCs leading to identification of low toxicity modalities for combination cancer therapy. | 2012 | Clin. Cancer Res. | pmid:22811583 |
Fleiss B et al. | Neuroprotection by the histone deacetylase inhibitor trichostatin A in a model of lipopolysaccharide-sensitised neonatal hypoxic-ischaemic brain injury. | 2012 | J Neuroinflammation | pmid:22512781 |
Yang PM et al. | CD1d induction in solid tumor cells by histone deacetylase inhibitors through inhibition of HDAC1/2 and activation of Sp1. | 2012 | Epigenetics | pmid:22419072 |
Mostovich LA et al. | Integrin alpha9 (ITGA9) expression and epigenetic silencing in human breast tumors. | 2011 Sep-Oct | Cell Adh Migr | pmid:21975548 |
Stepanek I et al. | Effects of 5-azacytidine and trichostatin A on dendritic cell maturation. | 2011 Oct-Dec | J. Biol. Regul. Homeost. Agents | pmid:22217985 |
Kee HJ et al. | Trichostatin A prevents neointimal hyperplasia via activation of Krüppel like factor 4. | 2011 Nov-Dec | Vascul. Pharmacol. | pmid:21763782 |
Meng CF et al. | DNA demethylation is superior to histone acetylation for reactivating cancer-associated genes in ovarian cancer cells. | 2011 Nov-Dec | Mol Med Rep | pmid:21850374 |
Cowell IG et al. | Histone deacetylase inhibition redistributes topoisomerase IIβ from heterochromatin to euchromatin. | 2011 Jan-Feb | Nucleus | pmid:21647300 |
Arany I et al. | Epigenetic modifiers exert renal toxicity through induction of p66shc. | 2011 | Anticancer Res. | pmid:21965735 |
Sasaki Y et al. | p53 negatively regulates the hepatoma growth factor HDGF. | 2011 | Cancer Res. | pmid:22006999 |
Aoyama K et al. | Nuclear c-Abl-mediated tyrosine phosphorylation induces chromatin structural changes through histone modifications that include H4K16 hypoacetylation. | 2011 | Exp. Cell Res. | pmid:22001646 |
Jeon HG et al. | Induction of caspase mediated apoptosis and down-regulation of nuclear factor-κB and Akt signaling are involved in the synergistic antitumor effect of gemcitabine and the histone deacetylase inhibitor trichostatin A in human bladder cancer cells. | 2011 | J. Urol. | pmid:21944112 |
Hirata H et al. | Wnt antagonist DKK1 acts as a tumor suppressor gene that induces apoptosis and inhibits proliferation in human renal cell carcinoma. | 2011 | Int. J. Cancer | pmid:20549706 |
Jafari S et al. | Epigenetic modification does not determine the time of POU5F1 transcription activation in cloned bovine embryos. | 2011 | J. Assist. Reprod. Genet. | pmid:22020531 |
Tseng AS et al. | HDAC activity is required during Xenopus tail regeneration. | 2011 | PLoS ONE | pmid:22022609 |
Rajak H et al. | 2,5-Disubstituted-1,3,4-oxadiazoles/thiadiazole as surface recognition moiety: design and synthesis of novel hydroxamic acid based histone deacetylase inhibitors. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21875796 |
He HM et al. | [The effects of a histone deacetylase (HDAC) inhibitor on endotoxin-induced endothelial cell injury]. | 2011 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:22005560 |
Sanders YY et al. | Epigenetic regulation of thy-1 by histone deacetylase inhibitor in rat lung fibroblasts. | 2011 | Am. J. Respir. Cell Mol. Biol. | pmid:20724553 |
Acun T et al. | SIP1 is downregulated in hepatocellular carcinoma by promoter hypermethylation. | 2011 | BMC Cancer | pmid:21645397 |
Hou J et al. | Structure-based optimization of click-based histone deacetylase inhibitors. | 2011 | Eur J Med Chem | pmid:21621883 |
Gaub P et al. | The histone acetyltransferase p300 promotes intrinsic axonal regeneration. | 2011 | Brain | pmid:21705428 |
Song K et al. | Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3B1, a novel epithelial-mesenchymal transition inducer in pancreatic cancer. | 2011 | Cancer Biol. Ther. | pmid:21709440 |
Hauff KD et al. | Mifepristone treatment results in differential regulation of glycerolipid biosynthesis in baby hamster kidney cells expressing a mifepristone-inducible ABCA1. | 2011 | Lipids | pmid:21710238 |
Zhou S et al. | Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction. | 2011 | Circ. Res. | pmid:21778425 |
Yoo YE and Ko CP | Treatment with trichostatin A initiated after disease onset delays disease progression and increases survival in a mouse model of amyotrophic lateral sclerosis. | 2011 | Exp. Neurol. | pmid:21712032 |
Sar P et al. | 3, 3'5 Triiodo L thyronine induces apoptosis in human breast cancer MCF-7 cells, repressing SMP30 expression through negative thyroid response elements. | 2011 | PLoS ONE | pmid:21687737 |
Cosner CC and Helquist P | Concise, convergent syntheses of (±)-trichostatin A utilizing a Pd-catalyzed ketone enolate α-alkenylation reaction. | 2011 | Org. Lett. | pmid:21688856 |
Kojima S et al. | Asymmetric leaves2 and Elongator, a histone acetyltransferase complex, mediate the establishment of polarity in leaves of Arabidopsis thaliana. | 2011 | Plant Cell Physiol. | pmid:21700721 |
Chik CL et al. | Histone modifications on the adrenergic induction of type II deiodinase in rat pinealocytes. | 2011 | Mol. Cell. Endocrinol. | pmid:21704117 |
Zhang L et al. | ABA treatment of germinating maize seeds induces VP1 gene expression and selective promoter-associated histone acetylation. | 2011 | Physiol Plant | pmid:21679193 |
Lin S et al. | HIV-1 reactivation induced by apicidin involves histone modification in latently infected cells. | 2011 | Curr. HIV Res. | pmid:21631428 |
Jugová A et al. | Effects of epigenetic-based anti-cancer drugs in leukaemia and multiple myeloma cells. | 2011 | Cell Biol. Int. | pmid:21635225 |
Wong CY et al. | Epigenetic regulation of phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 gene expression in prostate cancer cells. | 2011 | J. Biol. Chem. | pmid:21636851 |
Hayashi-Takanaka Y et al. | Tracking epigenetic histone modifications in single cells using Fab-based live endogenous modification labeling. | 2011 | Nucleic Acids Res. | pmid:21576221 |
Qian Y et al. | DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiation. | 2011 | J. Biol. Chem. | pmid:21317427 |
Zhang F et al. | Role of HDAC3 on p53 expression and apoptosis in T cells of patients with multiple sclerosis. | 2011 | PLoS ONE | pmid:21346816 |
Hizaki K et al. | Epigenetic inactivation of calcium-sensing receptor in colorectal carcinogenesis. | 2011 | Mod. Pathol. | pmid:21317879 |
Zhou X et al. | Trichostatin differentially regulates Th1 and Th2 responses and alleviates rheumatoid arthritis in mice. | 2011 | J. Clin. Immunol. | pmid:21305388 |
Meli M et al. | Histone deacetylase inhibition modulates deoxyribonucleotide pools and enhances the antitumor effects of the ribonucleotide reductase inhibitor 3'-C-methyladenosine in leukaemia cells. | 2011 | Int. J. Oncol. | pmid:21318222 |
Turovets N et al. | Human parthenogenetic stem cells produce enriched populations of definitive endoderm cells after trichostatin A pretreatment. | 2011 | Differentiation | pmid:21306817 |
Xiao J et al. | Discovery, synthesis, and biological evaluation of novel SMN protein modulators. | 2011 | J. Med. Chem. | pmid:21819082 |
Yang H et al. | Enrichment of Nur77 mediated by retinoic acid receptor β leads to apoptosis of human hepatocellular carcinoma cells induced by fenretinide and histone deacetylase inhibitors. | 2011 | Hepatology | pmid:21319187 |
Patel T et al. | Chromatin remodeling resets the immune system to protect against autoimmune diabetes in mice. | 2011 | Immunol. Cell Biol. | pmid:21321581 |
Chaurasia P et al. | Chromatin-modifying agents promote the ex vivo production of functional human erythroid progenitor cells. | 2011 | Blood | pmid:21355088 |
Shi G et al. | The regulatory role of histone deacetylase inhibitors in Fgf4 expression is dependent on the differentiation state of pluripotent stem cells. | 2011 | J. Cell. Physiol. | pmid:21321941 |
Furuta K et al. | The CKH2/PKL chromatin remodeling factor negatively regulates cytokinin responses in Arabidopsis calli. | 2011 | Plant Cell Physiol. | pmid:21357580 |
Fan Y et al. | Derivation of cloned human blastocysts by histone deacetylase inhibitor treatment after somatic cell nuclear transfer with β-thalassemia fibroblasts. | 2011 | Stem Cells Dev. | pmid:21322785 |
Kim YJ et al. | Comparison of potency between histone deacetylase inhibitors trichostatin A and valproic acid on enhancing in vitro development of porcine somatic cell nuclear transfer embryos. | 2011 | In Vitro Cell. Dev. Biol. Anim. | pmid:21359816 |
Jang ER et al. | Different effect of protein kinase B/Akt and extracellular signal-regulated kinase inhibition on trichostatin A-induced apoptosis in epithelial ovarian carcinoma cell lines. | 2011 | Mol. Cell. Biochem. | pmid:21380726 |
Fan T et al. | EZH2-dependent suppression of a cellular senescence phenotype in melanoma cells by inhibition of p21/CDKN1A expression. | 2011 | Mol. Cancer Res. | pmid:21383005 |
Yang J et al. | [Study of RASSF1A expression and promoter demethylation in Hep-2 cell line]. | 2011 | Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi | pmid:21473137 |
Cui XS et al. | Trichostatin A modulates apoptotic-related gene expression and improves embryo viability in cloned bovine embryos. | 2011 | Cell Reprogram | pmid:21473694 |
Chen X et al. | Design, synthesis and biological evaluation of hydroxamic acid derivatives as potential high density lipoprotein (HDL) receptor CLA-1 up-regulating agents. | 2011 | Molecules | pmid:22048700 |
Sun JY et al. | Histone deacetylase inhibitors demonstrate significant preclinical activity as single agents, and in combination with bortezomib in Waldenström's macroglobulinemia. | 2011 | Clin Lymphoma Myeloma Leuk | pmid:21454220 |
Kong QR et al. | [TSA improve transgenic porcine cloned embryo development and transgene expression]. | 2011 | Yi Chuan | pmid:22049689 |
Min XJ et al. | Dysfunction of volume-sensitive chloride channels contributes to cisplatin resistance in human lung adenocarcinoma cells. | 2011 | Exp. Biol. Med. (Maywood) | pmid:21454376 |
Belakavadi M et al. | Thyroid hormone suppression of β-amyloid precursor protein gene expression in the brain involves multiple epigenetic regulatory events. | 2011 | Mol. Cell. Endocrinol. | pmid:21458529 |
Dávalos-Salas M et al. | Gain of DNA methylation is enhanced in the absence of CTCF at the human retinoblastoma gene promoter. | 2011 | BMC Cancer | pmid:21663659 |
El-Serafi AT et al. | Epigenetic modifiers influence lineage commitment of human bone marrow stromal cells: Differential effects of 5-aza-deoxycytidine and trichostatin A. | 2011 | Differentiation | pmid:20970916 |
Zelko IN et al. | Histone acetylation regulates the cell-specific and interferon-γ-inducible expression of extracellular superoxide dismutase in human pulmonary arteries. | 2011 | Am. J. Respir. Cell Mol. Biol. | pmid:21493784 |
Zhang FQ et al. | Cell-cycle-dependent variations in the FTIR spectroscopy of HeLa cells treated with trichostatin A. | 2011 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:22007388 |
da Costa Prando E et al. | Evidence of epigenetic regulation of the tumor suppressor gene cluster flanking RASSF1 in breast cancer cell lines. | 2011 | Epigenetics | pmid:22139571 |
Nagamine MK et al. | In vitro inhibitory effect of trichostatin A on canine grade 3 mast cell tumor. | 2011 | Vet. Res. Commun. | pmid:21472452 |
Maruoka H et al. | Low-molecular-weight compounds having neurotrophic activity in cultured PC12 cells and neurons. | 2011 | J. Biochem. | pmid:21908547 |
Biermann J et al. | Histone deacetylase inhibitors sodium butyrate and valproic acid delay spontaneous cell death in purified rat retinal ganglion cells. | 2011 | Mol. Vis. | pmid:21311741 |
Li S et al. | Autotaxin is induced by TSA through HDAC3 and HDAC7 inhibition and antagonizes the TSA-induced cell apoptosis. | 2011 | Mol. Cancer | pmid:21314984 |
Zhang CZ et al. | Trichostatin A sensitizes HBx-expressing liver cancer cells to etoposide treatment. | 2011 | Apoptosis | pmid:21468663 |
Chen YT et al. | Isolation of mesenchymal stem cells from human ligamentum flavum: implicating etiology of ligamentum flavum hypertrophy. | 2011 | Spine | pmid:21343850 |
Lee MJ et al. | Trichostatin A promotes the development of bovine somatic cell nuclear transfer embryos. | 2011 | J. Reprod. Dev. | pmid:20834196 |
Amoêdo ND et al. | Energy metabolism in H460 lung cancer cells: effects of histone deacetylase inhibitors. | 2011 | PLoS ONE | pmid:21789245 |
Sengupta S et al. | Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1. | 2011 | Oncogene | pmid:20856196 |
Arzenani MK et al. | Genomic DNA hypomethylation by histone deacetylase inhibition implicates DNMT1 nuclear dynamics. | 2011 | Mol. Cell. Biol. | pmid:21791605 |
Costa VL et al. | TCF21 and PCDH17 methylation: An innovative panel of biomarkers for a simultaneous detection of urological cancers. | 2011 | Epigenetics | pmid:21847011 |
Akagi S et al. | Treatment with a histone deacetylase inhibitor after nuclear transfer improves the preimplantation development of cloned bovine embryos. | 2011 | J. Reprod. Dev. | pmid:20962457 |
Fu S et al. | Involvement of histone acetylation of Sox17 and Foxa2 promoters during mouse definitive endoderm differentiation revealed by microRNA profiling. | 2011 | PLoS ONE | pmid:22132182 |
Mayor R et al. | Dynamics of bivalent chromatin domains upon drug induced reactivation and resilencing in cancer cells. | 2011 | Epigenetics | pmid:21852760 |
Kumar A et al. | γ-radiation induces cellular sensitivity and aberrant methylation in human tumor cell lines. | 2011 | Int. J. Radiat. Biol. | pmid:21815748 |
Tan L et al. | Trichostatin A restores Apaf-1 function in chemoresistant ovarian cancer cells. | 2011 | Cancer | pmid:20925046 |
Jackson K et al. | Epigenetic silencing of somatostatin in gastric cancer. | 2011 | Dig. Dis. Sci. | pmid:20927589 |
Sahu GK and Cloyd MW | Latent HIV in primary T lymphocytes is unresponsive to histone deacetylase inhibitors. | 2011 | Virol. J. | pmid:21838863 |
Yu D et al. | Clonal Rett Syndrome cell lines to test compounds for activation of wild-type MeCP2 expression. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21840716 |
Atanackovic D et al. | Cancer-testis antigen expression and its epigenetic modulation in acute myeloid leukemia. | 2011 | Am. J. Hematol. | pmid:21898529 |
Paterson S et al. | Histone deacetylase inhibitors increase human arylamine N-acetyltransferase-1 expression in human tumor cells. | 2011 | Drug Metab. Dispos. | pmid:20870783 |
Puppin C et al. | In thyroid cancer cell lines expression of periostin gene is controlled by p73 and is not related to epigenetic marks of active transcription. | 2011 | Cell Oncol (Dordr) | pmid:21290209 |
Ishiguro K et al. | Cutting edge: tubulin α functions as an adaptor in NFAT-importin β interaction. | 2011 | J. Immunol. | pmid:21278340 |
Ma AN et al. | Histone deacetylation directs DNA methylation in survivin gene silencing. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21130077 |
Pianta A et al. | Nucleophosmin delocalization in thyroid tumour cells. | 2011 | Endocr. Pathol. | pmid:21258971 |
Gómez MC et al. | Trichostatin A modified histone covalent pattern and enhanced expression of pluripotent genes in interspecies black-footed cat cloned embryos but did not improve in vitro and in vivo viability. | 2011 | Cell Reprogram | pmid:21718106 |
Whitehead L et al. | Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors. | 2011 | Bioorg. Med. Chem. | pmid:21723733 |
Yin H et al. | Histonedeacetylase inhibitor Oxamflatin increase HIV-1 transcription by inducing histone modification in latently infected cells. | 2011 | Mol. Biol. Rep. | pmid:21181272 |
Stoppani E et al. | Point mutated caveolin-3 form (P104L) impairs myoblast differentiation via Akt and p38 signalling reduction, leading to an immature cell signature. | 2011 | Biochim. Biophys. Acta | pmid:21182936 |
Puppin C et al. | Histone deacetylase inhibitors control the transcription and alternative splicing of prohibitin in thyroid tumor cells. | 2011 | Oncol. Rep. | pmid:21152868 |
Tsai PF et al. | Interplay between PKCδ and Sp1 on histone deacetylase inhibitor-mediated Epstein-Barr virus reactivation. | 2011 | J. Virol. | pmid:21159880 |
Nandakumar V et al. | (-)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells. | 2011 | Carcinogenesis | pmid:21209038 |
Kang H and Roh S | Extended exposure to trichostatin A after activation alters the expression of genes important for early development in nuclear transfer murine embryos. | 2011 | J. Vet. Med. Sci. | pmid:21187677 |
Mitmaker EJ et al. | Modulation of matrix metalloproteinase activity in human thyroid cancer cell lines using demethylating agents and histone deacetylase inhibitors. | 2011 | Surgery | pmid:21193210 |