Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Li L et al. | In Vivo Screening Using Transgenic Zebrafish Embryos Reveals New Effects of HDAC Inhibitors Trichostatin A and Valproic Acid on Organogenesis. | 2016 | PLoS ONE | pmid:26900852 |
Lim SY et al. | Enhancing Human Cardiomyocyte Differentiation from Induced Pluripotent Stem Cells with Trichostatin A. | 2016 | Methods Mol. Biol. | pmid:25520285 |
Dai Q et al. | Histone deacetylase inhibitors attenuate P-aIgA1-induced cell proliferation and extracellular matrix synthesis in human renal mesangial cells in vitro. | 2016 | Acta Pharmacol. Sin. | pmid:26775659 |
Hou X et al. | Histone deacetylase inhibitor regulates the balance of Th17/Treg in allergic asthma. | 2016 | Clin Respir J | pmid:25307458 |
Pallocca G et al. | Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. | 2016 | Arch. Toxicol. | pmid:26705709 |
Robert C et al. | Histone deacetylase inhibitors decrease NHEJ both by acetylation of repair factors and trapping of PARP1 at DNA double-strand breaks in chromatin. | 2016 | Leuk. Res. | pmid:27064363 |
Mohammadi-Bardbori A et al. | Chromatin remodeling by curcumin alters endogenous aryl hydrocarbon receptor signaling. | 2016 | Chem. Biol. Interact. | pmid:27041069 |
Li W et al. | Epigenetics Reactivation of Nrf2 in Prostate TRAMP C1 Cells by Curcumin Analogue FN1. | 2016 | Chem. Res. Toxicol. | pmid:26991801 |
Wu TC et al. | The enhancing effect of genistein on apoptosis induced by trichostatin A in lung cancer cells with wild type p53 genes is associated with upregulation of histone acetyltransferase. | 2016 | Toxicol. Appl. Pharmacol. | pmid:26768552 |
Zhang Y and Zhang B | Trichostatin A, an Inhibitor of Histone Deacetylase, Inhibits the Viability and Invasiveness of Hypoxic Rheumatoid Arthritis Fibroblast-Like Synoviocytes via PI3K/Akt Signaling. | 2016 | J. Biochem. Mol. Toxicol. | pmid:26509796 |
Contreras-Leal E et al. | Histone deacetylase inhibitors promote the expression of ATP2A3 gene in breast cancer cell lines. | 2016 | Mol. Carcinog. | pmid:26331238 |
Bricambert J et al. | Impaired histone deacetylases 5 and 6 expression mimics the effects of obesity and hypoxia on adipocyte function. | 2016 | Mol Metab | pmid:27900262 |
Adachi T et al. | Histone deacetylase inhibitors stimulate the susceptibility of A549Â cells to a plasma-activated medium treatment. | 2016 | Arch. Biochem. Biophys. | pmid:27470189 |
Deng Z et al. | Histone Deacetylase Inhibitor Trichostatin a Promotes the Apoptosis of Osteosarcoma Cells through p53 Signaling Pathway Activation. | 2016 | Int. J. Biol. Sci. | pmid:27877082 |
Kim HR et al. | Aberrant Expression of TIMP-2 and PBEF Genes in the Placentae of Cloned Mice Due to Epigenetic Reprogramming Error. | 2016 | PLoS ONE | pmid:27855185 |
Tombolan L et al. | Global DNA methylation profiling uncovers distinct methylation patterns of protocadherin alpha4 in metastatic and non-metastatic rhabdomyosarcoma. | 2016 | BMC Cancer | pmid:27842508 |
Tao W et al. | Histone deacetylase inhibitor-induced emergence of synaptic δ-opioid receptors and behavioral antinociception in persistent neuropathic pain. | 2016 | Neuroscience | pmid:27646288 |
Chen W et al. | MicroRNA-455-3p modulates cartilage development and degeneration through modification of histone H3 acetylation. | 2016 | Biochim. Biophys. Acta | pmid:27638301 |
Bauer I et al. | A Class 1 Histone Deacetylase with Potential as an Antifungal Target. | 2016 | MBio | pmid:27803184 |
Xu Q et al. | Changes in cardiac Nav1.5 expression, function, and acetylation by pan-histone deacetylase inhibitors. | 2016 | Am. J. Physiol. Heart Circ. Physiol. | pmid:27638876 |
Wang S et al. | Sex steroid-induced DNA methylation changes and inflammation response in prostate cancer. | 2016 | Cytokine | pmid:27500645 |
Por ED et al. | Trichostatin A Inhibits Retinal Pigmented Epithelium Activation in an In Vitro Model of Proliferative Vitreoretinopathy. | 2016 | J Ocul Pharmacol Ther | pmid:27494828 |
Liu Y et al. | DNA methylation of claudin-6 promotes breast cancer cell migration and invasion by recruiting MeCP2 and deacetylating H3Ac and H4Ac. | 2016 | J. Exp. Clin. Cancer Res. | pmid:27461117 |
Feng Q et al. | Histone deacetylase inhibitors suppress RSV infection and alleviate virus-induced airway inflammation. | 2016 | Int. J. Mol. Med. | pmid:27460781 |
Miyake Y et al. | Structural insights into HDAC6 tubulin deacetylation and its selective inhibition. | 2016 | Nat. Chem. Biol. | pmid:27454931 |
Li C et al. | PU.1-Bim axis is involved in Trichostatin A-induced apoptosis in murine pro-B lymphoma FL5.12 cells. | 2016 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:27451443 |
Igaz N et al. | Modulating chromatin structure and DNA accessibility by deacetylase inhibition enhances the anti-cancer activity of silver nanoparticles. | 2016 | Colloids Surf B Biointerfaces | pmid:27434153 |
Qu H et al. | Trichostatin A increases the TIMP-1/MMP ratio to protect against osteoarthritis in an animal model of the disease. | 2016 | Mol Med Rep | pmid:27431944 |
Choi SY et al. | Class I HDACs specifically regulate E-cadherin expression in human renal epithelial cells. | 2016 | J. Cell. Mol. Med. | pmid:27420561 |
Dhoke NR et al. | Histone deacetylases differentially regulate the proliferative phenotype of mouse bone marrow stromal and hematopoietic stem/progenitor cells. | 2016 | Stem Cell Res | pmid:27394013 |
Drzewiecka H et al. | Decreased expression of connective tissue growth factor in non-small cell lung cancer is associated with clinicopathological variables and can be restored by epigenetic modifiers. | 2016 | J. Cancer Res. Clin. Oncol. | pmid:27393180 |
Zhang NH et al. | Rejection of adenovirus infection is independent of coxsackie and adenovirus receptor expression in cisplatin-resistant human lung cancer cells. | 2016 | Oncol. Rep. | pmid:27373420 |
Chang I and Wang CY | Inhibition of HDAC6 Protein Enhances Bortezomib-induced Apoptosis in Head and Neck Squamous Cell Carcinoma (HNSCC) by Reducing Autophagy. | 2016 | J. Biol. Chem. | pmid:27369083 |
Clarke CJ et al. | ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation. | 2016 | J. Lipid Res. | pmid:27013100 |
Zhang HP et al. | Association between histone hyperacetylation status in memory T lymphocytes and allergen-induced eosinophilic airway inflammation. | 2016 | Respirology | pmid:26991676 |
Sharma K et al. | Constitutive hyperactivity of histone deacetylases enhances radioresistance in Lepidopteran Sf9 insect cells. | 2016 | Biochim. Biophys. Acta | pmid:26968462 |
Majumdar G and Raghow R | Trichostatin A induces a unique set of microRNAs including miR-129-5p that blocks cyclin-dependent kinase 6 expression and proliferation in H9c2 cardiac myocytes. | 2016 | Mol. Cell. Biochem. | pmid:26946427 |
Sakharkar AJ et al. | A role for histone acetylation mechanisms in adolescent alcohol exposure-induced deficits in hippocampal brain-derived neurotrophic factor expression and neurogenesis markers in adulthood. | 2016 | Brain Struct Funct | pmid:26941165 |
Cui W et al. | A SUMO-acetyl switch in PXR biology. | 2016 | Biochim. Biophys. Acta | pmid:26883953 |
Ma X et al. | Identification of genes regulated by histone acetylation during root development in Populus trichocarpa. | 2016 | BMC Genomics | pmid:26847576 |
Li L et al. | Trichostatin A potentiates TRAIL-induced antitumor effects via inhibition of ERK/FOXM1 pathway in gastric cancer. | 2016 | Tumour Biol. | pmid:26831669 |
Rios EC et al. | The role of nitric oxide in the epigenetic regulation of THP-1 induced by lipopolysaccharide. | 2016 | Life Sci. | pmid:26826317 |
Deguise MO et al. | Differential induction of muscle atrophy pathways in two mouse models of spinal muscular atrophy. | 2016 | Sci Rep | pmid:27349908 |
Wang X et al. | The synergistic effect of 5Azadc and TSA on maintenance of pluripotency of chicken ESCs by overexpression of NANOG gene. | 2016 | In Vitro Cell. Dev. Biol. Anim. | pmid:26822431 |
Kuan CS et al. | Sp1 and Sp3 Are the Transcription Activators of Human ek1 Promoter in TSA-Treated Human Colon Carcinoma Cells. | 2016 | PLoS ONE | pmid:26807725 |
Saini M et al. | Treatment of buffalo (Bubalus bubalis) donor cells with trichostatin A and 5-aza-2'-deoxycytidine alters their growth characteristics, gene expression and epigenetic status and improves the in vitro developmental competence, quality and epigenetic status of cloned embryos. | 2016 | Reprod. Fertil. Dev. | pmid:25409339 |
Trifunović D et al. | HDAC inhibition in the cpfl1 mouse protects degenerating cone photoreceptors in vivo. | 2016 | Hum. Mol. Genet. | pmid:28172811 |
Alizadeh E et al. | Upregulation of MiR-122 via Trichostatin A Treatments in Hepatocyte-like Cells Derived from Mesenchymal Stem Cells. | 2016 | Chem Biol Drug Des | pmid:26360933 |
Kim HJ et al. | Enhancement of human mesenchymal stem cell differentiation by combination treatment with 5-azacytidine and trichostatin A. | 2016 | Biotechnol. Lett. | pmid:26341652 |
Tan CS et al. | Epigenetic Regulation of Cytosolic Phospholipase A2 in SH-SY5Y Human Neuroblastoma Cells. | 2016 | Mol. Neurobiol. | pmid:26162318 |