Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Ruh MF et al. | The effects of histone acetylation on estrogen responsiveness in MCF-7 cells. | 1999 | Endocrine | pmid:10709763 |
Imai S et al. | Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. | 2000 | Nature | pmid:10693811 |
Stöckel B et al. | Characterization of the 5'-flanking region of the human multidrug resistance protein 2 (MRP2) gene and its regulation in comparison withthe multidrug resistance protein 3 (MRP3) gene. | 2000 | Eur. J. Biochem. | pmid:10691972 |
Shin JY et al. | Mechanism for inactivation of the KIP family cyclin-dependent kinase inhibitor genes in gastric cancer cells. | 2000 | Cancer Res. | pmid:10667572 |
Kim YB et al. | Selective induction of cyclin-dependent kinase inhibitors and their roles in cell cycle arrest caused by trichostatin A, an inhibitor of histone deacetylase. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10667219 |
Sowa Y et al. | Histone deacetylase inhibitor activates the p21/WAF1/Cip1 gene promoter through the Sp1 sites. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10667218 |
Yoshida M and Horinouchi S | Trichostatin and leptomycin. Inhibition of histone deacetylation and signal-dependent nuclear export. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10667200 |
Garrison PM et al. | Effects of histone deacetylase inhibitors on the Ah receptor gene promoter. | 2000 | Arch. Biochem. Biophys. | pmid:10666294 |
Hodny Z et al. | Sp1 and chromatin environment are important contributors to the formation of repressive chromatin structures on the transfected human adenine nucleotide translocase-2 promoter. | 2000 | Biochem. J. | pmid:10657244 |
Smith RD et al. | Quantitative PCR analysis of HbF inducers in primary human adult erythroid cells. | 2000 | Blood | pmid:10648397 |
Marenzi S et al. | Efficiency of expression of transfected genes depends on the cell cycle. | 1999 | Mol. Biol. Rep. | pmid:10634509 |
Xiao H et al. | p300 collaborates with Sp1 and Sp3 in p21(waf1/cip1) promoter activation induced by histone deacetylase inhibitor. | 2000 | J. Biol. Chem. | pmid:10625687 |
Chen WY and Townes TM | Molecular mechanism for silencing virally transduced genes involves histone deacetylation and chromatin condensation. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10618426 |
Gray SG et al. | Modulating IGFBP-3 expression by trichostatin A: potential therapeutic role in the treatment of hepatocellular carcinoma. | 2000 | Int. J. Mol. Med. | pmid:10601571 |
Taddei A et al. | Duplication and maintenance of heterochromatin domains. | 1999 | J. Cell Biol. | pmid:10601331 |
Chien PY et al. | A fusion protein of the estrogen receptor (ER) and nuclear receptor corepressor (NCoR) strongly inhibits estrogen-dependent responses in breast cancer cells. | 1999 | Mol. Endocrinol. | pmid:10598586 |
Gray SG et al. | IGF-II enhances trichostatin A-induced TGFbeta1 and p21(Waf1,Cip1, sdi1) expression in Hep3B cells. | 1999 | Exp. Cell Res. | pmid:10585285 |
Jung M et al. | Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation. | 1999 | J. Med. Chem. | pmid:10579829 |
Schmidt K et al. | Inhibitors of histone deacetylase suppress the growth of MCF-7 breast cancer cells. | 1999 | Arch. Pharm. (Weinheim) | pmid:10575368 |
Habeck M | Gelsolin: a new marker for breast cancer? | 1999 | Mol Med Today | pmid:10562712 |