Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Wunder T et al. | Expression of the coxsackie adenovirus receptor in neuroendocrine lung cancers and its implications for oncolytic adenoviral infection. | 2013 | Cancer Gene Ther. | pmid:23196273 |
Oliveira CS et al. | HDAC inhibition decreases XIST expression on female IVP bovine blastocysts. | 2013 | Reproduction | pmid:23104973 |
Lakshmi SV et al. | Oxidative stress in coronary artery disease: epigenetic perspective. | 2013 | Mol. Cell. Biochem. | pmid:23160801 |
Jackson MF et al. | Genetic manipulation of myoblasts and a novel primary myosatellite cell culture system: comparing and optimizing approaches. | 2013 | FEBS J. | pmid:23173931 |
Bianco C et al. | Regulation of human Cripto-1 expression by nuclear receptors and DNA promoter methylation in human embryonal and breast cancer cells. | 2013 | J. Cell. Physiol. | pmid:23129342 |
Carbajal A et al. | A novel method for purification of polymerizable tubulin with a high content of the acetylated isotype. | 2013 | Biochem. J. | pmid:23140207 |
Luo Y et al. | High mobility group box 1 released from necrotic cells enhances regrowth and metastasis of cancer cells that have survived chemotherapy. | 2013 | Eur. J. Cancer | pmid:23040637 |
Culley KL et al. | Class I histone deacetylase inhibition modulates metalloproteinase expression and blocks cytokine-induced cartilage degradation. | 2013 | Arthritis Rheum. | pmid:23575963 |
Brown CO et al. | Scavenger receptor class A member 3 (SCARA3) in disease progression and therapy resistance in multiple myeloma. | 2013 | Leuk. Res. | pmid:23537707 |
Gang H et al. | Epigenetic regulation of canonical TNFα pathway by HDAC1 determines survival of cardiac myocytes. | 2013 | Am. J. Physiol. Heart Circ. Physiol. | pmid:23585133 |
Yacqub-Usman K et al. | Preincubation of pituitary tumor cells with the epidrugs zebularine and trichostatin A are permissive for retinoic acid-augmented expression of the BMP-4 and D2R genes. | 2013 | Endocrinology | pmid:23539512 |
Aseem O et al. | Cubilin expression is monoallelic and epigenetically augmented via PPARs. | 2013 | BMC Genomics | pmid:23773363 |
Wang H et al. | Histone deacetylase inhibitors facilitate partner preference formation in female prairie voles. | 2013 | Nat. Neurosci. | pmid:23727821 |
Humphreys KJ et al. | Histone deacetylase inhibition in colorectal cancer cells reveals competing roles for members of the oncogenic miR-17-92 cluster. | 2013 | Mol. Carcinog. | pmid:22308110 |
Gao B et al. | Inhibition of histone deacetylase activity suppresses IFN-γ induction of tripartite motif 22 via CHIP-mediated proteasomal degradation of IRF-1. | 2013 | J. Immunol. | pmid:23729439 |
Luo B et al. | A possible strategy to produce pigs resistant to porcine reproductive and respiratory syndrome virus. | 2013 | Antiviral Res. | pmid:23732571 |
Tigges J et al. | Aryl hydrocarbon receptor repressor (AhRR) function revisited: repression of CYP1 activity in human skin fibroblasts is not related to AhRR expression. | 2013 | J. Invest. Dermatol. | pmid:22951721 |
Doñas C et al. | Trichostatin A promotes the generation and suppressive functions of regulatory T cells. | 2013 | Clin. Dev. Immunol. | pmid:23737814 |
Flight MH | Behaviour: epigenetically bonded. | 2013 | Nat. Rev. Neurosci. | pmid:23756635 |
Zhao TC et al. | HDAC inhibition elicits myocardial protective effect through modulation of MKK3/Akt-1. | 2013 | PLoS ONE | pmid:23762381 |
BurlibaÅŸa L and Zarnescu O | In vivo effects of Trichostatin A - A histone deacetylase inhibitor - On chromatin remodeling during Triturus cristatus spermatogenesis. | 2013 | Anim. Reprod. Sci. | pmid:24100069 |
Kang KA et al. | Compound K, a metabolite of ginseng saponin, inhibits colorectal cancer cell growth and induces apoptosis through inhibition of histone deacetylase activity. | 2013 | Int. J. Oncol. | pmid:24100442 |
Moldrich RX et al. | Inhibition of histone deacetylase in utero causes sociability deficits in postnatal mice. | 2013 | Behav. Brain Res. | pmid:24103642 |
Yamamura A et al. | Suppressed expression of NDRG2 correlates with poor prognosis in pancreatic cancer. | 2013 | Biochem. Biophys. Res. Commun. | pmid:24134849 |
Xu M et al. | Histone deacetylase inhibitors induce human renal cell carcinoma cell apoptosis through p-JNK activation. | 2013 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:24144737 |
Wang X et al. | Combined histone deacetylase and cyclooxygenase inhibition achieves enhanced antiangiogenic effects in lung cancer cells. | 2013 | Mol. Carcinog. | pmid:22121107 |
Wang YJ et al. | Histone acetylation in the olfactory bulb of young rats facilitates aversive olfactory learning and synaptic plasticity. | 2013 | Neuroscience | pmid:23262233 |
Diao JS et al. | Histone deacetylase inhibitor reduces hypertrophic scarring in a rabbit ear model. | 2013 | Plast. Reconstr. Surg. | pmid:23806955 |
Sharma A et al. | Trichostatin-A modulates claudin-1 mRNA stability through the modulation of Hu antigen R and tristetraprolin in colon cancer cells. | 2013 | Carcinogenesis | pmid:23880304 |
Li Y et al. | Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer. | 2013 | Mol. Cancer | pmid:23379261 |
Oliveira CS et al. | Supplementation with the histone deacetylase inhibitor trichostatin A during in vitro culture of bovine embryos. | 2013 | Zygote | pmid:21867598 |
Joosten M et al. | Histone acetylation and DNA demethylation of T cells result in an anaplastic large cell lymphoma-like phenotype. | 2013 | Haematologica | pmid:22899583 |
Frame FM et al. | HDAC inhibitor confers radiosensitivity to prostate stem-like cells. | 2013 | Br. J. Cancer | pmid:24220693 |
Jagirdar K et al. | The NR4A2 nuclear receptor is recruited to novel nuclear foci in response to UV irradiation and participates in nucleotide excision repair. | 2013 | PLoS ONE | pmid:24223135 |
Hu X et al. | Histone deacetylase inhibitor trichostatin A promotes the osteogenic differentiation of rat adipose-derived stem cells by altering the epigenetic modifications on Runx2 promoter in a BMP signaling-dependent manner. | 2013 | Stem Cells Dev. | pmid:22873791 |
Liu Y et al. | Expression loss and revivification of RhoB gene in ovary carcinoma carcinogenesis and development. | 2013 | PLoS ONE | pmid:24223801 |
Yan G et al. | Curcumin enhances the anticancer effects of trichostatin a in breast cancer cells. | 2013 | Mol. Carcinog. | pmid:22290509 |
Lopez-Atalaya JP et al. | Genomic targets, and histone acetylation and gene expression profiling of neural HDAC inhibition. | 2013 | Nucleic Acids Res. | pmid:23821663 |
Okada T et al. | Identification of genes specifically methylated in Epstein-Barr virus-associated gastric carcinomas. | 2013 | Cancer Sci. | pmid:23829175 |
Cong P et al. | Effects of trichostatin A on histone acetylation and methylation characteristics in early porcine embryos after somatic cell nuclear transfer. | 2013 | Anim. Sci. J. | pmid:23607426 |
Munro SK et al. | Histone deacetylase inhibition by trichostatin A mitigates LPS induced TNFα and IL-10 production in human placental explants. | 2013 | Placenta | pmid:23623485 |
Hayakawa K et al. | Epigenetic switching by the metabolism-sensing factors in the generation of orexin neurons from mouse embryonic stem cells. | 2013 | J. Biol. Chem. | pmid:23625921 |
Neumann F et al. | EBV-transformed lymphoblastoid cell lines as vaccines against cancer testis antigen-positive tumors. | 2013 | Cancer Immunol. Immunother. | pmid:23619976 |
Yang H et al. | Induction of the liver cancer-down-regulated long noncoding RNA uc002mbe.2 mediates trichostatin-induced apoptosis of liver cancer cells. | 2013 | Biochem. Pharmacol. | pmid:23643933 |
Montero-Melendez T et al. | Gene expression signature-based approach identifies a pro-resolving mechanism of action for histone deacetylase inhibitors. | 2013 | Cell Death Differ. | pmid:23222458 |
McBrian MA et al. | Histone acetylation regulates intracellular pH. | 2013 | Mol. Cell | pmid:23201122 |
Shi H et al. | Synergistic induction of miR-126 by hypoxia and HDAC inhibitors in cardiac myocytes. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23201405 |
Hutz JE et al. | The multidimensional perturbation value: a single metric to measure similarity and activity of treatments in high-throughput multidimensional screens. | 2013 | J Biomol Screen | pmid:23204073 |
Nakazawa Y et al. | Evaluation of long-term transgene expression in piggyBac-modified human T lymphocytes. | 2013 | J. Immunother. | pmid:23211626 |
Tavakoli-Yaraki M et al. | Induction of apoptosis by Trichostatin A in human breast cancer cell lines: involvement of 15-Lox-1. | 2013 | Tumour Biol. | pmid:23055198 |