Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Wolf G et al. | Epigenetic marking and repression of porcine endogenous retroviruses. | 2013 | J. Gen. Virol. | pmid:23324470 |
Laska MJ et al. | (Some) cellular mechanisms influencing the transcription of human endogenous retrovirus, HERV-Fc1. | 2013 | PLoS ONE | pmid:23382858 |
Bhargavan B et al. | Epigenetic repression of LEDGF during UVB exposure by recruitment of SUV39H1 and HDAC1 to the Sp1-responsive elements within LEDGF promoter CpG island. | 2013 | Epigenetics | pmid:23386123 |
Peng L et al. | Epigenetic inactivation of ADAMTS9 via promoter methylation in multiple myeloma. | 2013 | Mol Med Rep | pmid:23358566 |
Corvetta D et al. | Physical interaction between MYCN oncogene and polycomb repressive complex 2 (PRC2) in neuroblastoma: functional and therapeutic implications. | 2013 | J. Biol. Chem. | pmid:23362253 |
Dhawan D et al. | DNMT1: an emerging target in the treatment of invasive urinary bladder cancer. | 2013 | Urol. Oncol. | pmid:22609058 |
Oikawa M et al. | RNAi-mediated knockdown of Xist does not rescue the impaired development of female cloned mouse embryos. | 2013 | J. Reprod. Dev. | pmid:23363561 |
Dagnas M et al. | HDAC inhibition facilitates the switch between memory systems in young but not aged mice. | 2013 | J. Neurosci. | pmid:23365234 |
Fernandez G et al. | Targeting IκB proteins for HIV latency activation: the role of individual IκB and NF-κB proteins. | 2013 | J. Virol. | pmid:23365428 |
Meng F et al. | Anticancer efficacy of cisplatin and trichostatin A or 5-aza-2'-deoxycytidine on ovarian cancer. | 2013 | Br. J. Cancer | pmid:23370212 |
Wang Z et al. | Arabidopsis paired amphipathic helix proteins SNL1 and SNL2 redundantly regulate primary seed dormancy via abscisic acid-ethylene antagonism mediated by histone deacetylation. | 2013 | Plant Cell | pmid:23371947 |
Horvat T et al. | Reversibility of membrane N-glycome of HeLa cells upon treatment with epigenetic inhibitors. | 2013 | PLoS ONE | pmid:23336012 |
Li H et al. | Epigenetic regulation of CXCR4 expression by the ocular microenvironment. | 2013 | Invest. Ophthalmol. Vis. Sci. | pmid:23188729 |
Gill RK et al. | Regulation of intestinal serotonin transporter expression via epigenetic mechanisms: role of HDAC2. | 2013 | Am. J. Physiol., Cell Physiol. | pmid:23195070 |
Wessels I et al. | Activation of IL-1β and TNFα genes is mediated by the establishment of permissive chromatin structures during monopoiesis. | 2013 | Immunobiology | pmid:23195574 |
Wunder T et al. | Expression of the coxsackie adenovirus receptor in neuroendocrine lung cancers and its implications for oncolytic adenoviral infection. | 2013 | Cancer Gene Ther. | pmid:23196273 |
Kuno A et al. | Resveratrol improves cardiomyopathy in dystrophin-deficient mice through SIRT1 protein-mediated modulation of p300 protein. | 2013 | J. Biol. Chem. | pmid:23297412 |
Su SF et al. | miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer. | 2013 | Oncogene | pmid:23085757 |
Ziesché E et al. | The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB. | 2013 | Nucleic Acids Res. | pmid:23087373 |
Eriksson I et al. | The histone deacetylase inhibitor trichostatin A reduces lysosomal pH and enhances cisplatin-induced apoptosis. | 2013 | Exp. Cell Res. | pmid:23063877 |
Seuter S et al. | Chromatin acetylation at transcription start sites and vitamin D receptor binding regions relates to effects of 1α,25-dihydroxyvitamin D3 and histone deacetylase inhibitors on gene expression. | 2013 | Nucleic Acids Res. | pmid:23093607 |
Jin H et al. | HDAC inhibitor trichostatin A promotes proliferation and odontoblast differentiation of human dental pulp stem cells. | 2013 | Tissue Eng Part A | pmid:23013422 |
Luo Y et al. | High mobility group box 1 released from necrotic cells enhances regrowth and metastasis of cancer cells that have survived chemotherapy. | 2013 | Eur. J. Cancer | pmid:23040637 |
Chen CH et al. | Synergistic effect of trichostatin A and scriptaid on the development of cloned rabbit embryos. | 2013 | Theriogenology | pmid:23566670 |
Sato A et al. | Suppressive effect of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) on hepatitis C virus replication. | 2013 | J. Cell. Biochem. | pmid:23519646 |
Wang Y et al. | Nuclear factor κB mediates suppression of canonical transient receptor potential 6 expression by reactive oxygen species and protein kinase C in kidney cells. | 2013 | J. Biol. Chem. | pmid:23525112 |
Sato T et al. | Enhancement of inflammatory protein expression and nuclear factor Κb (NF-Κb) activity by trichostatin A (TSA) in OP9 preadipocytes. | 2013 | PLoS ONE | pmid:23555753 |
Mateen S et al. | Silibinin synergizes with histone deacetylase and DNA methyltransferase inhibitors in upregulating E-cadherin expression together with inhibition of migration and invasion of human non-small cell lung cancer cells. | 2013 | J. Pharmacol. Exp. Ther. | pmid:23461975 |
Chambliss AB et al. | Simultaneously defining cell phenotypes, cell cycle, and chromatin modifications at single-cell resolution. | 2013 | FASEB J. | pmid:23538711 |
Wang YG et al. | Mechanisms of trichostatin A inhibiting AGS proliferation and identification of lysine-acetylated proteins. | 2013 | World J. Gastroenterol. | pmid:23745024 |
Guo SW et al. | Dysmenorrhea and its severity are associated with increased uterine contractility and overexpression of oxytocin receptor (OTR) in women with symptomatic adenomyosis. | 2013 | Fertil. Steril. | pmid:22999795 |
Pitta CA et al. | Reversal of ER-β silencing by chromatin modifying agents overrides acquired tamoxifen resistance. | 2013 | Cancer Lett. | pmid:23752064 |
Zhang C et al. | Decreased PADI4 mRNA association with global hypomethylation in hepatocellular carcinoma during HBV exposure. | 2013 | Cell Biochem. Biophys. | pmid:22907585 |
Van Beneden K et al. | Comparison of trichostatin A and valproic acid treatment regimens in a mouse model of kidney fibrosis. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23707763 |
Meng F et al. | Inhibition of DNA methyltransferases, histone deacetylases and lysine-specific demethylase-1 suppresses the tumorigenicity of the ovarian cancer ascites cell line SKOV3. | 2013 | Int. J. Oncol. | pmid:23709006 |
Liu Y et al. | MCM-2 is a therapeutic target of Trichostatin A in colon cancer cells. | 2013 | Toxicol. Lett. | pmid:23770000 |
Welch MD et al. | Hypomethylation of the CTGF gene locus is a common feature of paediatric pre-B acute lymphoblastic leukaemia. | 2013 | Br. J. Haematol. | pmid:23772794 |
Aseem O et al. | Cubilin expression is monoallelic and epigenetically augmented via PPARs. | 2013 | BMC Genomics | pmid:23773363 |
Wang H et al. | Histone deacetylase inhibitors facilitate partner preference formation in female prairie voles. | 2013 | Nat. Neurosci. | pmid:23727821 |
Lauffer BE et al. | Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability. | 2013 | J. Biol. Chem. | pmid:23897821 |
Lu JC et al. | Trichostatin A modulates thiazolidinedione-mediated suppression of tumor necrosis factor α-induced lipolysis in 3T3-L1 adipocytes. | 2013 | PLoS ONE | pmid:23951179 |
Seo J et al. | Trichostatin A epigenetically increases calpastatin expression and inhibits calpain activity and calcium-induced SH-SY5Y neuronal cell toxicity. | 2013 | FEBS J. | pmid:24200051 |
Spallotta F et al. | A nitric oxide-dependent cross-talk between class I and III histone deacetylases accelerates skin repair. | 2013 | J. Biol. Chem. | pmid:23463510 |
Chandwani S et al. | Induction of DARPP-32 by brain-derived neurotrophic factor in striatal neurons in vitro is modified by histone deacetylase inhibitors and Nab2. | 2013 | PLoS ONE | pmid:24204683 |
Liesz A et al. | Boosting regulatory T cells limits neuroinflammation in permanent cortical stroke. | 2013 | J. Neurosci. | pmid:24174668 |
Wu DS et al. | Epigallocatechin-3-gallate and trichostatin A synergistically inhibit human lymphoma cell proliferation through epigenetic modification of p16INK4a. | 2013 | Oncol. Rep. | pmid:24064951 |
Al-Nakhle H et al. | Regulation of estrogen receptor β1 expression in breast cancer by epigenetic modification of the 5' regulatory region. | 2013 | Int. J. Oncol. | pmid:24068253 |
Yu CW et al. | Quinazolin-4-one derivatives as selective histone deacetylase-6 inhibitors for the treatment of Alzheimer's disease. | 2013 | J. Med. Chem. | pmid:23905680 |
Chikamatsu K et al. | Alteration of cancer stem cell-like phenotype by histone deacetylase inhibitors in squamous cell carcinoma of the head and neck. | 2013 | Cancer Sci. | pmid:23992541 |
Oksenych V et al. | Histone methyltransferase DOT1L drives recovery of gene expression after a genotoxic attack. | 2013 | PLoS Genet. | pmid:23861670 |
Itoh M et al. | Trichostatin A enhances glutamate transporter GLT-1 mRNA levels in C6 glioma cells via neurosteroid-mediated cell differentiation. | 2013 | J. Mol. Neurosci. | pmid:22711563 |
Fujiki R et al. | A proapoptotic effect of valproic acid on progenitors of embryonic stem cell-derived glutamatergic neurons. | 2013 | Cell Death Dis | pmid:23788034 |
Chang X et al. | DNA methylation of NDRG2 in gastric cancer and its clinical significance. | 2013 | Dig. Dis. Sci. | pmid:23010743 |
Li KK et al. | MiR-383 is downregulated in medulloblastoma and targets peroxiredoxin 3 (PRDX3). | 2013 | Brain Pathol. | pmid:23227829 |
Matsubara K et al. | Dynamics and regulation of lysine-acetylation during one-cell stage mouse embryos. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23567968 |
Contreras AU et al. | Deacetylation of p53 induces autophagy by suppressing Bmf expression. | 2013 | J. Cell Biol. | pmid:23629966 |
Duo J et al. | Metformin synergistically enhances antitumor activity of histone deacetylase inhibitor trichostatin a against osteosarcoma cell line. | 2013 | DNA Cell Biol. | pmid:23451817 |
Chen CQ et al. | Pure curcumin increases the expression of SOCS1 and SOCS3 in myeloproliferative neoplasms through suppressing class I histone deacetylases. | 2013 | Carcinogenesis | pmid:23430957 |
Han B et al. | Trichostatin A stabilizes the expression of pluripotent genes in human mesenchymal stem cells during ex vivo expansion. | 2013 | PLoS ONE | pmid:24312356 |
Choi S et al. | Histone deacetylases inhibitor trichostatin A modulates the extracellular release of APE1/Ref-1. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23665318 |
Katsuno M et al. | [Dysfunction of dynactin 1 in motor neuron degeneration]. | 2013 | Rinsho Shinkeigaku | pmid:24291886 |
Wang YJ et al. | Histone acetylation in the olfactory bulb of young rats facilitates aversive olfactory learning and synaptic plasticity. | 2013 | Neuroscience | pmid:23262233 |
Ning SF et al. | Methylation characteristics and developmental potential of Guangxi Bama minipig (Sus scrofa domestica) cloned embryos from donor cells treated with trichostatin A and 5-aza-2'-deoxycytidine. | 2013 | Zygote | pmid:22355002 |
Oliveira CS et al. | Supplementation with the histone deacetylase inhibitor trichostatin A during in vitro culture of bovine embryos. | 2013 | Zygote | pmid:21867598 |
Wang P et al. | Trichostatin A protects against cisplatin-induced ototoxicity by regulating expression of genes related to apoptosis and synaptic function. | 2013 | Neurotoxicology | pmid:23558232 |
Joosten M et al. | Histone acetylation and DNA demethylation of T cells result in an anaplastic large cell lymphoma-like phenotype. | 2013 | Haematologica | pmid:22899583 |
Krause M et al. | Probing the compressibility of tumor cell nuclei by combined atomic force-confocal microscopy. | 2013 | Phys Biol | pmid:24304807 |
Tran HT et al. | Improved therapeutic effect against leukemia by a combination of the histone methyltransferase inhibitor chaetocin and the histone deacetylase inhibitor trichostatin A. | 2013 | J. Korean Med. Sci. | pmid:23400519 |
Cho JS et al. | Effects of histone deacetylase inhibitor on extracellular matrix production in human nasal polyp organ cultures. | 2013 | Am J Rhinol Allergy | pmid:23406592 |
Miyatake Y et al. | Protective roles of epithelial cells in the survival of adult T-cell leukemia/lymphoma cells. | 2013 | Am. J. Pathol. | pmid:23474084 |
Hansberg-Pastor V et al. | The role of DNA methylation and histone acetylation in the regulation of progesterone receptor isoforms expression in human astrocytoma cell lines. | 2013 | Steroids | pmid:23474171 |
Biernacka KM et al. | Hyperglycaemia-induced chemoresistance of prostate cancer cells due to IGFBP2. | 2013 | Endocr. Relat. Cancer | pmid:23959956 |
Arora DS et al. | Hyposensitivity to gamma-aminobutyric acid in the ventral tegmental area during alcohol withdrawal: reversal by histone deacetylase inhibitors. | 2013 | Neuropsychopharmacology | pmid:23474591 |
Lee AR et al. | Nicotinamide: a class III HDACi delays in vitro aging of mouse oocytes. | 2013 | J. Reprod. Dev. | pmid:23474603 |
Chatterjee N et al. | Histone deacetylase inhibitors modulate miRNA and mRNA expression, block metaphase, and induce apoptosis in inflammatory breast cancer cells. | 2013 | Cancer Biol. Ther. | pmid:23792638 |
Zych J et al. | The epigenetic modifiers 5-aza-2'-deoxycytidine and trichostatin A influence adipocyte differentiation in human mesenchymal stem cells. | 2013 | Braz. J. Med. Biol. Res. | pmid:23797495 |
Guo LH et al. | The Tumor Suppressor Roles of miR-433 and miR-127 in Gastric Cancer. | 2013 | Int J Mol Sci | pmid:23880861 |
Jo SJ et al. | Valproic acid promotes human hair growth in in vitro culture model. | 2013 | J. Dermatol. Sci. | pmid:23810771 |
Huang L et al. | Down-regulation of miR-301a suppresses pro-inflammatory cytokines in Toll-like receptor-triggered macrophages. | 2013 | Immunology | pmid:23808420 |
Keuser B et al. | Influences of histone deacetylase inhibitors and resveratrol on DNA repair and chromatin compaction. | 2013 | Mutagenesis | pmid:23814181 |
Lim SY et al. | Trichostatin A enhances differentiation of human induced pluripotent stem cells to cardiogenic cells for cardiac tissue engineering. | 2013 | Stem Cells Transl Med | pmid:23884641 |
Shim SH et al. | Histone deacetylase inhibitors suppress coxsackievirus B3 growth in vitro and myocarditis induced in mice. | 2013 | Acta Virol. | pmid:24294962 |
Asthana J et al. | Inhibition of HDAC6 deacetylase activity increases its binding with microtubules and suppresses microtubule dynamic instability in MCF-7 cells. | 2013 | J. Biol. Chem. | pmid:23798680 |
Gundersen B | Pair-bonding through epigenetics. | 2013 | Nat. Neurosci. | pmid:23799469 |
Feng T et al. | Novel N-hydroxyfurylacrylamide-based histone deacetylase (HDAC) inhibitors with branched CAP group (Part 2). | 2013 | Bioorg. Med. Chem. | pmid:23820574 |
Lopez-Atalaya JP et al. | Genomic targets, and histone acetylation and gene expression profiling of neural HDAC inhibition. | 2013 | Nucleic Acids Res. | pmid:23821663 |
Ignatius MS et al. | Distinct functional and temporal requirements for zebrafish Hdac1 during neural crest-derived craniofacial and peripheral neuron development. | 2013 | PLoS ONE | pmid:23667588 |
Webster SJ et al. | Regulation of GTP-binding protein (Gαs) expression in human myometrial cells: a role for tumor necrosis factor in modulating Gαs promoter acetylation by transcriptional complexes. | 2013 | J. Biol. Chem. | pmid:23297421 |
Lee MS et al. | Stabilization of p21 (Cip1/WAF1) following Tip60-dependent acetylation is required for p21-mediated DNA damage response. | 2013 | Cell Death Differ. | pmid:23238566 |
Kamiya H et al. | Enhanced transgene expression from chromatinized plasmid DNA in mouse liver. | 2013 | Int J Pharm | pmid:23247018 |
Yang L et al. | Trichostatin A inhibits transforming growth factor-β-induced reactive oxygen species accumulation and myofibroblast differentiation via enhanced NF-E2-related factor 2-antioxidant response element signaling. | 2013 | Mol. Pharmacol. | pmid:23284002 |
Zhang S et al. | Effect of trichostatin A and paclitaxel on the proliferation and apoptosis of lung adenocarcinoma cells. | 2013 | Chin. Med. J. | pmid:23286491 |
Gao C et al. | Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex. | 2013 | Blood | pmid:23287862 |
Marek L et al. | Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells. | 2013 | J. Med. Chem. | pmid:23252603 |
Li KK et al. | MIR-137 suppresses growth and invasion, is downregulated in oligodendroglial tumors and targets CSE1L. | 2013 | Brain Pathol. | pmid:23252729 |
Seuter S et al. | The gene for the transcription factor BHLHE40/DEC1/stra13 is a dynamically regulated primary target of the vitamin D receptor. | 2013 | J. Steroid Biochem. Mol. Biol. | pmid:23220548 |
Singh T et al. | Inhibition of class I histone deacetylases in non-small cell lung cancer by honokiol leads to suppression of cancer cell growth and induction of cell death in vitro and in vivo. | 2013 | Epigenetics | pmid:23221619 |
Montero-Melendez T et al. | Gene expression signature-based approach identifies a pro-resolving mechanism of action for histone deacetylase inhibitors. | 2013 | Cell Death Differ. | pmid:23222458 |
McBrian MA et al. | Histone acetylation regulates intracellular pH. | 2013 | Mol. Cell | pmid:23201122 |
Chen CQ et al. | Histone deacetylases inhibitor trichostatin A increases the expression of Dleu2/miR-15a/16-1 via HDAC3 in non-small cell lung cancer. | 2013 | Mol. Cell. Biochem. | pmid:23867991 |