trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lee SK et al. | Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor. | 2000 | J. Biol. Chem. | pmid:10777532 |
| Zhang HS et al. | Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF. | 2000 | Cell | pmid:10778858 |
| Fu M et al. | p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation. | 2000 | J. Biol. Chem. | pmid:10779504 |
| Gays F et al. | The mouse tumor cell lines EL4 and RMA display mosaic expression of NK-related and certain other surface molecules and appear to have a common origin. | 2000 | J. Immunol. | pmid:10799866 |
| McInerney JM et al. | Long-term silencing of retroviral vectors is resistant to reversal by trichostatin A and 5-azacytidine. | 2000 | Gene Ther. | pmid:10800088 |
| McBlane F and Boyes J | Stimulation of V(D)J recombination by histone acetylation. | 2000 | Curr. Biol. | pmid:10801420 |
| Hobbs CA and Gilmour SK | High levels of intracellular polyamines promote histone acetyltransferase activity resulting in chromatin hyperacetylation. | 2000 | J. Cell. Biochem. | pmid:10760944 |
| Yoshida M and Horinouchi S | [Histone deacetylase inhibitors--new anticancer agents?]. | 2000 | Tanpakushitsu Kakusan Koso | pmid:10771678 |
| Zhou Q et al. | Rapid induction of histone hyperacetylation and cellular differentiation in human breast tumor cell lines following degradation of histone deacetylase-1. | 2000 | J. Biol. Chem. | pmid:10938272 |
| Xu RH et al. | Histone acetylation is a checkpoint in FGF-stimulated mesoderm induction. | 2000 | Dev. Dyn. | pmid:10906781 |
| Gray SG et al. | IGF-II and IL-2 act synergistically to alter HDAC1 expression following treatments with trichostatin a. | 2000 | Cytokine | pmid:10880258 |
| Su GH et al. | A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library. | 2000 | Cancer Res. | pmid:10866300 |
| Lin F et al. | Unique anti-activator protein-1 activity of retinoic acid receptor beta. | 2000 | Cancer Res. | pmid:10866321 |
| Hemavathy K et al. | Human Slug is a repressor that localizes to sites of active transcription. | 2000 | Mol. Cell. Biol. | pmid:10866665 |
| Jin S et al. | Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10841572 |
| Claassen GF and Hann SR | A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta -induced cell-cycle arrest. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10920185 |
| Mao C and Shapiro DJ | A histone deacetylase inhibitor potentiates estrogen receptor activation of a stably integrated vitellogenin promoter in HepG2 cells. | 2000 | Endocrinology | pmid:10875235 |
| DiRenzo J et al. | BRG-1 is recruited to estrogen-responsive promoters and cooperates with factors involved in histone acetylation. | 2000 | Mol. Cell. Biol. | pmid:11003650 |
| Hu JF et al. | Allele-specific histone acetylation accompanies genomic imprinting of the insulin-like growth factor II receptor gene. | 2000 | Endocrinology | pmid:11108251 |
| Tobias CA et al. | Improved recombinant retroviral titers utilizing trichostatin A. | 2000 | BioTechniques | pmid:11056820 |
| Fukuda K | Apoptosis-associated cleavage of beta-catenin in human colon cancer and rat hepatoma cells. | 1999 Mar-Apr | Int. J. Biochem. Cell Biol. | pmid:10224675 |
| Schmidt K et al. | Inhibitors of histone deacetylase suppress the growth of MCF-7 breast cancer cells. | 1999 | Arch. Pharm. (Weinheim) | pmid:10575368 |
| Jung M et al. | Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation. | 1999 | J. Med. Chem. | pmid:10579829 |
| Ruh MF et al. | The effects of histone acetylation on estrogen responsiveness in MCF-7 cells. | 1999 | Endocrine | pmid:10709763 |
| Yoshida M and Horinouchi S | Trichostatin and leptomycin. Inhibition of histone deacetylation and signal-dependent nuclear export. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10667200 |
| Sowa Y et al. | Histone deacetylase inhibitor activates the p21/WAF1/Cip1 gene promoter through the Sp1 sites. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10667218 |
| Kim YB et al. | Selective induction of cyclin-dependent kinase inhibitors and their roles in cell cycle arrest caused by trichostatin A, an inhibitor of histone deacetylase. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10667219 |
| Marenzi S et al. | Efficiency of expression of transfected genes depends on the cell cycle. | 1999 | Mol. Biol. Rep. | pmid:10634509 |
| Gray SG et al. | IGF-II enhances trichostatin A-induced TGFbeta1 and p21(Waf1,Cip1, sdi1) expression in Hep3B cells. | 1999 | Exp. Cell Res. | pmid:10585285 |
| Condreay JP et al. | Transient and stable gene expression in mammalian cells transduced with a recombinant baculovirus vector. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9874783 |
| Feng YQ et al. | Enhancer-dependent transcriptional oscillations in mouse erythroleukemia cells. | 1999 | Mol. Cell. Biol. | pmid:10373540 |
| Böger H and Gruss P | Functional determinants for the tetracycline-dependent transactivator tTA in transgenic mouse embryos. | 1999 | Mech. Dev. | pmid:10381574 |
| Ghosh AK et al. | MBP-1 physically associates with histone deacetylase for transcriptional repression. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10403782 |
| Gradin K et al. | Repression of dioxin signal transduction in fibroblasts. Identification Of a putative repressor associated with Arnt. | 1999 | J. Biol. Chem. | pmid:10224119 |
| Kim YB et al. | Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase. | 1999 | Oncogene | pmid:10229197 |
| Johnson BS et al. | Retinoid X receptor (RXR) agonist-induced activation of dominant-negative RXR-retinoic acid receptor alpha403 heterodimers is developmentally regulated during myeloid differentiation. | 1999 | Mol. Cell. Biol. | pmid:10207061 |
| Niki T et al. | A histone deacetylase inhibitor, trichostatin A, suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture. | 1999 | Hepatology | pmid:10051490 |
| Hasegawa T et al. | Cloning of a GADD34-like gene that interacts with the zinc-finger transcription factor which binds to the p21(WAF) promoter. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10066455 |
| Inokoshi J et al. | Neuronal differentiation of neuro 2a cells by inhibitors of cell cycle progression, trichostatin A and butyrolactone I. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10079191 |
| Olsson TG et al. | Transient inhibition of histone deacetylase activity overcomes silencing in the mating-type region in fission yeast. | 1999 | Curr. Genet. | pmid:10079326 |
| Zabel MD et al. | Lymphoid transcription of the murine CD21 gene is positively regulated by histone acetylation. | 1999 | J. Immunol. | pmid:10453011 |
| Bernhard D et al. | Interaction between dexamethasone and butyrate in apoptosis induction: non-additive in thymocytes and synergistic in a T cell-derived leukemia cell line. | 1999 | Cell Death Differ. | pmid:10453071 |
| Liu Z et al. | Steroid receptor coactivator-1 (SRC-1) enhances ligand-dependent and receptor-dependent cell-free transcription of chromatin. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10449719 |
| Wang J et al. | Inhibitors of histone deacetylase relieve ETO-mediated repression and induce differentiation of AML1-ETO leukemia cells. | 1999 | Cancer Res. | pmid:10383127 |
| Suzuki T et al. | Synthesis and histone deacetylase inhibitory activity of new benzamide derivatives. | 1999 | J. Med. Chem. | pmid:10425110 |
| Tagami T et al. | Mechanisms that mediate negative regulation of the thyroid-stimulating hormone alpha gene by the thyroid hormone receptor. | 1999 | J. Biol. Chem. | pmid:10428804 |
| Radkov SA et al. | Epstein-Barr virus nuclear antigen 3C interacts with histone deacetylase to repress transcription. | 1999 | J. Virol. | pmid:10364319 |
| Croft JA et al. | Differences in the localization and morphology of chromosomes in the human nucleus. | 1999 | J. Cell Biol. | pmid:10366586 |
| Criqui-Filipe P et al. | Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation. | 1999 | EMBO J. | pmid:10369679 |
| Zhao W et al. | Trichostatin A up-regulates human papillomavirus type 11 upstream regulatory region-E6 promoter activity in undifferentiated primary human keratinocytes. | 1999 | J. Virol. | pmid:10233965 |