Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Liu M et al. | Decreased H3K9ac level of StAR mediated testicular dysplasia induced by prenatal dexamethasone exposure in male offspring rats. | 2018 | Toxicology | pmid:29902490 |
Li Q et al. | Bisphenol A and Phthalates Modulate Peritoneal Macrophage Function in Female Mice Involving SYMD2-H3K36 Dimethylation. | 2018 | Endocrinology | pmid:29718165 |
Cribbs A et al. | Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells. | 2018 | J. Biol. Chem. | pmid:29301935 |
Cheng YW et al. | The histone deacetylase inhibitor panobinostat exerts anticancer effects on esophageal squamous cell carcinoma cells by inducing cell cycle arrest. | 2018 | Cell Biochem. Funct. | pmid:30484863 |
Jang B et al. | Trichostatin A induces apoptosis in oral squamous cell carcinoma cell lines independent of hyperacetylation of histones. | 2018 | J Cancer Res Ther | pmid:30249871 |
Wang Y et al. | Inhibition of Histone Deacetylases Prevents Cardiac Remodeling After Myocardial Infarction by Restoring Autophagosome Processing in Cardiac Fibroblasts. | 2018 | Cell. Physiol. Biochem. | pmid:30235443 |
Feng Y et al. | Short-Chain Fatty Acids Manifest Stimulative and Protective Effects on Intestinal Barrier Function Through the Inhibition of NLRP3 Inflammasome and Autophagy. | 2018 | Cell. Physiol. Biochem. | pmid:30138914 |
Lugenbiel P et al. | Inhibition of Histone Deacetylases Induces K+ Channel Remodeling and Action Potential Prolongation in HL-1 Atrial Cardiomyocytes. | 2018 | Cell. Physiol. Biochem. | pmid:30134221 |
Wang JH et al. | HDAC inhibitors, trichostatin A and valproic acid, increase E‑cadherin and vimentin expression but inhibit migration and invasion of cholangiocarcinoma cells. | 2018 | Oncol. Rep. | pmid:29767267 |
Shi Y et al. | Histone deacetylase inhibitors alter the expression of molecular markers in breast cancer cells via microRNAs. | 2018 | Int. J. Mol. Med. | pmid:29620153 |
Jang BG et al. | Trichostatin A and Sirtinol Regulate the Expression and Nucleocytoplasmic Shuttling of Histone Deacetylases in All-Trans Retinoic Acid-Induced Differentiation of Neuroblastoma Cells. | 2018 | J. Mol. Neurosci. | pmid:29516351 |
Zhang X et al. | Tyrphostin B42 attenuates trichostatin A-mediated resistance in pancreatic cancer cells by antagonizing IL-6/JAK2/STAT3 signaling. | 2018 | Oncol. Rep. | pmid:29393444 |
Cai MH et al. | Depletion of HDAC1, 7 and 8 by Histone Deacetylase Inhibition Confers Elimination of Pancreatic Cancer Stem Cells in Combination with Gemcitabine. | 2018 | Sci Rep | pmid:29374219 |
Gao L et al. | Histone deacetylase inhibitor trichostatin A and autophagy inhibitor chloroquine synergistically exert anti-tumor activity in H-ras transformed breast epithelial cells. | 2018 | Mol Med Rep | pmid:29344672 |
Tiffon C | Histone Deacetylase Inhibition Restores Expression of Hypoxia-Inducible Protein NDRG1 in Pancreatic Cancer. | 2018 | Pancreas | pmid:29303911 |
Bodas M et al. | Inhibition of histone-deacetylase activity rescues inflammatory cystic fibrosis lung disease by modulating innate and adaptive immune responses. | 2018 | Respir. Res. | pmid:29301535 |
Seo SK et al. | Trichostatin A Induces NAG-1 Expression and Apoptosis in Human Endometriotic Stromal Cells. | 2018 | Reprod Sci | pmid:29157123 |
Kalaiarasi A et al. | Copper oxide nanoparticles induce anticancer activity in A549 lung cancer cells by inhibition of histone deacetylase. | 2018 | Biotechnol. Lett. | pmid:29116558 |
Lillico R et al. | Increased Post-Translational Lysine Acetylation of Myelin Basic Protein Is Associated with Peak Neurological Disability in a Mouse Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis. | 2018 | J. Proteome Res. | pmid:29111742 |
Dalla Pozza E et al. | Trichostatin A alters cytoskeleton and energy metabolism of pancreatic adenocarcinoma cells: An in depth proteomic study. | 2018 | J. Cell. Biochem. | pmid:29095525 |
Xing M et al. | Histone deacetylase inhibitor stimulates E2 and P4 secretion in sika deer ovarian granulosa cells at a moderate dose. | 2018 | Cell Biol. Int. | pmid:29064603 |
Zhang C et al. | An epigenetic bioactive composite scaffold with well-aligned nanofibers for functional tendon tissue engineering. | 2018 | Acta Biomater | pmid:28963019 |
Chan ST et al. | Quercetin enhances the antitumor effect of trichostatin A and suppresses muscle wasting in tumor-bearing mice. | 2018 | Food Funct | pmid:29292417 |
Jayaraman A et al. | Amelioration of progressive autoimmune encephalomyelitis by epigenetic regulation involves selective repression of mature neutrophils during the preclinical phase. | 2018 | Exp. Neurol. | pmid:29453977 |
Wu Y et al. | Regulatory Roles of Histone Deacetylases 1 and 2 in Pb-induced Neurotoxicity. | 2018 | Toxicol. Sci. | pmid:29301062 |
Lu Y and Zhang K | Cellular Reprogramming in the Retina - Seeing the Light. | 2018 | N. Engl. J. Med. | pmid:29539280 |
Sun P et al. | Effect of trichostatin A on Burkitt's lymphoma cells: Inhibition of EPS8 activity through Phospho-Erk1/2 pathway. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29462617 |
Motawi TK et al. | Combinatorial strategy of epigenetic and hormonal therapies: A novel promising approach for treating advanced prostate cancer. | 2018 | Life Sci. | pmid:29455003 |
Gurgul A et al. | Evaluation of changes arising in the pig mesenchymal stromal cells transcriptome following cryopreservation and Trichostatin A treatment. | 2018 | PLoS ONE | pmid:29390033 |
Wood M et al. | Trichostatin A inhibits deacetylation of histone H3 and p53 by SIRT6. | 2018 | Arch. Biochem. Biophys. | pmid:29233643 |
Buishand FO et al. | Trichostatin A preferentially reverses the upregulation of gene-expression levels induced by gain of chromosome 7 in colorectal cancer cell lines. | 2018 | Genes Chromosomes Cancer | pmid:28940826 |
Azuma R et al. | Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer. | 2018 | J Vis Exp | pmid:29757287 |
Palazzese L et al. | Nuclear quiescence and histone hyper-acetylation jointly improve protamine-mediated nuclear remodeling in sheep fibroblasts. | 2018 | PLoS ONE | pmid:29543876 |
Sanaei M et al. | Genistein and Trichostatin A Induction of Estrogen Receptor Alpha Gene Expression, Apoptosis and Cell Growth Inhibition in Hepatocellular Carcinoma HepG 2 Cells | 2017 | Asian Pac. J. Cancer Prev. | pmid:29286617 |
Yeakley JM et al. | A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling. | 2017 | PLoS ONE | pmid:28542535 |
Choiniere J et al. | Pyruvate Dehydrogenase Kinase 4 Deficiency Results in Expedited Cellular Proliferation through E2F1-Mediated Increase of Cyclins. | 2017 | Mol. Pharmacol. | pmid:28003426 |
Lin S et al. | Silencing of ATP4B of ATPase H/K Transporting Beta Subunit by Intragenic Epigenetic Alteration in Human Gastric Cancer Cells. | 2017 | Oncol. Res. | pmid:28281974 |
Li LF et al. | Trichostatin A attenuates ventilation-augmented epithelial-mesenchymal transition in mice with bleomycin-induced acute lung injury by suppressing the Akt pathway. | 2017 | PLoS ONE | pmid:28234968 |
Wu Y et al. | Suppression of Excessive Histone Deacetylases Activity in Diabetic Hearts Attenuates Myocardial Ischemia/Reperfusion Injury via Mitochondria Apoptosis Pathway. | 2017 | J Diabetes Res | pmid:28191472 |
Vanneste M et al. | Hyaluronate synthase-2 overexpression alters estrogen dependence and induces histone deacetylase inhibitor-like effects on ER-driven genes in MCF7 breast tumor cells. | 2017 | Mol. Cell. Endocrinol. | pmid:28137613 |
Wang XJ et al. | Opposing Roles of Acetylation and Phosphorylation in LIFR-Dependent Self-Renewal Growth Signaling in Mouse Embryonic Stem Cells. | 2017 | Cell Rep | pmid:28122243 |
Cao Z et al. | TSA and BIX-01294 Induced Normal DNA and Histone Methylation and Increased Protein Expression in Porcine Somatic Cell Nuclear Transfer Embryos. | 2017 | PLoS ONE | pmid:28114389 |
Chen L et al. | PI3K/mTOR dual inhibitor BEZ235 and histone deacetylase inhibitor Trichostatin A synergistically exert anti-tumor activity in breast cancer. | 2017 | Oncotarget | pmid:28060760 |
Hrgovic I et al. | Histone deacetylase inhibitors interfere with angiogenesis by decreasing endothelial VEGFR-2 protein half-life in part via a VE-cadherin-dependent mechanism. | 2017 | Exp. Dermatol. | pmid:27487811 |
Green AL et al. | Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1. | 2017 | Neuropharmacology | pmid:28743636 |
Hartl M et al. | Lysine acetylome profiling uncovers novel histone deacetylase substrate proteins in . | 2017 | Mol. Syst. Biol. | pmid:29061669 |
Wei ZQ et al. | Curcumin inhibits hepatitis B virus infection by down-regulating cccDNA-bound histone acetylation. | 2017 | World J. Gastroenterol. | pmid:28974891 |
Xie C et al. | In vitro analysis of factors influencing expression as potential determinants of interindividual variation. | 2017 | Pharmacol Res Perspect | pmid:28357125 |
Hichino A et al. | Down-regulation of Claudin-2 Expression and Proliferation by Epigenetic Inhibitors in Human Lung Adenocarcinoma A549 Cells. | 2017 | J. Biol. Chem. | pmid:28057758 |
Gilardini Montani MS et al. | Histone deacetylase inhibitors VPA and TSA induce apoptosis and autophagy in pancreatic cancer cells. | 2017 | Cell Oncol (Dordr) | pmid:28160167 |