Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Ellis JK et al. | Effect of the histone deacetylase inhibitor trichostatin a on the metabolome of cultured primary hepatocytes. | 2010 | J. Proteome Res. | pmid:19894772 |
Bhuiyan MM et al. | Production of Sei whale (Balaenoptera borealis) cloned embryos by inter- and intra-species somatic cell nuclear transfer. | 2010 | J. Reprod. Dev. | pmid:19893277 |
Dong G et al. | Inhibitors of histone deacetylases suppress cisplatin-induced p53 activation and apoptosis in renal tubular cells. | 2010 | Am. J. Physiol. Renal Physiol. | pmid:19889954 |
Ma X et al. | Identification of LIV1, a putative zinc transporter gene responsible for HDACi-induced apoptosis, using a functional gene screen approach. | 2009 | Mol. Cancer Ther. | pmid:19887557 |
Ninios YP et al. | Histone H1 subtype preferences of DFF40 and possible nuclear localization of DFF40/45 in normal and trichostatin A-treated NB4 leukemic cells. | 2010 | Apoptosis | pmid:19882353 |
Krishnan M et al. | HDAC inhibitors regulate claudin-1 expression in colon cancer cells through modulation of mRNA stability. | 2010 | Oncogene | pmid:19881542 |
Kusakabe M et al. | Impact of DNA demethylation of the G0S2 gene on the transcription of G0S2 in squamous lung cancer cell lines with or without nuclear receptor agonists. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19878646 |
Li X et al. | Mta3-NuRD complex is a master regulator for initiation of primitive hematopoiesis in vertebrate embryos. | 2009 | Blood | pmid:19864643 |
Meng CF et al. | Role of histone modifications and DNA methylation in the regulation of O6-methylguanine-DNA methyltransferase gene expression in human stomach cancer cells. | 2010 | Cancer Invest. | pmid:19857042 |
Ai J et al. | HDAC6 regulates androgen receptor hypersensitivity and nuclear localization via modulating Hsp90 acetylation in castration-resistant prostate cancer. | 2009 | Mol. Endocrinol. | pmid:19855091 |
Di Renzo F et al. | VPA-related axial skeletal defects and apoptosis: a proposed event cascade. | 2010 | Reprod. Toxicol. | pmid:19850124 |
Wang Y et al. | HDAC inhibitor trichostatin A-inhibited survival of dopaminergic neuronal cells. | 2009 | Neurosci. Lett. | pmid:19835929 |
Röhrs S et al. | Hypomethylation and expression of BEX2, IGSF4 and TIMP3 indicative of MLL translocations in acute myeloid leukemia. | 2009 | Mol. Cancer | pmid:19835597 |
Puca R et al. | HIPK2 modulates p53 activity towards pro-apoptotic transcription. | 2009 | Mol. Cancer | pmid:19828042 |
Li C et al. | Induction of myelogenous leukemia cells with histone deacetylase inhibitors through down-regulating the Daxx protein expression. | 2009 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:19821084 |
Hara D et al. | Persistent BDNF exon I-IX mRNA expression following the withdrawal of neuronal activity in neurons. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19818730 |
Gray SG et al. | Regulation of EP receptors in non-small cell lung cancer by epigenetic modifications. | 2009 | Eur. J. Cancer | pmid:19818596 |
Hui KF and Chiang AK | Suberoylanilide hydroxamic acid induces viral lytic cycle in Epstein-Barr virus-positive epithelial malignancies and mediates enhanced cell death. | 2010 | Int. J. Cancer | pmid:19816947 |
Lee JH et al. | Notch signal activates hypoxia pathway through HES1-dependent SRC/signal transducers and activators of transcription 3 pathway. | 2009 | Mol. Cancer Res. | pmid:19808903 |
Li X et al. | Gene silencing of MIR22 in acute lymphoblastic leukaemia involves histone modifications independent of promoter DNA methylation. | 2010 | Br. J. Haematol. | pmid:19807731 |
Gibbs A et al. | Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19805354 |
Sasaki K et al. | Real-time imaging of histone H4 hyperacetylation in living cells. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19805290 |
Liberatore RA et al. | NF-kappaB activity is constitutively elevated in c-Abl null fibroblasts. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19805123 |
Wu P et al. | Ubiquitin B: an essential mediator of trichostatin A-induced tumor-selective killing in human cancer cells. | 2010 | Cell Death Differ. | pmid:19798105 |
Sponziello M et al. | Regulation of sodium/iodide symporter and lactoperoxidase expression in four human breast cancer cell lines. | 2010 | J. Endocrinol. Invest. | pmid:19794300 |
Federman N et al. | Histone acetylation is recruited in consolidation as a molecular feature of stronger memories. | 2009 | Learn. Mem. | pmid:19794185 |
Iljin K et al. | High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growth. | 2009 | Clin. Cancer Res. | pmid:19789329 |
Meng CF et al. | Promoter histone H3 lysine 9 di-methylation is associated with DNA methylation and aberrant expression of p16 in gastric cancer cells. | 2009 | Oncol. Rep. | pmid:19787243 |
Law AY and Wong CK | Stanniocalcin-2 is a HIF-1 target gene that promotes cell proliferation in hypoxia. | 2010 | Exp. Cell Res. | pmid:19786016 |
Chen CZ et al. | The Scar-in-a-Jar: studying potential antifibrotic compounds from the epigenetic to extracellular level in a single well. | 2009 | Br. J. Pharmacol. | pmid:19785660 |
Higashiyama R et al. | Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis. | 2010 | Mod Rheumatol | pmid:19784544 |
Ninios YP et al. | Differential sensitivity of human leukemic cell lines to the histone deacetylase inhibitor, trichostatin A. | 2010 | Leuk. Res. | pmid:19782399 |
Beebe LF et al. | Cytochalasin B and trichostatin a treatment postactivation improves in vitro development of porcine somatic cell nuclear transfer embryos. | 2009 | Cloning Stem Cells | pmid:19780698 |
Fan J et al. | Expression and function of CD9 in melanoma cells. | 2010 | Mol. Carcinog. | pmid:19777564 |
Obier N and Müller AM | Chromatin flow cytometry identifies changes in epigenetic cell states. | 2010 | Cells Tissues Organs (Print) | pmid:19776550 |
Diplas AI et al. | Demonstration of all-or-none loss of imprinting in mRNA expression in single cells. | 2009 | Nucleic Acids Res. | pmid:19767614 |
Kim HN et al. | Trichostatin A inhibits osteoclastogenesis and bone resorption by suppressing the induction of c-Fos by RANKL. | 2009 | Eur. J. Pharmacol. | pmid:19766111 |
Cervera RP et al. | Trichostatin A affects histone acetylation and gene expression in porcine somatic cell nucleus transfer embryos. | 2009 | Theriogenology | pmid:19765811 |
Vire B et al. | Anti-leukemia activity of MS-275 histone deacetylase inhibitor implicates 4-1BBL/4-1BB immunomodulatory functions. | 2009 | PLoS ONE | pmid:19759901 |
Chiou SK and Hoa N | Up-regulation of GADD45alpha expression by NSAIDs leads to apoptotic and necrotic colon cancer cell deaths. | 2009 | Apoptosis | pmid:19757064 |
Hirata H et al. | Wnt antagonist gene DKK2 is epigenetically silenced and inhibits renal cancer progression through apoptotic and cell cycle pathways. | 2009 | Clin. Cancer Res. | pmid:19755393 |
Wang X et al. | Correction of the abnormal trafficking of primary myelofibrosis CD34+ cells by treatment with chromatin-modifying agents. | 2009 | Cancer Res. | pmid:19752087 |
Sterthaus O et al. | Evaluation of in vitro cultured rat oocytes, from different strains, by spindle morphology and maturation-promoting-factor activity combined with nuclear-transfer experiments. | 2009 | Cloning Stem Cells | pmid:19751114 |
Lugrin J et al. | Histone deacetylase inhibitors repress macrophage migration inhibitory factor (MIF) expression by targeting MIF gene transcription through a local chromatin deacetylation. | 2009 | Biochim. Biophys. Acta | pmid:19747950 |
Dandrea M et al. | MeCP2/H3meK9 are involved in IL-6 gene silencing in pancreatic adenocarcinoma cell lines. | 2009 | Nucleic Acids Res. | pmid:19745053 |
Dombrowsky H et al. | Conserved responses to trichostatin A in rodent lungs exposed to endotoxin or stretch. | 2009 | Pulm Pharmacol Ther | pmid:19744573 |
Yoshizawa Y et al. | Impaired active demethylation of the paternal genome in pronuclear-stage rat zygotes produced by in vitro fertilization or intracytoplasmic sperm injection. | 2010 | Mol. Reprod. Dev. | pmid:19743475 |
Meng CF et al. | [Effects of 5-Aza-2'-deoxycytidine and trichostatin A on P16, hMLH1 and MGMT genes and DNA methylation in human gastric cancer cells]. | 2009 | Zhonghua Wei Chang Wai Ke Za Zhi | pmid:19742343 |
Bennett KL et al. | AP-2alpha induces epigenetic silencing of tumor suppressive genes and microsatellite instability in head and neck squamous cell carcinoma. | 2009 | PLoS ONE | pmid:19742317 |
Kashiwagi Y et al. | Trichostatin A-induced TGF-beta type II receptor expression in retinoblastoma cell lines. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:19737884 |
Ong DC et al. | LARG at chromosome 11q23 has functional characteristics of a tumor suppressor in human breast and colorectal cancer. | 2009 | Oncogene | pmid:19734946 |
Mousa SA et al. | Stress resistant human embryonic stem cells as a potential source for the identification of novel cancer stem cell markers. | 2010 | Cancer Lett. | pmid:19733430 |
Kee HJ and Kook H | Krüppel-like factor 4 mediates histone deacetylase inhibitor-induced prevention of cardiac hypertrophy. | 2009 | J. Mol. Cell. Cardiol. | pmid:19729022 |
Her S et al. | Trichostatin A stimulates steroid 5alpha-reductase gene expression in rat C6 glioma cells via a mechanism involving Sp1 and Sp3 transcription factors. | 2010 | J. Mol. Neurosci. | pmid:19728174 |
Alao JP et al. | Inhibition of type I histone deacetylase increases resistance of checkpoint-deficient cells to genotoxic agents through mitotic delay. | 2009 | Mol. Cancer Ther. | pmid:19723888 |
Vamadevan AS et al. | Regulation of Toll-like receptor 4-associated MD-2 in intestinal epithelial cells: a comprehensive analysis. | 2010 | Innate Immun | pmid:19710105 |
Olsen CA and Ghadiri MR | Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides. | 2009 | J. Med. Chem. | pmid:19705846 |
Yamanaka K et al. | Acetylation level of histone H3 in early embryonic stages affects subsequent development of miniature pig somatic cell nuclear transfer embryos. | 2009 | J. Reprod. Dev. | pmid:19700928 |
Guo W et al. | Abrogation of TGF-beta1-induced fibroblast-myofibroblast differentiation by histone deacetylase inhibition. | 2009 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:19700647 |
Davies GF et al. | Troglitazone inhibits histone deacetylase activity in breast cancer cells. | 2010 | Cancer Lett. | pmid:19699029 |
Ma XX et al. | Histone deacetylase inhibitor trichostatin A modulates cell cycles in A2780 human ovarian cancer cell lines. | 2009 | Eur. J. Gynaecol. Oncol. | pmid:19697617 |
Carambula SF et al. | Repression of induced apoptosis in the 2-cell bovine embryo involves DNA methylation and histone deacetylation. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19665989 |
Dagtas AS et al. | Histone deacetylase inhibitor uses p21(Cip1) to maintain anergy in CD4+ T cells. | 2009 | Int. Immunopharmacol. | pmid:19664724 |
Hong Z et al. | Microarray study of mechanism of trichostatin a inducing apoptosis of Molt-4 cells. | 2009 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:19662360 |
Pang M et al. | Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy. | 2009 | Am. J. Physiol. Renal Physiol. | pmid:19640900 |
Shiau RJ et al. | Genistein and beta-carotene enhance the growth-inhibitory effect of trichostatin A in A549 cells. | 2010 | Eur J Nutr | pmid:19639378 |
Imesch P et al. | MLH1 protects from resistance acquisition by the histone deacetylase inhibitor trichostatin A in colon tumor cells. | 2009 | Int. J. Oncol. | pmid:19639184 |
Chandrasekaran S et al. | Histone deacetylases facilitate sodium/calcium exchanger up-regulation in adult cardiomyocytes. | 2009 | FASEB J. | pmid:19638401 |
Song S et al. | Trichostatin A enhances proliferation and migration of vascular smooth muscle cells by downregulating thioredoxin 1. | 2010 | Cardiovasc. Res. | pmid:19633316 |
Giustiniani J et al. | Basal endothelial nitric oxide synthase (eNOS) phosphorylation on Ser(1177) occurs in a stable microtubule- and tubulin acetylation-dependent manner. | 2009 | Exp. Cell Res. | pmid:19632222 |
Ma GD et al. | [Role of histone deacetylase in inhibiting invasion of human gastric carcinoma cell line SGC-7901 by PPARgamma-mediated pathway]. | 2009 | Ai Zheng | pmid:19624894 |
Fujii K et al. | Co-treatment with deoxycholic acid and azoxymethane accelerates secretion of HMGB1 in IEC6 intestinal epithelial cells. | 2009 | Cell Prolif. | pmid:19614672 |
Monks A et al. | Gene expression-signature of belinostat in cell lines is specific for histone deacetylase inhibitor treatment, with a corresponding signature in xenografts. | 2009 | Anticancer Drugs | pmid:19606018 |
Rahim R and Strobl JS | Hydroxychloroquine, chloroquine, and all-trans retinoic acid regulate growth, survival, and histone acetylation in breast cancer cells. | 2009 | Anticancer Drugs | pmid:19584707 |
Thiel A et al. | 15-hydroxyprostaglandin dehydrogenase is down-regulated in gastric cancer. | 2009 | Clin. Cancer Res. | pmid:19584167 |
Watson JA et al. | Hyperacetylation in prostate cancer induces cell cycle aberrations, chromatin reorganization and altered gene expression profiles. | 2010 | J. Cell. Mol. Med. | pmid:19583812 |
Sawarkar R et al. | Histone deacetylases regulate multicellular development in the social amoeba Dictyostelium discoideum. | 2009 | J. Mol. Biol. | pmid:19576222 |
Wang XX and Fu L | [Recent advances in DNA demethylation in tumor therapy]. | 2009 | Zhonghua Bing Li Xue Za Zhi | pmid:19575888 |
Gan YH and Zhang S | PTEN/AKT pathway involved in histone deacetylases inhibitor induced cell growth inhibition and apoptosis of oral squamous cell carcinoma cells. | 2009 | Oral Oncol. | pmid:19574087 |
Lee JH et al. | Structural and functional studies of the yeast class II Hda1 histone deacetylase complex. | 2009 | J. Mol. Biol. | pmid:19573535 |
Ma XL et al. | [Construction of anti-sense cDNA library of human breast cancer cells during apoptosis induced by trichostatin A and preliminary screening of essential genes]. | 2009 | Zhonghua Yi Xue Za Zhi | pmid:19567099 |
Tian F et al. | NMDA receptor activation induces differential epigenetic modification of Bdnf promoters in hippocampal neurons. | 2010 | Amino Acids | pmid:19565326 |
Jonsen MD et al. | The 26-amino acid beta-motif of the Pit-1beta transcription factor is a dominant and independent repressor domain. | 2009 | Mol. Endocrinol. | pmid:19556346 |
Noh H et al. | Histone deacetylase-2 is a key regulator of diabetes- and transforming growth factor-beta1-induced renal injury. | 2009 | Am. J. Physiol. Renal Physiol. | pmid:19553350 |
Hsu PY et al. | Xenoestrogen-induced epigenetic repression of microRNA-9-3 in breast epithelial cells. | 2009 | Cancer Res. | pmid:19549897 |
Moon C et al. | Use of epigenetic modification to induce FOXP3 expression in naïve T cells. | 2009 | Transplant. Proc. | pmid:19545742 |
Dubois F et al. | Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni. | 2009 | Mol. Biochem. Parasitol. | pmid:19538992 |
Casero RA and Woster PM | Recent advances in the development of polyamine analogues as antitumor agents. | 2009 | J. Med. Chem. | pmid:19534534 |
Chen IH et al. | Cytotoxic triterpenoids from the stems of Microtropis japonica. | 2009 | J. Nat. Prod. | pmid:19534471 |
Link PA et al. | Distinct roles for histone methyltransferases G9a and GLP in cancer germ-line antigen gene regulation in human cancer cells and murine embryonic stem cells. | 2009 | Mol. Cancer Res. | pmid:19531572 |
Nadasi E et al. | Epigenetic modifiers exacerbate oxidative stress in renal proximal tubule cells. | 2009 | Anticancer Res. | pmid:19528494 |
Sugimura S et al. | Interspecies somatic cell nucleus transfer with porcine oocytes as recipients: A novel bioassay system for assessing the competence of canine somatic cells to develop into embryos. | 2009 | Theriogenology | pmid:19524287 |
Takaya T et al. | MicroRNA-1 and MicroRNA-133 in spontaneous myocardial differentiation of mouse embryonic stem cells. | 2009 | Circ. J. | pmid:19521018 |
Nakajima S et al. | Trichostatin A with adenovirus-mediated p53 gene transfer synergistically induces apoptosis in breast cancer cell line MDA-MB-231. | 2009 | Oncol. Rep. | pmid:19513516 |
Chang J et al. | The NIMA-family kinase Nek3 regulates microtubule acetylation in neurons. | 2009 | J. Cell. Sci. | pmid:19509051 |
Bonetto A et al. | Deacetylase inhibitors modulate the myostatin/follistatin axis without improving cachexia in tumor-bearing mice. | 2009 | Curr Cancer Drug Targets | pmid:19508174 |
Kondo T et al. | Epigenetic silencing of TTF-1/NKX2-1 through DNA hypermethylation and histone H3 modulation in thyroid carcinomas. | 2009 | Lab. Invest. | pmid:19506552 |
Ku WC et al. | Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2. | 2009 | Mol. Cell Proteomics | pmid:19505873 |
Pulukuri SM et al. | Frequent loss of cystatin E/M expression implicated in the progression of prostate cancer. | 2009 | Oncogene | pmid:19503093 |
Araki H et al. | Cord blood stem cell expansion is permissive to epigenetic regulation and environmental cues. | 2009 | Exp. Hematol. | pmid:19501128 |