Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Sharifulina SA et al. | Epigenetic regulation of death of crayfish glial cells but not neurons induced by photodynamic impact. | 2014 | Brain Res. Bull. | pmid:24502940 |
Nieto-Pelegrin E et al. | Nck adaptors, besides promoting N-WASP mediated actin-nucleation activity at pedestals, influence the cellular levels of enteropathogenic Escherichia coli Tir effector. | 2014 | Cell Adh Migr | pmid:25482634 |
Svegliati S et al. | Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis. | 2014 | Sci Signal | pmid:25185156 |
Lu HG et al. | TET1 partially mediates HDAC inhibitor-induced suppression of breast cancer invasion. | 2014 | Mol Med Rep | pmid:25175940 |
Zohre S et al. | Trichostatin A-induced apoptosis is mediated by Kruppel-like factor 4 in ovarian and lung cancer. | 2014 | Asian Pac. J. Cancer Prev. | pmid:25169491 |
Saini M et al. | Trichostatin A alters the expression of cell cycle controlling genes and microRNAs in donor cells and subsequently improves the yield and quality of cloned bovine embryos in vitro. | 2014 | Theriogenology | pmid:25151601 |
Charni Chaabane S et al. | PDGF-D expression is down-regulated by TGFβ in fibroblasts. | 2014 | PLoS ONE | pmid:25280005 |
Knobloch J et al. | Resveratrol attenuates the release of inflammatory cytokines from human bronchial smooth muscle cells exposed to lipoteichoic acid in chronic obstructive pulmonary disease. | 2014 | Basic Clin. Pharmacol. Toxicol. | pmid:23981542 |
Kiliccioglu I et al. | Apoptotic effects of proteasome and histone deacetylase inhibitors in prostate cancer cell lines. | 2014 | Genet. Mol. Res. | pmid:24854658 |
Yang DH et al. | Dynamic rearrangement of F-actin is required to maintain the antitumor effect of trichostatin A. | 2014 | PLoS ONE | pmid:24846135 |
Kumafuji M et al. | Mediator MED18 subunit plays a negative role in transcription via the CDK/cyclin module. | 2014 | Genes Cells | pmid:24840924 |
Balmer NV et al. | From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. | 2014 | Arch. Toxicol. | pmid:24935251 |
Deng Y et al. | [Expression of neprilysin gene is associated with methylation and histone modification on promoter in mouse neuroblastoma Neuro-2a cells]. | 2014 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:25108432 |
Fang J et al. | Epigenetic modulation of neuronal apoptosis and cognitive functions in sepsis-associated encephalopathy. | 2014 | Neurol. Sci. | pmid:23925573 |
Kong Q et al. | Telomere elongation facilitated by trichostatin a in cloned embryos and pigs by somatic cell nuclear transfer. | 2014 | Stem Cell Rev | pmid:24510582 |
Liu J et al. | DNA promoter and histone H3 methylation downregulate NGX6 in gastric cancer cells. | 2014 | Med. Oncol. | pmid:24338274 |
Al-Rayyan N et al. | 5-Aza-2-deoxycytidine and trichostatin A increase COUP-TFII expression in antiestrogen-resistant breast cancer cell lines. | 2014 | Cancer Lett. | pmid:24513177 |
Yang W et al. | Trichostatin A increases the levels of plasma gelsolin and amyloid beta-protein in a transgenic mouse model of Alzheimer's disease. | 2014 | Life Sci. | pmid:24486299 |
Bezecny P | Histone deacetylase inhibitors in glioblastoma: pre-clinical and clinical experience. | 2014 | Med. Oncol. | pmid:24838514 |
Alsarraf O et al. | Acetylation: a lysine modification with neuroprotective effects in ischemic retinal degeneration. | 2014 | Exp. Eye Res. | pmid:25064603 |