trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Han B et al. | Trichostatin A stabilizes the expression of pluripotent genes in human mesenchymal stem cells during ex vivo expansion. | 2013 | PLoS ONE | pmid:24312356 |
| Hou SY et al. | Expressions of MAGE-A9 and MAGE-A11 in breast cancer and their expression mechanism. | 2014 | Arch. Med. Res. | pmid:24316396 |
| Liu J et al. | DNA promoter and histone H3 methylation downregulate NGX6 in gastric cancer cells. | 2014 | Med. Oncol. | pmid:24338274 |
| Zhu M et al. | Histone decacetylase inhibitors prevent mitochondrial fragmentation and elicit early neuroprotection against MPP+. | 2014 | CNS Neurosci Ther | pmid:24351065 |
| Tian Y et al. | Ubiquitin B in cervical cancer: critical for the maintenance of cancer stem-like cell characters. | 2013 | PLoS ONE | pmid:24367661 |
| Alcarraz-Vizán G et al. | Validation of NCM460 cell model as control in antitumor strategies targeting colon adenocarcinoma metabolic reprogramming: trichostatin A as a case study. | 2014 | Biochim. Biophys. Acta | pmid:24368265 |
| Mahmud N et al. | Differential effects of epigenetic modifiers on the expansion and maintenance of human cord blood stem/progenitor cells. | 2014 | Biol. Blood Marrow Transplant. | pmid:24374212 |
| Koriyama Y et al. | Neuritogenic activity of trichostatin A in adult rat retinal ganglion cells through acetylation of histone H3 lysine 9 and RARβ induction. | 2014 | J. Pharmacol. Sci. | pmid:24389816 |
| Yoshida M et al. | Effects of trichostatins on differentiation of murine erythroleukemia cells. | 1987 | Cancer Res. | pmid:2439196 |
| Xie M et al. | Histone deacetylase inhibition blunts ischemia/reperfusion injury by inducing cardiomyocyte autophagy. | 2014 | Circulation | pmid:24396039 |
| Sathe A et al. | MicroRNA let-7f: a novel regulator of innate immune response in human endocervical cells. | 2014 | Am. J. Reprod. Immunol. | pmid:24405266 |
| Sugimoto K et al. | Improving allogeneic islet transplantation by suppressing Th17 and enhancing Treg with histone deacetylase inhibitors. | 2014 | Transpl. Int. | pmid:24410777 |
| Poljak M et al. | Class I to III histone deacetylases differentially regulate inflammation-induced matrix metalloproteinase 9 expression in primary amnion cells. | 2014 | Reprod Sci | pmid:24429678 |
| Oride A et al. | Trichostatin A specifically stimulates gonadotropin FSHβ gene expression in gonadotroph LβT2 cells. | 2014 | Endocr. J. | pmid:24430728 |
| Kumar P et al. | Histone deacetylase inhibitors modulate the transcriptional regulation of guanylyl cyclase/natriuretic peptide receptor-a gene: interactive roles of modified histones, histone acetyltransferase, p300, AND Sp1. | 2014 | J. Biol. Chem. | pmid:24451378 |
| Xiao W et al. | Trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and epithelial-mesenchymal transition in retinal pigment epithelium cells. | 2014 | J. Cell. Mol. Med. | pmid:24456602 |
| Li H et al. | The histone deacetylase inhibitor trichostatin a promotes totipotency in the male gametophyte. | 2014 | Plant Cell | pmid:24464291 |
| Sassi Fde A et al. | Inhibitory activities of trichostatin a in U87 glioblastoma cells and tumorsphere-derived cells. | 2014 | J. Mol. Neurosci. | pmid:24464841 |
| Smith S et al. | Histone deacetylase inhibitors selectively target homology dependent DNA repair defective cells and elevate non-homologous endjoining activity. | 2014 | PLoS ONE | pmid:24466340 |
| Karki P et al. | Yin Yang 1 is a repressor of glutamate transporter EAAT2, and it mediates manganese-induced decrease of EAAT2 expression in astrocytes. | 2014 | Mol. Cell. Biol. | pmid:24469401 |
| Michalak P | Evidence for maternal imprinting of 45S ribosomal RNA genes in Xenopus hybrids. | 2014 | Dev. Genes Evol. | pmid:24477594 |
| Li Z et al. | DNA methylation downregulated mir-10b acts as a tumor suppressor in gastric cancer. | 2015 | Gastric Cancer | pmid:24481854 |
| Yang W et al. | Trichostatin A increases the levels of plasma gelsolin and amyloid beta-protein in a transgenic mouse model of Alzheimer's disease. | 2014 | Life Sci. | pmid:24486299 |
| Sharifulina SA et al. | Epigenetic regulation of death of crayfish glial cells but not neurons induced by photodynamic impact. | 2014 | Brain Res. Bull. | pmid:24502940 |
| Brglez V et al. | Secreted phospholipases Aâ‚‚are differentially expressed and epigenetically silenced in human breast cancer cells. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24508801 |
| Kong Q et al. | Telomere elongation facilitated by trichostatin a in cloned embryos and pigs by somatic cell nuclear transfer. | 2014 | Stem Cell Rev | pmid:24510582 |
| Al-Rayyan N et al. | 5-Aza-2-deoxycytidine and trichostatin A increase COUP-TFII expression in antiestrogen-resistant breast cancer cell lines. | 2014 | Cancer Lett. | pmid:24513177 |
| Sakharkar AJ et al. | Effects of histone deacetylase inhibitors on amygdaloid histone acetylation and neuropeptide Y expression: a role in anxiety-like and alcohol-drinking behaviours. | 2014 | Int. J. Neuropsychopharmacol. | pmid:24528596 |
| Chu Y et al. | Chromatin composition alterations and the critical role of MeCP2 for epigenetic silencing of progesterone receptor-B gene in endometrial cancers. | 2014 | Cell. Mol. Life Sci. | pmid:24531693 |
| Zou JY and Crews FT | Release of neuronal HMGB1 by ethanol through decreased HDAC activity activates brain neuroimmune signaling. | 2014 | PLoS ONE | pmid:24551070 |
| McEachern LA and Murphy PR | Chromatin-remodeling factors mediate the balance of sense-antisense transcription at the FGF2 locus. | 2014 | Mol. Endocrinol. | pmid:24552587 |
| Saayman S et al. | An HIV-encoded antisense long noncoding RNA epigenetically regulates viral transcription. | 2014 | Mol. Ther. | pmid:24576854 |
| Blank M et al. | Basolateral amygdala activity is required for enhancement of memory consolidation produced by histone deacetylase inhibition in the hippocampus. | 2014 | Neurobiol Learn Mem | pmid:24583371 |
| Johnson JL et al. | The desmosomal protein desmoglein 1 aids recovery of epidermal differentiation after acute UV light exposure. | 2014 | J. Invest. Dermatol. | pmid:24594668 |
| Chen HY et al. | Histone deacetylase inhibitors trichostatin A and suberoylanilide hydroxamic acid attenuate ventilator-induced lung injury. | 2014 | Pharmazie | pmid:24601225 |
| Guilluy C et al. | Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus. | 2014 | Nat. Cell Biol. | pmid:24609268 |
| Kizuka Y et al. | Epigenetic regulation of a brain-specific glycosyltransferase N-acetylglucosaminyltransferase-IX (GnT-IX) by specific chromatin modifiers. | 2014 | J. Biol. Chem. | pmid:24619417 |
| Kilinc V et al. | Do iron chelators increase the antiproliferative effect of trichostatin A through a glucose-regulated protein 78 mediated mechanism? | 2014 | Tumour Biol. | pmid:24622883 |
| Sun S et al. | Trichostatin A targets the mitochondrial respiratory chain, increasing mitochondrial reactive oxygen species production to trigger apoptosis in human breast cancer cells. | 2014 | PLoS ONE | pmid:24626188 |
| Yuan TF et al. | The epigenetics changes in Parkinson's disease: a novel therapeutic target. | 2014 | CNS Neurosci Ther | pmid:24629108 |
| Aune SE et al. | Selective inhibition of class I but not class IIb histone deacetylases exerts cardiac protection from ischemia reperfusion. | 2014 | J. Mol. Cell. Cardiol. | pmid:24632412 |
| Varol N et al. | The epigenetically regulated effects of Wnt antagonists on the expression of genes in the apoptosis pathway in human bladder cancer cell line (T24). | 2014 | DNA Cell Biol. | pmid:24665856 |
| Sugimoto H et al. | Production of somatic cell nuclear transfer embryos using in vitro-grown and in vitro-matured oocytes in rabbits. | 2015 | Zygote | pmid:24666637 |
| Wisnieski F et al. | Differential expression of histone deacetylase and acetyltransferase genes in gastric cancer and their modulation by trichostatin A. | 2014 | Tumour Biol. | pmid:24668547 |
| Zuo X et al. | Breast cancer cells are arrested at different phases of the cell cycle following the re-expression of ARHI. | 2014 | Oncol. Rep. | pmid:24676336 |
| Cherry KE et al. | Identification of Tf1 integration events in S. pombe under nonselective conditions. | 2014 | Gene | pmid:24680781 |
| Yang J et al. | PTEN methylation involved in benzene-induced hematotoxicity. | 2014 | Exp. Mol. Pathol. | pmid:24680972 |
| Saccone V et al. | HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles. | 2014 | Genes Dev. | pmid:24682306 |
| Deneberg S et al. | microRNA-34b/c on chromosome 11q23 is aberrantly methylated in chronic lymphocytic leukemia. | 2014 | Epigenetics | pmid:24686393 |
| Boyer JG et al. | Myogenic program dysregulation is contributory to disease pathogenesis in spinal muscular atrophy. | 2014 | Hum. Mol. Genet. | pmid:24691550 |