Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Huang X et al. | Nitric oxide (NO), methylation and TIMP-1 expression in BL6 melanoma cells transfected with MHC class I genes. | 2000 | Clin. Exp. Metastasis | pmid:11448064 |
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Chang LK and Liu ST | Activation of the BRLF1 promoter and lytic cycle of Epstein-Barr virus by histone acetylation. | 2000 | Nucleic Acids Res. | pmid:11024171 |
Suzuki T et al. | Effect of trichostatin A on cell growth and expression of cell cycle- and apoptosis-related molecules in human gastric and oral carcinoma cell lines. | 2000 | Int. J. Cancer | pmid:11093826 |
Sutcliffe JE et al. | Retinoblastoma protein disrupts interactions required for RNA polymerase III transcription. | 2000 | Mol. Cell. Biol. | pmid:11094071 |
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Yu J et al. | Transcriptional repression by blimp-1 (PRDI-BF1) involves recruitment of histone deacetylase. | 2000 | Mol. Cell. Biol. | pmid:10713181 |
Adachi N et al. | Cell-cycle regulation of the DNA topoisomerase IIalpha promoter is mediated by proximal CCAAT boxes: possible involvement of acetylation. | 2000 | Gene | pmid:10713444 |
Stöckel B et al. | Characterization of the 5'-flanking region of the human multidrug resistance protein 2 (MRP2) gene and its regulation in comparison withthe multidrug resistance protein 3 (MRP3) gene. | 2000 | Eur. J. Biochem. | pmid:10691972 |
Imai S et al. | Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. | 2000 | Nature | pmid:10693811 |
Sirchia SM et al. | Evidence of epigenetic changes affecting the chromatin state of the retinoic acid receptor beta2 promoter in breast cancer cells. | 2000 | Oncogene | pmid:10734315 |
Hodny Z et al. | Sp1 and chromatin environment are important contributors to the formation of repressive chromatin structures on the transfected human adenine nucleotide translocase-2 promoter. | 2000 | Biochem. J. | pmid:10657244 |
Smith RD et al. | Quantitative PCR analysis of HbF inducers in primary human adult erythroid cells. | 2000 | Blood | pmid:10648397 |
Kim YB et al. | Mechanism of cell cycle arrest caused by histone deacetylase inhibitors in human carcinoma cells. | 2000 | J. Antibiot. | pmid:11132966 |
Eickhoff B et al. | Trichostatin A-mediated regulation of gene expression and protein kinase activities: reprogramming tumor cells for ribotoxic stress-induced apoptosis. | 2000 | Biol. Chem. | pmid:11154071 |
Yang X et al. | Transcriptional activation of estrogen receptor alpha in human breast cancer cells by histone deacetylase inhibition. | 2000 | Cancer Res. | pmid:11156387 |
Tobias CA et al. | Improved recombinant retroviral titers utilizing trichostatin A. | 2000 | BioTechniques | pmid:11056820 |
Fukuda K | Apoptosis-associated cleavage of beta-catenin in human colon cancer and rat hepatoma cells. | 1999 Mar-Apr | Int. J. Biochem. Cell Biol. | pmid:10224675 |
Taddei A et al. | Duplication and maintenance of heterochromatin domains. | 1999 | J. Cell Biol. | pmid:10601331 |
Nielsen AL et al. | Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family. | 1999 | EMBO J. | pmid:10562550 |
Habeck M | Gelsolin: a new marker for breast cancer? | 1999 | Mol Med Today | pmid:10562712 |
Saunders N et al. | Histone deacetylase inhibitors as potential anti-skin cancer agents. | 1999 | Cancer Res. | pmid:9927053 |
O'Neill LP et al. | A developmental switch in H4 acetylation upstream of Xist plays a role in X chromosome inactivation. | 1999 | EMBO J. | pmid:10329635 |
Strouboulis J et al. | Transcriptional repression by XPc1, a new Polycomb homolog in Xenopus laevis embryos, is independent of histone deacetylase. | 1999 | Mol. Cell. Biol. | pmid:10330136 |
Bakin AV and Curran T | Role of DNA 5-methylcytosine transferase in cell transformation by fos. | 1999 | Science | pmid:9888853 |
Verdel A and Khochbin S | Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers. | 1999 | J. Biol. Chem. | pmid:9891014 |
Coffee B et al. | Acetylated histones are associated with FMR1 in normal but not fragile X-syndrome cells. | 1999 | Nat. Genet. | pmid:10319871 |
Xiao H et al. | Both Sp1 and Sp3 are responsible for p21waf1 promoter activity induced by histone deacetylase inhibitor in NIH3T3 cells. | 1999 | J. Cell. Biochem. | pmid:10321829 |
Mielnicki LM et al. | Epigenetic regulation of gelsolin expression in human breast cancer cells. | 1999 | Exp. Cell Res. | pmid:10328963 |
Krajewski WA | Effect of in vivo histone hyperacetylation on the state of chromatin fibers. | 1999 | J. Biomol. Struct. Dyn. | pmid:10333179 |
Yoshida M | [Discovery of cell cycle inhibitors and their application to molecular biology]. | 1999 | Jpn J Antibiot | pmid:10221182 |
Feng YQ et al. | Enhancer-dependent transcriptional oscillations in mouse erythroleukemia cells. | 1999 | Mol. Cell. Biol. | pmid:10373540 |
Böger H and Gruss P | Functional determinants for the tetracycline-dependent transactivator tTA in transgenic mouse embryos. | 1999 | Mech. Dev. | pmid:10381574 |
Ghosh AK et al. | MBP-1 physically associates with histone deacetylase for transcriptional repression. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10403782 |
Gradin K et al. | Repression of dioxin signal transduction in fibroblasts. Identification Of a putative repressor associated with Arnt. | 1999 | J. Biol. Chem. | pmid:10224119 |
Vanden Berghe W et al. | The nuclear factor-kappaB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter. | 1999 | J. Biol. Chem. | pmid:10542243 |
Ng HH et al. | MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. | 1999 | Nat. Genet. | pmid:10471499 |
Sowa Y et al. | Sp3, but not Sp1, mediates the transcriptional activation of the p21/WAF1/Cip1 gene promoter by histone deacetylase inhibitor. | 1999 | Cancer Res. | pmid:10485470 |
Finnin MS et al. | Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors. | 1999 | Nature | pmid:10490031 |
Huang Y et al. | Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes. | 1999 | Nat. Neurosci. | pmid:10491605 |
List HJ et al. | Inhibition of histone deacetylation augments dihydrotestosterone induction of androgen receptor levels: an explanation for trichostatin A effects on androgen-induced chromatin remodeling and transcription of the mouse mammary tumor virus promoter. | 1999 | Exp. Cell Res. | pmid:10527637 |
Bordonaro M et al. | Butyrate-induced apoptotic cascade in colonic carcinoma cells: modulation of the beta-catenin-Tcf pathway and concordance with effects of sulindac and trichostatin A but not curcumin. | 1999 | Cell Growth Differ. | pmid:10547075 |
KraevskiÄ VA and Prasolov VS | [Comparative analysis of higher levels of organization of normal and hyperacetylated chromatin]. | 1999 | Dokl. Akad. Nauk. | pmid:10439916 |
Zabel MD et al. | Lymphoid transcription of the murine CD21 gene is positively regulated by histone acetylation. | 1999 | J. Immunol. | pmid:10453011 |
Bernhard D et al. | Interaction between dexamethasone and butyrate in apoptosis induction: non-additive in thymocytes and synergistic in a T cell-derived leukemia cell line. | 1999 | Cell Death Differ. | pmid:10453071 |
Liu Z et al. | Steroid receptor coactivator-1 (SRC-1) enhances ligand-dependent and receptor-dependent cell-free transcription of chromatin. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10449719 |
Wang J et al. | Inhibitors of histone deacetylase relieve ETO-mediated repression and induce differentiation of AML1-ETO leukemia cells. | 1999 | Cancer Res. | pmid:10383127 |