| MeSH term | MeSH ID | Detail |
|---|---|---|
| Osteosarcoma | D012516 | 50 associated lipids |
| Brain Neoplasms | D001932 | 15 associated lipids |
| Leukemia, Erythroblastic, Acute | D004915 | 41 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Muscular Dystrophies | D009136 | 10 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Intellectual Disability | D008607 | 13 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Liu M et al. | Decreased H3K9ac level of StAR mediated testicular dysplasia induced by prenatal dexamethasone exposure in male offspring rats. | 2018 | Toxicology | pmid:29902490 |
| Li Q et al. | Bisphenol A and Phthalates Modulate Peritoneal Macrophage Function in Female Mice Involving SYMD2-H3K36 Dimethylation. | 2018 | Endocrinology | pmid:29718165 |
| Cribbs A et al. | Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells. | 2018 | J. Biol. Chem. | pmid:29301935 |
| Cheng YW et al. | The histone deacetylase inhibitor panobinostat exerts anticancer effects on esophageal squamous cell carcinoma cells by inducing cell cycle arrest. | 2018 | Cell Biochem. Funct. | pmid:30484863 |
| Jang B et al. | Trichostatin A induces apoptosis in oral squamous cell carcinoma cell lines independent of hyperacetylation of histones. | 2018 | J Cancer Res Ther | pmid:30249871 |
| Wang Y et al. | Inhibition of Histone Deacetylases Prevents Cardiac Remodeling After Myocardial Infarction by Restoring Autophagosome Processing in Cardiac Fibroblasts. | 2018 | Cell. Physiol. Biochem. | pmid:30235443 |
| Feng Y et al. | Short-Chain Fatty Acids Manifest Stimulative and Protective Effects on Intestinal Barrier Function Through the Inhibition of NLRP3 Inflammasome and Autophagy. | 2018 | Cell. Physiol. Biochem. | pmid:30138914 |
| Lugenbiel P et al. | Inhibition of Histone Deacetylases Induces K+ Channel Remodeling and Action Potential Prolongation in HL-1 Atrial Cardiomyocytes. | 2018 | Cell. Physiol. Biochem. | pmid:30134221 |
| Wang JH et al. | HDAC inhibitors, trichostatin A and valproic acid, increase E‑cadherin and vimentin expression but inhibit migration and invasion of cholangiocarcinoma cells. | 2018 | Oncol. Rep. | pmid:29767267 |
| Shi Y et al. | Histone deacetylase inhibitors alter the expression of molecular markers in breast cancer cells via microRNAs. | 2018 | Int. J. Mol. Med. | pmid:29620153 |
| Jang BG et al. | Trichostatin A and Sirtinol Regulate the Expression and Nucleocytoplasmic Shuttling of Histone Deacetylases in All-Trans Retinoic Acid-Induced Differentiation of Neuroblastoma Cells. | 2018 | J. Mol. Neurosci. | pmid:29516351 |
| Zhang X et al. | Tyrphostin B42 attenuates trichostatin A-mediated resistance in pancreatic cancer cells by antagonizing IL-6/JAK2/STAT3 signaling. | 2018 | Oncol. Rep. | pmid:29393444 |
| Cai MH et al. | Depletion of HDAC1, 7 and 8 by Histone Deacetylase Inhibition Confers Elimination of Pancreatic Cancer Stem Cells in Combination with Gemcitabine. | 2018 | Sci Rep | pmid:29374219 |
| Gao L et al. | Histone deacetylase inhibitor trichostatin A and autophagy inhibitor chloroquine synergistically exert anti-tumor activity in H-ras transformed breast epithelial cells. | 2018 | Mol Med Rep | pmid:29344672 |
| Tiffon C | Histone Deacetylase Inhibition Restores Expression of Hypoxia-Inducible Protein NDRG1 in Pancreatic Cancer. | 2018 | Pancreas | pmid:29303911 |
| Bodas M et al. | Inhibition of histone-deacetylase activity rescues inflammatory cystic fibrosis lung disease by modulating innate and adaptive immune responses. | 2018 | Respir. Res. | pmid:29301535 |
| Seo SK et al. | Trichostatin A Induces NAG-1 Expression and Apoptosis in Human Endometriotic Stromal Cells. | 2018 | Reprod Sci | pmid:29157123 |
| Kalaiarasi A et al. | Copper oxide nanoparticles induce anticancer activity in A549 lung cancer cells by inhibition of histone deacetylase. | 2018 | Biotechnol. Lett. | pmid:29116558 |
| Lillico R et al. | Increased Post-Translational Lysine Acetylation of Myelin Basic Protein Is Associated with Peak Neurological Disability in a Mouse Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis. | 2018 | J. Proteome Res. | pmid:29111742 |
| Dalla Pozza E et al. | Trichostatin A alters cytoskeleton and energy metabolism of pancreatic adenocarcinoma cells: An in depth proteomic study. | 2018 | J. Cell. Biochem. | pmid:29095525 |
| Xing M et al. | Histone deacetylase inhibitor stimulates E2 and P4 secretion in sika deer ovarian granulosa cells at a moderate dose. | 2018 | Cell Biol. Int. | pmid:29064603 |
| Zhang C et al. | An epigenetic bioactive composite scaffold with well-aligned nanofibers for functional tendon tissue engineering. | 2018 | Acta Biomater | pmid:28963019 |
| Chan ST et al. | Quercetin enhances the antitumor effect of trichostatin A and suppresses muscle wasting in tumor-bearing mice. | 2018 | Food Funct | pmid:29292417 |
| Jayaraman A et al. | Amelioration of progressive autoimmune encephalomyelitis by epigenetic regulation involves selective repression of mature neutrophils during the preclinical phase. | 2018 | Exp. Neurol. | pmid:29453977 |
| Wu Y et al. | Regulatory Roles of Histone Deacetylases 1 and 2 in Pb-induced Neurotoxicity. | 2018 | Toxicol. Sci. | pmid:29301062 |
| Lu Y and Zhang K | Cellular Reprogramming in the Retina - Seeing the Light. | 2018 | N. Engl. J. Med. | pmid:29539280 |
| Sun P et al. | Effect of trichostatin A on Burkitt's lymphoma cells: Inhibition of EPS8 activity through Phospho-Erk1/2 pathway. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29462617 |
| Motawi TK et al. | Combinatorial strategy of epigenetic and hormonal therapies: A novel promising approach for treating advanced prostate cancer. | 2018 | Life Sci. | pmid:29455003 |
| Gurgul A et al. | Evaluation of changes arising in the pig mesenchymal stromal cells transcriptome following cryopreservation and Trichostatin A treatment. | 2018 | PLoS ONE | pmid:29390033 |
| Wood M et al. | Trichostatin A inhibits deacetylation of histone H3 and p53 by SIRT6. | 2018 | Arch. Biochem. Biophys. | pmid:29233643 |
| Buishand FO et al. | Trichostatin A preferentially reverses the upregulation of gene-expression levels induced by gain of chromosome 7 in colorectal cancer cell lines. | 2018 | Genes Chromosomes Cancer | pmid:28940826 |
| Azuma R et al. | Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer. | 2018 | J Vis Exp | pmid:29757287 |
| Palazzese L et al. | Nuclear quiescence and histone hyper-acetylation jointly improve protamine-mediated nuclear remodeling in sheep fibroblasts. | 2018 | PLoS ONE | pmid:29543876 |
| Shinde V et al. | Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Tox and STOP-Tox tests. | 2017 | Arch. Toxicol. | pmid:27188386 |
| Choiniere J et al. | Pyruvate Dehydrogenase Kinase 4 Deficiency Results in Expedited Cellular Proliferation through E2F1-Mediated Increase of Cyclins. | 2017 | Mol. Pharmacol. | pmid:28003426 |
| Porter NJ et al. | Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors. | 2017 | Proc. Natl. Acad. Sci. U.S.A. | pmid:29203661 |
| Bagheri-Hosseinabadi Z et al. | Differentiation of human adipose-derived stem cells into cardiomyocyte-like cells in fibrin scaffold by a histone deacetylase inhibitor. | 2017 | Biomed Eng Online | pmid:29169361 |
| Lam YM et al. | Histone deacetylase inhibitors induce leukemia gene expression in cord blood hematopoietic stem cells expanded ex vivo. | 2017 | Int. J. Hematol. | pmid:27531147 |
| Campo VA | Comparative effects of histone deacetylases inhibitors and resveratrol on Trypanosoma cruzi replication, differentiation, infectivity and gene expression. | 2017 | Int J Parasitol Drugs Drug Resist | pmid:28038431 |
| Alqinyah M et al. | Regulator of G Protein Signaling 10 (Rgs10) Expression Is Transcriptionally Silenced in Activated Microglia by Histone Deacetylase Activity. | 2017 | Mol. Pharmacol. | pmid:28031332 |
| Mazzio EA and Soliman KF | HTP Nutraceutical Screening for Histone Deacetylase Inhibitors and Effects of HDACis on Tumor-suppressing miRNAs by Trichostatin A and Grapeseed (Vitis vinifera) in HeLa cells. | 2017 | Cancer Genomics Proteomics | pmid:28031235 |
| Duan H et al. | The effect of histone deacetylase inhibition on the expression of P-glycoprotein in human placental trophoblast cell lines. | 2017 | Placenta | pmid:28012453 |
| Wittayarat M et al. | Epigenetic modulation on cat-cow interspecies somatic cell nuclear transfer embryos by treatment with trichostatin A. | 2017 | Anim. Sci. J. | pmid:27506538 |
| Zapletal O et al. | Butyrate alters expression of cytochrome P450 1A1 and metabolism of benzo[a]pyrene via its histone deacetylase activity in colon epithelial cell models. | 2017 | Arch. Toxicol. | pmid:27830268 |
| Guo Y et al. | Trichostatin A attenuates oxidative stress-mediated myocardial injury through the FoxO3a signaling pathway. | 2017 | Int. J. Mol. Med. | pmid:28849190 |
| Tao LL et al. | TSA increases C/EBP‑α expression by increasing its lysine acetylation in hepatic stellate cells. | 2017 | Mol Med Rep | pmid:28849174 |
| Kudo K et al. | Biosynthetic Origin of the Hydroxamic Acid Moiety of Trichostatin A: Identification of Unprecedented Enzymatic Machinery Involved in Hydroxylamine Transfer. | 2017 | J. Am. Chem. Soc. | pmid:28497964 |
| Lin W et al. | Klotho restoration via acetylation of Peroxisome Proliferation-Activated Receptor γ reduces the progression of chronic kidney disease. | 2017 | Kidney Int. | pmid:28416226 |
| Zhang XF et al. | Novel biomolecule lycopene-reduced graphene oxide-silver nanoparticle enhances apoptotic potential of trichostatin A in human ovarian cancer cells (SKOV3). | 2017 | Int J Nanomedicine | pmid:29075115 |
| Hichino A et al. | Down-regulation of Claudin-2 Expression and Proliferation by Epigenetic Inhibitors in Human Lung Adenocarcinoma A549 Cells. | 2017 | J. Biol. Chem. | pmid:28057758 |