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Histone deacetylase inhibitors induce apoptosis in peripheral blood lymphocytes along with histone H4 acetylation and the expression of the linker histone variant, H1 degrees. |
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Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis. |
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Biol. Chem. |
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2000 Mar-Apr |
Anticancer Res. |
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Oncogenic ras mediates apoptosis in response to protein kinase C inhibition through the generation of reactive oxygen species. |
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Genetic reprogramming in pathways of colonic cell maturation induced by short chain fatty acids: comparison with trichostatin A, sulindac, and curcumin and implications for chemoprevention of colon cancer. |
2000 |
Cancer Res. |
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Modulating IGFBP-3 expression by trichostatin A: potential therapeutic role in the treatment of hepatocellular carcinoma. |
2000 |
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Molecular mechanism for silencing virally transduced genes involves histone deacetylation and chromatin condensation. |
2000 |
Proc. Natl. Acad. Sci. U.S.A. |
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p300 collaborates with Sp1 and Sp3 in p21(waf1/cip1) promoter activation induced by histone deacetylase inhibitor. |
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Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors. |
2000 |
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Trichostatin A modulates expression of p21waf1/cip1, Bcl-xL, ID1, ID2, ID3, CRAB2, GATA-2, hsp86 and TFIID/TAFII31 mRNA in human lung adenocarcinoma cells. |
2000 |
Biol. Chem. |
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Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor. |
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Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF. |
2000 |
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Huang X et al. |
Nitric oxide (NO), methylation and TIMP-1 expression in BL6 melanoma cells transfected with MHC class I genes. |
2000 |
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Histone deacetylase inhibitor but not arsenic trioxide differentiates acute promyelocytic leukaemia cells with t(11;17) in combination with all-trans retinoic acid. |
2000 |
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Cell signaling switches HOX-PBX complexes from repressors to activators of transcription mediated by histone deacetylases and histone acetyltransferases. |
2000 |
Mol. Cell. Biol. |
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Diamond SE and Gutierrez-Hartmann A |
The Pit-1beta domain dictates active repression and alteration of histone acetylation of the proximal prolactin promoter. |
2000 |
J. Biol. Chem. |
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Chang LK and Liu ST |
Activation of the BRLF1 promoter and lytic cycle of Epstein-Barr virus by histone acetylation. |
2000 |
Nucleic Acids Res. |
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Modulation of complement component (C3 and factor B) biosynthesis by a histone deacetylase inhibitor in human intestinal epithelial cells. |
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Int. J. Mol. Med. |
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p53 promotes selection for Fas-mediated apoptotic resistance. |
2000 |
Cancer Res. |
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The super anti-apoptotic factor Bcl-xFNK constructed by disturbing intramolecular polar interactions in rat Bcl-xL. |
2000 |
J. Biol. Chem. |
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Histone deacetylation is involved in the transcriptional repression of hTERT in normal human cells. |
2000 |
J. Biol. Chem. |
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Receptor-interacting protein 140 directly recruits histone deacetylases for gene silencing. |
2000 |
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Long-term hydroxytamoxifen treatment of an MCF-7-derived breast cancer cell line irreversibly inhibits the expression of estrogenic genes through chromatin remodeling. |
2000 |
Cancer Res. |
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Butyrate and trichostatin A effects on the proliferation/differentiation of human intestinal epithelial cells: induction of cyclin D3 and p21 expression. |
2000 |
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Inhibition of mitogenesis in Balb/c-3T3 cells by Trichostatin A. Multiple alterations in the induction and activation of cyclin-cyclin-dependent kinase complexes. |
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Rapid induction of histone hyperacetylation and cellular differentiation in human breast tumor cell lines following degradation of histone deacetylase-1. |
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Histone acetylation is a checkpoint in FGF-stimulated mesoderm induction. |
2000 |
Dev. Dyn. |
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IGF-II and IL-2 act synergistically to alter HDAC1 expression following treatments with trichostatin a. |
2000 |
Cytokine |
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A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library. |
2000 |
Cancer Res. |
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Unique anti-activator protein-1 activity of retinoic acid receptor beta. |
2000 |
Cancer Res. |
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Human Slug is a repressor that localizes to sites of active transcription. |
2000 |
Mol. Cell. Biol. |
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Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation. |
2000 |
Proc. Natl. Acad. Sci. U.S.A. |
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Claassen GF and Hann SR |
A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta -induced cell-cycle arrest. |
2000 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:10920185
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Mao C and Shapiro DJ |
A histone deacetylase inhibitor potentiates estrogen receptor activation of a stably integrated vitellogenin promoter in HepG2 cells. |
2000 |
Endocrinology |
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Phosphoacetylation of histone H3 on c-fos- and c-jun-associated nucleosomes upon gene activation. |
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EMBO J. |
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Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases. |
2000 |
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Transcriptional repression by blimp-1 (PRDI-BF1) involves recruitment of histone deacetylase. |
2000 |
Mol. Cell. Biol. |
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Adachi N et al. |
Cell-cycle regulation of the DNA topoisomerase IIalpha promoter is mediated by proximal CCAAT boxes: possible involvement of acetylation. |
2000 |
Gene |
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Mechanism for inactivation of the KIP family cyclin-dependent kinase inhibitor genes in gastric cancer cells. |
2000 |
Cancer Res. |
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BRG-1 is recruited to estrogen-responsive promoters and cooperates with factors involved in histone acetylation. |
2000 |
Mol. Cell. Biol. |
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Allele-specific histone acetylation accompanies genomic imprinting of the insulin-like growth factor II receptor gene. |
2000 |
Endocrinology |
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Eickhoff B et al. |
Trichostatin A-mediated regulation of gene expression and protein kinase activities: reprogramming tumor cells for ribotoxic stress-induced apoptosis. |
2000 |
Biol. Chem. |
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Transcriptional activation of estrogen receptor alpha in human breast cancer cells by histone deacetylase inhibition. |
2000 |
Cancer Res. |
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Epigenetic regulation of androgen receptor gene expression in human prostate cancers. |
2000 |
Lab. Invest. |
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Butyrate upregulates stromelysin-1 production by intestinal mesenchymal cells. |
2000 |
Am. J. Physiol. Gastrointest. Liver Physiol. |
pmid:11052988
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Tobias CA et al. |
Improved recombinant retroviral titers utilizing trichostatin A. |
2000 |
BioTechniques |
pmid:11056820
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